Corporate Banner
Satellite Banner
Cell Culture
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Key Role of a Protein in the Segregation of Genetic Material During Cell Division

Published: Wednesday, December 11, 2013
Last Updated: Wednesday, December 11, 2013
Bookmark and Share
Researchers at IDIBELL have reported an article which delves into the regulator mechanisms of mitosis.

Cell-cycle

Cells in all organisms grow and divide into two daughter cells by an ordered sequence of events called "cell cycle". Basically , the cells have to complete four main processes during the cell cycle : growth ( G1 and G2 phases ) , doubling the DNA ( S phase ) , segregate chromosomes ( M phase , mitosis) and divide ( cytokinesis ).

In the S phase , or replication of DNA, the genetic material doubles and then, during the M phase or mitosis, the cells separate the duplicated chromosomes into the two daughter cells. In this way the correct inheritance of genetic information from one generation of cells to the next is assured. The transmission of genetic information (DNA ) from parent to child (or equivalently , from cell to cell ) is a fundamental question in biology.

Aneuploidy , ie lack or excess of chromosomes, is a feature present in almost all human cancers and promotes tumor development . The regulation of mitosis is particularly important to maintain chromosome stability : for example , the aneuploid tumor cells arise as a consequence of defects in chromosome segregation , which originate in cells with varying normal genetic material . However, despite its importance , little is known of the regulation of mitotic exit.

The Hippo tumor suppressor pathway

The article published in the journal Plos Genetics decribes the latest advances in the mechanisms of regulation of mitotic exit . The protein called ' separase " is a key component for proper chromosome segregation and the regulation of mitosis. In previous work Queralt group first described the involvement of protein phosphatase PP2A in mitosis. These proteins cooperate with 'separase' to ensure correct genetic inheritance between cells.

" In this study," explained Queralt " we have delved into the molecular mechanism by which this protein PP2A regulates mitosis and contributes to the correct segregation of chromosomes by identifying two new substrates , two components of the route Hippo tumor suppressor - ".

As explained by the researcher " in recent times are very powerful publishing studies on the use of this pathway as a therapeutic target in cancer. However, in my opinion , before that, we should better understand their molecular mechanisms. " In that sense it said that " this work contributes to advancing knowledge of Hippo tumor suppressor pathway on the regulation of mitosis. And the application of such basic knowledge will help develop more specific and direct against different types of cancer treatments.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,400+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
‘Mini-Brains’ to Study Zika
Novel tool expected to speed research on brain and drug development.
Cytokine Triggers Immune Response at Expense of Blood Renewal
Research highlights promise of Anti-IL-1 drugs to treat chronic inflammatory disease.
Micro Heart Muscle Created from Stem Cells
Researchers have designed a new way to create micro heart muscle from stem cells using a unique dog bone dish.
“Secret Sauce” for Personalized, Functional Insulin-producing Cells
Researchers uncover molecular switch to make effective sugar-responsive, insulin-releasing cells in a dish, offering hope for diabetes therapy.
Insights into Early Human Embryo Development
Researchers at Karolinska Institutet and the Ludwig Cancer Research in Stockholm have conducted a detailed molecular analysis of the embryo’s first week of development.
Boosting Gene Transfer Capabilities
A new and highly efficient method for gene transfer has been developed.
Liver-On-Chip Tracks Dynamics of Cellular Function
Hebrew University’s liver-on-chip platform is uniquely able to monitor metabolic changes indicating mitochondrial damage occurring at drug concentrations previously regarded as safe.
EU Project Aims to Cure Type 1 Diabetes
Researchers develop organoids from insulin-producing cells for transplantation.
Hope for Combating Muscular Dystrophy
Decoding a sugar molecule and identifying a mechanism linking it to MS could help in the development of therapy for the disease.
Decoding Sugar Molecules Offers New Key For Combating Muscular Dystrophy
Japanese scientists find a rare sugar unit called ribitol 5-phosphate within the sugar molecules on the surface of muscle cells. Mutations in 3 genes linked to muscular dystrophy affect the creation of this sugar molecule.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,400+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!