Corporate Banner
Satellite Banner
Cell Culture
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Phasefocus Announces the Availability of the VL Series of Live Cell Imaging Systems

Published: Wednesday, February 05, 2014
Last Updated: Wednesday, February 05, 2014
Bookmark and Share
A family of phase microscopy systems for live cell imaging.

Phase Focus Ltd has announced a family of innovative phase microscopy systems for live cell imaging using the Phasefocus Virtual Lens®.

The Virtual Lens, VL, acquisition and processing engine uses a technique known as ptychography, to provide quantitative, high contrast, label-free images of cells for long term time-lapse studies.

The use of fluorescent probes is commonplace for labelling fixed specimens. However, when used in living cells, these can be toxic and ultimately perturb the natural cell function. The use of laser illumination can also be phototoxic to cells.

The Phasefocus VL20 upright and VL21 inverted live cell imaging systems use very low power laser illumination thereby enabling long term time-lapse cell imaging, including multi-area time-lapse, to produce high contrast quantitative image information.

In addition to this, the quantitative nature of the phase information means that data such as cell thickness, cell volume, and cell motility can be measured on a familiar and easy-to-use system for the study of both individual cells and cell populations.

The Virtual Lens is based on technology developed at the University of Sheffield by Professor John Rodenburg. It provides an iterative solution of the diffraction pattern phase problem and is applicable to visible light imaging, X-ray imaging and atomic resolution electron imaging.

Phasefocus has applied the technology to develop and install two systems at the University of York in the Department of Biology as one of many technology-leading techniques in the Imaging and Cytometry group managed by Dr Peter O'Toole.

Dr O'Toole describes ptychography as "one of the most important breakthroughs in imaging. It addresses many of the fundamental problems inherent in current microscopy techniques. Put simply, what you get is more than what you see! Artefacts of sample preparation which may arise from labelling or use of markers are negated. I have been most impressed by Phasefocus and their ability to quickly respond to feedback and then to develop products to meet the needs of the user."

In conjunction with the development of the Virtual Lens, Phasefocus is supporting a KTP Associate at York, - Dr Rakesh Suman - who works in Dr O'Toole's group tutoring members of the department in the use of the technique for the study of many different sample types including cancer and stem cells and applications relating to immunology and neurology.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Mitochondria Shown to Trigger Cell Ageing
An international team of scientists has for the first time shown that mitochondria, the batteries of the cells, are essential for ageing.
Cancer Cells Kill Off Healthy Neighbours
Cancer cells create space to grow by killing off surrounding healthy cells, according to UK researchers working with fruit flies.
Editing of Embryos Approved in the UK
The Human Fertilisation and Embryology Authority (HFEA) has approved a research application from the Francis Crick Institute to use new "gene editing" techniques on human embryos.
Microbes Take Their Vitamins
Scientists exploit organisms' needs in order to track 'vitamin mimics' in bacteria.
Machine Learning Uncovers Unknown Bacterial Features
Technique robustly identified characteristic gene expression patterns in response to antibiotics, low oxygen conditions.
CRISPR-Cas9 Gene Editing Advances Again
UC Berkeley researchers have made a major improvement in CRISPR-Cas9 technology that achieves an unprecedented success rate of 60 percent when replacing a short stretch of DNA with another.
Disrupting Cell’s Supply Chain Freezes Cancer Virus
When the cancer-causing Epstein-Barr virus moves into a B-cell of the human immune system, it tricks the cell into rapidly making more copies of itself, each of which will carry the virus.
Why Do Some Infections Persist?
In preparing for the possibility of an antibiotic onslaught, some bacterial cultures adopt an all-for-one/one-for-all strategy that would make a socialist proud, University of Vermont researchers have found.
ASCB: A CELLebration of Cell Biology
The last major congress of the year, ASCB is less a platform for launching new products, but one for confirming and consolidating the trends that have emerged over the past 12 months.
Squeezing Cells into Stem Cells
EPFL scientists have developed a new method that helps cells turn in usable stem cells. The new approach involves “squeezing” cells with a gel, and paves the way for large-scale production of stem cells for medical purposes.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!