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High Titre BacMam viruses improve transduction efficiency of mammalian cells
Robert Possee, Elisabetta Locanto, Adam Chambers, Linda King

We present a method for producing high titre BacMam virus vectors for the efficient transduction of mammalian cells.

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Identification and Characterisation of Novel Positive Allosteric Modulators of the Galanin 2 Receptor
Hayley Jones

An HTS against GalR2 was carried out to find novel PAMs to treat neuropathic pain.

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The Longest Way Round is the Shortest Way Home: HTS Assay Development for Complex Multi-domain Protein Kinases
Doris Hafenbrandl, Vanessa Nardese, Maria Cristina Sidoli, Valeria Wanke, Mariantonietta Rubino and Daniele Carettoni

This study strongly supports the possibility to overcome the major bottlenecks in the production of long kinase recombinant forms, in order to perform drug discovery programmes with proteins more closely preserving the structural and functional properties of the native enzymes.

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Automated Fluorescence Detection and Imaging of RNA Species in Live Cells
Paul Held, Victor Koong, Don Weldon, Peter Banks

This poster describes the detection and quantification of RNA species in Live cells through automated imaging.

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Validation of a Novel Tumoroid-Based Cell Culture Model to Perform 3D in vitro Cell Signaling Analyses
Brad Larson 1, Grant Cameron 2, Nicolas Pierre 3, and Peter Banks 1

Here we demonstrate an in vitro HTRF® microplate assay that can quantify total, as well as phosphorylated elF4E.

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Validation of a 3-Dimensional Human Liver Microtissue Model for Long-term Hepatotoxicity Studies
Brad Larson1, Stewart Hunt2, Timothy Moeller3, Diana Long4, and Peter Banks1

Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of drug commonly used as analgesics and antipyretics, as well as for management of rheumatological disorders. They are one of the most highly prescribed drug families around the world, and consequently, along with antimicrobial agents, are the most frequent causes of druginduced liver injury (DILI) (Bjornsson et al., 2010).

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Liposomes and Nanoparticles as Delivery Vehicles for the Treatment of Lung Diseases
Raisa Kiseleva1, Jennifer Mulligan2, Carl Atkinson2, Rodney Schlossser2, Alexey Vertegel1

Targeted nanoparticle-based drug delivery to the lungs is an emerging area of interest for both scientists and medical workers because it allows better drug retention in the lungs and can provide prolonged drug release. In our study we investigated the potential of using liposomes and polymeric nanoparticles surface modified with a specific antibody as drug carriers for targeted drug delivery to the lungs.

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Side by Side: An Evaluation of 2D vs. 3D Cell Culture for High Throughput Screening in Drug Discovery
Sophie Quick 1,2, Sinead Knight 1, Jon Winter 3

•3D cell culture has the potential to provide a more physiologically relevant model compared to standard tissue culture plastic.
•From a screening perspective the technology offers the possibility of more predictive drug responses but has an increased cost.
•The question: is it possible and, more importantly, is it worthwhile moving towards screening in High Throughput using a 3D model?

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Progressing 3D Spheroid Analysis into a HTS Drug Discovery Method
Sarah Kessel, Eric Sincoff, Olivier Dery, Lori Fitton

3D Tumorspheroid models for improved predictivity in cancer drug discovery.

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Gut Microbial Metabolites and Hepatic Xenobiotic Metabolism: A High Throughput Screening Approach
Glynn Martin, James Sidaway, Jonathan Swann

This poster highlights the combination of metabonomics and high throughput screening by the identification of gut microbial metabolites and a screening assay designed to determine their cytotoxicity to liver-like cell cultures.

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Showing Results 1 - 10 of 33
Scientific News
Lab-developed Intestinal Organoids form Mature Human Tissue in Mice
Study produces unprecedented model to study intestinal diseases.
Culture System Replicates Course Of Alzheimer’s Disease
Three-dimensional system should significantly reduce time and costs of drug development.
Researchers Describe New Method for Cell Line Authentication
SNP profiling, an effective method to detect misidentification, contamination, and chromosomal abnormalities in mouse cell lines.
Giant Leap Against Diabetes
Ability to produce embryonic stem cells will allow researchers to push faster toward cure.
Vital New Insight into How we Produce New Brain Cells
Researchers have identified a key mechanism in the birth of new brain cells, with implications for treating brain injury and diseases.
How Fluid Flow Influences Neuron Growth
A University of Texas at Arlington team exploring how neuron growth can be controlled in the lab and, possibly, in the human body has published a new paper in Nature Scientific Reports on how fluid flow could play a significant role.
A New Molecule Allows for an Increase in Stem Cell Transplants
A clinical study using UM171 and a new type of bioreactor developed for stem culture will be initiated in December 2014.
Scientists Discover Neurochemical Imbalance in Schizophrenia
Researchers discovers that neurons from schizophrenia patients secrete higher amounts of three neurotransmitters.
Diabetes Researchers Find Faster Way to Create Insulin-producing Cells
A new protocol can turn stem cells into reliable, insulin-producing cells in about six weeks.
New Defence Mechanism Against Viruses Discovered
Mechanism may represent one of the oldest defence mechanisms against viruses in evolutionary history.
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