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Webcasts
Rapid and Sensitive Identification of Host Cell Proteins with SWATH® LC-MS AcquisitionRapid and Sensitive Identification of Host Cell Proteins with SWATH® LC-MS Acquisition
Join Eric Johansen PhD, Senior Scientist at Stemcentrx, to learn how to dramatically increase the speed of acquisition of HCP data.
How to optimize sample preparation step prior to extractionHow to optimize sample preparation step prior to extraction
In this free to attend On Demand webcast presented by Stephane Karoubi, Product Manager, and Sophie Dubacq, Application Engineer, from Bertin Technologies.

Market Reports
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Scientific News
Structure of Essential Digestive Enzyme Uncovered
Using a powerful combination of techniques from biophysics to mathematics, researchers have revealed new insights into the mechanism of a liver enzyme that is critical for human health.
Why do Tomatoes Smell "Grassy"?
Researchers identify enzymes that convert the grassy smell of tomatoes into a sweeter scent.
Plasma Biomarkers for Breast Cancer Diagnosis
Plasma lipidomics profiling identified lipid biomarkers in distinguishing early-stage breast cancer from benign lesions.
A Mechanistic Tool for Studying Fungal Pathogens
This study presents an overview of lipid extraction, chromatographic separation and mass spectrometry employed in qualitative and quantitative sphingolipidomics in fungi.
Newborn Screening Test Developed For Rare, Deadly Neurological Disorder
Scientists have developed a new dried blood spot screening test for Niemann-Pick type C, with goal to speed diagnosis and treatment.
Grant to Fund Million Peaks Project
The European Research Council (ERC) has awarded a prestigious Advanced Grant to Prof. Peter Schoenmakers, Prof. Albert Polman and Prof. Huib Bakker, all three of whom work at the University of Amsterdam (UvA).
Altered Metabolism of Four Compounds Drives Glioblastoma Growth
Findings suggest new ways to treat the malignancy, slow its progression and reveal its extent more precisely.
Why Bearcats Smell Like Buttered Popcorn
Researchers pinpoint chemical compound that gives rare animal its popcorn-like scent.
Human Gut Microbiome Evolution
Westerners have a less-diverse gut microbiome compared to hunter-gatherers, but how and why these microbe collections diverged has largely remained a mystery.
Potential Diagnostic for Dengue Fever
Scientists from Colorado State University have explored the use of small molecules in patient serum for diagnosis of dengue fever and potentially predicting progression to the severe disease.
Business News
Grace to Focus on Pharma, Nutraceutical Business
W. R. Grace & Co. has affirmed its commitment to three growing service lines for the pharmaceutical and nutraceutical industries, and announced agreements to sell product lines associated with its chromatography instruments, columns, and related laboratory products.
Thermo Extends Collaboration with University of Birmingham
New Phenome Centre Birmingham, UK to use Thermo Scientific mass spectrometry instruments to advance metabolic phenotyping and metabolomics studies.
Bruker Reports First Quarter 2016 Financial Results
Bruker Corporation reported financial results for its first quarter ended March 31, 2016.
JSR Establishes Life Sciences Division
The company is leveraging its material and polymer expertise to expand into the life sciences industry in the two major industry categories of bioprocessing and diagnostic and research products.
SCIEX, QPS Holdings Collaborate
Agreement aims to advance the hybrid LBA-LCMS workflow for biologics quantification.
Trajan Acquires LEAP Technologies
Bringing LEAP into the Trajan Group will complement the widening capability of Trajan.
Repligen Acquires Atoll
Acquisition expands Repligen’s pre-packed column chromatography portfolio into high throughput process development screening.
Scion Announces Appointment of US General Manager
Scion Instruments has appointed Julian Phillips as the new General Manager for Scion Instruments in the United States.
Techcomp Appoints New CEO to Lead Scion Instruments
Paul Gillyon has been appointed as Chief Executive Officer of Scion Instruments.
Metrohm USA Extends Young Chemist Award to Honor Top 5 Submissions
The Young Chemist Award is open to all graduate, post-graduate and doctorate students residing and studying in the U.S. and Canada, who are performing novel research in the fields of titration, ion chromatography, spectroscopy and electrochemistry.

Events
40th International Symposium o
29 May 2016
40th International Symposium o ...
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HPLC 2016
19 Jun 2016
HPLC 2016 ...
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CMC Strategy Forum: Drug Produ
18 Jul 2016
CMC Strategy Forum: Drug Produ ...
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Food & Beverage Analysis
19 Aug 2016
Food & Beverage Analysis ...
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ePosters
A Unified Software Platform for Laboratory Informatics
Advanced Chemistry Development, Inc. (ACD/Labs), Toronto, Canada.

Reported here are capabilities in automated workflows involving analytical data with chemical structures. Specifically described is automated homogenization of data from a set of instruments, including NMR structure verification, as one solution.
Analysis of Terpenes Using Gas Chromatography with Vacuum Ultraviolet
The University of Texas at Arlington and VUV Analytics

The VUV absorption spectra for different terpenes were distinctive and differentiable. GC-VUV demonstrated the capabilities for qualitative and quantitative analysis of terpenes in turpertine mixtures. Chromatographic coeluting signals can be deconvolved by the VUV data analysis software.

Determination of C2-C12 Aldehydes in Water by SPME Arrow On-Fiber Derivatization and GC/MS
1 BGB Analytik AG, Lettenstrasse 97, 8134 Adliswil, Switzerland; 2 CTC Analytics AG, Industriestrasse 20, 4222 Zwingen, Switzerland

A method applying SPME Arrow extraction and on-fiber derivatization for the quantitation of C2-C12 aldehydes in water by GC/MS is described.
Assessing Diversity in Cassava through the Application of Metabolomics
aSchool of Biological Sciences, Royal Holloway University of London, Egham, UK bInternational Center for Tropical Agriculture, CIAT

In the present study metabolomic platforms have been established for Cassava and used to assess the biodiversity present in Cassava germplasm collections and elucidate underlying biochemical mechanisms associated with traits of interest.
PredRet: Prediction of Retention Time by Direct Mapping between Multiple Chromatographic Systems
Department of Food Quality and Nutrition, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all’Adige (TN), Italy.; Department of Stress and Developmental Biology, Leibniz Institute

Retention time (RT) information is under-utilized in LC-MS based metabolomics and sharing of RTs between systems is not currently possible. PredRet is a new system that allows highly accurate mapping and prediction of RTs between LC systems.
Minimizing Carry-over for High Throughput Analysis
1FHNW Fachhochschule Nordwestschweiz, Hochschule für Life Sciences Gründenstrasse 40 CH-4132 Muttenz; 2CTC Analytics AG Industriestrasse 20 CH-4222 Zwingen; Switzerland

Minimal carry-over is a prerequisite for high throughput analysis. However, minimized carry-over and cycle time are competing and a careful optimization is mandatory. In this study the influence of wash conditions on carry-over of various compounds was investigated. A strategy to minimize carry-over was developed. The influences of different wash tasks were investigated. Finally the contribution of different system components such as injector valve or column was studied.
A Comparison of ITEX Dynamic Headspace–GC/MS to other Enrichment Techniques for Analysis of Flavoring Compounds
1Aspen Research Corporation, Maple Grove, MN; 2CTC Analytics, Zwingen, Switzerland

Enrichment techniques are commonly used for the analysis of flavoring compounds in different matrices with GC/MS. Analysis of flavoring compounds is done by purge & trap, SPME or headspace, depending on requirements for sensitivity. The In-Tube Ex¬traction (ITEX) Dynamic Headspace uses a micro trap filled with an adsorbent material to efficiently extract the compounds. Here we evaluate if the ITEX can be used to effectively analyze for these compounds and reduce the analyst’s time involved.
Optimization of a Vacuum Ultraviolet Photoionization source for Gas Chromatography used with a High Resolution Time of Flight Mass Spectrometer
LECO Corporation

-Tune solution allows optimization of ion source parameters for
both proton transfer and direct ionization
-Independent ionization processes exist for M+ and MH+
-Optimizing for dopant signal intensity yields inferior results
-Degree of fragmentation remains relatively constant over a
range of source conditions
High Performance Comprehensive Two-Dimensional Gas Chromatography Coupled with a High Resolution Multi-Reflecting TOFMS for Confident Non-Target Analyte Identification
LECO Corporation, Restek Corporation

The use of comprehensive two-dimensional gas chromatography to help increase chromatographic resolution is a major step in tackling the problem of confident peak identification in a complex sample matrix. Combining the separation power of two-dimensional gas chromatography, with resolving power greater than 25,000, and sub ppm mass accuracies of a high resolution multi-reflecting TOFMS is the ideal solution to confident compound identification within a complex sample matrix.
Fragmentation Trees for Automated de novo Interpretation of Impure Electron Ionization Spectra from Gas Chromatographic Complex Mixture Analysis—Chemical Deconvolution
LECO Corporation, Mass Spectrometry Consulting Ltd., Moscow State University

-Chemical deconvolution algorithms accurately reported independent
components of dead coelutions where such components belong to distinct chemical classes.
-Present algorithms fail to distinguish chemically similar analytes such as branched and linear alkanes, thus chemical deconvolution is not a
substitute for GCxGC.
-Chemical deconvolution algorithms accurately rejected more than 80% of spurious signals from manually curated spectra found to be contaminated with unrelated signa
Application Notes
Characterization of Protein-Protein Interactions using Triple Detection Size Exclusion Chromatography (SEC-TD)
Malvern Instruments Limited

In this application note, triple detection size exclusion chromatography (SEC-TD) is used to understand the ability of proteins to form ordered, structured complexes. The controlling mechanism behind these protein complexes is fundamental to our knowledge of protein signaling pathways and the physiological responses they control.
Characterization of IgG Monomers & Their Aggregates
Malvern Instruments Limited

A comparison between column calibration & multi-detection SEC.
Differentiation of Polymer Branching and Composition Using the Mark–Houwink Plot
Malvern Instruments Limited

In this application note, we will show, using polystyrene, how to separate the effects of a structural difference induced by a compositional change (bromination) and the structural change induced by polymer chain branching using the Mark- Houwink plot.
Automated Sample Preparation - Analysis of 25-OH-Vitamin D3 and 25-OH-Vitamin D2 by LC/MS/MS
Beckman Coulter Life Sciences


Automated Sample Preparation for the Monitoring of Pharmaceutical and Illicit Drugs by LC-MS/MS
Beckman Coulter Life Sciences


Automated Sample Preparation for the Monitoring of Ethanol Metabolites in Urine by LC-MS/MS
Beckman Coulter Life Sciences


Automating Protein Digestion for Reproducible Proteomics
Beckman Coulter Life Sciences


Use Of Microcalorimetry And Its Correlation With Size Exclusion Chromatography For Rapid Screening Of The Physical Stability Of Large Pharmaceutical Proteins In Solution
Malvern Instruments Limited


How to Maximize Absolute Molecular Weight Measurement Accuracy: Synthetic Polymers
Malvern Instruments Limited


Structural Elucidation of Dextrans and other Polysaccharides using OMNISEC Multi- Detection GPC
Malvern Instruments Limited

A series of dextran samples ranging in molecular weight from about 1– 650 kDa are characterized using OMNISEC. Structural comparisons to other polysaccharides, gum arabic and pectin are presented.
SELECTBIO

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