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Webcasts
Flow Chemistry from Milligrams to Metric TonsFlow Chemistry from Milligrams to Metric Tons
Scott May, Eli Lilly & Co, speaking at Flow Chemistry Congress 2014.
Advances in Volatile Analyses for Disease DiagnosisAdvances in Volatile Analyses for Disease Diagnosis
Norman Ratcliffe, University of the West of England, speaking at Advances in Biodetection & Biosensors 2014.

Market Reports
Analytical Instrument Market in the US 2014-2018
Infinity Research

TechNavio's report focuses on the US and has been prepared based on an in-depth market analysis with inputs from industry experts.
Chromatography Resin Market by Application, Techniques & Type - Trends & Forecast to 2018
MarketsandMarkets

The chromatography resin market is expected to grow at a decent pace during the coming decade driven by its increasing application in monoclonal antibody production and food analytics.
Chromatography Accessories and Consumables Market by Types, Technology & End-users - Trends & Global Forecasts to 2018
MarketsandMarkets

The chromatography accessories and consumables market demands significant investments in R&D in order to constantly come up with new and innovative products and technologies.
Food Diagnostics Systems Market, Consumables Market & By Geography - Global Trends & Forecast To 2018
MarketsandMarkets

The food diagnostics market size is projected to increase with rising concerns over food quality and safety, and the implementation of stringent regulations on food safety and foodborne illness prevention.
Chromatography Reagents Market By Type, Bed Shape, Mobile Phase, Separation Mechanism & End User - Global Forecasts to 2018
MarketsandMarkets

The market is expected to witness a high growth due to high demand of chromatography reagents in the growing pharmaceutical market.
Biomarkers
RI Technologies

This report on focuses on the different types of biomarkers and their impact on various disease areas. The study also provides global market analysis for biomarkers by disease area and by prominent biomarker identification technologies.
Life Science Consumables 2013: Markets and Opportunities
Biopharm Reports

Techniques such as PCR, DNA microarray, DNA sequencing, mass spectrometry and flow cytometry have grown significantly in the last decade and by 2015 markets for these five areas are expected to exceed $50 billion, globally. In these and related fields, consumables are generally the second or third largest area in cost terms, after instrumentation.
Mass Spectrometry 2013: A Focus on Sales Growth
Biopharm Reports

Mass Spectrometry 2013 presents the findings of a global market study of mass spectrometry, involving the participation of 567 buyers and end-users in this field. With a focus on market development, sales growth and commercial opportunities, the study profiled current and evolving areas of this market, as outlined below. Its findings provide valuable product and market information, and decision-making support to suppliers in the mass spectrometry field.
Mass-Spec Based Screening Assay Trends 2013
HTStec

This market report summarizes the results of HTStec's 1st industry-wide global web-based benchmarking survey on mass spectrometry (MS)-based screening assays carried out in February 2013.
Lab Instrument Rental Trends 2012
HTStec

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on lab instrument rental carried out in September 2012.
Scientific News
Assessing Anticancer Drugs Efficacy by Amino Acid Metabolomics
Researchers aimed to develop a method that determines the therapeutic efficacy of anticancer drugs based on the changes in amino acid metabolism at the cellular level.
Reimagining UHPLC
To learn more about the new Vanquish UHPLC system from Thermo Fisher Scientific we spoke to Wulff Niedner, Director of HPLC Product Marketing.
UHPLC: The Greening Face of Liquid Chromatography
Greening pathways for liquid chromatography is especially significant for drug analysis in the pharmaceutical matrix.
Evaluating Acute Hydrogen Sulfide Poisoning in Rats through Serum Metabolomics
Through the use of GC/MS-based metabolomics, researchers have evaluated the effect of acute hydrogen sulfide poisoning on the metabolic profiles of rats.
Separation of mAbs Molecular Variants by Analytical HIC-HPLC
HIC-HPLC is a less widely used analytical technique compared with standard methods for separating variants based on size, charge or electrophoretic mobility.
Simultaneous Determination of Free Urinary Steroids
Researchers have described an LC–MS/MS method that accurate, precise and is in accordance with FDA guidelines.
Moment Analysis of Chromatographic Behavior of Separation Media for Fast HPLC
Chromatographic behavior in RPLC using the C18-silica monolith and C18-core-shell particles was analyzed by the two equations from the kinetic points of view.
Human Proteome Project Uncovers 193 Proteins Not Known to Exist
The team of international researchers reports the identification of 193 novel proteins that came from regions of the genome not predicted to code for proteins.
Miniature Gas Chromatograph Could Aid Early Crop Disease Detection
About the size of a 9-volt battery, the technology’s portability could provide farmers with a tool to quickly evaluate the health of their crops.
Comparison of Pesticide Residues in Surface and Ground Water
Measurement of pesticide residues can be used as baseline levels to monitor the future changes and to predict their future impact on the population of the area.
Business News
Thermo to Sell Cole-Parmer for $480M
Company has signed a definitive agreement to sell its Cole-Parmer channel business to private equity firm GTCR, LLC for $480 million in cash.
Waters, Chinese Pharmacopeia Commission Establish Joint Open Laboratory
Located in the laboratory building of Beijing Zhendong Guangming Drug Research Institute, the new facility is over 400m2.
IROA Technologies, University of Florida Announce Biomarker Collaboration
Company will support the University of Florida in a collaborative search for biomarkers of liver cancer and other liver diseases.
Trajan Completes Integration of SGE Analytical Science
Completion of integration at all major operational centers in Australia, Europe, the US and Asia.
Agilent, Bruker Enter Chromatographic Data System Agreement
Instrument driver exchange enhances laboratory efficiency and flexibility.
ASMS 2014 Overview
We take a look at some of the major new product announcements from ASMS 2014.
Thermo Registers San Jose Facility with FDA
The site has established a quality system in accordance with the FDA Quality System Regulations to design and manufacture devices for analyzing samples from patients for in vitro diagnostic use.
Shimadzu, Indigo BioSystems Announce Partnership
The companies will leverage the power of ASCENT™ clinical solutions on ultra-fast mass spectrometry platforms.
Shimadzu Corporation, MacCoss Lab of Biological Mass Spectrometry, UW Collaborate
The companies will leverage the power of ASCENT™ clinical solutions on ultra-fast mass spectrometry platforms.
Waters, Prosolia Exclusive Agreement for DESI Technology for Clinical MS Applications
Prosolia DESI Technology now available on SYNAPT G2 Si and Xevo G2-XS QTof mass spectrometers.

Events
CMC Strategy Forum LATAM 2014
21 Aug 2014
CMC Strategy Forum LATAM 2014 ...
More information
Analytical Method Development,
09 Sep 2014
Analytical Method Development, ...
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International Bioanalytical Co
09 Sep 2014
International Bioanalytical Co ...
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Metabomeeting 2014
10 Sep 2014
Metabomeeting 2014 ...
More information

ePosters
Intact Protein LC-MS: How to Overcome the Challenges?
Thermo Fisher Scientific

Purpose: Facilitate intact protein LC-MS without compromising performance.
Methods: Construct prototypes of integrated column and sprayer dedicated for intact protein separations and compare performance.
Results: Three prototypes have been directly compared and all showed good protein separations, each with their unique area of strength.
Instant Connect Gas Sampling Valve Module Introducing a New Flexibility in Gas Sampling for GC and GCMS
Thermo Fisher Scientific

Purpose: We present a newly developed gas sampling valve module for the Thermo Scientific™ TRACE™ 1300 Series Gas Chromatograph (GC).
GC-MS/MS ANALYSIS OF BENZODIAZEPINES USING ANALYTE PROTECTANTS
Thermo Fisher Scientific

Purpose: Assess the feasibility of using analyte protectants to improve the analysis of benzodiazepines.

GC-MS/MS Analysis of Pesticide Residues in Green Tea Extracted by QuEChERS with Acetonitrile as Final Solvent
Thermo Fisher Scientific

This poster describes the analysis of several challenging pesticides from green tea samples using GC-MS/MS and acetonitrile as final extraction solvent. The compounds analysed are representatives of various classes of pesticides, such as carboxamids, OC, OP, pyrethriods, aromatic, phenylamides.
Exploring The Benefits Of Automated Unattended Sample Derivatization Prior To Gas Chromatography Analysis
Thermo Fisher Scientific

Purpose: Exploring the possibility to perform the sample preparation steps necessary for the derivatization of analytes in a fully automated and reliable way by means of the same robotic sampler used for sample injection into the gas chromatograph.
Methods: As an example of application we screened dairy products for melamine and its derivates presence via GC-MS/MS.
Results: The outcome are good and precise results that show how it is possible to reliably automate sample preparation opera
Determination of Veterinary Drug Residues in Milk by GC/MS and GC/ECD
Thermo Fisher Scientific

Purpose: Develop a rapid, sensitive method for determining amitraz and its metabolites in milk.
Methods: Samples were hydrolyzed in acidic condition and extracted with hexane. After derivativation, the samples were analyzed by GC-ECD or directly by GC-MS.
Results: The results show that GC-MS determination of amitraz and its metabolites is rapid and sensitive.
Automated, Rapid And Reliable Determination Of Dissolved Gases In Water By Static Headspace – Gas Chromatography
Thermo Fisher Scientific

Purpose: Exploring the possibility to perform a quantitative determination of dissolved gases in water in a reliable and accurate way. Methods: The quantification of dissolved gases is performed by building a calibration curve spiking blank water samples with increasing quantities of saturated water followed by headspace sampling and GC/ FID analysis. Results: The results show good correlation factors and limit of quantification lower than 10ppb for the four gas analyzed.
Characterization of Antibody-Drug Conjugates by SEC with Combined Light Scattering
Wyatt Technology Corporation

Drug Antibody Ratio (DAR) is a critical factor to the effective design of antibody-drug conjugates (ADC). This poster presents a method for DAR determination based on SEC-MALS in conjunction with UV absorption and differential refractive index detection.
GC-MS Comparison of Lavindin Grosso Oil Obtained by Steam Distillation and SFE
Miami University Middletown

Oil was extracted from Lavindin Grosso using steam distillation and using supercritical fluid extraction (SFE). Multiple analyses of the same extract demonstrated repeatability of the analytical method. The variability between batches of distillate bracketed the composition obtained by SFE. The differences among the oils could be attributed more to where the lavender was grown than to the extraction method.
Identification and classification of antifouling compounds secreted by anti MIC microorganisms. A metabolomic analysis.
University of Burgos, INBIOTEC, CSIC and ACCIONA Infraestructuras, Spain

BIOCORIN project, aims to develop a green alternative to the coatings and solutions used up to date for MIC corrosion control. Some of the results of this project are presented here, with the identification of several relevant antifouling compounds secreted by environmentally isolated anti-MIC strains of microorganisms via a metabolomic approach.
Application Notes
Simple sample preparation for the determination of vitamin D in serum by LC-MSMS
Tecan Group Ltd.

A growing number of laboratories have moved from the use of immunoassay methods to liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) for the determination of vitamin D. The advantage of the latter method is unparalleled specificity combined with high sensitivity, offering the potential for the determination of multiple analytes, such as 25OH-vitamin D3 and 25OH-vitamin D2.
Automated Sample Preparation of 25-OH-Vitamin D3/D2 from Serum with the AC Extraction Plate and the Tecan Freedom EVO® for the quantification by LC-MS/MS
Tecan Group Ltd.

There is an increasing demand for the determination of Vitamin D status which is based on the quantification of the two metabolites 25-OH-Vitamin D3/D2. Numerous laboratories have moved from the use of immunoassay methods to liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) because of its specificity combined with high sensitivity. Moreover LC-MS/MS offers the potential for multianalyte determination which is required for Vitamin D status determination.
Sample preparation with the AC Extraction Plate: extraction of urinary THC metabolites for LC-MSMS quantification
Tecan Group Ltd.

In many countries, routine workplace drug testing involves screening for the free THC-COOH metabolite obtained by hydrolyzing THC-COOH glucuronide. Tecan’s AC Extraction Plate with TICE technology enables a straightforward workflow that is reproducible and cost efficient. Liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) provides an easy and cost-effective means for fast, sensitive and precise analysis of THC and its metabolites.
Automated sample preparation for the determination of testosterone in serum by LC-MSMS
Tecan Group Ltd.

For accurate, reproducible quantification of testosterone, a growing number of laboratories are shifting from immunoassay to liquid chromatography coupled with tandem mass spectrometry. This application note describes the preparation of serum samples for subsequent LC-MS analysis of testosterone, focusing on a streamlined workflow suitable for automation.
Protein Purification Workflow Development Using Bio-Rad's NCO' Chromatography System
Bio-Rad Laboratories

High purity protein is a common requirement for biochemical and structural studies. A common approach is to recombinantly express an affinity-tagged version of the protein of interest. This is, however, not always a viable option. This application note discusses protein purification workflow development for untagged proteins and introduce a new indicator of method performance, the purity quotient difference.
The Analysis of Common Drugs of Abuse in an Oral Fluid Matrix using a New Q TRAP® Platform
AB SCIEX

The multiplexing analysis of several compound classes, such as common prescription drugs along with drugs of abuse is very important. The measurement of these drugs has generally been performed using urine as the sample matrix. However, many research laboratories are finding the need to analyze these compounds in oral fluid matrices.
Quantification of Ethylglucuronide in hair by Liquid Chromatography Tandem Mass Spectrometry
AB SCIEX

An advantage of the use of ethylglucuronide (ETG) in hair is that it is not subject to the effect of bacteria. It also offers the opportunity to extend the window of detection up to 6 months compared to hours- days in blood and urine.
Can LC-MS/MS Be Used in Horse Meat Detection?
AB SCIEX

Following the Food Standards Agency’s announcement that horse and pig DNA had been identified in beef products sold by several supermarket chains, further testing has revealed widespread incidences of such contamination. This application note details a rapid, robust, sensitive and specific LC-MS/MS assay for the simultaneous detection of horse meat and the banned substance phenylbutazone (BUTE).
Advanced Automated Library Searching for Compound Identification in Forensic Toxicology Samples
AB SCIEX

LC-MS/MS utilization in forensic toxicology screening for drugs and drug metabolites has become increasingly popular due to the selectivity, sensitivity and the speed of LC-MS/MS analysis. MS/MS confirmation with automated searching against available spectral libraries has proven to add a superior level of confidence to the compound identification.
Tryptic Mapping Automated on the CyBi®-RoboSpense and Integration of an Agilent 1100/1200 HPLC System for Peptide Analysis
CyBio

This application note describes automation of the tryptic mapping process on the CyBi®-RoboSpense liquid handling platform. The automation is completed through integrating an Agilent 1100/1200 HPLC system.
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