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Webcasts
The Lipidyzer™ Platform: A Revolutionary Tool for Understanding the Role of Lipids in DiseaseThe Lipidyzer™ Platform: A Revolutionary Tool for Understanding the Role of Lipids in Disease
Join us to learn about the key challenges in lipid analysis and how the Lipidyzer platform can help you overcome them.
How to Optimize Sample Preparation Step Prior to ExtractionHow to Optimize Sample Preparation Step Prior to Extraction
Discover the benefits of bead-binding for sample preparation in this on demand webinar from Bertin Technologies.

Market Reports
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Scientific News
How Cloud Connectivity Can Combat the Reproducibility Crisis
This infographic explains the reproducibility crisis, and how cloud connectivity can help overcome this problem.
Simplifying Drug Development
Scientists have for the first time revealed the nanostructure of the mesoporous magnesium carbonate Upsalite® and controlled pore size without organic molecules as templates or swelling agent.
Two New Carcinogens Found in E-cig Vapor
Berkeley Lab study identifies two additional carcinogens not previously reported in e-cigarette vapor.
Quantifying Water Content in Solid Pharma Drugs
UTA chemists devise cheaper, faster, more accurate, automated method to quantify water content in solid pharmaceutical drugs.
Core-Shell Columns in HPLC: Food Analysis Applications
Explore the most recent applications of core-shell columns in food analysis.
Review of the Analysis of Haemoglobin A1c for Diabetes Diagnostics
This paper aims to clarify methods, units, quality requirements, reference and cutoff limits for hemoglobin A1c (HbA1c) and ratio of blood glucose/HbA1c on the basis of the results from Finnish quality control surveys by comparing them to the literature.
Determination of 13 Organic Toxicants in Human Blood
Researchers have utilised liquid-liquid extraction coupling HPLC-MS/MS to identify and quantify organic toxicants in human blood.
Massive Helium Discovery a "Game Changer" for Medical Industry
A new development is gas exploration has yielded the discovery of a huge helium gas field, which could help relieve the dwindling supply.
Making Metabolite Identification More Efficient
Metasense combines the industry's most-comprehensive metabolic transformation prediction with efficient analysis of LC/MS analytical measurements to identify, visualize, and report chemical biotransformations.
ASMS 2016: Targeting Mass Spectrometry Tools for the Masses
The expanding application range of MS in life sciences, food, energy, and health sciences research was highlighted at this year's ASMS meeting in San Antonio, Texas.
Business News
IBO Announces Industrial Design Award Winners
IBO announced their Industrial Design Awards winners in three separate award categories.
Overcoming the Challenges of KF Analysis
Metrohm USA is pleased to announce a series of seminars dedicated to Karl Fischer (KF) analysis hosted in 16 cities across the US and Canada.
InSource Launches Clinical Trial Focused on PGx
Physicians' offices invited to become research sites and enroll patients.
SCIEX Works with the Francis Crick Institute and the University of Cambridge
New proteomic study to develop advanced resource for precision medicine research by using Microflow SWATH® Acquisition for HT industrialized proteomics.
Thermo, NIBRT Announce Collaboration
Analytical solutions designed to streamline workflows, quickly generate data for deeper understanding of molecular complexes.
Waters Collaborates with Singapore’s Bioprocessing Technology Institute
Organizations partner to enhance the development of analytical methods and glycan libraries for cancer glycobiology, focusing on glycosphingolipids.
£18m Lab Opens to Discover the Clues to Individuals’ Illnesses
The Centre will identify biomarkers – the molecular clues that indicate the presence of a disease or condition.
Biotage Achieves ISO 14001:2004 Certification
This certificate is an international standard for an environmental management system (EMS) that helps businesses such as Biotage control and improve practices that are potentially harmful to the environment.
IDT Acquires Oligonucleotide Synthesis Company ValueGene
Company welcomes new customers with promise to provide seamless support for genomics research.
LEAP Technologies, Antec Collaborate
LEAP Technologies and Antec announced their collaboration in the field of sample preparation for HDX/MS.

Events
4th International Conference a
29 Aug 2016
4th International Conference a ...
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CASSS CMC Strategy Forum Latin
05 Sep 2016
CASSS CMC Strategy Forum Latin ...
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Food Safety & Analysis Congres
06 Sep 2016
Food Safety & Analysis Congres ...
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BioAnalytical and Formulation
14 Sep 2016
BioAnalytical and Formulation ...
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ePosters
Platform Agnostic Data Processing Routine for Targeted and Untargeted Metabolite Identification in Drug Discovery
1Advanced Chemistry Development, Inc. (ACD/Labs), 8 King Street East, Toronto, ON. M5C 1B5. Canada; 2ACD/Labs, Moscow, Russia

A discussion of a new informatics solution that addresses common challenges in metabolite identification and characterization--from LC/MS data processing and metabolites prediction to reporting and databasing of assembled biotransformation knowledge.
Accurate Mass Spectral Database: Harnessing the Power of High Performance Mass Spectrometry at Long Last
LECO Corporation, Moscow State University

Standard mixtures comprising of alkanes, PAHs, semivolatiles, and pesticides were analyzed using a high resolution time-of-flight (HRTOF) mass spectrometer—Pegasus GC-HRT (LECO Corporation, Saint Joseph,MI)—at 10 spectra-per-second (m/z40–300) in high resolution mode (25,000 at FWHH). The resulting chromatographic peaks were automatically found, deconvoluted, and curated into an Accurate Mass Library (AML).
Automated Sample Preparation of Whole Blood for Therapeutic Drug Monitoring and Diagnostics by LC-MS using a Commercial Autosampler
1 University of Applied Sciences and Arts Northwestern Switzerland FHNW, Institute for Chemistry and Bioanalytics , Gründenstrasse 40, 4132 Muttenz; 2 CTC Analytics AG; Industriestrasse 20, CH-4222 Zw

In this poster the parameters necessary to automatically prepare whole blood samples for online LC-MS applications in the field of diagnostics and TDM have been investigated. A strategy and the most important parameters are shown for the optimization of a PAL RTC autosampler
for the preparation of whole blood samples.
A Unified Software Platform for Laboratory Informatics
Advanced Chemistry Development, Inc. (ACD/Labs), Toronto, Canada.

Reported here are capabilities in automated workflows involving analytical data with chemical structures. Specifically described is automated homogenization of data from a set of instruments, including NMR structure verification, as one solution.
Analysis of Terpenes Using Gas Chromatography with Vacuum Ultraviolet
The University of Texas at Arlington and VUV Analytics

The VUV absorption spectra for different terpenes were distinctive and differentiable. GC-VUV demonstrated the capabilities for qualitative and quantitative analysis of terpenes in turpertine mixtures. Chromatographic coeluting signals can be deconvolved by the VUV data analysis software.

Determination of C2-C12 Aldehydes in Water by SPME Arrow On-Fiber Derivatization and GC/MS
1 BGB Analytik AG, Lettenstrasse 97, 8134 Adliswil, Switzerland; 2 CTC Analytics AG, Industriestrasse 20, 4222 Zwingen, Switzerland

A method applying SPME Arrow extraction and on-fiber derivatization for the quantitation of C2-C12 aldehydes in water by GC/MS is described.
Assessing Diversity in Cassava through the Application of Metabolomics
aSchool of Biological Sciences, Royal Holloway University of London, Egham, UK bInternational Center for Tropical Agriculture, CIAT

In the present study metabolomic platforms have been established for Cassava and used to assess the biodiversity present in Cassava germplasm collections and elucidate underlying biochemical mechanisms associated with traits of interest.
PredRet: Prediction of Retention Time by Direct Mapping between Multiple Chromatographic Systems
Department of Food Quality and Nutrition, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all’Adige (TN), Italy.; Department of Stress and Developmental Biology, Leibniz Institute

Retention time (RT) information is under-utilized in LC-MS based metabolomics and sharing of RTs between systems is not currently possible. PredRet is a new system that allows highly accurate mapping and prediction of RTs between LC systems.
Minimizing Carry-over for High Throughput Analysis
1FHNW Fachhochschule Nordwestschweiz, Hochschule für Life Sciences Gründenstrasse 40 CH-4132 Muttenz; 2CTC Analytics AG Industriestrasse 20 CH-4222 Zwingen; Switzerland

Minimal carry-over is a prerequisite for high throughput analysis. However, minimized carry-over and cycle time are competing and a careful optimization is mandatory. In this study the influence of wash conditions on carry-over of various compounds was investigated. A strategy to minimize carry-over was developed. The influences of different wash tasks were investigated. Finally the contribution of different system components such as injector valve or column was studied.
A Comparison of ITEX Dynamic Headspace–GC/MS to other Enrichment Techniques for Analysis of Flavoring Compounds
1Aspen Research Corporation, Maple Grove, MN; 2CTC Analytics, Zwingen, Switzerland

Enrichment techniques are commonly used for the analysis of flavoring compounds in different matrices with GC/MS. Analysis of flavoring compounds is done by purge & trap, SPME or headspace, depending on requirements for sensitivity. The In-Tube Ex¬traction (ITEX) Dynamic Headspace uses a micro trap filled with an adsorbent material to efficiently extract the compounds. Here we evaluate if the ITEX can be used to effectively analyze for these compounds and reduce the analyst’s time involved.
Application Notes
A Novel Lipid Screening Platform that Provides a Complete Solution for Lipidomics Research
SCIEX

The Lipidyzer™ Platform, powered by Metabolon®.
Novel Chemical Standards Kits Enable Facile Lipid Quantitation
SCIEX

The Lipidyzer platform provides more accurate lipid analysis with less quantitative bias.
Characterization of Protein-Protein Interactions using Triple Detection Size Exclusion Chromatography (SEC-TD)
Malvern Instruments Limited

In this application note, triple detection size exclusion chromatography (SEC-TD) is used to understand the ability of proteins to form ordered, structured complexes. The controlling mechanism behind these protein complexes is fundamental to our knowledge of protein signaling pathways and the physiological responses they control.
Characterization of IgG Monomers & Their Aggregates
Malvern Instruments Limited

A comparison between column calibration & multi-detection SEC.
Differentiation of Polymer Branching and Composition Using the Mark–Houwink Plot
Malvern Instruments Limited

In this application note, we will show, using polystyrene, how to separate the effects of a structural difference induced by a compositional change (bromination) and the structural change induced by polymer chain branching using the Mark- Houwink plot.
Automated Sample Preparation - Analysis of 25-OH-Vitamin D3 and 25-OH-Vitamin D2 by LC/MS/MS
Beckman Coulter Life Sciences


Automated Sample Preparation for the Monitoring of Pharmaceutical and Illicit Drugs by LC-MS/MS
Beckman Coulter Life Sciences


Automated Sample Preparation for the Monitoring of Ethanol Metabolites in Urine by LC-MS/MS
Beckman Coulter Life Sciences


Automating Protein Digestion for Reproducible Proteomics
Beckman Coulter Life Sciences


Use Of Microcalorimetry And Its Correlation With Size Exclusion Chromatography For Rapid Screening Of The Physical Stability Of Large Pharmaceutical Proteins In Solution
Malvern Instruments Limited


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