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 | Guiding Treatment Decisions in Cancer using Protein Biomarker Measurements: from Design to Utility Prof. Stephen Pennington, University College Dublin, speaking at Discovery Chemistry Congress 2013. |
 | Typical Phospho-form Abundance Profile of Cellular ERK Discovered by Quantitative UPLC-MS Wolf Lehmann, German Cancer Research Center, speaking at Systems Biology Europe 2012 |
Lab Instrument Rental Trends 2012
HTStec
This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on lab instrument rental carried out in September 2012.
Life Science and Chemical Instrumentation Market (2011 - 2016)
MarketsandMarkets
Spectroscopy, Chromatography, DNA Sequencer & Amplifier, Lab Automation, Array, Flow Cytometer, Electrophoresis, Immuno Assay & Others
Biomarkers
RI Technologies
This market insight report on Biomarkers focuses on the different types of biomarkers and their impact on various disease areas such as oncology, neurology, cardiology and other areas including metabolomic turmoil, arthritis, gynecology, oxidative stress, liver disease, pulmonary disease and aging.
Chiral Chemicals
RI Technologies
This market insight report on Chiral Chemicals focuses on the different Methods and Applications of Chiral Chemicals and their impact.
HTStec
This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on lab instrument rental carried out in September 2012.
Life Science and Chemical Instrumentation Market (2011 - 2016)
MarketsandMarkets
Spectroscopy, Chromatography, DNA Sequencer & Amplifier, Lab Automation, Array, Flow Cytometer, Electrophoresis, Immuno Assay & Others
Biomarkers
RI Technologies
This market insight report on Biomarkers focuses on the different types of biomarkers and their impact on various disease areas such as oncology, neurology, cardiology and other areas including metabolomic turmoil, arthritis, gynecology, oxidative stress, liver disease, pulmonary disease and aging.
Chiral Chemicals
RI Technologies
This market insight report on Chiral Chemicals focuses on the different Methods and Applications of Chiral Chemicals and their impact.
Method Development and Validation of Almotriptan in Human Plasma by HPLC Tandem MS: Application to Pharmacokinetic Study
It was demonstrated how this method can be utilised for clinical and pharmacokinetic studies.
Whole Gel Processing Procedure for GeLC-MS/MS Based Proteomics
The procedure will enable clinical proteomics for which GeLC-MS/MS is a popular workflow and sample numbers are relatively high.
Waters Users’ Meeting at ASMS 2013
Register for the Waters Users’ meeting at ASMS 2013 and learn about the latest developments in Mass Spectrometry from Waters experts as we reveal our new technologies and solutions.
MultiAlign: A Multiple LC-MS Analysis Tool for Targeted Omics Analysis
This article demonstrates how two dissimilar LC-MS feature maps could be analyzed using MultiAlign’s MS/MS traceback and spectral clustering capability.
Measurement of Pore Diffusivity in Separation Media for High Performance Liquid Chromatography
Researchers from Rikkyo University have demonstrated that the peak parking-moment analysis method could be used as an alternative for the measurement of pore diffusivity in porous packing materials for HPLC.
Simultaneous Determination of Hormonal Residues in Treated Waters using UHPLC-MS/MS
The identification of hormone residues in environment is of special interest because as this is a requirement to take measures in order to regulate and minimize their environmental impact.
Derivatization in Liquid Chromatography for Mass Spectrometric Detection
This review presents an overview of the derivatization reagents in LC/ESI-MS/MS that have been applied to the low molecular weight compounds over the past five years.
Evaporative Light Scattering Detection Based HPLC Method for the Determination of Polysorbate 80 in Therapeutic Protein Formulations
The suitability of the new method has been evaluated by testing its specificity, linearity, precision, sensitivity and accuracy.
Development and Characterization of a Novel Plug and Play LC-MS Source
This article reports the development and characterization of a novel, vendor neutral, ultra-high pressure compatible (~10,000 psi) LC-MS source.
Optimal Precursor Ion Selection for LC-MALDI MS/MS
Researchers present two algorithms for inclusion list creation that formulate precursor ion selection as an optimization problem.
It was demonstrated how this method can be utilised for clinical and pharmacokinetic studies.
Whole Gel Processing Procedure for GeLC-MS/MS Based Proteomics
The procedure will enable clinical proteomics for which GeLC-MS/MS is a popular workflow and sample numbers are relatively high.
Waters Users’ Meeting at ASMS 2013
Register for the Waters Users’ meeting at ASMS 2013 and learn about the latest developments in Mass Spectrometry from Waters experts as we reveal our new technologies and solutions.
MultiAlign: A Multiple LC-MS Analysis Tool for Targeted Omics Analysis
This article demonstrates how two dissimilar LC-MS feature maps could be analyzed using MultiAlign’s MS/MS traceback and spectral clustering capability.
Measurement of Pore Diffusivity in Separation Media for High Performance Liquid Chromatography
Researchers from Rikkyo University have demonstrated that the peak parking-moment analysis method could be used as an alternative for the measurement of pore diffusivity in porous packing materials for HPLC.
Simultaneous Determination of Hormonal Residues in Treated Waters using UHPLC-MS/MS
The identification of hormone residues in environment is of special interest because as this is a requirement to take measures in order to regulate and minimize their environmental impact.
Derivatization in Liquid Chromatography for Mass Spectrometric Detection
This review presents an overview of the derivatization reagents in LC/ESI-MS/MS that have been applied to the low molecular weight compounds over the past five years.
Evaporative Light Scattering Detection Based HPLC Method for the Determination of Polysorbate 80 in Therapeutic Protein Formulations
The suitability of the new method has been evaluated by testing its specificity, linearity, precision, sensitivity and accuracy.
Development and Characterization of a Novel Plug and Play LC-MS Source
This article reports the development and characterization of a novel, vendor neutral, ultra-high pressure compatible (~10,000 psi) LC-MS source.
Optimal Precursor Ion Selection for LC-MALDI MS/MS
Researchers present two algorithms for inclusion list creation that formulate precursor ion selection as an optimization problem.
Agilent, University of Rouen and A*STAR’s Bioprocessing Technology Institute to Collaborate
The collaborations aims to further innovation in biopharmaceuticals and glycomics through developing tools to effectively analyze biologics and vaccines.
Merck Millipore to Highlight LC-MS Capabilities at ASMS
Merck Millipore will highlight their new ZIC®-HILIC technology, a zwitterionic HILIC phase for LC-MS separation of polar compounds.
Phenomenex to Host AACC Workshop on LC/MS/MS for Clinical Diagnostics
Two-day, hands-on program to be held May 15 and 16.
Shimadzu UK Grows Sales Orders by 30%!
Company has achieved sales order growth across many products in the Shimadzu range.
Phenomenex Serves Growing Korean Market with Translated Website
Site also introduces a new industry-focused interface to help customers quickly find the best columns and methods for their needs.
Thermo Fisher Scientific Reports First Quarter 2013 Results
Adjusted earnings per share grew 17% to a record $1.37 with revenue increased 4% to a first quarter record of $3.19 billion.
Phenomenex Expert Selected to Present on Residues and Contaminants in Food
United Nations Agencies Fund Initiative to improve food safety in developing countries.
Waters Reports First Quarter 2013 Financial Results
Waters Corporation reported first quarter 2013 sales of $430 million, an increase of 2% from sales of $420 million in the first quarter of 2012.
Upfront Chromatography Chosen as a 2013 Red Herring Top 100 Europe
Award honors Europe’s leading private companies.
Bruker and the Genome British Columbia Proteomics Centre to Collaborate
The collaborative effort covers the development and validation of high-throughput assays for determining hemoglobin variants and diabetes risk.
The collaborations aims to further innovation in biopharmaceuticals and glycomics through developing tools to effectively analyze biologics and vaccines.
Merck Millipore to Highlight LC-MS Capabilities at ASMS
Merck Millipore will highlight their new ZIC®-HILIC technology, a zwitterionic HILIC phase for LC-MS separation of polar compounds.
Phenomenex to Host AACC Workshop on LC/MS/MS for Clinical Diagnostics
Two-day, hands-on program to be held May 15 and 16.
Shimadzu UK Grows Sales Orders by 30%!
Company has achieved sales order growth across many products in the Shimadzu range.
Phenomenex Serves Growing Korean Market with Translated Website
Site also introduces a new industry-focused interface to help customers quickly find the best columns and methods for their needs.
Thermo Fisher Scientific Reports First Quarter 2013 Results
Adjusted earnings per share grew 17% to a record $1.37 with revenue increased 4% to a first quarter record of $3.19 billion.
Phenomenex Expert Selected to Present on Residues and Contaminants in Food
United Nations Agencies Fund Initiative to improve food safety in developing countries.
Waters Reports First Quarter 2013 Financial Results
Waters Corporation reported first quarter 2013 sales of $430 million, an increase of 2% from sales of $420 million in the first quarter of 2012.
Upfront Chromatography Chosen as a 2013 Red Herring Top 100 Europe
Award honors Europe’s leading private companies.
Bruker and the Genome British Columbia Proteomics Centre to Collaborate
The collaborative effort covers the development and validation of high-throughput assays for determining hemoglobin variants and diabetes risk.
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Ion Chromatography ICP-Q-MS for the Detection of Arsenic Species in Apple Juice
Thermo Scientific
Interest in the determination of Arsenic species in fruit juices has been triggered by recent media reports in the United States claiming that some apple juices may contain high amounts of Arsenic. Inorganic forms of Arsenic (As3+ and As5+) are highly toxic, whereas the organic forms (e.g. arsenobetaine) are not considered toxic. A robust IC-ICP-MS system was developed and shown to be a highly selective and sensitive technique for determination of trace element species.
Streamlined QbD HPLC Method Development with Automated Data Processing
ACD/Labs
Quality by Design (QbD) has been widely applied to pharmaceutical manufacturing to enhance process robustness, and improve product quality and manufacturing productivity. Recently, there arose tremendous interests from both the pharmaceutical industry and regulatory agents to expand it to analytical methodology.
Characterizing Small Molecules in Biological Extracts using IntelliXtract Data Processing on High Resolution Accurate Mass Time-of-Flight Data
ACD Labs
To detect small molecules in biological extracts, LC/MS performed using high resolution time of flight with accurate mass analysis is a powerful technology. Together with advanced data processing algorithms, accurate mass and relative isotope abundance measurements, molecular formulae can be determined and compounds identified.
The LAB2LAB™Advantage
1Novartis 2TTPLabtech Ltd
Lab2Lab is a novel approach to submitting and transporting samples for analysis across an entire site. Sample tubes are registered and methods selected, an ELN reference is assigned and the sample tube is placed into the “Sender”. The system transports the samples using low pressure compressed air and directs them to the most appropriate analytical instrumentation available. The analytical results are then automatically returned to the originators ELN.
Qualitative Comparison of Wine Process Samples with UHPLC and Ultra-High Resolution TOFMS
Leco Corporation
The evaluation, identification, and quantitation of flavones, antioxidants and related nutrients, biogenic amines, and potential contaminants in wine and other foodstuffs provides valuable information on their nutritional and health values.
Analysis of Pesticide Residues in JonaGold Apples Using QuEChERS Approach and Comprehensive Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometry (GCxGC-TOFMS)
LECO Corporation
Screening and quantitation of pesticide residues in fruits and vegetables is of utmost importance for public health and safety concerns. These commodities can contain hundreds-to-thousands of analytes, making them extremely difficult for the screening and accurate quantitation of pesticide residues.
Analysis of Fruit Commodities by GC-TOFMS and GCxGC-TOFMS Using QuEChERS Approach
LECO Corporation
The availability of fruit commodities from a wide variety of sources has increased the need for rapid and accurate screening for pesticides in fruit. Not all fruit commodities are brought to market under the strict guidelines of the United States Department of Agriculture. Determining whether or not the Environmental Protection Agency tolerances for various pesticides have been violated is important in the risk assessment for consumers in the United States.
Characterization of Nutrients and Actives in Herbal Supplements and Nutriceuticals Using UHPLC-Multi-Reflecting Time-of-Flight Mass Spectrometry
LECO Corporation
The qualitative and quantitative analysis of the content of nutritional supplements and alternative medicinal therapies is becoming more important and regulation by the FDA is imminent. High resolution mass spectrometry provides a rapid, selective, and useful mechanism for QC of extracts and finished dosage forms, producing a minable, comprehensive data set.
Facing the challenges in bio-pharmaceutical production: newly developed polymer-based ion exchange chromatography media and their application to the purification for Immunoglobulin – from egg yolk
YMC
Much attention has been given to ion exchange (IEX) media as a means to improve productivity as a result of increasing demand for higher efficiency on the downstream process. Until recently, strain optimisation for high productivity and upstream purification were the bottlenecks for most bio-processes.
Detection of Environmental Contaminants Caused by the Oil Spill in the Gulf of Mexico by GC and HPLC
Phenomenex
In order to help understand the impact that the oil spill has caused, laboratories are looking for rapid and robust analytical procedures to characterize the hydrocarbon contaminants. This work provides SPE, GPC, GC-FID, GC/MS, and HPLC analytical methods for analyzing the most common contaminants that originated from the leak.
Thermo Scientific
Interest in the determination of Arsenic species in fruit juices has been triggered by recent media reports in the United States claiming that some apple juices may contain high amounts of Arsenic. Inorganic forms of Arsenic (As3+ and As5+) are highly toxic, whereas the organic forms (e.g. arsenobetaine) are not considered toxic. A robust IC-ICP-MS system was developed and shown to be a highly selective and sensitive technique for determination of trace element species.
Streamlined QbD HPLC Method Development with Automated Data Processing
ACD/Labs
Quality by Design (QbD) has been widely applied to pharmaceutical manufacturing to enhance process robustness, and improve product quality and manufacturing productivity. Recently, there arose tremendous interests from both the pharmaceutical industry and regulatory agents to expand it to analytical methodology.
Characterizing Small Molecules in Biological Extracts using IntelliXtract Data Processing on High Resolution Accurate Mass Time-of-Flight Data
ACD Labs
To detect small molecules in biological extracts, LC/MS performed using high resolution time of flight with accurate mass analysis is a powerful technology. Together with advanced data processing algorithms, accurate mass and relative isotope abundance measurements, molecular formulae can be determined and compounds identified.
The LAB2LAB™Advantage
1Novartis 2TTPLabtech Ltd
Lab2Lab is a novel approach to submitting and transporting samples for analysis across an entire site. Sample tubes are registered and methods selected, an ELN reference is assigned and the sample tube is placed into the “Sender”. The system transports the samples using low pressure compressed air and directs them to the most appropriate analytical instrumentation available. The analytical results are then automatically returned to the originators ELN.
Qualitative Comparison of Wine Process Samples with UHPLC and Ultra-High Resolution TOFMS
Leco Corporation
The evaluation, identification, and quantitation of flavones, antioxidants and related nutrients, biogenic amines, and potential contaminants in wine and other foodstuffs provides valuable information on their nutritional and health values.
Analysis of Pesticide Residues in JonaGold Apples Using QuEChERS Approach and Comprehensive Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometry (GCxGC-TOFMS)
LECO Corporation
Screening and quantitation of pesticide residues in fruits and vegetables is of utmost importance for public health and safety concerns. These commodities can contain hundreds-to-thousands of analytes, making them extremely difficult for the screening and accurate quantitation of pesticide residues.
Analysis of Fruit Commodities by GC-TOFMS and GCxGC-TOFMS Using QuEChERS Approach
LECO Corporation
The availability of fruit commodities from a wide variety of sources has increased the need for rapid and accurate screening for pesticides in fruit. Not all fruit commodities are brought to market under the strict guidelines of the United States Department of Agriculture. Determining whether or not the Environmental Protection Agency tolerances for various pesticides have been violated is important in the risk assessment for consumers in the United States.
Characterization of Nutrients and Actives in Herbal Supplements and Nutriceuticals Using UHPLC-Multi-Reflecting Time-of-Flight Mass Spectrometry
LECO Corporation
The qualitative and quantitative analysis of the content of nutritional supplements and alternative medicinal therapies is becoming more important and regulation by the FDA is imminent. High resolution mass spectrometry provides a rapid, selective, and useful mechanism for QC of extracts and finished dosage forms, producing a minable, comprehensive data set.
Facing the challenges in bio-pharmaceutical production: newly developed polymer-based ion exchange chromatography media and their application to the purification for Immunoglobulin – from egg yolk
YMC
Much attention has been given to ion exchange (IEX) media as a means to improve productivity as a result of increasing demand for higher efficiency on the downstream process. Until recently, strain optimisation for high productivity and upstream purification were the bottlenecks for most bio-processes.
Detection of Environmental Contaminants Caused by the Oil Spill in the Gulf of Mexico by GC and HPLC
Phenomenex
In order to help understand the impact that the oil spill has caused, laboratories are looking for rapid and robust analytical procedures to characterize the hydrocarbon contaminants. This work provides SPE, GPC, GC-FID, GC/MS, and HPLC analytical methods for analyzing the most common contaminants that originated from the leak.
Tryptic Mapping Automated on the CyBi®-RoboSpense and Integration of an Agilent 1100/1200 HPLC System for Peptide Analysis
CyBio
This application note describes automation of the tryptic mapping process on the CyBi®-RoboSpense liquid handling platform. The automation is completed through integrating an Agilent 1100/1200 HPLC system.
Sodium, Potassium, Calcium and Magnesium in cooling water
Metrohm AG
This application note outlines the determination of sodium, potassium, calcium and magnesium in cooling water using cation chromatography with direct conductivity detection.
Visualisation and Comparison of SYNAPT G2-S LC/MS Data with Progenesis LC/MS
Waters Corporation
In this technology brief, we present the precise large scale, label-free analysis of high-density proteomic LC/MS data combined with a qualitative protein strategy that accurately identifies proteins and software that accurately quantifies proteins - both with high reproducibility.
Data Independent Label-Free Quantification of Low Abundance Proteins
Waters Corporation
The depth to which a complex sample can be interrogated is crucial as this defines the lowest abundance limit of proteins that may be quantified. Waters® SYNAPT® G2-S Mass Spectrometry System has substantial improvements in performance: mass resolution and accuracy, dynamic range, and sensitivity.
Qualitative and Quantitative Characterization of the Metabolome, Lipidome, and Proteome of Human Hepatocytes Stably Transfected with Cytochrome P450 2E1 Using Data Independent LC/MS
Waters Corporation
Drug toxicity is a major reason for the failure of candidate pharmaceuticals during their development. Therefore, it is important to realize the potential for toxicity in a timely fashion. A label-free multi-omics approach has been applied for the analysis of the transfected human hepatocyte cells by implementing LC/HDMSE, providing both qualitative and quantitative information within a single experiment.
TransOmics Informatics Powered by Nonlinear Dynamics
Waters Corporation
This application note introduces the workflow of TransOmics Informatics Software that has been specifically developed for the larger scale analysis of ion mobility MS data from proteomics and metabolomics data sets, comprising technical and biological replicates.
Increased Throughput for the Determination of Synthetic Dyes in Beverages Using HRes Fast-LC Technology
PerkinElmer
The color of food has a great impact on consumer’s ultimate perception of food’s quality and flavor. Color additives are used for decorative purposes, enhance product identity, minimize variations in natural color and provide color stability on the shelf. Dye content is a tightly-controlled food-product characteristic with liquid chromatography being a widely accepted QA/QC technique for its determination.
Determining Carbohydrates in Essential and Non-essential Foodstuffs using Ion Chromatography
Metrohm AG
While carbohydrate determination of most foodstuffs requires only minimal sample preparation such as dilution and filtration, samples with interfering matrices such as protein-containing dairy products have to be dialysed before injection. This application note describes a straightforward ion chromatographic method to sensitively determine water-soluble polyols and sugar alcohols as well as mono-, di- and oligosaccharides.
EN 15779 — Gas Chromatographic Analysis of Polyunsaturated FAME in Biodiesel Made From Algae and Marine Oils
Agilent Technologies
This application note describes the configuration and performance of the Agilent 7890A GC system when using this method for the analysis of B100 biodiesel derived from algae oil.
Detection of Sulfur Compounds in Natural Gas According to ASTM D5504 with Agilent's Sulfur Chemiluminescence Detector
Agilent Technologies
Agilent Technologies DP technology is the detector of choice for sulfur analysis when dealing with a hydrocarbon matrix.
CyBio
This application note describes automation of the tryptic mapping process on the CyBi®-RoboSpense liquid handling platform. The automation is completed through integrating an Agilent 1100/1200 HPLC system.
Sodium, Potassium, Calcium and Magnesium in cooling water
Metrohm AG
This application note outlines the determination of sodium, potassium, calcium and magnesium in cooling water using cation chromatography with direct conductivity detection.
Visualisation and Comparison of SYNAPT G2-S LC/MS Data with Progenesis LC/MS
Waters Corporation
In this technology brief, we present the precise large scale, label-free analysis of high-density proteomic LC/MS data combined with a qualitative protein strategy that accurately identifies proteins and software that accurately quantifies proteins - both with high reproducibility.
Data Independent Label-Free Quantification of Low Abundance Proteins
Waters Corporation
The depth to which a complex sample can be interrogated is crucial as this defines the lowest abundance limit of proteins that may be quantified. Waters® SYNAPT® G2-S Mass Spectrometry System has substantial improvements in performance: mass resolution and accuracy, dynamic range, and sensitivity.
Qualitative and Quantitative Characterization of the Metabolome, Lipidome, and Proteome of Human Hepatocytes Stably Transfected with Cytochrome P450 2E1 Using Data Independent LC/MS
Waters Corporation
Drug toxicity is a major reason for the failure of candidate pharmaceuticals during their development. Therefore, it is important to realize the potential for toxicity in a timely fashion. A label-free multi-omics approach has been applied for the analysis of the transfected human hepatocyte cells by implementing LC/HDMSE, providing both qualitative and quantitative information within a single experiment.
TransOmics Informatics Powered by Nonlinear Dynamics
Waters Corporation
This application note introduces the workflow of TransOmics Informatics Software that has been specifically developed for the larger scale analysis of ion mobility MS data from proteomics and metabolomics data sets, comprising technical and biological replicates.
Increased Throughput for the Determination of Synthetic Dyes in Beverages Using HRes Fast-LC Technology
PerkinElmer
The color of food has a great impact on consumer’s ultimate perception of food’s quality and flavor. Color additives are used for decorative purposes, enhance product identity, minimize variations in natural color and provide color stability on the shelf. Dye content is a tightly-controlled food-product characteristic with liquid chromatography being a widely accepted QA/QC technique for its determination.
Determining Carbohydrates in Essential and Non-essential Foodstuffs using Ion Chromatography
Metrohm AG
While carbohydrate determination of most foodstuffs requires only minimal sample preparation such as dilution and filtration, samples with interfering matrices such as protein-containing dairy products have to be dialysed before injection. This application note describes a straightforward ion chromatographic method to sensitively determine water-soluble polyols and sugar alcohols as well as mono-, di- and oligosaccharides.
EN 15779 — Gas Chromatographic Analysis of Polyunsaturated FAME in Biodiesel Made From Algae and Marine Oils
Agilent Technologies
This application note describes the configuration and performance of the Agilent 7890A GC system when using this method for the analysis of B100 biodiesel derived from algae oil.
Detection of Sulfur Compounds in Natural Gas According to ASTM D5504 with Agilent's Sulfur Chemiluminescence Detector
Agilent Technologies
Agilent Technologies DP technology is the detector of choice for sulfur analysis when dealing with a hydrocarbon matrix.
