Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

High Throughput Natural Product Discovery

Published: Monday, January 28, 2013
Last Updated: Sunday, January 27, 2013
Bookmark and Share
A technical article from Genevac details how its HT-24 centrifugal evaporation system can find and isolate novel flavour ingredients from nature.

Natural product derived discovery of novel flavour molecules is a highly complex process. Natural product sources yield complex extracts containing many components, which often do not lend themselves to processing and analysis.

Conventionally, many steps of fractionation and evaluation are necessary until a compound is obtained from natural sources at the purity required for structural analysis.

In the article a fractionation process using a Sepbox® Preparative HPLC - SPE system and a Genevac® HT-24 centrifugal evaporator is described.

The Sepbox enables two dimensional, preparative scale fractionation of natural products using high performance liquid chromatography - solid phase extraction (HPLC-SPE).

In sequential HPLC-SPE / HPLC-SPE steps individual components are isolated from complex mixtures. Each separation run produced 320 samples of approximately 45ml volume.

A Genevac HT-24 Evaporator was chosen to dry the samples because of its high sample capacity, unique technology that eliminates cross contamination due to sample bumping and automated monitoring of temperature and pressure to prevent sample degradation.

Able to evaporate 192 sample vials simultaneously the HT-24 took just two days to dry all the fractions ready for further liquid handling and testing.

Compact in design and offering a very high capacity for a wide range of sample formats including microplates, tubes, vials, fraction collector racks and Genevac’s hybrid HPLC blocks the HT-24 offers the versatility and productivity to assist chemists in high-throughput environments.

The high-throughput design of the HT-24 allows up to 96 shallow-well microplates to be dried down at the same time, while capacity for standard 16 x 100mm fraction collector tubes is an outstanding 576 tubes per run.

Benefiting from Genevac’s 20+ years of designing centrifugal evaporators the HT-24 is easy to use, reliable, robust and safe to both operator and sample integrity.

Further aiding productivity the HT-24 includes facility for rapid defrosting, and pull-out sample shelves for easy loading and unloading.

Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,100+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Post Purification Sample Handling
Company has developed a suite of proprietary technological solutions to facilitate post purification sample handling.
Tuesday, February 23, 2016
Genevac Consolidate German Evaporator & Freeze Dryer Operations
Company appoints LMS as the exclusive German distributor for its market leading evaporator systems.
Wednesday, April 22, 2015
Genevac Introduces Guide to Evaporation
Genevac, a world leader in solvent removal technologies, has released a new 24-page guide ‘Introduction to Evaporation’.
Tuesday, February 24, 2015
Scientific News
Food Analysis Applications of Core-Shell Columns in HPLC
Despite applications of core-shell particles columns in food analysis being at an early stage, articles describing their use for improving separations of several classes of compounds are becoming more frequent.
New Pathway for COPD Biomarker Development
A study from Philip Morris International has highlighted multi-lipid profiling as a potential new pathway for COPD biomarker development.
Reclaim from the Drain - The Importance of Water Reuse
This infographic explains the importance of reusing water to meet the world's increasing water demand.
Clinical Trial Finds Medicine Program Alters Blood Serum
Meditation, yoga and vegetarian diet linked to decline in plasma metabolites associated with inflammation and cardiovascular disease risk.
Curcumin Shows Promise as Cancer Treatment
When delivered at the correct circadian phase, curcumin demonstrates sustained toxicity in cancer cells and should be considered for use in patient care.
3D-Printing in Science: Conference Co-Staged with LABVOLUTION
LABVOLUTION 2017 will have an added highlight of a simultaneous conference, "3D-Printing in Science".
Antibiotic Resistance Can Occur Naturally in Soil Bacteria
Scientists have found natural anti-biotic resistant bacteria in soils with little to no human exposure.
Impact of Emerging Contaminants in Our Water Supply
Emerging contaminants, any synthetic or naturally occurring chemical not commonly monitored in the environment, in our water supply are becoming of increasing concern due to their potential ecological and/or human health effects.
Collaboration to Develop Cannabis Testing Standards
SCIEX workflow solution enables cannabis labs to ensure product safety with robust, cost-effective analytical methods to facilitate routine testing.
Antibiotic Resistance Genes in Indoor Dust
Genetic analyisis of dust samples discovered antimicrobial chemicals and antibiotic-resistance genes.

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,100+ scientific videos