Corporate Banner
Satellite Banner
Chromatography
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Thermo Scientific Extends UHPLC Performance to Biopharmaceutical Workflows

Published: Friday, March 22, 2013
Last Updated: Thursday, March 21, 2013
Bookmark and Share
Thermo Scientific Dionex UltiMate 3000 BioRS chromatography system combines corrosion resistance and UHPLC capability for bioseparations.

Thermo Fisher Scientific Inc. has announced that it will feature its Thermo Scientific Dionex UltiMate 3000 Biocompatible Rapid Separation (BioRS) liquid chromatography system during Pittcon 2013.

This system is designed to combine the performance advantages of ultrahigh-performance liquid chromatography (UHPLC) with the corrosion resistant flow path demanded by the analysis of proteins, peptides, nucleic acids and biotherapeutics.

Thermo Fisher will showcase the new system within booth 1835 during Pittcon 2013, being held in Philadelphia from March 17-21, 2013.

“We’ve designed this system to accelerate research into promising biotherapies, such as monoclonal antibody variants, and also to support biopharmaceutical research and QA/QC, including glycan analysis,” said Wulff Niedner, director, HPLC product marketing, for Thermo Fisher Scientific.

Niedner continued, “There is strong demand for a true high-performance biological separation platform, offering capabilities beyond reverse phase UHPLC. This combination of state-of-the-art technology and low-dispersion flow path is engineered to provide the high-peak capacity and sensitivity needed to analyze complex biomolecules.”

The system was developed for reliability and durability, even with harsh solvents used for many bioseparations.

The flow path is built of corrosion-resistant materials, enhancing robustness and extending the life of biocolumns, even under high salt or extreme pH conditions.

In addition, the materials used are designed to significantly reduce the risk of analytes interacting with internal surfaces of the flow path, protecting data quality.

The UltiMate 3000 BioRS system is powered by UltiMate 3000 Rapid Separation technology to support the high pressures required to separate many bioanalytes on high resolution UHPLC columns.

The system is engineered to operate at pressures as high as 1,000 bar (15,000 psi) and flow rates up to 8 mL/min. This wide flow/pressure footprint supports many biomolecule characterizations, including development, identification and quality control.

The tool-free biocompatible Thermo Scientific Dionex Viper fingertight fitting system is designed to facilitate connections without dead volume to combat peak-broadening effects.

The modular system offers many configuration options to accommodate most large molecule workflows. These include binary, quaternary and dual gradient mobile phase delivery, as well as parallel and tandem LC configurations.

Columns designed to optimize system performance
Thermo Fisher Scientific also chose Pittcon 2013 to introduce columns developed specifically to complement the performance of the UltiMate 3000 BioRS system.

The Thermo Scientific MAbPac SCX-10 RS column is designed for UHPLC separations of monoclonal antibodies. The Thermo Scientific DNAPac PA200 RS column can be used to analyze single nucleic acids and isomers to yield important structural information.

Both feature PEEK linings, providing highly inert flow paths designed to remain stable at UHPLC pressures, and ultra-stable packed beds designed for excellent retention reproducibility and long life.

Another biocolumn choice is the new Thermo Scientific Dionex GlycanPac AXH-1 column, designed to enhance glycan analysis with simultaneous charge, size and polarity HPLC separations.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Thermo Fisher Scientific Receives IVDD CE Mark for LC-MS Products
Now available to clinical laboratories in Europe for general in vitro diagnostic use.
Friday, September 11, 2015
Thermo Fisher Q3 Revenues up 31 Percent
Thermo Fisher announced that revenues grew 31% to $4.17 billion for the third quarter ended September 27, 2014.
Thursday, October 23, 2014
Thermo Fisher, NRLs Team to Confirm Dioxins in Feed and Food
Thermo Fisher Scientific worked closely with national reference labs (NRLs) in the European Union to support the development of new regulation.
Monday, September 08, 2014
Thermo Completes Sale of Cole-Parmer to GTCR
Thermo Fisher Scientific Inc. announced that it has completed the sale of its Cole-Parmer customer channel business to private equity firm GTCR LLC for approximately $480 million in cash.
Wednesday, August 20, 2014
Thermo Supports Distinguished Analytical Chemistry Seminar Series at NC State
An endowment established by the company provides opportunities to attend presentations by leading analytical chemistry authorities.
Tuesday, August 19, 2014
Thermo to Sell Cole-Parmer for $480M
Company has signed a definitive agreement to sell its Cole-Parmer channel business to private equity firm GTCR, LLC for $480 million in cash.
Monday, July 21, 2014
Reimagining UHPLC
To learn more about the new Vanquish UHPLC system from Thermo Fisher Scientific we spoke to Wulff Niedner, Director of HPLC Product Marketing.
Thursday, July 17, 2014
Thermo Registers San Jose Facility with FDA
The site has established a quality system in accordance with the FDA Quality System Regulations to design and manufacture devices for analyzing samples from patients for in vitro diagnostic use.
Monday, June 16, 2014
Thermo Fisher, BioAnalytix Collaborate
Collaboration to develop advanced biopharmaceutical analysis workflows.
Thursday, June 12, 2014
Thermo Reports 22% Revenue Rise in Q1 2014
Results include the addition of Life Technologies as of February 4, 2014, and exclude the previously announced related divestitures as of March 22, 2014.
Wednesday, April 23, 2014
Thermo, Harvard Establish Center for Multiplexed Proteomics
Thermo Fisher Scientific Center for Multiplexed Proteomics at Harvard Medical School aims to expedite understanding of complex disease mechanisms.
Thursday, March 20, 2014
Thermo Reports 6% Q4 Revenue Growth
Thermo Fisher Scientific Inc. reported its financial results for the fourth quarter and full year ended December 31, 2013.
Friday, January 31, 2014
Biosimilar Characterization R&D Facility Opens in Austria
University of Salzburg, Sandoz and Thermo Fisher Scientific collaborate to advance protein-based pharmaceutical development, production, QA/QC.
Wednesday, October 23, 2013
Thermo Fisher Scientific and the DTU Form Systems Biology Collaboration
Orbitrap Fusion Tribrid LC-MS technology to power new cellular signaling network research.
Monday, September 02, 2013
Thermo Fisher Scientific Establishes Pesticide Analysis Center of Excellence
The center helps users apply the latest technology and expertise to challenging pesticide analysis in food and environmental laboratories.
Thursday, August 15, 2013
Scientific News
Impact of Emerging Contaminants in Our Water Supply
Emerging contaminants, any synthetic or naturally occurring chemical not commonly monitored in the environment, in our water supply are becoming of increasing concern due to their potential ecological and/or human health effects.
Collaboration to Develop Cannabis Testing Standards
SCIEX workflow solution enables cannabis labs to ensure product safety with robust, cost-effective analytical methods to facilitate routine testing.
Antibiotic Resistance Genes in Indoor Dust
Genetic analyisis of dust samples discovered antimicrobial chemicals and antibiotic-resistance genes.
Hacking Microbes
Startup’s engineered yeast helps clients produce fragrances and flavors more efficiently.
Identifying People Using Human Hair Proteins
In an important breakthrough for the forensic science community, researchers have developed the first-ever biological identification method that exploits the information encoded in proteins of human hair.
Peptide Mutants Help Identify Vulnerability in Tumor Cells
Researchers can detect mutant proteins based on MS data and the results of exome sequencing.
Diverse Fungi Secrete Similar Suite of Decomposition Enzymes
A recent study reveals different fungal species secrete a rich set of enzymes that share similar functions, despite species-specific differences in the amino acid sequences of these enzymes.
Lower Mortality with Polyunsaturated Fat
In a study from Uppsala University the fatty acid linoleic acid (Omega 6) in subcutaneous adipose tissue was linked to lower mortality among older men followed over a 15-year period.
How Cloud Connectivity Can Combat the Reproducibility Crisis
This infographic explains the reproducibility crisis, and how cloud connectivity can help overcome this problem.
Simplifying Drug Development
Scientists have for the first time revealed the nanostructure of the mesoporous magnesium carbonate Upsalite® and controlled pore size without organic molecules as templates or swelling agent.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!