Corporate Banner
Satellite Banner
Chromatography
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Thermo Scientific Introduces New-generation Triple Quadrupole LC-MS Platform

Published: Tuesday, June 11, 2013
Last Updated: Tuesday, June 11, 2013
Bookmark and Share
New Thermo Scientific TSQ Quantiva LC-MS breaks attogram sensitivity barrier.

Thermo Fisher Scientific Inc. has introduced a new-generation triple quadrupole liquid chromatography-mass spectrometry (LC-MS) platform designed to transform quantitation experiments with extreme sensitivity, productivity, precision and usability.

The platform, which includes the new Thermo Scientific Quantiva triple-stage quadrupole mass spectrometer and the new Thermo Scientific Endura triple-stage quadrupole mass spectrometer, made its debut at the ASMS Conference on Mass Spectrometry and Allied Topics, being held in Minneapolis from June 9-13 at the Minneapolis Convention Center in booth 154.

“Evolving applications continue to push the limits of instrument performance,” said Iain Mylchreest, vice president of research and development, chromatography and mass spectrometry, Thermo Fisher Scientific.

Mylchreest continued, “We have created a completely new instrument platform, built from the ground up, to deliver extreme sensitivity and uptime. Equally important is a great user experience, easy method creation and accessible data analysis and review. We believe this is the highest-performing, most-usable triple quad on the market today.”

The TSQ Quantiva triple quadrupole mass spectrometer employs Active Ion Management (AIM) to optimize ion creation and transmission from the source to the detector, resulting in extreme sensitivity.

This enhanced level of sensitivity greatly improves results in applications such as peptide quantitation, metabolomics and biopharmaceutical QA/QC compared to previous Thermo Fisher triple quads.

In company laboratories, AIM-enhanced systems have measured 70 attograms of verapamil in plasma on column with excellent precision, an unprecedented level of performance.

The TSQ Quantiva MS system is also extremely productive, with the ability to perform 500 SRM experiments per second, and positive/negative polarity switching in 20ms with no signal loss.

Productivity is enhanced by a new Ion Beam Guide and Neutral Blocker that helps keep components free of contamination and eases maintenance when it is required.

The TSQ Quantiva MS has been shown using synthetic serum stress tests to operate approximately three times longer between maintenance intervals than the company’s previous best systems, without loss of signal.

The TSQ Endura triple quadrupole mass spectrometer shares much of the advanced technology of the TSQ Quantiva MS, but was designed to deliver higher uptime than any competitive triple quadrupole instrument.

It was built for workhorse applications requiring trace level quantitation, such as food testing, environmental analysis and pharmaceutical QA/QC.

Common Sources and Software
The TSQ Quantiva MS system uses the same source housings as the company’s new Orbitrap Fusion Tribrid LC-MS system, which was also introduced at ASMS. Both are designed for plug-and-play exchange between each other.

Gas and electrical connections are made automatically when sources are installed, and ESI, APCI, and nanospray housings and probes are automatically recognized by the system.

The new triple quads share common software with the new Orbitrap Fusion Tribrid system, making it easier to learn and use both systems. Method parameters can automatically pass between systems to support discovery and verification studies employing both instruments.

“Improved usability was a core goal of this project,” added Mylchreest. “We know many customers use both our hybrid and our triple quad technologies, and we have created an environment that makes it as easy as possible to leverage both systems in the same laboratory.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Thermo Extends Collaboration with University of Birmingham
New Phenome Centre Birmingham, UK to use Thermo Scientific mass spectrometry instruments to advance metabolic phenotyping and metabolomics studies.
Tuesday, May 24, 2016
Thermo Fisher Scientific Chosen for Two Awards
Thermo Scientific Vanquish UHPLC System voted Scientists’ Choice Best New Separations Product, Thermo Fisher Scientific voted Reviewers’ Choice Company of the Year.
Thursday, March 12, 2015
Thermo, University of Birmingham Partner to Study Brominated Flame Retardant Pollution
Research aims to increase understanding of the environmental fate and behavior of brominated persistent organic chemicals through deploying recent advances in analytical instrumentation.
Thursday, August 28, 2014
Thermo Fisher Scientific Signs Distribution Agreement with MKI
The agreement sees Thermo become the exclusive worldwide marketer and distributor of MKI’s Lipid Search software for interpretation of lipidomic research data.
Tuesday, July 09, 2013
Thermo Fisher Scientific and Newman-Lakka Institute to Collaborate
The collaboration will research diagnostic approaches for personalized cancer treatment.
Tuesday, June 25, 2013
Scientific News
Why do Tomatoes Smell "Grassy"?
Researchers identify enzymes that convert the grassy smell of tomatoes into a sweeter scent.
Plasma Biomarkers for Breast Cancer Diagnosis
Plasma lipidomics profiling identified lipid biomarkers in distinguishing early-stage breast cancer from benign lesions.
A Mechanistic Tool for Studying Fungal Pathogens
This study presents an overview of lipid extraction, chromatographic separation and mass spectrometry employed in qualitative and quantitative sphingolipidomics in fungi.
Newborn Screening Test Developed For Rare, Deadly Neurological Disorder
Scientists have developed a new dried blood spot screening test for Niemann-Pick type C, with goal to speed diagnosis and treatment.
Grant to Fund Million Peaks Project
The European Research Council (ERC) has awarded a prestigious Advanced Grant to Prof. Peter Schoenmakers, Prof. Albert Polman and Prof. Huib Bakker, all three of whom work at the University of Amsterdam (UvA).
Altered Metabolism of Four Compounds Drives Glioblastoma Growth
Findings suggest new ways to treat the malignancy, slow its progression and reveal its extent more precisely.
Why Bearcats Smell Like Buttered Popcorn
Researchers pinpoint chemical compound that gives rare animal its popcorn-like scent.
Human Gut Microbiome Evolution
Westerners have a less-diverse gut microbiome compared to hunter-gatherers, but how and why these microbe collections diverged has largely remained a mystery.
Potential Diagnostic for Dengue Fever
Scientists from Colorado State University have explored the use of small molecules in patient serum for diagnosis of dengue fever and potentially predicting progression to the severe disease.
Non-Destructive Sensing of Fish Freshness
Is there any reliable way to know whether frozen fish is fresh or not?
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!