Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

AB SCIEX Drives Expanded Use of Micro LC for Regulated Bioanalysis

Published: Thursday, July 04, 2013
Last Updated: Thursday, July 04, 2013
Bookmark and Share
Introduction of 21CFR Part 11 module for software control of Eksigent systems to accelerate adoption of micro LC technology.

AB SCIEX has announced the availability of new software and service offerings to simplify and accelerate the integration of micro LC technology into regulated bioanalytical laboratories.

The addition of a new software module supporting 21CFR Part 11 and a new IQ/OQ/PQ service to the Eksigent line of liquid chromatography solutions gives pharmaceutical companies, contract research organizations and other high-throughput laboratories the opportunity to use a validated approach to micro LC for increasing sensitivity and speed while reducing the cost of running a laboratory.

Regulated bioanalytical labs have been looking for ways to improve productivity and efficiency for their ADME and bioanalysis assays but haven’t been able to take advantage of micro LC because of the lack of tools and precedence to integrate it into an existing lab that follows GLP regulations.

The new 21CFR Part 11 module and the new service to qualify the LC system for GLP solve this dilemma for regulated labs by eliminating any doubt that a micro LC solution can be configured to meet required rules and regulations.

For researchers looking for improved sensitivity, efficiency and cost savings, micro LC technology, such as the Eksigent ekspert™ microLC 200 UHPLC system, delivers up to a 4x increase in sensitivity and as much as a 3x increase in throughput while minimizing sample injection volumes. It also can reduce solvent consumption and costs by up to 95%.

Among the regulated labs that are using micro LC is Alturas Analytics Inc., a contract research organization that provides LC/MS-based services to the pharmaceutical and biotech industries.

Scientists at Alturas are using an Eksigent micro LC solution along with AB SCIEX QTRAP technology for an integrated quantitative/qualitative approach.

“By improving the limits of detection with micro LC technology, regulated labs can improve results in bioanalysis,” said Shane Needham, Ph.D., Lab Director, Alturas Analytics, Inc.

Needham continued, “The availability of the 21CFR Part 11 software module is significant because now we can use micro LC for assays that require regulatory compliance, which gives CROs like us a competitive advantage.”

AB SCIEX’s industry-leading, Ekisgent-branded micro LC solutions complement its line of analytical flow LC and nano LC solutions.

The company expanded its chromatography product portfolio in 2012, delivering simplified UHPLC-MS solutions that are tailor-made for a variety of applications.

“AB SCIEX is driving a ‘micro LC for the masses’ philosophy, simplifying the integration of micro LC technology into an existing high-throughput laboratory,” said Ben Moshiri, Ph.D, Director of the Separations Business, AB SCIEX.

Moshiri continued, “End-users can improve productivity, get faster inject-to-inject times, higher sensitivity and reduced costs with the microLC 200 system. We are now enabling the regulated market to take advantage of the power of micro LC in ways that non-regulated markets have known for years.”

The new qualification services for the micro LC and mass spectrometers will provide testing and documentation to verify the proper installation and operation of the system hardware.

Additionally, the LCMS PQ will test and document the overall performance of the micro LC and mass spectrometry instrumentation as a complete system.

The new software module supporting 21CFR Part 11, in conjunction with these qualification services, provides a comprehensive solution that supports customers in achieving a compliant use of these systems for regulated labs.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

SCIEX, University of Manchester Partner
SWATH® Acquisition-based next-generation proteomics technology promises to make industrial proteomics a reality.
Thursday, October 29, 2015
SCIEX and New Objective Announce Partnership
New nanospray sources to offer maximum sensitivity and robustness for NanoLC-MS.
Tuesday, June 02, 2015
SCIEX and New Objective Partner
Partnership will provide advanced nanospray ionization technologies for next-generation proteomics.
Tuesday, May 26, 2015
Dr. Gyula Vigh wins Arnold O. Beckman Award
SCIEX sponsored award recognizes outstanding contributions to the field of electrodriven separation techniques.
Thursday, May 07, 2015
New Capabilities for Bioanalysis Studies at the International Pharmaceutical Research Center
AB SCIEX Triple Quad™ 6500 LC/MS/MS systems enable new levels of sensitivity for clinical trials of inhaled drugs.
Wednesday, February 11, 2015
AB SCIEX Scientist Wins HUPO 2014 Science and Technology Award
Winner becomes second team member to be recognized for the commercialization of transformative chemistries such as iTRAQ® eagents.
Monday, October 06, 2014
AB SCIEX, Dalton Pharma Services Announce ADC Partnership
Research collaboration aims to develop Antibody-Drug Conjugate analysis capabilities.
Wednesday, August 27, 2014
Barry Karger Receives Arnold O. Beckman Award
Award honors Prof Karger for his outstanding achievements in the field of electrodriven separation techniques.
Monday, April 28, 2014
AB SCIEX to Present ESI-MS Workshop
The workshop will be presented at HPLC 2014.
Tuesday, April 22, 2014
Halal Meat Authenticity Testing Reassures Consumers of No Pig or Horse Contamination
New LC/MS/MS-based meat speciation method allows food testing laboratories to detect pig and horse contamination in diverse food products, with higher accuracy than existing methods.
Tuesday, January 28, 2014
AB SCIEX Brings MASStastic Voyage to Ireland
The tour features a state-of-the-art mobile laboratory and will coincide with a special conference being held by the Irish Separation Science Cluster (ISSC).
Monday, November 11, 2013
AB SCIEX Expands in Singapore
AB SCIEX announce the next major phase of its expansion in Singapore, with the grand opening of a new R&D centre.
Friday, November 01, 2013
AB SCIEX Proteomics Scientist Wins HUPO 2013 Science and Technology Award
Dr. Christie Hunter is being recognized for her contributions to the development and commercialization of a breakthrough approach for targeted proteomics.
Tuesday, September 10, 2013
AB Sciex to Combine Eksigent Chromatography with Capillary Electrophoresis from Beckman
The move brings together Beckman Coulter’s expertise in microscale separation with the expertise in microfluidics of the Eksigent chromatography team of AB Sciex.
Thursday, July 11, 2013
AB SCIEX and LECO Announces Co-marketing Agreement
Bundled solutions leverage the synergy between two technology leaders.
Thursday, July 04, 2013
Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
New Analysis Technique for Chiral Activity in Molecules
Professor Hyunwoo Kim of the Chemistry Department and his research team have developed a technique that can easily analyze the optical activity of charged compounds by using nuclear magnetic resonance (NMR) spectroscopy.
Metabolic Profiles Distinguish Early Stage Ovarian Cancer with Unprecedented Accuracy
Studying blood serum compounds of different molecular weights has led scientists to a set of biomarkers that may enable development of a highly accurate screening test for early-stage ovarian cancer.
Genetically Engineering Algae to Kill Cancer Cells
New interdisciplinary research has revealed the frontline role tiny algae could play in the battle against cancer, through the innovative use of nanotechnology.
Acetaldehyde and Formaldehyde Content in Foods
Korean researchers have determined the content of the toxic and carcinogenic aldehydes, acetaldehyde and formaldehyde, in a variety of food groups.
Combining the Power of Mass Spectrometry & Microscopy
A tool that provides world-class microscopy and spatially resolved chemical analysis shows considerable promise for advancing a number of areas of study, including chemical science, pharmaceutical development and disease progression.
Advancing Lithium-Ion Battery Research
The increasing number of components in a lithium-ion battery makes it essential to use a variety of analytical methods to attain complete characterization.
Fruit Fly Pheromone Flags Great Real Estate for Starting a Family
Finding could aid efforts to control mosquito-borne diseases like malaria by manipulating odorants
Education and Expense: The Barriers to Mass Spectrometry in Clinical Laboratories?
Here we examine the perceived barriers to mass spec in clinical laboratories and explore the possible drivers behind the recent shift in uptake of the technology in clinical settings.
Metabolomic Platform Reveals Fundamental Flaw in Common Lab Technology
A new study led by scientists at The Scripps Research Institute (TSRI) shows that a technology used in thousands of laboratories, called gas chromatography mass spectrometry (GC-MS), fundamentally alters the samples it analyzes.

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos