Corporate Banner
Satellite Banner
Chromatography
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New AB SCIEX Software Accelerates Drug Screening for Clinical Research Laboratories

Published: Wednesday, July 31, 2013
Last Updated: Wednesday, July 31, 2013
Bookmark and Share
Software expands possibilities in clinical research with speed and precision of accurate mass technology.

AB SCIEX has announced the availability of MPX™ TF 1.0 Software to accelerate drug screening with accurate mass-based technology for laboratories performing clinical research.

The new software is designed to deliver faster turnaround times, increased sample throughput and lower costs compared to single-stream, mass spectrometry (MS) methods.

This new software will be showcased to researchers at the American Association for Clinical Chemistry (AACC) conference in Houston, Texas this week.

With the new MPX TF Software, researchers are now able to increase throughput by as much as twofold. This is made possible by enabling the use of two parallel liquid chromatography streams.

The ability to stagger chromatographic runs while collecting sample data allows the use of instrument "dead time" to increase the number of samples run in a given time period. This means identifying more compounds in a shorter period of time.

By combining the increased throughput of the MPX software with the capability of the AB SCIEX TripleTOF® 4600 accurate mass system to produce reliable data for a large number of compounds, researchers will be able to do more in less time compared to single-stream MS methods while significantly reducing rates of false positives and false negatives, thanks to LC separation of potential interferences and the enhanced specificity of high-resolution accurate mass technology.

Among the researchers who are using accurate mass technology is Dr. Kara Lynch, PhD. from the University of California, San Francisco (UCSF). She uses a TripleTOF platform to identify unknown compounds, complementing the targeted analysis she does with triple quadrupole instrumentation.

“As the list of drugs and their metabolites are always changing, the value of high resolution, accurate mass technology is identifying unknowns with high specificity,” said Dr. Lynch at UCSF. “Accurate mass-based analysis with a TripleTOF system helps identify compounds that could be missed in a targeted approach if a certain drug is not in the original method. Furthermore, with this technology, you are able to re-interrogate the data at a later date to answer new questions, without needing to re-run the samples.”

AB SCIEX is committed to providing the tools to enable the adoption of accurate mass technology in clinical research laboratories.

By applying MS/MS on an accurate mass system, clinical researchers can take advantage of the enhanced specificity of compound-specific MS/MS fragmentation. This enables more confident compound identification, including ID of unknown compounds, such as new ‘designer’ drugs.

“AB SCIEX continues to drive innovation in clinical research to address existing issues, such as slow turnaround times and false positives or negatives, which hinder these labs from increasing productivity and improving data quality,” said Rainer Blair, President of AB SCIEX. “We are helping clinical research labs reshape how they conduct drug screening to accurately identify not only known but also unknown compounds.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,400+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

SCIEX, QPS Holdings Collaborate
Agreement aims to advance the hybrid LBA-LCMS workflow for biologics quantification.
Wednesday, April 06, 2016
SCIEX, Children's Medical Research Institute Collaborate
SCIEX industrialized proteomics solutions, using SWATH® Acquisition-based workflows and powered by the OneOmics™ Project, will enable large scale proteome studies to advance cancer research.
Thursday, February 11, 2016
SCIEX, University of Manchester Partner
SWATH® Acquisition-based next-generation proteomics technology promises to make industrial proteomics a reality.
Thursday, October 29, 2015
SCIEX and New Objective Announce Partnership
New nanospray sources to offer maximum sensitivity and robustness for NanoLC-MS.
Tuesday, June 02, 2015
SCIEX and New Objective Partner
Partnership will provide advanced nanospray ionization technologies for next-generation proteomics.
Tuesday, May 26, 2015
Dr. Gyula Vigh wins Arnold O. Beckman Award
SCIEX sponsored award recognizes outstanding contributions to the field of electrodriven separation techniques.
Thursday, May 07, 2015
New Capabilities for Bioanalysis Studies at the International Pharmaceutical Research Center
AB SCIEX Triple Quad™ 6500 LC/MS/MS systems enable new levels of sensitivity for clinical trials of inhaled drugs.
Wednesday, February 11, 2015
AB SCIEX Scientist Wins HUPO 2014 Science and Technology Award
Winner becomes second team member to be recognized for the commercialization of transformative chemistries such as iTRAQ® eagents.
Monday, October 06, 2014
AB SCIEX, Dalton Pharma Services Announce ADC Partnership
Research collaboration aims to develop Antibody-Drug Conjugate analysis capabilities.
Wednesday, August 27, 2014
Barry Karger Receives Arnold O. Beckman Award
Award honors Prof Karger for his outstanding achievements in the field of electrodriven separation techniques.
Monday, April 28, 2014
AB SCIEX to Present ESI-MS Workshop
The workshop will be presented at HPLC 2014.
Tuesday, April 22, 2014
Halal Meat Authenticity Testing Reassures Consumers of No Pig or Horse Contamination
New LC/MS/MS-based meat speciation method allows food testing laboratories to detect pig and horse contamination in diverse food products, with higher accuracy than existing methods.
Tuesday, January 28, 2014
AB SCIEX Brings MASStastic Voyage to Ireland
The tour features a state-of-the-art mobile laboratory and will coincide with a special conference being held by the Irish Separation Science Cluster (ISSC).
Monday, November 11, 2013
AB SCIEX Expands in Singapore
AB SCIEX announce the next major phase of its expansion in Singapore, with the grand opening of a new R&D centre.
Friday, November 01, 2013
AB SCIEX Proteomics Scientist Wins HUPO 2013 Science and Technology Award
Dr. Christie Hunter is being recognized for her contributions to the development and commercialization of a breakthrough approach for targeted proteomics.
Tuesday, September 10, 2013
Scientific News
Grant to Fund Million Peaks Project
The European Research Council (ERC) has awarded a prestigious Advanced Grant to Prof. Peter Schoenmakers, Prof. Albert Polman and Prof. Huib Bakker, all three of whom work at the University of Amsterdam (UvA).
Altered Metabolism of Four Compounds Drives Glioblastoma Growth
Findings suggest new ways to treat the malignancy, slow its progression and reveal its extent more precisely.
Why Bearcats Smell Like Buttered Popcorn
Researchers pinpoint chemical compound that gives rare animal its popcorn-like scent.
Human Gut Microbiome Evolution
Westerners have a less-diverse gut microbiome compared to hunter-gatherers, but how and why these microbe collections diverged has largely remained a mystery.
Potential Diagnostic for Dengue Fever
Scientists from Colorado State University have explored the use of small molecules in patient serum for diagnosis of dengue fever and potentially predicting progression to the severe disease.
Non-Destructive Sensing of Fish Freshness
Is there any reliable way to know whether frozen fish is fresh or not?
‘Smelling’ Prostate Cancer
A research team from the University of Liverpool and the University of the West of England (UWE Bristol) has reached an important milestone towards creating a urine diagnostic test for prostate cancer that could mean that invasive diagnostic procedures that men currently undergo eventually become a thing of the past.
Charting Kidney Cancer Metabolism
Changes in cell metabolism are increasingly recognized as an important way tumors develop and progress, yet these changes are hard to measure and interpret. A new tool designed by MSK scientists allows users to identify metabolic changes in kidney cancer tumors that may one day be targets for therapy.
Portable Kit Can Recover Traces of Chemical Evidence
A chemist at the National Institute of Standards and Technology (NIST) has developed a portable version of his method for recovering trace chemicals such as environmental pollutants and forensic evidence including secret graves and arson fire debris.
Diagnosis of Two Rare Childhood Diseases Improved
For the first time, researchers have developed tests that could improve the diagnosis of two rare childhood diseases known as congenital disorders of glycosylation (CDGs) and metachromatic leukodystrophy, and that could even lead to new treatments for CDGs.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,400+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!