The patent concerns the use of Evaporative Light Scattering Detection (ELSD) with flash chromatography, which is a key component of the REVELERIS® flash chromatography system. The technology covered in this allowed claim enables streamlined purification of new chemical/biological entities for drug discovery.
Grace previously announced receipt of similar U.S. patents (US8115930, US8314934, US8305581, and US8305582), which are generally directed to various aspects of flash chromatography using two kinds of detectors, such as ELSD and UV, to collect sample fractions. These techniques improve new molecule purification by increasing recovery, improving reliability, and simplifying instrument operation.
“This additional Australian Patent further confirms our global leadership in flash chromatography technology,” said Laurie Andriate, Vice President and General Manager Engineered Materials at Grace. “Our cutting-edge technology has advanced the capabilities of flash chromatography, resulting in cost savings and productivity enhancements for our customers,” she said.
The award-winning REVELERIS® flash chromatography system and Grace’s innovative silica cartridges are used by most leading pharmaceutical companies in the world. Grace has combined its expertise as the world’s largest manufacturer of specialty silica gel with its pioneering ELSD know-how to optimize flash purification for a broad range of applications.