|Detection and Identification of Dispersants (COREXIT® 9527 and 9500) by GC/MS and LC-MS/MS|
Sky Countryman, Matthew Trass, Seyed Sadjadi, Jeff Layne
Dispersants are plasticizers commonly used to prevent clumping and help dissipate oil slicks. In this work, we used GC/MS and LC-MS/ MS to detect and indentify two of the most widely used dispersants (Corexit 9527 and 9500).
|Understanding the Role of Quality by Design in Chromatographic Method Development|
Michael McBrien, Juan Wang, Teresa Ponzio and Tara Sinclair
Quality by Design (QbD) has become popular within the pharmaceutical industry and the FDA has cited a risk-based approach to drug development as a desirable state for the near future.1 In this state, more complete information and transparency relating to risk assessment will be made available for new drug aplications speeding the approval process, and preventing late-stage failures.
|Ensuring the Quality of Registered Compounds in a Drug Discovery Environment – A Multidisciplinary Approach|
Ryan Sasaki and Tara Sinclair
Lexicon Pharmaceuticals have demonstrated that a practical automated verification system using HPLC, LC/MS, and 1D and 2D NMR can be implemented in an industrial/pharmaceutical environment. This system has proven to be robust, and provides added value to compound collection integrity and quality.
|A Self-Monitoring Quality Management System Incorporating Spectral and Chromatographic Data|
David Snyderman, Colin Read and Tara Sinclair
LIMS are useful in managing certain types of data for quality management and sample tracking. However, these systems are generally limited in the types of information they can process and store. A unique automated quality management system has been developed and implemented at a fragrance manufacturer to evaluate chromatographic and spectral data of samples during quality testing.
|Highly Accurate Measurements of Ochratoxin A (OTA) in Different Foodstuffs|
Andreas Breidbach, J. Stroka and F. Ulberth
The European Union-Reference Laboratory for Mycotoxins at the Institute of Reference Materials and Measurements of the Joint Research Centers of the European Commission regularly conducts proficiency tests to assess the measurement capabilities of the National Reference Laboratories of the EU-Member States.
|A Triple Ionization Source for LC/MS|
Kaveh Jorabchi, Karl Hanold and Jack Syage
This poster reports the development of a triple ionization source consisting of ESI, APCI and APPI sources. The source uses two probes, one for ESI and a nebulizer/vaporizer for APCI and APPI.
|Dual Dopant Approach for Simultaneous LC-APPI-MS/MS Analysis of Low and High Proton Affinity Pesticides|
Sheng-Suan (Victor) Cai, Kaveh Jorabchi and Jack Syage
The objectives of the work detailed in this poster was to explore dual dopant approach to maximizing APPI sensitivity for simultaneous analysis of low and high proton affinity compounds.
|Reversed-Phase Point-of-use Purifier for the Removal of Trace Organics in High Purity Water|
Coralie Monferran, Cecilia Devaux, Maricar Tarun, Estelle Riche and Daniel Darbouret
Recent developments of Liquid Chromatography instrumentation, such as UHPLC coupled with mass spectrometry, have increased the separation efficiency and sensitivity. Unfortunately, there are some
unwelcome consequences. One of these is the detection of trace contamination in the solvents used to prepare mobile phases. The aim of this work was to design a cartridge which produces high water quality for very sensitive LC-MS applications.
|Trace Analysis of Isothiazolinones in Water Samples by Large-Volume Direct Injection Liquid Chromatography Tandem Mass Spectrometry|
P. Speksnijder, J. van Ravestijn, and P. de Voogt
Isothiazolinones are used as preservatives, biocides and desinfectants in variety of industrial and domestic applications. The purpose of this study was to develop and optimize an LC–MS/MS method that would enable the determination without any derivatization or preconcentration step of isothiazolinones used in membrane technology for water purification and in household products, at levels relevant for the water cycle.
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