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The Longest Way Round is the Shortest Way Home: HTS Assay Development for Complex Multi-domain Protein Kinases
Doris Hafenbrandl, Vanessa Nardese, Maria Cristina Sidoli, Valeria Wanke, Mariantonietta Rubino and Daniele Carettoni

This study strongly supports the possibility to overcome the major bottlenecks in the production of long kinase recombinant forms, in order to perform drug discovery programmes with proteins more closely preserving the structural and functional properties of the native enzymes.

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Amino-Coated Metallofullerene Nanoparticles for Glioblastoma Mutiforme Tumor Detection
Tinghui Li , Susan. Murphy, Kanwarpal Bakshi, Steven LaConte, Zhi Sheng, and Harry Dorn

We report the preparation of a new functionalized trimetallic nitride endohedral metallofullerene, with a cage surface consisting of positively charged amino groups, which is expected to bind more efficiently to negatively charged cell phospholipid bi-layer cellular surfaces and will more readily undergo endocytosis. We now report that this Gd-nanoplatform when subsequently conjugated with an IL-13 peptide, (IL-13-Gd3N@C80(OH)x(NH2)y) exhibits enhanced targeting of U-251 GBM cell lines.

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Significant Increase of Sensitivity on Rapid Influenza Antigen Assays Using Silver Amplification Immunochromatography.
Satoshi KIMURA1), Hideyoshi OHTO2), Hayato YAMAGUCHI1), Seiji FUKUOKA1), Emiko NAKAMA1), Akiko TERADA3), and Yoh UMEDA2)

We have developed a new rapid bed-side assay system for in vitro diagnosis of infectious diseases, using “silver amplification method”, an application of photography-developing technology. The automatic analyzer brings results in fifteen minutes, enhancing sensitivity up to 1000 times compared to the conventional immunochromatography. We applied the technology for diagnosis of hospitalized children. The analyzer was useful for rapid and precise diagnosis of influenza A and B.

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MsCompare: An Untargeted LC & GC/MS Metabolomics Platform for Quality Control, Precise Deconvolution and Data Analysis
Marco Ruijken

A GC/MS or LC/MS workflow for Metabolomics applications includes a number of distinct steps: experimental design, sampling, sample preparation, data acquisition, data processing, deconvolution, identification and data interpretation.

The MsXelerator software includes Quality Control procedures and Analysis of Variance (ANOVA) to properly control each step in this workflow and to obtain reliable results for both quantitation and identification.

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Analysis of 10 systemic pesticide residues in various baby foods using liquid chromatography-tandem mass spectrometry
Jae-Han Shim, Angel Yang, A. M. Abd El-Aty, Jong-Hyouk Park, Ayman Goudah, Md. Musfiqur Rahman, Jung-Ah Do

The method developed was sensitive and selective, and detected the analytes below the MRL established by the European Commission and the Korea Food and Drug Administration. The combination of QuEChERS sample preparation and LC-MS/MS analysis provided acceptable quantitative and qualitative results in baby food.

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Residue Analysis of Etoxazole in Red Pepper using Gas Chromatography: Application to Dissipation Pattern
Sung-Woo Kim, Jin Jang, Md. Musfiqur Rahman, A. M. Abd El-Aty, Ah-Young Ko, Jong-Heui Choi, Jae-Han Shim

The dSPE of QuEChERS was replaced with an SPE cartridge, which provided a very clean chromatogram, although a small recovery percentage was obtained. The method fulfilled all validation criteria and was useful for monitoring etoxazole residues in red pepper. It can also be used and optimized for other fruit and vegetable matrices.

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Simultaneous multi-determination and transfer of eight pesticide residues from green tea leaves to infusion using gas chromatography
Sung-Woo Kim, Soon-Kil Cho, A. M. Abd El-Aty, Md. Musfiqur Rahman, Jeong-Heui Choi, Jae-Han Shim

Acetonitrile was used as the extraction solvent with sodium chloride to enhance the partitioning of analytes into the organic phase. Recovery indicated good method accuracy and repeatability, and was within the acceptable range for residue determinations. The mere presence of pesticide residues in tea does not necessarily mean that the tea has become toxic and would pose a health hazard. We revealed that only a negligible or small percentage of pesticides in tea is transferred to the infusion.

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Matrix enhancement effect: A blessing or curse for gas chromatography?
Jae-Han Shim, Md. Musfiqur Rahman, A. M. Abd El-Aty

A sharp, narrow, and sensitive peak is a pre-condition for a sensitive GC analysis. Therefore, a protectant is needed to protect the analyte from any type of distortion for integration and to prevent overestimation. Existing solutions do not overcome these problems completely due to limitations. As the matrix enhancement problem originated from matrix components, its solution should come from similar components.

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HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR DETERMINATION OF LIPOIC ACID IN THE FORM OF 2-S-PYRIDINIUM DERIVATIVE
Chwatko G. (1), Krawczyk M. J. (1), Iciek M. (2), Bilska-Wilkosz A. (2), Marcykiewicz B. (3), Glowacki R. (1)

* The method can be used for routine clinical monitoring of LA in human plasma and urine.
* The method was validated for urine and plasma samples.
* The imprecision, expressed as relative standard deviation value, were within range 0.8-7.7% and 0.9-6.2% for plasma and urine samples, respectively.
* The analytical recovery were from 97.3 to 117.0% for plasma and from 96.5% to 111.5% for urine samples.

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Showing Results 11 - 20 of 74
Scientific News
Utilizing Fast HPLC Screening Methods for the Detection of Steroids
Analysis of steroids improved by choosing the optimal HPLC column for the separation.
Benefits of SPE for the Analysis of Mycotoxins
Fast and cost-effective sample preparation is essential for the analysis of mycotoxins in food and feed.
Pharmaceuticals, Personal Care Products Could Taint Swimming Pools
A new study suggests pharmaceuticals and chemicals from personal care products end up in swimming pools, possibly interacting with chlorine to produce disinfection byproducts with unknown properties and health effects.
More Efficient, Sensitive Estrogen Detection Developed
A new method for detecting trace amounts of estrogen in small samples that holds the potential to improve research into cancer and other diseases has been developed.
Chestnuts Roasting On An Open Fire
ORNL work with scientists funded by The American Chestnut Foundation confirms increased blight-resistance of former forest giant.
Metabolomics Data Normalization with EigenMS
In this study, a singular value decomposition-based method, called EigenMS, for normalization of metabolomics data was tested.
Agilent Technologies - Making Better GC Connections
Improving GC connections for reliable, robust and reproducible results.
How to Achieve High-Speed, High-Resolution Glycan Mapping for mAb Characterization
The full characterization of biotherapeutics is required by regulatory authorities as properties such as safety, efficacy and the serum half-life of therapeutic proteins can be affected by differences in their glycosylation pattern.
Odour That Smells Like Blood
The study, conducted at Kolmården Wildlife Park, found that for the animals, one particular component of blood odour was just as engaging as the blood odour itself.
Bridging Quantitative Analysis and Untargeted Metabolomics
Untargeted metabolomics has become a popular tool in metabolite biomarker discovery and in the evaluation of metabolic pathway changes associated with disease.
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