|Exploring The Benefits Of Automated Unattended Sample Derivatization Prior To Gas Chromatography Analysis|
A. Caruso, M. Santoro, P. Magni, S. Pelagatti, R. Facchetti
Purpose: Exploring the possibility to perform the sample preparation steps necessary for the derivatization of analytes in a fully automated and reliable way by means of the same robotic sampler used for sample injection into the gas chromatograph.
Methods: As an example of application we screened dairy products for melamine and its derivates presence via GC-MS/MS.
Results: The outcome are good and precise results that show how it is possible to reliably automate sample preparation opera
|Determination of Veterinary Drug Residues in Milk by GC/MS and GC/ECD|
Yu Chongtian, Lv Jianxia
Purpose: Develop a rapid, sensitive method for determining amitraz and its metabolites in milk.
Methods: Samples were hydrolyzed in acidic condition and extracted with hexane. After derivativation, the samples were analyzed by GC-ECD or directly by GC-MS.
Results: The results show that GC-MS determination of amitraz and its metabolites is rapid and sensitive.
|Automated, Rapid And Reliable Determination Of Dissolved Gases In Water By Static Headspace – Gas Chromatography|
A. Caruso, M. Santoro, F. Bedini, P. Magni, S. Pelagatti
Purpose: Exploring the possibility to perform a quantitative determination of dissolved gases in water in a reliable and accurate way. Methods: The quantification of dissolved gases is performed by building a calibration curve spiking blank water samples with increasing quantities of saturated water followed by headspace sampling and GC/ FID analysis. Results: The results show good correlation factors and limit of quantification lower than 10ppb for the four gas analyzed.
|AUTOMATED WORKFLOW FOR THE DETERMINATION OF FATTY ACID METHYL ESTERS (FAME)|
Beat Schilling1, Reto Bolliger2, Guenter Boehm2
Transesterification of fatty acid esters with Na-methoxide is a fast, efficient and very robust method for fat analysis in food samples. With the use of three ISs the completeness of the transesterification as well as the extent of undesired saponification can be checked.
The PALworkstation allows to fully automate the FAME preparation, including injection into the GC.
|Characterization of Antibody-Drug Conjugates by SEC with Combined Light Scattering |
Chris C. Broomell
Drug Antibody Ratio (DAR) is a critical factor to the effective design of antibody-drug conjugates (ADC). This poster presents a method for DAR determination based on SEC-MALS in conjunction with UV absorption and differential refractive index detection.
|GC-MS Comparison of Lavindin Grosso Oil Obtained by Steam Distillation and SFE|
Claudia Worley, Lisa Zona, Susan Sonchik Marine
Oil was extracted from Lavindin Grosso using steam distillation and using supercritical fluid extraction (SFE). Multiple analyses of the same extract demonstrated repeatability of the analytical method. The variability between batches of distillate bracketed the composition obtained by SFE. The differences among the oils could be attributed more to where the lavender was grown than to the extraction method.
|Trace Level Analysis of Perchlorate and Bromate in Various Water Matrices using Suppressed Ion Chromatography|
Dr. Jay Gandhi, DR. Stuart Procter
Bromate and Perchlorate are ubiquitous analytes in various water matrices and analysis in trace level is a challenge
|Identification and classification of antifouling compounds secreted by anti MIC microorganisms. A metabolomic analysis.|
Albillos SM; Balaña-Fouce R; Montero O; Barreiro-Mendez C; Blas-Galindo E; Barros-García R; Guedella-Bustamante E; Ullán RV
BIOCORIN project, aims to develop a green alternative to the coatings and solutions used up to date for MIC corrosion control. Some of the results of this project are presented here, with the identification of several relevant antifouling compounds secreted by environmentally isolated anti-MIC strains of microorganisms via a metabolomic approach.
|Employing Design of Experiments (DoE) to Evaluate the Robustness of an Automated Content Uniformity Method for the Triple Fixed Dose Combination Tablets|
Irena Maksimovic, Dongsheng Bu, David Lloyd
The Design of Experiments study was employed to optimize the operating ranges of the critical sample extraction parameters for the content uniformity determination of three actives in Triple Fixed Dose Combination tablets using Tablet Processing Workstation bench-top robotic system.