|Analysis of Fruit Commodities by GC-TOFMS and GCxGC-TOFMS Using QuEChERS Approach|
Doug Staples, Joe Binkley and John Heim
The availability of fruit commodities from a wide variety of sources has increased the need for rapid and accurate screening for pesticides in fruit. Not all fruit commodities are brought to market under the strict guidelines of the United States Department of Agriculture. Determining whether or not the Environmental Protection Agency tolerances for various pesticides have been violated is important in the risk assessment for consumers in the United States.
|Characterization of Nutrients and Actives in Herbal Supplements and Nutriceuticals Using UHPLC-Multi-Reflecting Time-of-Flight Mass Spectrometry|
Jeffrey S. Patrick, Kevin Siek and Joe Binkley
The qualitative and quantitative analysis of the content of nutritional supplements and alternative medicinal therapies is becoming more important and regulation by the FDA is imminent. High resolution mass spectrometry provides a rapid, selective, and useful mechanism for QC of extracts and finished dosage forms, producing a minable, comprehensive data set.
|Facing the challenges in bio-pharmaceutical production: newly developed polymer-based ion exchange chromatography media and their application to the purification for Immunoglobulin – from egg yolk|
Masakatsu Omote, Noriko Shoji, Naohiro Kuriyama and Daniel Kune
Much attention has been given to ion exchange (IEX) media as a means to improve productivity as a result of increasing demand for higher efficiency on the downstream process. Until recently, strain optimisation for high productivity and upstream purification were the bottlenecks for most bio-processes.
|Detection of Environmental Contaminants Caused by the Oil Spill in the Gulf of Mexico by GC and HPLC|
Sky Countryman, Ngoc Nguyen, Jeff Layne, Kory Kelly and Zeshan Aqeel
In order to help understand the impact that the oil spill has caused, laboratories are looking for rapid and robust analytical procedures to characterize the hydrocarbon contaminants. This work provides SPE, GPC, GC-FID, GC/MS, and HPLC analytical methods for analyzing the most common contaminants that originated from the
|Detection and Identification of Dispersants (COREXIT® 9527 and 9500) by GC/MS and LC-MS/MS|
Sky Countryman, Matthew Trass, Seyed Sadjadi, Jeff Layne
Dispersants are plasticizers commonly used to prevent clumping and help dissipate oil slicks. In this work, we used GC/MS and LC-MS/ MS to detect and indentify two of the most widely used dispersants (Corexit 9527 and 9500).
|Understanding the Role of Quality by Design in Chromatographic Method Development|
Michael McBrien, Juan Wang, Teresa Ponzio and Tara Sinclair
Quality by Design (QbD) has become popular within the pharmaceutical industry and the FDA has cited a risk-based approach to drug development as a desirable state for the near future.1 In this state, more complete information and transparency relating to risk assessment will be made available for new drug aplications speeding the approval process, and preventing late-stage failures.
|Ensuring the Quality of Registered Compounds in a Drug Discovery Environment – A Multidisciplinary Approach|
Ryan Sasaki and Tara Sinclair
Lexicon Pharmaceuticals have demonstrated that a practical automated verification system using HPLC, LC/MS, and 1D and 2D NMR can be implemented in an industrial/pharmaceutical environment. This system has proven to be robust, and provides added value to compound collection integrity and quality.
|A Self-Monitoring Quality Management System Incorporating Spectral and Chromatographic Data|
David Snyderman, Colin Read and Tara Sinclair
LIMS are useful in managing certain types of data for quality management and sample tracking. However, these systems are generally limited in the types of information they can process and store. A unique automated quality management system has been developed and implemented at a fragrance manufacturer to evaluate chromatographic and spectral data of samples during quality testing.
|Highly Accurate Measurements of Ochratoxin A (OTA) in Different Foodstuffs|
Andreas Breidbach, J. Stroka and F. Ulberth
The European Union-Reference Laboratory for Mycotoxins at the Institute of Reference Materials and Measurements of the Joint Research Centers of the European Commission regularly conducts proficiency tests to assess the measurement capabilities of the National Reference Laboratories of the EU-Member States.
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