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Thursday, November 27, 2014
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Crown Antibodies...
Structure Alignment of Proteins...World of Technology & Science 2014...Improved Oral Delivery of Antiretroviral...

Featured Products
Featured Project - Protein Crystallization Starter Kit
Protein Crystallization Starter Kit

Webcasts
Identification of Atg-8–Atg 3 protein-protein interaction inhibitor
Jürgen Bosch, Johns Hopkins University, speaking at Drug Discovery and Development 2014
Approaches to the Discovery of Small-molecule MDM2-p53 Inhibitors
Dr Ian Hardcastle, Newcastle University, speaking at Discovery Chemistry Congress 2013.

Market Reports
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Analytical Instrument Market in the US 2014-2018
Infinity Research

TechNavio's report focuses on the US and has been prepared based on an in-depth market analysis with inputs from industry experts.
Atomic Spectroscopy Market by Technology & Application - Competitive Landscape, Global Forecasts & Trends to 2018
MarketsandMarkets

The global atomic spectroscopy market was valued at an estimated $4.02 billion in 2013 and is expected to grow at a CAGR of 6.4%.
Protein Crystallization & Crystallography Market by Technology, Products & End-Users - Forecast to 2018
MarketsandMarkets

The growing need to identify new ligands for the drug discovery process and the rising popularity of structure-based/rational drug design are factors that present opportunities for the protein crystallization & crystallography market.
Life Science Software 2013: Markets and Opportunities
Biopharm Reports

This reports into in the life science field examines the use of specialist software and databases relating to the conduct of PCR, DNA sequencing, DNA microarray, flow cytometry, mass spectrometry and disease biomarker studies. The studies were carried out to assist software developers and vendors to identify market opportunities in these fields.
Lab Instrument Rental Trends 2012
HTStec

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on lab instrument rental carried out in September 2012.
Novel Antibodies & Therapeutic Proteins: Technological Challenges & Future Prospects
Select Biosciences Ltd

This innovative & analytical report can be used to assess market trends & appraise the potential of new antibodies & therapeutic proteins. It provides perspective to gain an in-depth understanding of the marketplace, players, products & leading technologies driving the field.
Multiplexed Diagnostics 2010
Select Biosciences Ltd

The multiplexed diagnostics market has grown rapidly and generated sales of approximately $2.4 billon in 2009, but is now balanced on multiple tipping points.
Scientific News
Did You Hear The One About The Two Businessmen On A Plane?
EquipNet’s vision ‘to revolutionize the way companies manage their surplus assets’ was first conceived at 30,000 feet somewhere between Chicago and Boston in 1999. Here we learn more about the company's first 15 years.
How the Environment Contributes to Human Diseases
Using a new imaging technique, NIH researchers have found that the biological machinery that builds DNA can insert molecules into the DNA strand that are damaged as a result of environmental exposures.
Protein-engineered Cages Aid Studies of Cell Functions
The Cages, from researchers at Tokyo Institute of Technology, to deliver an important signalling molecule, carbon monoxide, into cells.
Scientists Discover Bacteria’s Clever Defence Mechanism
Structure of EzrA protein could help identify new antibiotic targets.
UCLA Biochemists Build Largest Synthetic Molecular ‘Cage’ Ever
New nanoscale protein container could lead to synthetic vaccines and offer a way to deliver medicine inside of human cells.
SLAC X-ray Laser Brings Key Cell Structures into Focus
Experiment is Important Step Toward Atomic-Scale Imaging of Intact Biological Particles.
A Greasy Way to Take Better Protein Snapshots
Researchers used a newly developed grease to suspend small crystals of lysozyme, glucose isomerase, thaumatin, and fatty acid-binding protein type-3.
Scripps Research Institute Scientists Capture Picture of 'MicroRNA' in Action
The Findings Will Help Guide Drug Design.
Team Discovers How Microbes Build a Powerful Antibiotic
Researchers discovery opens up new avenues of research into thousands of similar molecules.
Major Step Forward in Understanding of Viruses
Scientists unlock exact structure of Hepatitis A virus.
Business News
Eleven More Countries Adopt Cambridge Structural Database System National Provision
Academia in 17 countries enjoy unlimited access to Cambridge Structural Database.
Calixar, Aston University Announce Multidrug Resistance Collaboration
Purpose is to study the extraction, stabilization and crystallization of full-length human ABC transporters involved in multidrug resistance.
Anatrace, Microlytic Partnership to Enable Membrane Protein Research
Partnership will develop and commercialize Analytic, a new brand of products targeted to the membrane protein research community.
Norwich Research Park Receives £12.5M Investment
Government will fund 125 PhD students through the Norwich Research Park Doctoral Training Partnership over the next five years.
Investment in New Capability for Materials Analysis
Johnson Matthey, Oxford University, Diamond Light Source announce the creation a state-of-the-art materials characterisation facility at the Harwell Science and Innovation Campus.
TTP Labtech Revenues up 43%
The company has reported an impressive 43% increase in revenues and an associated increase in profits over 2013.
Investment Provides Access to the World’s Most Advanced Crystallography Technology
The UK community will benefit thanks to a £5.64M investment from UK research funders.
Proteros Announces Changes in Management Team
The changes see a new Chief Financial Officer, and a promotion to Chief Operating Officer.
Rigaku Corp, Supplier for £1M Enhancement to X-ray Facility
The company will supply X-ray equipment to University of St Andrews.
Faster Visa Endorsement will Support International Mobility for Top Researchers
This visa route is designed for the brightest and best bringing them from outside the European Economic Area to the UK.

Events
SLAS2015
07 Feb 2015
SLAS2015 ...
More information
Screening Europe
17 Feb 2015
Screening Europe ...
More information
Discovery Chemistry Congress
17 Feb 2015
Discovery Chemistry Congress ...
More information
Pittcon 2015
08 Mar 2015
Pittcon 2015 ...
More information

ePosters
"In-vitro studies on hydroxamic acid- CT DNA binding"
Research Scholar

In vitro studies of five the interaction between five different derivatives of hydroxamic acids, N-phenyl 2,4dichloro phenoxybutyro, N-m-tolyl 2,4 dichlorophenoxyglutero, N-m-tolyl-4-chlorophenoxyaceto, N-m-chloro-phenyl-tertiarybutylbenzo and N-p-tolyl-iso-valero hydroxamic acids and calf thymus DNA was investigated under simulated physiological condition.
Rapid Quantification of Proteins in Complex Matrices using the DeNovix DS11 Microvolume Spectrophotometer
1) Swift Analytical Ltd, The Catalyst, Baird Lane, York, YO10 5GW 2) DeNovix Inc, 3411 Silverside Road, Hanby Building, Wilmington, DE 19810 USA

In this poster, we will introduce the DeNovix DS-11 as the next generation in microvolume spectrophotometry.
Coping with BIG DATA Image Formats: Integration of CBF, NeXus and HDF5, A Progress Report
[1] Department of Mathematics and Computer Science, Dowling College, Oakdale, NY 11769 (USA); [2] Diamond Light Source, Harwell Science and Innovation Campus, OX11 0DE (UK); [3] http://wiki.nexusforma

The best of CBF/imgCIF (the Crystallographic Binary File, which has a complete description of the experiment), NeXus (a common data framework for neutron, X-ray and muon science, which gracefully handles large data sets) and HDF5 (Hierarchical Data Format, version 5, the high-performance data format used by NeXus) are being combined for the management of BIG DATA at synchrotrons.
mosquito® Crystal and mosquito® LCP: fast, reliable automation of protein crystallisation drop set-up
TTP Labtech

This poster demonstrates the ability of TTP Labtech’s mosquito® Crystal and mosquito® LCP to address the issues inherent in the automated set-up of protein crystallisation screen trials, without needing constant instrument configuration changes.
mosquito® Crystal and mosquito® LCP: fast, reliable automation of protein crystallisation drop set-up
TTP Labtech

This poster demonstrates the ability of TTP Labtech’s mosquito® Crystal and mosquito® LCP to address the issues inherent in the automated set-up of protein crystallisation screen trials, without needing constant instrument configuration changes.
Structure determination of the virulence factor AsaP1 from Aeromonas salmonicida subsp. Achromogenes
CyBio

Aeromonas commonly found in waters, wastewaters and mud are non-motile gram negative bacteria. Atypical strains of Aeromonas salmonicida are known to be largely responsible for causing a lethal disease in Atlantic salmons and other farmed fishes.
Stable N-phosphorylated triazol-5-ylidenes
National Academy of Sciences of Ukraine

Considering probable generality of “carbene” mechanism for 1,3-azoles, investigation of intermediates of phosphorylation of 1,2,4-triazoles is of interest.
A Crystallographic-Based Fragment Screen Against Human BRD4 Bromodomain 1
BioFocus

Fragment-based drug discovery has now become firmly established as an important method in the lead discovery process, and is an integral component of drug discovery at BioFocus. Using a selection of compounds from our fragment collection, we have performed a crystallographic-based screen against human BRD4 bromodomain 1.
A fast and fully automated solution for Lipidic Cubic Phase (LCP) screening using mosquito LCP
1TTP Labtech Ltd 2MRC

Membrane proteins, such as G-protein-coupled receptors, are known to be much more difficult to purify and crystallise than soluble proteins due to their native environment within the lipid bilayer of the cell membrane. The in meso (lipidic cubic phase or LCP) crystallisation technique has revolutionised the process of crystallising membrane proteins. This method utilises highly viscous lipid mesophases to contain the membrane proteins for crystallisation.
mosquito® Crystal: Fast, reliable automation of Protein Crystallization drop set-up
TTP Labtech Ltd

Automation of protein crystallography screening has contributed significantly to the rapid progress of crystallography based structural biology. Automation allows samples to be screened using smaller volumes of both protein and screen solutions, reducing costs and saving valuable protein. Additional benefits include increased throughput and accuracy. One of the challenges to automating this process is the necessity to accurately pipette solutions of varying viscosities
Application Notes
Fully automated sitting drop protein crystallization with CyBi®-CrystalCreator using JBScreen Basic HTS Kit
CyBio

Growing high-quality protein crystals is still a major bottleneck and very time consuming step in this process. This application note describes screening experiments using the fully automated CyBi®-CrystalCreator in combination with a commercially available crystallization screen from Jena Bioscience.
Nanoliter Scale High-Throughput Protein Crystallography Screening with the Echo Liquid Handler
Labcyte

The Echo® liquid handler enables protein crystal formation with sitting drop volumes as small as 50 nL. Nanoliter volumes of protein and crystallography reagents can be transferred into sitting drop wells of crystallography plates. Precise and accurate drop placement eliminates cross-contamination and ensures drop-on-drop placement for blending protein and crystallography solutions.
Precision of the 96-Channel Heads of the CyBi-CrystalCreator
CyBio

This application note shows precision data in the low volume range of the 96-channel head of the CyBi-CrystalCreator using different volumes and pipetting modes. The precision was determined using a standardized absorption method.
Acoustic matrix microseeding: improving protein crystal growth with minimal chemical bias
CyBio

Using this technique, it was found that while buffer components alone without seed can marginally promote crystal growth in some cases, crystal seeding is far more effective in boosting the number of sparsematrix conditions that yield protein crystals.
mosquito® Crystal for the rapid screening and optimisation of crystallisation conditions of the bacterial periplasmic binding protein, HbpA
TTP LabTech

Glutathione is one of the major antioxidants/redox molecules in most aerobic cells, playing an important role in cell metabolism, differentiation, proliferation, and apoptosis. The reduced form of glutathione (GSH) is required for the detoxification of drugs and reactive compounds of both endogenous and exogenous origin.
Heating on an Atlas Hotplate
Syrris Ltd

In the following experiments, different vessels were heated using the Atlas hotplate, with and without the Atlas Stacking Drybath. In every case, an external thermocouple probe has been used with the system to accurately measure “reaction” temperature.
Analysing Endotherms using Atlas
Syrris Ltd

This application note shows how atlas and reaction monitoring can be used to look at endothermic processes.
Tracking Exotherms using Atlas Reaction Monitoring
Syrris Ltd

This application note shows how atlas and reaction monitoring can be used to look at exothermic processes.
Reaction Monitoring with Atlas 1
Syrris Ltd

This application note reports the use of the atlas system to monitor the hydrolysis of acetic anhydride, a typical test reaction for exothermic processes.
Reaction Monitoring with Atlas 2
Syrris Ltd

This application note details an experiment to show the repeatability and scalability of reaction monitoring signals by using an electrical heater system.
SELECTBIO
SELECTBIO Market Reports
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