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Tuesday, October 21, 2014
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Improved Oral Delivery of Antiretroviral...
Crown Antibodies...Structure Alignment of Proteins...Technical Innovation Enhances Crystallis...

Featured Products
Featured Project - Protein Crystallization Starter Kit
Protein Crystallization Starter Kit

Webcasts
Approaches to the Discovery of Small-molecule MDM2-p53 Inhibitors
Dr Ian Hardcastle, Newcastle University, speaking at Discovery Chemistry Congress 2013.
Chemical Biology Approaches to Target Protein Modification in Disease
Megan Wright, Imperial College London, speaking at Discovery Chemistry Congress 2013.

Market Reports
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Analytical Instrument Market in the US 2014-2018
Infinity Research

TechNavio's report focuses on the US and has been prepared based on an in-depth market analysis with inputs from industry experts.
Atomic Spectroscopy Market by Technology & Application - Competitive Landscape, Global Forecasts & Trends to 2018
MarketsandMarkets

The global atomic spectroscopy market was valued at an estimated $4.02 billion in 2013 and is expected to grow at a CAGR of 6.4%.
Protein Crystallization & Crystallography Market by Technology, Products & End-Users - Forecast to 2018
MarketsandMarkets

The growing need to identify new ligands for the drug discovery process and the rising popularity of structure-based/rational drug design are factors that present opportunities for the protein crystallization & crystallography market.
Life Science Software 2013: Markets and Opportunities
Biopharm Reports

This reports into in the life science field examines the use of specialist software and databases relating to the conduct of PCR, DNA sequencing, DNA microarray, flow cytometry, mass spectrometry and disease biomarker studies. The studies were carried out to assist software developers and vendors to identify market opportunities in these fields.
Lab Instrument Rental Trends 2012
HTStec

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on lab instrument rental carried out in September 2012.
Novel Antibodies & Therapeutic Proteins: Technological Challenges & Future Prospects
Select Biosciences Ltd

This innovative & analytical report can be used to assess market trends & appraise the potential of new antibodies & therapeutic proteins. It provides perspective to gain an in-depth understanding of the marketplace, players, products & leading technologies driving the field.
Multiplexed Diagnostics 2010
Select Biosciences Ltd

The multiplexed diagnostics market has grown rapidly and generated sales of approximately $2.4 billon in 2009, but is now balanced on multiple tipping points.
Scientific News
Breakthrough Allows Researchers to Watch Molecules “Wiggle”
A new crystallographic technique developed at the University of Leeds is set to transform scientists’ ability to observe how molecules work.
X-Ray Free Electron Laser for Fixed-Target Protein Serial Microcrystallography
The article presents the first proof-of-principle results from fixed-target serial crystallography using the Linac Coherent Light Source.
Identifying, Studying and Making Good Use of Macromolecular Crystals
Techniques that extend the observation of crystals beyond the optical microscope will enhance structural biology in the future.
'Evolved' Protein May Stop Cancer From Spreading
Experimental therapy stopped the metastasis of breast and ovarian cancers in lab mice, pointing toward a safe and effective alternative to chemotherapy.
Protein Crystalline Frameworks: A New Class of Materials
Scientists at the Helmholtz Center Berlin (HZB) along with researchers at China’s Fudan University have characterized a new class of materials called protein crystalline frameworks (PCFs).
Worm Virus Details Come to Light
Rice University scientists have won a race to find the crystal structure of rare nematode virus, known to infect the most abundant animal on Earth.
Structure of Molecular Machine for Targeted Viral DNA Destruction Determined
The MSU-led research provides the first detailed blueprint of a multi-subunit “molecular machinery” that bacteria use to detect and destroy invading viruses.
Flu’s Mechanisms Clues Uncovered
Researchers from Rice University and Baylor College of Medicine have analyzed how influenza-related proteins help infect cells.
Innovative Technology Enables First Crystal Structure of mGlu5 Transmembrane Domain to be Determined
Several novel drug candidates have been identified to help treat specific neuropsychiatric disorders.
Neutron Crystallography Resolves Long-Standing Molecular Mystery
Research has implications for understanding of oxidative processes within living cells which is crucially important for drug development.
Business News
Norwich Research Park Receives £12.5M Investment
Government will fund 125 PhD students through the Norwich Research Park Doctoral Training Partnership over the next five years.
Investment in New Capability for Materials Analysis
Johnson Matthey, Oxford University, Diamond Light Source announce the creation a state-of-the-art materials characterisation facility at the Harwell Science and Innovation Campus.
TTP Labtech Revenues up 43%
The company has reported an impressive 43% increase in revenues and an associated increase in profits over 2013.
Investment Provides Access to the World’s Most Advanced Crystallography Technology
The UK community will benefit thanks to a £5.64M investment from UK research funders.
Proteros Announces Changes in Management Team
The changes see a new Chief Financial Officer, and a promotion to Chief Operating Officer.
Rigaku Corp, Supplier for £1M Enhancement to X-ray Facility
The company will supply X-ray equipment to University of St Andrews.
Faster Visa Endorsement will Support International Mobility for Top Researchers
This visa route is designed for the brightest and best bringing them from outside the European Economic Area to the UK.
Novel Crystallography Beamline Takes Delivery of in Vacuum X-Ray Detector
The Diamond Light Source beamline will facilitate challenging research on DNA, RNA, native proteins and other building blocks of life.
PANalytical Participates in the International Year of Crystallography 2014
A large number of events around the world will aim to spread crystallographic knowledge, inspire young people and promote education and research in crystallography.
Proteros Elects New Supervisory Board Member
Shareholders confirmed the appointment of Prof. Eric-Paul Pâques as a new member of the Supervisory Board.

Events
Lab Innovations 2014
05 Nov 2014
Lab Innovations 2014 ...
More information
Drug Delivery Strategy: Advanc
02 Dec 2014
Drug Delivery Strategy: Advanc ...
More information
SLAS2015
07 Feb 2015
SLAS2015 ...
More information
Screening Europe
17 Feb 2015
Screening Europe ...
More information

ePosters
Rapid Quantification of Proteins in Complex Matrices using the DeNovix DS11 Microvolume Spectrophotometer
1) Swift Analytical Ltd, The Catalyst, Baird Lane, York, YO10 5GW 2) DeNovix Inc, 3411 Silverside Road, Hanby Building, Wilmington, DE 19810 USA

In this poster, we will introduce the DeNovix DS-11 as the next generation in microvolume spectrophotometry.
Coping with BIG DATA Image Formats: Integration of CBF, NeXus and HDF5, A Progress Report
[1] Department of Mathematics and Computer Science, Dowling College, Oakdale, NY 11769 (USA); [2] Diamond Light Source, Harwell Science and Innovation Campus, OX11 0DE (UK); [3] http://wiki.nexusforma

The best of CBF/imgCIF (the Crystallographic Binary File, which has a complete description of the experiment), NeXus (a common data framework for neutron, X-ray and muon science, which gracefully handles large data sets) and HDF5 (Hierarchical Data Format, version 5, the high-performance data format used by NeXus) are being combined for the management of BIG DATA at synchrotrons.
mosquito® Crystal and mosquito® LCP: fast, reliable automation of protein crystallisation drop set-up
TTP Labtech

This poster demonstrates the ability of TTP Labtech’s mosquito® Crystal and mosquito® LCP to address the issues inherent in the automated set-up of protein crystallisation screen trials, without needing constant instrument configuration changes.
mosquito® Crystal and mosquito® LCP: fast, reliable automation of protein crystallisation drop set-up
TTP Labtech

This poster demonstrates the ability of TTP Labtech’s mosquito® Crystal and mosquito® LCP to address the issues inherent in the automated set-up of protein crystallisation screen trials, without needing constant instrument configuration changes.
Structure determination of the virulence factor AsaP1 from Aeromonas salmonicida subsp. Achromogenes
CyBio

Aeromonas commonly found in waters, wastewaters and mud are non-motile gram negative bacteria. Atypical strains of Aeromonas salmonicida are known to be largely responsible for causing a lethal disease in Atlantic salmons and other farmed fishes.
Stable N-phosphorylated triazol-5-ylidenes
National Academy of Sciences of Ukraine

Considering probable generality of “carbene” mechanism for 1,3-azoles, investigation of intermediates of phosphorylation of 1,2,4-triazoles is of interest.
A Crystallographic-Based Fragment Screen Against Human BRD4 Bromodomain 1
BioFocus

Fragment-based drug discovery has now become firmly established as an important method in the lead discovery process, and is an integral component of drug discovery at BioFocus. Using a selection of compounds from our fragment collection, we have performed a crystallographic-based screen against human BRD4 bromodomain 1.
A fast and fully automated solution for Lipidic Cubic Phase (LCP) screening using mosquito LCP
1TTP Labtech Ltd 2MRC

Membrane proteins, such as G-protein-coupled receptors, are known to be much more difficult to purify and crystallise than soluble proteins due to their native environment within the lipid bilayer of the cell membrane. The in meso (lipidic cubic phase or LCP) crystallisation technique has revolutionised the process of crystallising membrane proteins. This method utilises highly viscous lipid mesophases to contain the membrane proteins for crystallisation.
mosquito® Crystal: Fast, reliable automation of Protein Crystallization drop set-up
TTP Labtech Ltd

Automation of protein crystallography screening has contributed significantly to the rapid progress of crystallography based structural biology. Automation allows samples to be screened using smaller volumes of both protein and screen solutions, reducing costs and saving valuable protein. Additional benefits include increased throughput and accuracy. One of the challenges to automating this process is the necessity to accurately pipette solutions of varying viscosities
Analysis of overall success of robotic crystallization
Laboratory of Structural Biology, School of Biological Sciences

A total of about 140 different proteins have been commissioned and 62 have been crystallized with a quality suitable for X-ray diffraction (45%). On a per-drop basis, 300 crystallization experiments have been successful, representing an over¬all success rate of 3%. PEG 3350 was the precipitant for 20, making it the single most successful crystallization agent.
Application Notes
Fully automated sitting drop protein crystallization with CyBi®-CrystalCreator using JBScreen Basic HTS Kit
CyBio

Growing high-quality protein crystals is still a major bottleneck and very time consuming step in this process. This application note describes screening experiments using the fully automated CyBi®-CrystalCreator in combination with a commercially available crystallization screen from Jena Bioscience.
Nanoliter Scale High-Throughput Protein Crystallography Screening with the Echo Liquid Handler
Labcyte

The Echo® liquid handler enables protein crystal formation with sitting drop volumes as small as 50 nL. Nanoliter volumes of protein and crystallography reagents can be transferred into sitting drop wells of crystallography plates. Precise and accurate drop placement eliminates cross-contamination and ensures drop-on-drop placement for blending protein and crystallography solutions.
Precision of the 96-Channel Heads of the CyBi-CrystalCreator
CyBio

This application note shows precision data in the low volume range of the 96-channel head of the CyBi-CrystalCreator using different volumes and pipetting modes. The precision was determined using a standardized absorption method.
Acoustic matrix microseeding: improving protein crystal growth with minimal chemical bias
CyBio

Using this technique, it was found that while buffer components alone without seed can marginally promote crystal growth in some cases, crystal seeding is far more effective in boosting the number of sparsematrix conditions that yield protein crystals.
mosquito® Crystal for the rapid screening and optimisation of crystallisation conditions of the bacterial periplasmic binding protein, HbpA
TTP LabTech

Glutathione is one of the major antioxidants/redox molecules in most aerobic cells, playing an important role in cell metabolism, differentiation, proliferation, and apoptosis. The reduced form of glutathione (GSH) is required for the detoxification of drugs and reactive compounds of both endogenous and exogenous origin.
Heating on an Atlas Hotplate
Syrris Ltd

In the following experiments, different vessels were heated using the Atlas hotplate, with and without the Atlas Stacking Drybath. In every case, an external thermocouple probe has been used with the system to accurately measure “reaction” temperature.
Analysing Endotherms using Atlas
Syrris Ltd

This application note shows how atlas and reaction monitoring can be used to look at endothermic processes.
Tracking Exotherms using Atlas Reaction Monitoring
Syrris Ltd

This application note shows how atlas and reaction monitoring can be used to look at exothermic processes.
Reaction Monitoring with Atlas 1
Syrris Ltd

This application note reports the use of the atlas system to monitor the hydrolysis of acetic anhydride, a typical test reaction for exothermic processes.
Reaction Monitoring with Atlas 2
Syrris Ltd

This application note details an experiment to show the repeatability and scalability of reaction monitoring signals by using an electrical heater system.
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