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Choosing & Using Fragments in the Genera...Manual Removal of Push Caps...Life of a Scientific Poster...

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Featured Project - Protein Crystallization Starter Kit
Protein Crystallization Starter Kit

Webcasts
Discovery of Potent and Selective Inhibitors of Monopolar Spindle 1 (MPS1) Kinase
Rob van Montfort, The Institute of Cancer Research, speaking at Discovery Chemistry Congress 2015.
Choosing & Using Fragments in the Generation of Selective Kinase Inhibitors
Lee Walmsley, Vernalis Ltd, speaking at Discovery Chemistry Congress 2015.

Market Reports
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Analytical Instrument Market in the US 2014-2018
Infinity Research

TechNavio's report focuses on the US and has been prepared based on an in-depth market analysis with inputs from industry experts.
Atomic Spectroscopy Market by Technology & Application - Competitive Landscape, Global Forecasts & Trends to 2018
MarketsandMarkets

The global atomic spectroscopy market was valued at an estimated $4.02 billion in 2013 and is expected to grow at a CAGR of 6.4%.
Protein Crystallization & Crystallography Market by Technology, Products & End-Users - Forecast to 2018
MarketsandMarkets

The growing need to identify new ligands for the drug discovery process and the rising popularity of structure-based/rational drug design are factors that present opportunities for the protein crystallization & crystallography market.
Life Science Software 2013: Markets and Opportunities
Biopharm Reports

This reports into in the life science field examines the use of specialist software and databases relating to the conduct of PCR, DNA sequencing, DNA microarray, flow cytometry, mass spectrometry and disease biomarker studies. The studies were carried out to assist software developers and vendors to identify market opportunities in these fields.
Lab Instrument Rental Trends 2012
HTStec

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on lab instrument rental carried out in September 2012.
Novel Antibodies & Therapeutic Proteins: Technological Challenges & Future Prospects
Select Biosciences Ltd

This innovative & analytical report can be used to assess market trends & appraise the potential of new antibodies & therapeutic proteins. It provides perspective to gain an in-depth understanding of the marketplace, players, products & leading technologies driving the field.
Multiplexed Diagnostics 2010
Select Biosciences Ltd

The multiplexed diagnostics market has grown rapidly and generated sales of approximately $2.4 billon in 2009, but is now balanced on multiple tipping points.
Scientific News
Solving Streptide from Structure to Biosynthesis
Researchers reveal new information about how bacteria communicate via the protein, streptide.
Near-Atomic Resolution of Protein Structure Holds Promise for Drug Discovery
A new study shows that it is possible to use an imaging technique called cryo-electron microscopy to view the architecture of a metabolic enzyme bound to a drug that blocks its activity.
X-ray Study May Aid in Designing Better Blood Pressure Drugs
New atomic-scale details could help create more effective medications with fewer side effects.
Unique Insight into the Function of a Key Muscle Protein
In a muscle every protein has to pull its weight. Thanks to high-resolution structural analysis the role of the essential muscle protein a-Actinin is now better understood.
Antibiotic Mechanism Discovered
A structural study revealed how an antibiotic called borrelidin stops bacterial growth.
First Look at ‘Wasabi Receptor’ Brings Insights for Pain Drug Development
Protein’s structure will guide hunt for new treatments of inflammation-induced pain.
'Shield' Gives Tricky Proteins a New Identity
Solubilization of Integral Membrane Proteins with high Levels of Expression.
Roll Up Your Screen and Stow it Away?
TAU researchers develop molecular backbone of super-slim, bendable digital displays.
Saccharin Shows Promise as Cancer Inhibitor
Researchers have found that the artificial sweetener can inhibit cancer cell growth.
TSRI Scientists Find Clues to Cancer Drug Failure
A pair of studies show how the primary protein responsible for multidrug chemotherapy resistance changes shape.
Business News
Proteros Achieves Key Milestone in Janssen Lead Discovery Collaboration
Company to discover potent and selective small molecule inhibitor series against a novel protein target.
Rigaku Announce New President & COO
Company appoints Mr. Yoichi Yokomizo as Chief Operating Officer of RAH.
Rigaku to Acquire Agilent’s X-Ray Diffraction Business
Company plans to combine XRD with its existing crystallography business to form a new business unit.
Dr Tom Oldfield Joins Dotmatics as Principal Software Architect
Appointment of renowned technologist strengthens company position in big data analytics and biology.
Proteros Enters into a Collaboration with Bayer
Collaboration to develop new cardiovascular drug compounds for an integral membrane protein.
Diamond Celebrates a Glittering Year of Crystallography
From film premieres to major scientific breakthroughs, Diamond Light Source helped make the International Year of Crystallography a memorable event.
ZoBio, Domainex Partner to support FORMA Therapeutics’ Drug Discovery Programs
ZoBio and Domainex Ltd. announce a collaboration with FORMA Therapeutics to provide NMR-based structural biology services for a substantial panel of FORMA drug targets.
Eleven More Countries Adopt Cambridge Structural Database System National Provision
Academia in 17 countries enjoy unlimited access to Cambridge Structural Database.
Calixar, Aston University Announce Multidrug Resistance Collaboration
Purpose is to study the extraction, stabilization and crystallization of full-length human ABC transporters involved in multidrug resistance.
Anatrace, Microlytic Partnership to Enable Membrane Protein Research
Partnership will develop and commercialize Analytic, a new brand of products targeted to the membrane protein research community.

Events
High-throughput Protein Produc
29 Jun 2015
High-throughput Protein Produc ...
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Annual Meeting of the American
25 Jul 2015
Annual Meeting of the American ...
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Advanced Software Development
20 Aug 2015
Advanced Software Development ...
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Drug Discovery & Development I
09 Sep 2015
Drug Discovery & Development I ...
More information

ePosters
Measuring the 2nd Virial Coeffient and Molecular Density of Proteins to Improve Crystallization
Malvern Instruments Ltd

The second virial coefficient of Human Serum Albumin (HSA) was measured using a SEC-MALS 20 detector connected to a Refractive Index concentration detector and an online differential viscometer. Two different buffer conditions, Phosphate buffer pH 7.4 and Citrate buffer pH 4.1 were used, which revealed interesting and contrasting data
"In-vitro studies on hydroxamic acid- CT DNA binding"
Research Scholar

In vitro studies of five the interaction between five different derivatives of hydroxamic acids, N-phenyl 2,4dichloro phenoxybutyro, N-m-tolyl 2,4 dichlorophenoxyglutero, N-m-tolyl-4-chlorophenoxyaceto, N-m-chloro-phenyl-tertiarybutylbenzo and N-p-tolyl-iso-valero hydroxamic acids and calf thymus DNA was investigated under simulated physiological condition.
Rapid Quantification of Proteins in Complex Matrices using the DeNovix DS11 Microvolume Spectrophotometer
1) Swift Analytical Ltd, The Catalyst, Baird Lane, York, YO10 5GW 2) DeNovix Inc, 3411 Silverside Road, Hanby Building, Wilmington, DE 19810 USA

In this poster, we will introduce the DeNovix DS-11 as the next generation in microvolume spectrophotometry.
Coping with BIG DATA Image Formats: Integration of CBF, NeXus and HDF5, A Progress Report
[1] Department of Mathematics and Computer Science, Dowling College, Oakdale, NY 11769 (USA); [2] Diamond Light Source, Harwell Science and Innovation Campus, OX11 0DE (UK); [3] http://wiki.nexusforma

The best of CBF/imgCIF (the Crystallographic Binary File, which has a complete description of the experiment), NeXus (a common data framework for neutron, X-ray and muon science, which gracefully handles large data sets) and HDF5 (Hierarchical Data Format, version 5, the high-performance data format used by NeXus) are being combined for the management of BIG DATA at synchrotrons.
mosquito® Crystal and mosquito® LCP: fast, reliable automation of protein crystallisation drop set-up
TTP Labtech

This poster demonstrates the ability of TTP Labtech’s mosquito® Crystal and mosquito® LCP to address the issues inherent in the automated set-up of protein crystallisation screen trials, without needing constant instrument configuration changes.
mosquito® Crystal and mosquito® LCP: fast, reliable automation of protein crystallisation drop set-up
TTP Labtech

This poster demonstrates the ability of TTP Labtech’s mosquito® Crystal and mosquito® LCP to address the issues inherent in the automated set-up of protein crystallisation screen trials, without needing constant instrument configuration changes.
Structure determination of the virulence factor AsaP1 from Aeromonas salmonicida subsp. Achromogenes
CyBio

Aeromonas commonly found in waters, wastewaters and mud are non-motile gram negative bacteria. Atypical strains of Aeromonas salmonicida are known to be largely responsible for causing a lethal disease in Atlantic salmons and other farmed fishes.
Stable N-phosphorylated triazol-5-ylidenes
National Academy of Sciences of Ukraine

Considering probable generality of “carbene” mechanism for 1,3-azoles, investigation of intermediates of phosphorylation of 1,2,4-triazoles is of interest.
A Crystallographic-Based Fragment Screen Against Human BRD4 Bromodomain 1
BioFocus

Fragment-based drug discovery has now become firmly established as an important method in the lead discovery process, and is an integral component of drug discovery at BioFocus. Using a selection of compounds from our fragment collection, we have performed a crystallographic-based screen against human BRD4 bromodomain 1.
A fast and fully automated solution for Lipidic Cubic Phase (LCP) screening using mosquito LCP
1TTP Labtech Ltd 2MRC

Membrane proteins, such as G-protein-coupled receptors, are known to be much more difficult to purify and crystallise than soluble proteins due to their native environment within the lipid bilayer of the cell membrane. The in meso (lipidic cubic phase or LCP) crystallisation technique has revolutionised the process of crystallising membrane proteins. This method utilises highly viscous lipid mesophases to contain the membrane proteins for crystallisation.
Application Notes
Fully automated sitting drop protein crystallization with CyBi®-CrystalCreator using JBScreen Basic HTS Kit
CyBio

Growing high-quality protein crystals is still a major bottleneck and very time consuming step in this process. This application note describes screening experiments using the fully automated CyBi®-CrystalCreator in combination with a commercially available crystallization screen from Jena Bioscience.
Nanoliter Scale High-Throughput Protein Crystallography Screening with the Echo Liquid Handler
Labcyte

The Echo® liquid handler enables protein crystal formation with sitting drop volumes as small as 50 nL. Nanoliter volumes of protein and crystallography reagents can be transferred into sitting drop wells of crystallography plates. Precise and accurate drop placement eliminates cross-contamination and ensures drop-on-drop placement for blending protein and crystallography solutions.
Precision of the 96-Channel Heads of the CyBi-CrystalCreator
CyBio

This application note shows precision data in the low volume range of the 96-channel head of the CyBi-CrystalCreator using different volumes and pipetting modes. The precision was determined using a standardized absorption method.
Acoustic matrix microseeding: improving protein crystal growth with minimal chemical bias
CyBio

Using this technique, it was found that while buffer components alone without seed can marginally promote crystal growth in some cases, crystal seeding is far more effective in boosting the number of sparsematrix conditions that yield protein crystals.
mosquito® Crystal for the rapid screening and optimisation of crystallisation conditions of the bacterial periplasmic binding protein, HbpA
TTP LabTech

Glutathione is one of the major antioxidants/redox molecules in most aerobic cells, playing an important role in cell metabolism, differentiation, proliferation, and apoptosis. The reduced form of glutathione (GSH) is required for the detoxification of drugs and reactive compounds of both endogenous and exogenous origin.
Heating on an Atlas Hotplate
Syrris Ltd

In the following experiments, different vessels were heated using the Atlas hotplate, with and without the Atlas Stacking Drybath. In every case, an external thermocouple probe has been used with the system to accurately measure “reaction” temperature.
Analysing Endotherms using Atlas
Syrris Ltd

This application note shows how atlas and reaction monitoring can be used to look at endothermic processes.
Tracking Exotherms using Atlas Reaction Monitoring
Syrris Ltd

This application note shows how atlas and reaction monitoring can be used to look at exothermic processes.
Reaction Monitoring with Atlas 1
Syrris Ltd

This application note reports the use of the atlas system to monitor the hydrolysis of acetic anhydride, a typical test reaction for exothermic processes.
Reaction Monitoring with Atlas 2
Syrris Ltd

This application note details an experiment to show the repeatability and scalability of reaction monitoring signals by using an electrical heater system.
SELECTBIO

SELECTBIO Market Reports
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