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Thursday, April 24, 2014
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Featured Products
Featured Project - Non-Destructive Evaporation Technology Improves Polymorph Screening
Non-Destructive Evaporation Technology Improves Polymorph Screening
Featured Project - Protein Crystallization Starter Kit
Protein Crystallization Starter Kit

Webcasts
Approaches to the Discovery of Small-molecule MDM2-p53 Inhibitors
Dr Ian Hardcastle, Newcastle University, speaking at Discovery Chemistry Congress 2013.
Chemical Biology Approaches to Target Protein Modification in Disease
Megan Wright, Imperial College London, speaking at Discovery Chemistry Congress 2013.

Market Reports
Life Science Software 2013: Markets and Opportunities
Biopharm Reports

This reports into in the life science field examines the use of specialist software and databases relating to the conduct of PCR, DNA sequencing, DNA microarray, flow cytometry, mass spectrometry and disease biomarker studies. The studies were carried out to assist software developers and vendors to identify market opportunities in these fields.
Lab Instrument Rental Trends 2012
HTStec

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on lab instrument rental carried out in September 2012.
Novel Antibodies & Therapeutic Proteins: Technological Challenges & Future Prospects
Select Biosciences Ltd

This innovative & analytical report can be used to assess market trends & appraise the potential of new antibodies & therapeutic proteins. It provides perspective to gain an in-depth understanding of the marketplace, players, products & leading technologies driving the field.
Multiplexed Diagnostics 2010
Select Biosciences Ltd

The multiplexed diagnostics market has grown rapidly and generated sales of approximately $2.4 billon in 2009, but is now balanced on multiple tipping points.
Scientific News
Lab Scale Manufacturing Using Continuous Crystallization
A new METTLER TOLEDO On-demand webinar explores recent research that could revolutionize pharmaceutical production.
Cornell's ERL Research Supports New X-ray Laser
Scientists have developed a groundbreaking new synchrotron X-ray technology.
Scientists Uncover Bacterial War Tactics
The discovery paves the way for new drugs to fight bacterial infections.
‘Big Science’ uncovers another piece in the Alzheimer’s puzzle
Evidence found of the possible cause of brain-cell-damaging toxic iron.
Mosquitoes Resistant to DDT Also Resistant to Mosquito Net Insecticide
Understanding how resistance works will help to develop tests, stopping resistance genes from spreading amongst mosquito populations.
Curves Alter Crystallization
Curved surfaces can dramatically alter the shape of crystals as they form, a previously unseen phenomenon.
A Crisper View of DNA-Snipping Enzyme
HHMI scientists have created a portrait of a DNA-snipping protein called Cas9, a powerful research tool used in many labs for genome editing.
Swiss Cheese Crystal, or High-Tech Sponge?
The remarkable properties of a new, porous material could lead to advances in microscopic sponging
Scientists Solve 40-year Mystery of How Sodium Controls Opioid Brain Signaling
The findings pave way for new therapies for treating pain and mood disorders.
Tricky Protein May Help HIV Vaccine Development
Researchers have determined the structure of a key part of the HIV envelope protein, the gp41 membrane proximal external region, which previously eluded detailed structural description.
Business News
Rigaku Corp, Supplier for £1M Enhancement to X-ray Facility
The company will supply X-ray equipment to University of St Andrews.
Faster Visa Endorsement will Support International Mobility for Top Researchers
This visa route is designed for the brightest and best bringing them from outside the European Economic Area to the UK.
Novel Crystallography Beamline Takes Delivery of in Vacuum X-Ray Detector
The Diamond Light Source beamline will facilitate challenging research on DNA, RNA, native proteins and other building blocks of life.
PANalytical Participates in the International Year of Crystallography 2014
A large number of events around the world will aim to spread crystallographic knowledge, inspire young people and promote education and research in crystallography.
Proteros Elects New Supervisory Board Member
Shareholders confirmed the appointment of Prof. Eric-Paul Pâques as a new member of the Supervisory Board.
New Whitepaper from Wyatt on Branching in Synthetic and Natural Polymers
New whitepaper highlights the importance of multi-angle light scattering instrumentation.
BioVersys and SARomics Biostructures to Collaborate
The Companies join efforts to combat multidrug-resistant bacterial infections'
Year of Glittering Celebrations begins at Diamond Light Source
Activity to showcase 100 years of crystallography.
SARomics Biostructures and Xbrane Bioscience Form a Strategic Partnership
Strategic partnership to deliver “off-the-shelf” protein structure services.
Agilent Supports International Year of Crystallography
2014 partnership with international union of crystallography aimed at educating, inspiring young scientists.

Events
Advances in Automation & Robot
14 May 2014
Advances in Automation & Robot ...
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Hot Topics in Contemporary Cry
10 May 2014
Hot Topics in Contemporary Cry ...
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47th Course of the Internation
30 May 2014
47th Course of the Internation ...
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Current challenges in integrat
19 Jun 2014
Current challenges in integrat ...
More information

ePosters
mosquito® Crystal and mosquito® LCP: fast, reliable automation of protein crystallisation drop set-up
TTP Labtech

This poster demonstrates the ability of TTP Labtech’s mosquito® Crystal and mosquito® LCP to address the issues inherent in the automated set-up of protein crystallisation screen trials, without needing constant instrument configuration changes.
Structure determination of the virulence factor AsaP1 from Aeromonas salmonicida subsp. Achromogenes
CyBio

Aeromonas commonly found in waters, wastewaters and mud are non-motile gram negative bacteria. Atypical strains of Aeromonas salmonicida are known to be largely responsible for causing a lethal disease in Atlantic salmons and other farmed fishes.
Stable N-phosphorylated triazol-5-ylidenes
National Academy of Sciences of Ukraine

Considering probable generality of “carbene” mechanism for 1,3-azoles, investigation of intermediates of phosphorylation of 1,2,4-triazoles is of interest.
A Crystallographic-Based Fragment Screen Against Human BRD4 Bromodomain 1
BioFocus

Fragment-based drug discovery has now become firmly established as an important method in the lead discovery process, and is an integral component of drug discovery at BioFocus. Using a selection of compounds from our fragment collection, we have performed a crystallographic-based screen against human BRD4 bromodomain 1.
A fast and fully automated solution for Lipidic Cubic Phase (LCP) screening using mosquito LCP
1TTP Labtech Ltd 2MRC

Membrane proteins, such as G-protein-coupled receptors, are known to be much more difficult to purify and crystallise than soluble proteins due to their native environment within the lipid bilayer of the cell membrane. The in meso (lipidic cubic phase or LCP) crystallisation technique has revolutionised the process of crystallising membrane proteins. This method utilises highly viscous lipid mesophases to contain the membrane proteins for crystallisation.
mosquito® Crystal: Fast, reliable automation of Protein Crystallization drop set-up
TTP Labtech Ltd

Automation of protein crystallography screening has contributed significantly to the rapid progress of crystallography based structural biology. Automation allows samples to be screened using smaller volumes of both protein and screen solutions, reducing costs and saving valuable protein. Additional benefits include increased throughput and accuracy. One of the challenges to automating this process is the necessity to accurately pipette solutions of varying viscosities
Analysis of overall success of robotic crystallization
Laboratory of Structural Biology, School of Biological Sciences

A total of about 140 different proteins have been commissioned and 62 have been crystallized with a quality suitable for X-ray diffraction (45%). On a per-drop basis, 300 crystallization experiments have been successful, representing an over¬all success rate of 3%. PEG 3350 was the precipitant for 20, making it the single most successful crystallization agent.
Strategies for expression and solubility analysis


Production of soluble protein is one of the major bottlenecks that precede crystallographic studies.During the last years several techniques and strategies have been developed to address this problem. However, many of them imply an economical cost and technologies that are not always available. We will describe a general plan for protein solubility analysis by using a combination of four different but complementary strategies. In this plan, different constructs of a protein interest are designed
Automating Microseeding Protein Crystallography Set-ups Using Mosquito
TTP Labtech

Crystallising proteins, required for structure determination by X-ray diffraction, is a difficult and labour-intensive task. The mosquito liquid handler (TTP LabTech) is ideally suited to automating the complex set-ups required for microseeding due to its precide handling of extremely low volumes of even viscous solutions, and its ability to perform multiple aspirations and dispenses with each pipette.
Automated Single Crystal Structure Determination - A Tool for Synthetic Chemists?
Bruker AXS

During recent years large improvements in software functionality and its ease-of-use have made single crystal X-ray structure determination easier than ever. These days most structures can be measured, processed, solved and refined using well selected defaults with no or little crystallographic knowledge. Recently, microfocus sources and CCD detectors both air-cooled, have entered the marketplace. Combining these innovations with an automated sample loader and an intelligent graphical user inte
Application Notes
Fully automated sitting drop protein crystallization with CyBi®-CrystalCreator using JBScreen Basic HTS Kit
CyBio

Growing high-quality protein crystals is still a major bottleneck and very time consuming step in this process. This application note describes screening experiments using the fully automated CyBi®-CrystalCreator in combination with a commercially available crystallization screen from Jena Bioscience.
Nanoliter Scale High-Throughput Protein Crystallography Screening with the Echo Liquid Handler
Labcyte

The Echo® liquid handler enables protein crystal formation with sitting drop volumes as small as 50 nL. Nanoliter volumes of protein and crystallography reagents can be transferred into sitting drop wells of crystallography plates. Precise and accurate drop placement eliminates cross-contamination and ensures drop-on-drop placement for blending protein and crystallography solutions.
Precision of the 96-Channel Heads of the CyBi-CrystalCreator
CyBio

This application note shows precision data in the low volume range of the 96-channel head of the CyBi-CrystalCreator using different volumes and pipetting modes. The precision was determined using a standardized absorption method.
Acoustic matrix microseeding: improving protein crystal growth with minimal chemical bias
CyBio

Using this technique, it was found that while buffer components alone without seed can marginally promote crystal growth in some cases, crystal seeding is far more effective in boosting the number of sparsematrix conditions that yield protein crystals.
mosquito® Crystal for the rapid screening and optimisation of crystallisation conditions of the bacterial periplasmic binding protein, HbpA
TTP LabTech

Glutathione is one of the major antioxidants/redox molecules in most aerobic cells, playing an important role in cell metabolism, differentiation, proliferation, and apoptosis. The reduced form of glutathione (GSH) is required for the detoxification of drugs and reactive compounds of both endogenous and exogenous origin.
Heating on an Atlas Hotplate
Syrris Ltd

In the following experiments, different vessels were heated using the Atlas hotplate, with and without the Atlas Stacking Drybath. In every case, an external thermocouple probe has been used with the system to accurately measure “reaction” temperature.
Analysing Endotherms using Atlas
Syrris Ltd

This application note shows how atlas and reaction monitoring can be used to look at endothermic processes.
Tracking Exotherms using Atlas Reaction Monitoring
Syrris Ltd

This application note shows how atlas and reaction monitoring can be used to look at exothermic processes.
Reaction Monitoring with Atlas 1
Syrris Ltd

This application note reports the use of the atlas system to monitor the hydrolysis of acetic anhydride, a typical test reaction for exothermic processes.
Reaction Monitoring with Atlas 2
Syrris Ltd

This application note details an experiment to show the repeatability and scalability of reaction monitoring signals by using an electrical heater system.
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