Corporate Banner
Satellite Banner
Crystallography
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Calixar and Synthelis Team Up to Provide Unique Membrane Protein Services

Published: Friday, July 06, 2012
Last Updated: Thursday, July 05, 2012
Bookmark and Share
Partnership will enable life sciences researchers and industry to access a comprehensive and innovative range of services to obtain currently unavailable therapeutic targets.

Calixar has announced that they have entered into an alliance for the production and isolation of all types of target membrane proteins.

The results of this collaboration will have applications ranging from the development of antibodies to the discovery of new drugs, including the determination of the structure of these targets and vaccine formulations.

Instead of trying to produce these proteins themselves, users will be given access to production and purification technologies, enabling them to concentrate on their core activities.

Furthermore, thanks to the critical mass of skills and technologies made available to them, they will be assured of obtaining targets in their native conformation, thus guaranteeing the success of their programs for developing new drugs, vaccines and therapeutic antibodies.

Membrane proteins account for over 70 per cent of current therapeutic targets.

They are essential in discovering new drugs for the majority of the pathologies for which treatments are needed today: cancer, infectious diseases, neurodegenerative, metabolic and genetic diseases and so on.

As of now, however, there are fewer than ten companies specialized in this field around the world and, according to Calixar and Synthelis, none offers such a comprehensive and innovative range of services as their new alliance does.

The agreement provides for Synthelis to utilize its molecular biology know-how, deployed in multi-expression-systems and functional characterization configuration, to underpin the production phase.

Calixar will be responsible for the possible upstream identification and subsequent isolation, purification, stabilization and crystallization of targeted membrane proteins.

Calixar’s technology has already been validated in some 20 targets (including GPCR receptors, ionic channels, transporters and viral proteins) and its unique approach makes it possible to preserve the native conformation of membrane proteins in solution after their extraction and purification from any biological system.

Alongside Calixar’s results, Synthelis has validated its technology on more than 50 membrane targets.

The production processes it has developed are also known to avoid the denaturization of membrane proteins while ensuring they have a high level of expression and activity.

Moreover, Synthelis can produce large quantities (several mg) in two to three months, whereas traditional processes take up to a year.

“We have been undertaking joint R&D programs since the end of 2011, which has confirmed that our two companies have very complementary expertise,” said the president and co-founder of Calixar, Emmanuel Dejean.

Dejean continued, “We now want our customers to benefit from this critical mass of know-how and technology, which no other company currently offers in Europe.”

“Through this alliance, the two companies are strengthening every aspect of their business, not only their commercial clout, technical expertise and visibility but also their ability to innovate in their quest to find answers to complex sets of problems with great potential,” said the president and co-founder of Synthelis, Bruno Tillier. “This partnership also has an impact on the research structure in the Lyon-Grenoble area as the two companies are based in the region.”

The companies are going to undertake joint marketing campaigns to promote their product offer. Outside Europe, they also aim to get themselves known in North America and Asia.   


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Calixar, Aston University Announce Multidrug Resistance Collaboration
Purpose is to study the extraction, stabilization and crystallization of full-length human ABC transporters involved in multidrug resistance.
Wednesday, October 22, 2014
Scientific News
TOPLESS Plants Provide Clues to Human Molecular Interactions
Scientists at Van Andel Research Institute have revealed an important molecular mechanism in plants that has significant similarities to certain signaling mechanisms in humans, which are closely linked to early embryonic development and to diseases such as cancer.
Advancing Cancer Drug Design with Image of Key Protein
Scientists have pioneered the use of a high-powered imaging technique to picture in exquisite detail one of the central proteins of life – a cellular recycling unit with a role in many diseases.
Mould Unlocks New Route to Biofuels
Scientists at The University of Manchester have made an important discovery that forms the basis for the development of new applications in biofuels and the sustainable manufacturing of chemicals.
'Invisible' Protein Structure Explains the Power of Enzymes
A research group at Umeå University in Sweden has managed to capture and describe a protein structure that, until now, has been impossible to study.
Unraveling the Elusive Structure of HIV Protein
Snapshots of HIV virus’ proteins may help design new ways to fight the disease.
Blueprinting Cell Membrane Proteins
Recent breakthrough will make the blueprinting process faster, easier and cheaper, and should have major implications in the field of drug discovery and development.
Bacteria Use Chemical Harpoons to Hold on Their Hosts
Researchers reveal how a common disease causing bacteria latches on to the body during an infection.
Solving Streptide from Structure to Biosynthesis
Researchers reveal new information about how bacteria communicate via the protein, streptide.
Near-Atomic Resolution of Protein Structure Holds Promise for Drug Discovery
A new study shows that it is possible to use an imaging technique called cryo-electron microscopy to view the architecture of a metabolic enzyme bound to a drug that blocks its activity.
X-ray Study May Aid in Designing Better Blood Pressure Drugs
New atomic-scale details could help create more effective medications with fewer side effects.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!