Corporate Banner
Satellite Banner
Crystallography
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Cornell Partners in Structural Biology X-ray Center

Published: Monday, November 11, 2013
Last Updated: Monday, November 11, 2013
Bookmark and Share
Cornell is a partner in a $25 million National Science Foundation award to develop a science and technology center aimed at transforming the field of structural biology.

Eight universities and institutes, including Cornell, will work together to establish the new center.

The BioXFEL (pronounced bio-x-fell) research center, to be headquartered at the University at Buffalo, will focus on developing new X-ray techniques to solve the structures of biological molecules and complexes. These structures provide scientists with insights into how biological molecules self-assemble and function, what might be happening when disease occurs, and what compounds might be designed as drugs to modify this activity.

Scientists involved with the center will use a powerful new kind of X-ray beam developed at SLAC National Accelerator Laboratory at Stanford University called an X-ray free-electron laser (XFEL) that delivers X-rays in the form of highly intense, ultra-short pulses, lasting tens of femtoseconds. Each pulse contains enough energy to destroy the sample; structural information is extracted just before the sample vaporizes. New methods for measuring structures emerge as a result of the intense X-ray energy present in each pulse.

 Although much of the center’s efforts will focus on obtaining structures from proteins that are largely immobilized in ultrasmall crystals, Lois Pollack, professor of applied and engineering physics, has pioneered the application of X-ray scattering to study the  large-scale dynamics of proteins and RNA. She will bring to the center her group’s expertise in developing and applying specialized instruments to detect motions of biological molecules as they work.

“The XFEL has the potential to revolutionize the way we study biological molecules,” Pollack said. “Our challenge is in designing and building tools to handle the tremendous X-ray intensity of each XFEL pulse.”

The BioXFEL center will promote applications of its research through industrial partners in the Industrial Macromolecular Crystallography Association, which comprises such pharmaceutical companies as Bristol-Myers Squibb, Pfizer, Abbott, Merck and Novartis.

The NSF Science and Technology Centers: Integrative Partnerships program supports innovative, potentially transformative research and education projects that require large-scale, long-term awards. The centers foster cutting-edge research, education of the next generations of scientists, and broad distribution of the knowledge and technology produced.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 4,000+ scientific posters on ePosters
  • More than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

'Shield' Gives Tricky Proteins a New Identity
Solubilization of Integral Membrane Proteins with high Levels of Expression.
Saturday, April 11, 2015
Cornell's ERL Research Supports New X-ray Laser
Scientists have developed a groundbreaking new synchrotron X-ray technology.
Friday, April 11, 2014
Weird Science: Crystals Melt when they're Cooled
Scientists from Cornell University study the unusual properties of nanoparticle crystal growth.
Tuesday, May 28, 2013
Using X-rays to Study Ultra-Thin Transistors
Cornell scientists have helped develop a novel process of spreading extremely thin organic transistors, and used synchrotron X-rays to watch how the films crystallize.
Thursday, May 02, 2013
Scientific News
Human Astrovirus Structure Could Lead to Therapies, Vaccines
Study shows where neutralizing antibody binds to human astrovirus, a leading cause of viral diarrhoea in children, elderly, and the immune-compromised.
Drug Design Strategy to Improve Breast Cancer Treatment
Scientists develop novel structure-based drug design strategy aimed at altering the basic landscape of hormone-driven breast cancer treatment.
Crystals, Super Magnets in Drug Discovery
Scientists have produced larger superparamagnetic crystals that could revolutionise drug delivery.
Peer Review is in Crisis, But Should be Fixed, Not Abolished
After the time to get the science done, peer review has become the slowest step in the process of sharing studies, and some scientists have had enough.
Snapshots of Chemical Flipping a Biological Switch
X-ray laser gets first real-time snapshots of a chemical flipping a biological switch, opening new path to understanding how RNA works.
Uncovering Elusive Proteins
Researchers have determined the complete structure of elusive proteins, known as tetraspanins, for the first time.
Cannabinoid Receptor Structure Revealed
Scientists provided a detailed view of the primary molecule through which cannabinoids exert their effects on the brain. The findings might help guide the design of more targeted medicines with fewer side effects.
Alzheimer’s Treatment Moves a Step Closer
Merck scientists have reported the discovery of verubecestat, a structurally unique, orally bioavailable small molecule that has been shown to target the most visible sign of the disease in the brain.
Study Unocovers Cancer-Linked Protein’s Associates
Researchers have developed a new list of nearly 100 potential partners of a cancer-linked enzyme by studying its interactions with other proteins.
Scientists Uncover Why Hepatitis C Vaccine is Difficult to Make
Scientists have uncovered one reason why a successful hepatitis C vaccine continues to be elusive.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
4,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!