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Promise of Structure-Based Drug Design for GPCRs
Heptares Therapeutics announces the recent publication of a major review of the state of the art for GPCR drug discovery and new insights that, for the first time, can be obtained from structural biology. At Smallest Scale, Liquid Crystal Behaviour Portends New Materials Latest research has shown that liquid crystals may have some new technological tricks in store. Scripps Research Institute Scientists Find the Structure of a Key ‘Gene Silencer’ Protein The structure reveals potential therapeutic targets in area with ‘untapped potential’. The Protein Structure Initiative: Achievements and Visions for the Future The Protein Structure Initiative was established in 2000 by the National Institutes of General Medical Sciences with the long-term goal of providing 3D structural information for most proteins in nature. Increasing the X-ray Diffraction Power of Protein Crystals by Dehydration The crystallization and diffraction data of a new BSA crystal form, obtained by the hanging drop method using MPEG 5K as precipitating agent, are presented. Crystallography, Evolution, and the Structure of Viruses In this article, Michael Rossman accounts his journey from mathematician and physician through to crystallographer, with his ultimate ambition being the structural study of viruses. Crystal Structures of the Tetratricopeptide Repeat Domains of Kinesin Light Chains: Insight into Cargo Recognition Mechanisms This article outlines how researchers determined the structures of kinesin light chain tetratricopeptide repeat domains in KLC1 and 2, and how these interact with their various cargo during transportation. Onyx Pharmaceuticals Announces Cell Publication Demonstrating Selectivity of Immunoproteasome Inhibitor ONX 0914 Article describes the crystal structures of two forms of the proteasome found in mammalian cells. New Research Could Stop Tumour Cells from Spreading Researchers from the Department of Chemistry and Molecular Biology at the University of Gothenburg have managed for the first time to obtain detailed information about the role of the protein metastasin in the spread of tumour cells. Overexpression, Crystallization and Preliminary X-ray Crystallographic Analysis of the C-terminal Cytosolic Domain of Mouse Anoctamin 1 This article describes how researchers initiated structural study of the C-terminal cytosolic domain of mouse ANO1. 
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