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Targeting Acute Pancreatitis by Small Molecule Inhibitors of Cyclophilin D
M. Awais, E. Shore, R. Gibson, N. Kershaw, D. Latawiec, S. Pandalaneni, M.A. Javed, L. Wen, D.N. Criddle, N. Berry, L-Y. Lian, P. O’Neill, R. Sutton

Cyclophilin D (CypD) promotes opening of the mitochondrial permeability transition pore, a major contributor to acute pancreatitis. We are developing small molecule inhibitors of CypD as a possible treatment for AP and other conditions where the MPTP plays a role.

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Measuring the 2nd Virial Coeffient and Molecular Density of Proteins to Improve Crystallization
Michel Terray, John Stenson

The second virial coefficient of Human Serum Albumin (HSA) was measured using a SEC-MALS 20 detector connected to a Refractive Index concentration detector and an online differential viscometer. Two different buffer conditions, Phosphate buffer pH 7.4 and Citrate buffer pH 4.1 were used, which revealed interesting and contrasting data

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"In-vitro studies on hydroxamic acid- CT DNA binding"
Rubi Khilari

In vitro studies of five the interaction between five different derivatives of hydroxamic acids, N-phenyl 2,4dichloro phenoxybutyro, N-m-tolyl 2,4 dichlorophenoxyglutero, N-m-tolyl-4-chlorophenoxyaceto, N-m-chloro-phenyl-tertiarybutylbenzo and N-p-tolyl-iso-valero hydroxamic acids and calf thymus DNA was investigated under simulated physiological condition.

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Rapid Quantification of Proteins in Complex Matrices using the DeNovix DS11 Microvolume Spectrophotometer
Mebs A Surve & Dan Schieffer

In this poster, we will introduce the DeNovix DS-11 as the next generation in microvolume spectrophotometry.

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Coping with BIG DATA Image Formats: Integration of CBF, NeXus and HDF5, A Progress Report
Herbert J. Bernstein,[1] Jonathan M. Sloan,[2] Graeme Winter,[2] Tobias S. Richter,[2] NeXus International Advisory Committee,[3] Committee on the Maintenance of the CIF Standard[4]

The best of CBF/imgCIF (the Crystallographic Binary File, which has a complete description of the experiment), NeXus (a common data framework for neutron, X-ray and muon science, which gracefully handles large data sets) and HDF5 (Hierarchical Data Format, version 5, the high-performance data format used by NeXus) are being combined for the management of BIG DATA at synchrotrons.

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mosquito® Crystal and mosquito® LCP: fast, reliable automation of protein crystallisation drop set-up
Joby Jenkins, David Smith

This poster demonstrates the ability of TTP Labtech’s mosquito® Crystal and mosquito® LCP to address the issues inherent in the automated set-up of protein crystallisation screen trials, without needing constant instrument configuration changes.

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mosquito® Crystal and mosquito® LCP: fast, reliable automation of protein crystallisation drop set-up
Joby Jenkins, David Smith

This poster demonstrates the ability of TTP Labtech’s mosquito® Crystal and mosquito® LCP to address the issues inherent in the automated set-up of protein crystallisation screen trials, without needing constant instrument configuration changes.

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Structure determination of the virulence factor AsaP1 from Aeromonas salmonicida subsp. Achromogenes
Xenia Bogdanovic, Rajesh Kumar Singh, Gottfried J. Palm, Johanna Hentschke, Bjarnheidur K. Gudmundsdóttir & Winfried Hinrichs

Aeromonas commonly found in waters, wastewaters and mud are non-motile gram negative bacteria. Atypical strains of Aeromonas salmonicida are known to be largely responsible for causing a lethal disease in Atlantic salmons and other farmed fishes.

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Stable N-phosphorylated triazol-5-ylidenes
Kirilchuk,A. A.; Marchenko,A. P.; Koidan, H. G.; Zarudnitskii, E. V.; Huryeva, A. N.; Yurchenko, A. A.; Kostyuk, A. N.

Considering probable generality of “carbene” mechanism for 1,3-azoles, investigation of intermediates of phosphorylation of 1,2,4-triazoles is of interest.

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A Crystallographic-Based Fragment Screen Against Human BRD4 Bromodomain 1
Hubbard P, Ritchie A, Hughes S, Lipkin M, Blackaby W & MacLeod A

Fragment-based drug discovery has now become firmly established as an important method in the lead discovery process, and is an integral component of drug discovery at BioFocus. Using a selection of compounds from our fragment collection, we have performed a crystallographic-based screen against human BRD4 bromodomain 1.

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Scientific News
Designing Drugs with a Whole New Toolbox
Researchers develop methods to design small, targeted proteins with shapes not found in nature.
Protein Studies Discover Molecular Secrets
Two protein studies have mapped proteins that reveal the secrets to recycling carbon and healing cells.
Antibodies Block Norovirus’ Entrance into Cells
Scientists have uncovered a mechanism in the human body that targets and successfully blocks noroviruses.
Protein Findings Could Lead To New Class Of Antibiotics
Atomic-level images of a protein have revealed a characteristic that could form a basis of new antibiotic approach.
Worms Point Way Toward Viral Strategies
Rice University wins NIH grant to study how nematodes handle gastrointestinal viruses.
'Missing Evolutionary Link' of a Widely Used Natural Drug Source Found
A well-known family of natural compounds, called “terpenoids,” have a curious evolutionary origin. In particular, one question relevant to future drug discovery has puzzled scientists: exactly how does Nature make these molecules?
Mechanisms of Calcium Blockers
Researchers describe how the fundamental mode of action of two distinct chemical classes of calcium channel blockers differs.
Catching Proteins in the Act
Scientists can now observe light activated processes in proteins through the use of free-electron x-ray lasers.
'Missing Evolutionary Link' of Natural Drug Source Found
Scripps Florida study finds 'missing evolutionary link' of a widely used natural drug source
New Way of Displaying 3D Molecular Structures
Metal-organic frameworks provide a new platform for solving the structure of hard-to-study samples.
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