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Thursday, August 28, 2014
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Methods For Automated Structure Determination for Ligands Within a Protein-Ligand Complex
Gregory L. Warren and Matthew T. Stahl

Afitt is a software package for automated ligand conformation generation and placement within algorithmically identified unfilled electron density. Following real space refinement, the ligand solution is sent for subsequent refinement by Refmac or CNX, via coordinate and dictionary files. We have validated Afitt on forty publicly available data sets, chosen because it contains examples of highly strained ligand conformations.

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Automated, Low Volume Dynamic Light Scattering Technology to Accelerate Protein Crystallization
Kevin Jackson and Robert Collins

The quest for solving protein structure largely relies upon X-Ray diffraction, a method requiring crystalline forms of the target protein. Among the many steps comprising structure determination, the process of protein crystallization represents one of the most significant, time-consuming challenges. A new low sample volume, automated dynamic light scattering (DLS) technology has been developed – the DynaPro Plate Reader.

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A Solution for Low Volume Pipetting Applications Requiring High Accuracy of Sample Placement
Joby Jenkins, Rob Lewis, Tristan Cope and Chloë Milburn

Mosquito’s unique positive displacement disposable tips and precise X, Y and Z movements allow smaller drops with accurate and repeatable volumes to be positioned very precisely. This ability is essential for successful assay miniaturisation and the set-up of more effective serial dilutions or protein crystallography screens.

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Facilitating Low Volume Protein Crystallography Set-ups Using the Mosquito® Liquid Handler
Jas Sanghera, Joby Jenkins, Rob Lewis, Chloe Milburn

The mosquito® (TTP LabTech) offers fast positive displacement pipettingfor accurate and reproducible aspiration and dispensing throughout the 50 nL-1.2 µL range, producing CVs of <8% at 50 nLirrespective of viscosity. Mosquito’s micropipettes are also disposable, thus guaranteeing zero cross-contamination where required.

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From Medicinal Plants to Bioactive Drugs
Ilaria Lampronti, Mahmud T.H. Khan, Antoine M. Saab, Elisabetta Lambert, Letizia Penolazzi, Roberta Piva and Roberto Gambari

The aim of our study was to analyze the antiproliferative activity effects on human tumor cell lines and the differentiating activity on human erythroleukemic K562 cells of different extracts derived from medicinal plants of Bangladesh and Lebanon.

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Rapid and Miniaturized Robotic Crystallization Experiment using the Honeybee 963™ System
Malcolm Willson, Hamid Khoja and Charles Dang

The Honeybee 963 for automated sitting drop crystallization studies enables rapid, precise and accurate dispensing of nano-liter (nl) volumes of screening and protein solutions. Rapid dispensing to both reservoirs and shelves minimizes evaporation while precise and accurate dispensing allows for miniaturization and conserves precious protein.

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High-Quality Protein Crystallization in Space
Ari Yamanaka, et. al.

JAXA (Japan Aerospace Exploration Agency) has developed and established ultra-high quality protein crystallization technology using microgravity environments. High-quality protein crystals were grown based on technical improvements. Growing high-quality protein crystals in space can help better understand 3-dimensional protein structure.

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High-Throughput and High-Yield Purification of Recombinant Proteins Expressed in Escherichia coli.
Chiann-Tso Lin, Priscilla A. Moore, Deanna L. Auberry, Kristin D. Victry, Frank R. Collart and Vladimir Kery

We have developed a high throughput expression of recombinant proteins containing hexahistidine affinity tag in Escherichia coli followed by one step affinity purification of proteins on Ni2+ agarose beads.

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Showing Results 21 - 28 of 28
Scientific News
Flu’s Mechanisms Clues Uncovered
Researchers from Rice University and Baylor College of Medicine have analyzed how influenza-related proteins help infect cells.
Innovative Technology Enables First Crystal Structure of mGlu5 Transmembrane Domain to be Determined
Several novel drug candidates have been identified to help treat specific neuropsychiatric disorders.
Neutron Crystallography Resolves Long-Standing Molecular Mystery
Research has implications for understanding of oxidative processes within living cells which is crucially important for drug development.
Considering the ‘Anticrystal’
Researchers have evidence of a new concept, the anticrystal, a theoretical solid that is completely disordered.
How Developing Neurons Sense a Chemical Cue
An embryo organizes itself into left and right halves as it grows. But a certain set of nerve cells do something unusual: they cross from one side to the other.
High-speed Snapshots of Biomolecules
PETRA III pioneers protein serial crystallography at synchrotrons.
Stanford Researchers Discover Immune System’s Rules of Engagement
Study finds surprising similarities in the way immune system defenders bind to disease-causing invaders.
Discovery of New Structure of Cell’s Communication Channel Could Aid Drug Development
Researchers hope discovery will lead to improvements in drugs that act on the sodium channel to treat a range of cardiac and pain conditions.
Til’ Death Do Us Part - in the Plant World
Study describes the ultimate act of sacrifice and survival in the plant world.
Unlocking a Mystery of Human Disease . . . in Space
Researchers analyze crystals of full-length protein with X-ray crystallography to determine huntingtin's structure.
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