Low Volume Liquid Handling of Organic Solvents for Compound Storage and Dissolution using mosquito

The technology of storing dried microquots is an interesting new idea which aims to reduce very significantly the amount of material – and in particular of intermediate material – wasted in the process of synthesising new compounds. This technology may also benefit drug screening where there is a similar need to conserve material and where there are also concerns of material stability.

mosquito® (TTP LabTech) is a positive displacement liquid handling system capable of pipetting solutions with a high degree of accuracy (to within 5%) and precision (CVs of <10%) in the nanolitre range.

Here, we demonstrate mosquito’s ability to dispense accurately low volumes of organic solvents of low surface tension and to re-dissolve compounds which have been previously dried in storage wells.