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Structural Discoveries Could Aid in Better Drug Design
Scientists have uncovered the structural details of how some proteins interact to turn two different signals into a single integrated output.
New Mathematics Advances the Frontier of Macromolecular Imaging
Berkeley Lab’s M-TIP solves the reconstruction problem for fluctuation X-ray scattering.
Diamond Helps Develop New Way of Studying the Tiniest Microcrystals
Researchers have developed a new type of sample holder for ‘serial protein crystallography’.
Crystal Clear Images Uncover Secrets of Hormone Receptors
NIH researchers gain better understanding of how neuropeptide hormones trigger chemical reactions in cells.
TOPLESS Plants Provide Clues to Human Molecular Interactions
Scientists at Van Andel Research Institute have revealed an important molecular mechanism in plants that has significant similarities to certain signaling mechanisms in humans, which are closely linked to early embryonic development and to diseases such as cancer.
Advancing Cancer Drug Design with Image of Key Protein
Scientists have pioneered the use of a high-powered imaging technique to picture in exquisite detail one of the central proteins of life – a cellular recycling unit with a role in many diseases.
Mould Unlocks New Route to Biofuels
Scientists at The University of Manchester have made an important discovery that forms the basis for the development of new applications in biofuels and the sustainable manufacturing of chemicals.
'Invisible' Protein Structure Explains the Power of Enzymes
A research group at Umeå University in Sweden has managed to capture and describe a protein structure that, until now, has been impossible to study.
Unraveling the Elusive Structure of HIV Protein
Snapshots of HIV virus’ proteins may help design new ways to fight the disease.
Blueprinting Cell Membrane Proteins
Recent breakthrough will make the blueprinting process faster, easier and cheaper, and should have major implications in the field of drug discovery and development.

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Label-Free Binding Analysis Trends 2014
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The main objectives were to comprehensively document current experience of and future interest in investigating biomolecular interactions and binding analysis using LF technologies. The study also examined in detail the changing market landscape, application areas and future purchasing plans.

The report is a source of valuable information for vendors developing LF binding analysis systems, and provides the latest market information on this rapidly changing area.

Equal emphasis was given to soliciting opinion from Pharma, Biotech and Academic Research segments, active in either small molecule drug discovery or protein and biologics characterization.

The survey looked at the following aspects of LF binding analysis as practiced today (2014) and in some cases as predicted for the future (2016): areas where biomolecular binding analysis is primarily used; techniques used to assess binding interactions; how respondent’s research objectives are aided by LF technology; classification that most closely describes an LF binding assay; vendor’s LF technologies currently available in respondent’s lab; most recognizable LF instrument brands; current perception of different LF instrument suppliers; the most common limitation experienced using an LF assay approach: applications that LF binding assays are best suited for; application areas where LF binding assays are expected to gain most popularity over coming years; processes which could most benefit from the use or expanded use of LF binding assays; integration of any LF instruments/devices used for binding analysis into automated robotic systems; importance given to some application capabilities when purchasing a new LF system for binding analysis; attributes of a new label-free binding analysis system that impact a purchasing decision; what influences the timing of a decision to purchase a LF system; likelihood of purchasing a new LF instruments for binding analysis over the coming years; the primary use of respondent’s next LF instrument purchase; the top two vendors from which respondents are most likely to purchase a new LF instrument; annual capex and consumable budgets for LF binding analysis; resources most relied upon to learn about/gather information on new LF technologies and assays; conferences attended in the last 12 months; publications subscribed to, regularly read or visited online; and any unmet needs in LF binding analysis.

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