Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>Resources>Application Notes>This Application Note
  Application Notes
Scientific News
A New Way to Look at MOFs
International study challenges prevailing view on how metal organic frameworks store gases.
Major Advance in Crystal Structure Prediction Methods
The Cambridge Crystallographic Data Centre (CCDC) announces that the results of its 6th blind test of crystal structure prediction methods demonstrate significant advancement in in comparison with previous tests.
Protein Structure Discovery Opens Window on Basic Life Process
Biochemists at Oregon State University have made a fundamental discovery about protein structure that sheds new light on how proteins fold, which is one of the most basic processes of life.
Clearest Ever Images of Enzyme that Plays Key Roles in Aging, Cancer
UCLA-led research on telomerase could lead to new strategies for treating disease
New Approach to Treating Heparin-induced Blood Disorder
A potential treatment for a serious clotting condition that can strike patients who receive heparin to treat or prevent blood clots may lie within reach by elucidating the structure of the protein complex at its root.
Escape Prevention
Studying flu virus structure brings us a step closer to a permanent vaccine.
Structure of Protein at Root of Muscular Disease Decoded
Researchers at Rice University and Baylor College of Medicine have unlocked the structural details of a protein seen as key to treating a neuromuscular disease.
A Natural Light Switch
MIT scientists identify and map the protein behind a light-sensing mechanism.
First Complete Structural Study Of A Pegylated Protein
Significant data obtained at NUI Galway reports first crystal structure of a protein modified with a single PEG chain.
Cellular Contamination Pathway for Heavy Elements Identified
Berkeley Lab scientists find that an iron-binding protein can transport actinides into cells.
Scroll Up
Scroll Down

mosquito® Crystal for the rapid screening and optimisation of crystallisation conditions of the bacterial periplasmic binding protein, HbpA
Bookmark and Share

TTP LabTech

Recently, Vergauwen and colleagues identified a bacterial periplasmic lipoprotein in H. influenzaeRd, a global human pathogen that specifically binds both reduced glutathione (GSH) and oxidised glutathione (GSSG) with physiologically relevant affinity.

This discovery came as a complete surprise as this protein was previously thought to be a heme-binding protein A (HbpA) serving as a binding platform for heme. Vergauwen and colleagues employed a combination of structural, biochemical and cellular studies in establishing the physiological role of this protein, as a periplasmic binding protein that primes glutathione import via its cognate ABC-like dipeptide transporter DppBCDF.

This application note describes the use of mosquito® Crystal to screen and optimise crystallisation conditions for GbpA using limited amounts of protein, thus highlighting its ability to address complex biological questions in structural biology quickly and efficiently.

Further Information

Related Content

David Newble Joins TTP Labtech as New Managing Director
Recent appointment promises to drive innovation strategy and further strengthen R&D pipeline
Thursday, June 18, 2015
Innovative Technology Enables First Crystal Structure of mGlu5 Transmembrane Domain to be Determined
Several novel drug candidates have been identified to help treat specific neuropsychiatric disorders.
Saturday, July 19, 2014
TTP Labtech Revenues up 43%
The company has reported an impressive 43% increase in revenues and an associated increase in profits over 2013.
Monday, June 23, 2014
Major Protein Structure Discovery Achieved Using TTP Labtech’s Mosquito LCP
Researchers have successfully reported the structure of a Class B G-Protein Coupled Receptor (GPCR) using lipidic cubic phase (LCP) protein crystallisation.
Friday, July 26, 2013
TTP Labtech Announces On-Going Growth
An investment of £3.8M in global R&D sees product sales grow over 20%.
Thursday, July 11, 2013
TTP Labtech Announces Company Growth
New product offering demonstrates strong commitment to product development.
Friday, May 11, 2012
TTP LabTech Presents Protein Crystallography Community with News Service
TTP LabTech has launched the 2011 issue of its LabCrystal magazine, designed specifically for scientists who perform protein crystallography.
Monday, December 19, 2011
Webinar Places Spotlight on Mosquito Applications
Leading speakers discuss hot topics for TTP LabTech’s mosquito Crystal and mosquito LCP.
Tuesday, September 13, 2011
The Rapid Screening and Optimisation of Crystallisation Conditions of the Bacterial Periplasmic Binding Protein, HbpA and the Elucidation of its Role as a Glutathione Import Protein
A recent study reported in PNAS employed TTP LabTech’s mosquito® crystal for the identification of a bacterial periplasmic lipoprotein in H. influenzae Rd.
Monday, September 12, 2011
Driving the Science of the Future
TTP LabTech announce that they are founding sponsors of the inaugural European Lab Automation (ELA) conference and exhibition, to be held at the Conference Centre Hamburg (CCH), Hamburg, Germany, from the 30th June-1st July.
Friday, May 20, 2011
TTP LabTech to Demonstrate New mosquito® LCP at ACA, Chicago
Dedicated solution to increase throughput of lipid cubic phase screening
Wednesday, July 07, 2010
Screeners and Protein Crystallographers - Test Mosquito®
New dates added to TTP LabTech mosquito roadshow.
Wednesday, October 14, 2009
A Unique Approach to Hanging Drop Automation
TTP LabTech’s mosquito® can create several multi-component drops per well, even in high-density 96-well hanging drop set-ups allowing up to 288 drop conditions to be created per plate.
Wednesday, May 16, 2007
TTP Extends Global Reach
After building up a strong base of customers in the USA and Europe over the past three years, TTP LabTech have now appointed distributors for Japan, India and Australia/New Zealand.
Wednesday, April 04, 2007
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos