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Crouching Protein, Hidden Enzyme
A new study led by scientists at The Scripps Research Institute (TSRI) and the University of California (UC), Berkeley shows how a crucial molecular enzyme starts in a tucked-in somersault position and flips out when it encounters the right target.
Spotlight on Acoustic Liquid Handling
Journal of Laboratory Automation special issue highlights how acoustic liquid handling enables breakthrough innovations.
3D Images of Enzymes May Lead to Improved Antibiotics
Research advances understanding of how crucial proteins function.
Supply Chain
Chemists discover how a single enzyme maintains a cell’s pool of DNA building blocks.
Seeing DROSHA for the First Time
IBS team gets the first glimpse of elusive protein structure.
Scientists Blueprint Tiny Cellular ‘Nanomachine’
Scientists have drawn up molecular blueprints of a tiny cellular ‘nanomachine’, whose evolution is an extraordinary feat of nature, by using one of the brightest X-ray sources on Earth.
Pioneering Brain Cancer Technique Could Lead to Better Prognosis for Patients
4,000th paper published from Diamond research could improve outcomes for brain cancer sufferers.
Big Moves in Protein Structure Prediction and Design
Custom design with atomic level accuracy enables researchers to craft a whole new world of proteins.
Pushing Drug Discovery Forward
A new study, led by scientists at The Scripps Research Institute (TSRI), shows how different pharmaceutical drugs hit either the “on” or “off” switch of a signaling protein linked to asthma, obesity and type 2 diabetes.
Solved Structure of S. pneumoniae Enzyme Could Lead to New Antibiotics
Scientists solve structure of a key bacterial enzyme from streptococcus pneumoniae: a major cause of bacterial meningitis, bronchitis, ear infection and pneumonia.

Discovery of Potent and Selective Inhibitors of Monopolar Spindle 1 (MPS1) Kinase
Rob van Montfort, The Institute of Cancer Research, speaking at Discovery Chemistry Congress 2015.

Choosing & Using Fragments in the Generation of Selective Kinase Inhibitors
Lee Walmsley, Vernalis Ltd, speaking at Discovery Chemistry Congress 2015.

Identification of Atg-8–Atg 3 protein-protein interaction inhibitor
Jürgen Bosch, Johns Hopkins University, speaking at Drug Discovery and Development 2014

Approaches to the Discovery of Small-molecule MDM2-p53 Inhibitors
Dr Ian Hardcastle, Newcastle University, speaking at Discovery Chemistry Congress 2013.

Chemical Biology Approaches to Target Protein Modification in Disease
Megan Wright, Imperial College London, speaking at Discovery Chemistry Congress 2013.

Robust Three-dimensional Tools to Design Inhibitors Against Drug Targets Which Lack Explicit Specificity
Dr. Moses Mohandas Prabu, The Commonwealth Medical College, speaking at Discovery Chemistry Congress 2013.

ESPRIT: High Throughput Screening for Soluble Expression Constructs of Difficult-to-express Proteins
Darren Hart, European Molecular Biology Laboratory, speaking at European Lab Automation 2012

Fragment-Based Screening and Structure-Based Design at ICR: Discovering High Quality Leads in Cancer Drug Discovery
Rob Van Montfort, Institute of Cancer Research, speaking at Discovery Chemistry Conference 2012.

NMR as a Tool for Examining Mechanisms of Transport and Inhibition in CLC “Chloride Channels”
Shelley Elvington, Stanford University, speaking at Ion Channel Targets 2011.

Old Structures - New Targets for Antivirulence Salicylidene Acylhydrazide Compounds
Mads Gabrielsen, Post Doc, University of Glasgow, speaking at Advances in Protein Crystallography 2010.

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