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Microfluidic Systems for Biomarker Analy...Advances in Volatile Analyses for Diseas...Companion Diagnostics Development at the...

Featured Products
Featured Product - illumigeneMeridian Bioscience, Inc.
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Webcasts
Webcasts - Self-assembled Porphyrin Nanomaterials for New Approaches to Medical Imaging and TherapySelf-assembled Porphyrin Nanomaterials for New Approaches to Medical Imaging and Therapy
Jonathan Lovell, University at Buffalo, speaking at Nanomedicine 2014.
Webcasts - Circulating Tumor Cells as Liquid Biopsy for Cancer PatientsCirculating Tumor Cells as Liquid Biopsy for Cancer Patients
Klaus Pantel, University Medical Center Hamburg Eppendorf, speaking at Advances In Cellular Assays & Cell Culture

Market Reports
Epigenetic Modification Screening Trends 2014
HTStec

This market report summarizes the results of HTStec’s 3nd industry-wide global web-based benchmarking survey on epigenetic modification screening carried out in May 2014.
Chromatography Accessories and Consumables Market by Types, Technology & End-users - Trends & Global Forecasts to 2018
MarketsandMarkets

The chromatography accessories and consumables market demands significant investments in R&D in order to constantly come up with new and innovative products and technologies.
Molecular Spectroscopy Market by Technology & Application - Forecast to 2018
MarketsandMarkets

Over the years, the molecular spectroscopy market, comprising instruments, consumables, and services, has witnessed various technological advancements. These advancements have led to a growth in the number of molecular spectroscopy applications.
Multi-Channel Pipettor QC Trends 2014
HTStec

Multi-channel pipettors are essential tools in most life science laboratories today. Yet the impact of undertaking quality control (QC) measures on improving data quality, enhancing productivity/efficiency and reducing experimental failures has only relatively recently been recognized. Understanding how lab users approach the issue of pipettor QC is important as the industry struggles to adopt standards for automated pipetting.
Biomarkers Market 2013 - 2020
Allied Market Research

Disease diagnostic application remains the key area of application that is expected to reach 6.1 $billion in 2020. However, application of diagnostic biomarkers in forensics and molecular diagnostics is catching up quite significantly. Molecular diagnostics is expected to grow at a CAGR of 17.6% from 2013 to 2020.
DNA Sequencing
RI Technologies

This report presents an in depth analysis of DNA sequencing market. The study emphasizes on both, the methods and instruments/software of DNA sequencing in medical research, agriculture and animal husbandry and DNA testing and forensics application areas.
Blood - Components, Testing & Collection
RI Technologies

This market insight report gives an insight into global blood ? components, testing and collection market. The report also provides market analytics by Product Type.
Bionanotechnology
RI Technologies

This report on Bionanotechnology studies the impact of nanotechnology in various biotechnology applications. The study focuses on major applications including food, drug discovery and development, diagnostic tools and devices, and other (bionanosensors).
Multi-Mode Microplate Reader Trends 2013
HTStec

This market report summarizes the results of HTStec’s 4th industry-wide global web-based benchmarking survey on multi-mode microplate readers carried out in September 2013.
Biomarkers in Drug Discovery - Integration in Early Stage Promotes Use of Companion Diagnostics to Optimize Therapeutic Outcomes
Global Data

The report describes the history of biomarkers and their role in fulfilling the unmet needs of the conventional drug discovery process. The drivers and barriers for the biomarkers market, along with the key issues faced in the application of biomarkers in the drug discovery process, are highlighted.
Scientific News
Array Technology Could Screen for Emerging Viral Diseases
A microbe detection array technology could provide a new rapid method for public health authorities to conduct surveillance for emerging viral diseases.
Self-assembling Nanoparticle Could Improve MRI Scanning for Cancer Diagnosis
Scientists have designed the nanoparticle that targets tumours, to help doctors diagnose cancer earlier.
Researchers Invent Nanotech Microchip to Diagnose Type-1 Diabetes
The cheap, portable, microchip-based test could speed up diagnosis and enable studies of how the disease develops.
Significant Step Towards Blood Test for Alzheimer's
Scientists have identified a set of 10 proteins in the blood which can predict the onset of Alzheimer’s, marking a significant step towards developing a blood test for the disease.
Mass Spec Predicts Improved Response to Anti-HER2 Therapy in Breast Cancer
Immunohistochemistry is the standard technique for detecting HER2 protein expression, it does not provide absolute quantification of this receptor and is prone to false-positives.
New App Helps Patients Ensure Best Outcome from Surgery
MySurgery - New and innovative approach to reducing risk in surgery.
New Blood Test Identifies Risk of Sudden Cardiac Death
The test, PED MASTR, is already in use at the center of medical genetics of UZA/UAntwerp and will be launched worldwide from September 2014.
Hot Spots for Molecules
The accurate placement of molecules into gaps between gold nanoantennas enables ultra-high sensitivity molecular detection.
Ultra-Sensitive Nano-Chip for Early Cancer Detection
Device is able to detect very low concentrations of protein cancer markers, enabling diagnoses of the disease in its earliest stages.
Beaming Power To Medical Chips Deep Inside The Body
A Stanford electrical engineer has invented a way to wirelessly transfer power deep inside the body.
Business News
Quest Diagnostics Adds Vicky Gregg to Board of Directors
Company’s Board of Directors expand the Board to 10 members.
BioFire Dx Initiates Clinical Study for the FilmArray™ Meningitis/Encephalitis Panel
Clinical and analytical studies to evaluate company’s FilmArray Meningitis/Encephalitis (ME) Panel, with plans to seek both FDA clearance and CE IVD marking.
Epistem, Global Health Investment Fund Sign Collaborative Funding Agreement
Agreement will see GHIF support the roll-out of Epistem's Genedrive® molecular diagnostic platform.
Development of Oral Cancer Diagnostic Receives Backing
Zilico Ltd has received funding from the Technology Strategy Board, the UK’s innovation agency.
Waters Acquires REIMS Technology
Rapid Evaporation Ion Mass Spectrometry technology has been investigated for clinical diagnostic, microbiology and food safety applications.
Berry, Illumina Co-Develop NGS System for CFDA Review and Approval
Berry Genomics will use Illumina’s NGS technology to secure Chinese Food and Drug Administration regulatory approval for clinical applications, expanding access to NGS-based tests in China.
RAN Biotechnologies Announces Distributorship Agreement with Fluigent
Agreement with Fluigent in France provides industry-leading solution for droplet microfluidic applications throughout EU region.
Illumina Acquires CDx Firm Myraqa
Illumina has acquired Myraqa, a regulatory and quality consulting firm specializing in IVDs, particularly companion diagnostics.
Illumina Appoints Senior VP of Oncology
Company names Tina S. Nova as Senior Vice President and General Manager of oncology.
Ventana Enters into Agreement with Merck KGaA
Agreement to develop companion diagnostic test for cancer treatment.

Events
2014 AACC Annual Meeting
27 Jul 2014
2014 AACC Annual Meeting ...
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Event - 4th Digital Marketing for Medi
11 Aug 2014
4th Digital Marketing for Medi ...
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3rd Annual Medical Affairs For
26 Aug 2014
3rd Annual Medical Affairs For ...
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Biomarker Utilisation & Commer
10 Sep 2014
Biomarker Utilisation & Commer ...
More information

ePosters
A multianalyte algorithm PCR-based blood test outperforms single analyte ELISA-based blood tests for neuroendocrine tumor detection
Wren Laboratories

In a prospective study, in age-/sex- and ethnicity-matched patients and controls (n=82), a 51 panel multigene blood transcript test (NETest) was identified to be significantly more sensitive and accurate (>93%) than any single analyte assay (Chromogranin A, Pancreastatin or Neurokinin A) for neuroendocrine tumor detection.
Low-cost “Plug & Play” On-Chip Valve and Pump for Thermoplastic Microfluidics
SIMTech Microfluidics Foundry

Scientists have developed a novel on-chip valving solution for thermoplastic microfluidic devices, which is reliable, easy to implement, and has low-cost fabrication.
Evaluation of 2012 Bowel Cancer Awareness and Early Diagnosis Campaign at a District General Hospital
Brighton and Sussex University Hospitals

Following the regional Be Clear on Cancer campaign, the Department of Health launched a national bowel cancer awareness campaign from 30 January 2012. The campaign ran until the end of March.
FDG PET/CT Utility in Gynecologic Malignancies: A comprehensive review of anatomy, pathways of metastatic spread and scan findings
Emory University Hospital

Our objective was to review the five major gynaecologic cancers (cervical, ovarian, uterine, vaginal, and vulvar) and demonstrate the role of FDG PET/CT in diagnosis, surveillance, FIGO staging and treatment strategy.
Saliva’s Diagnostic Potential
Postgraduate Institute of Dental Sciences

Advantages and disadvantages of using saliva as a diagnostic source of information.
A Systematic Review of Lifestyle Modification in Adults with Non-Alcoholic Fatty Liver Disease
Newcastle University

This study reviews the causes of non-alcoholic fatty liver disease and the associated risk factor for type 2 diabetes and cardiovascular disease.
Rapid PCR for Integration in Sample-to-answer Analysis Platforms
Institut fuer Mikrotechnik Mainz

This poster describes how molecular testing at the point-of-care can increase time to results and yield rather specific information, concentrating on PCR on a chip layout which proves to be fast and robust.
Identification of novel autoantigensin patients with liver autoimmune diseases by Protein MicroArray
1Fondazione INGM, Istituto Nazionale Genetica Molecolare, Milan; 2Fondazione IRCCS Ospedale Maggiore Policlinico, Milano; 3Policlinico Sant’Orsola, Bologna; 4Azienda Ospedaliera Universitaria Pisana,

The characterization of autoimmune disease-specific biomarkers are of primary importance for the development of diagnostic tools and the comprehension of pathogenetic mechanisms leading to autoimmunity. To this aim a protein microarray was employed to analyze serum samples from patients with autoimmune hepatitis (e.g. AIH & PBC) and of healthy as controls. A panel of autoantigens able to discriminate among the groups of patients was identified for potential use as biomarkers.
MicroRNA expression in normal and malignant prostate tissues
University of Skövde

In this study the aim was to identify a miRNA expression signature that could be used to separate between normal and malignant prostate tissues. Nine miRNAs were found to be differentially expressed and they could be used to separate between the normal and malignant tissues. A cross-validation procedure confirmed the generality of this expression signature, showing an accuracy of 85%.
Point-of-Care Diagnostics for Sexually Transmitted Infections
Brunel University

This poster introduces the recently enlarged DoCLab research group at Brunel University, London. This large multidisciplinary group brings together electronic, mechanical and computer engineers with molecular biologists, biochemists and clinical collaborators to develop fully integrated, multiplex Point-Of-Care-Tests (POCT) for the self- diagnosis of infectious diseases.
Application Notes
Sample preparation with the AC Extraction Plate: extraction of urinary THC metabolites for LC-MSMS quantification
Tecan Group Ltd.

In many countries, routine workplace drug testing involves screening for the free THC-COOH metabolite obtained by hydrolyzing THC-COOH glucuronide. Tecan’s AC Extraction Plate with TICE technology enables a straightforward workflow that is reproducible and cost efficient. Liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) provides an easy and cost-effective means for fast, sensitive and precise analysis of THC and its metabolites.
Automated sample preparation for the determination of testosterone in serum by LC-MSMS
Tecan Group Ltd.

For accurate, reproducible quantification of testosterone, a growing number of laboratories are shifting from immunoassay to liquid chromatography coupled with tandem mass spectrometry. This application note describes the preparation of serum samples for subsequent LC-MS analysis of testosterone, focusing on a streamlined workflow suitable for automation.
Validating the Expression Consistency of a Housekeeping Protein
Bio-Rad Laboratories

Housekeeping proteins (HKP) are typically used as loading controls because it is assumed that the HKP expression level remains consistent across samples. However, there is evidence that HKP expression levels change in many scenarios, including siRNA treatment, cell death, cell differentiation, etc.
A Method for Greater Reliability in Western Blot Loading Controls: Stain-Free Total Protein Quantitation
Bio-Rad Laboratories

Reliable assessment of changes in target protein levels by western blot requires measurement of both the target and loading control proteins in the linear dynamic range. Stain-free technology is a novel method introduced by Bio-Rad to visualize and quantify proteins in gels and blots.
General V3 Western Blotting Protocol
Bio-Rad Laboratories

Western blotting is a very useful and widely adopted lab technique, but the traditional procedure can be long and tedious. Researchers can assess only whether a blot image is captured at the end of the long procedure and the quality of western blot data is sometimes challenged due to poor loading controls.
Determining the Appropriate Sample Load When Using a Stain-Free V3 Western Workflow™
Bio-Rad Laboratories

Traditional western blot workflows require an appropriate sample load to detect both target proteins and loading control proteins. The discrepancy between these quantities often leads to oversaturated protein bands, forcing researchers to sometimes run two duplicate gels or titrate down the antibody concentration in order to get quantitative results.
Determining the Appropriate Film Exposure Time
Bio-Rad Laboratories

Film has a limited linear dynamic range for light detection and is often easily saturated by the chemiluminescent signals from the blot.
Determining the Appropriate Sample Load for Western Blots
Bio-Rad Laboratories

Reliable western blot data can be generated only when the proper sample amount of protein is used. Loading too much protein leads to signal saturation in western blots, yet too little produces weak signals.
Avoiding Housekeeping Protein Detection Saturation
Bio-Rad Laboratories

Reliable western blot data require detection of the target and loading control proteins in the linear dynamic range. Many published western blot images show saturated protein bands, indicating that they were not measured in the linear dynamic range. Quantitative analysis based on this type of data is not reliable.
Purification of Genomic DNA from Saliva Using Oragene® Discover Collection Kits and the Akonni TruTip® Extraction System on the Hamilton Microlab® STAR Liquid Handling Workstation
Hamilton

In the following studies, we have demonstrated the high precision of the automated TruTip extraction technology in processing genomic DNA from low-volume saliva samples and its advantage over competitors.
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