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Digital PCR in the Clinical Virology Lab...Siemens Healthcare Diagnostics Answers V...Quick and Easy NGS Analysis with SureCal...

Featured Products
Featured Product - Help Improve Lab Safety with Thermo Scientific General Purpose CentrifugesThermo Scientific
Help Improve Lab Safety with Thermo Scientific General Purpose Centrifuges
Featured Product - Q-POC™: The Handheld LaboratoryQuantuMDx Group Ltd
Q-POC™: The Handheld Laboratory

Webcasts
Webcasts - Webinar: How to Overcome Assay Challenges Using Custom Recombinant AntibodiesWebinar: How to Overcome Assay Challenges Using Custom Recombinant Antibodies
Join this webinar to find out how custom-made recombinant antibodies can solve your challenges when designing and optimizing critical assays to support drug development, diagnostic assays or discovery studies.
Webcasts - Diagnostic Informatics Challenges – The Way ForwardDiagnostic Informatics Challenges – The Way Forward
This on-demand webinar provides a valuable look at the Diagnostic informatics challenges and issues that arise in the operation of the clinical laboratory.

Market Reports
Immunoassay Auto Trends 2014
HTStec

This report comprehensively documents current practices and preferences in immunoassays and to understand future user requirements, particularly with respect to immunoassay automation.
Epigenetic Modification Screening Trends 2014
HTStec

This market report summarizes the results of HTStec’s 3nd industry-wide global web-based benchmarking survey on epigenetic modification screening carried out in May 2014.
Chromatography Accessories and Consumables Market by Types, Technology & End-users - Trends & Global Forecasts to 2018
MarketsandMarkets

The chromatography accessories and consumables market demands significant investments in R&D in order to constantly come up with new and innovative products and technologies.
Molecular Spectroscopy Market by Technology & Application - Forecast to 2018
MarketsandMarkets

Over the years, the molecular spectroscopy market, comprising instruments, consumables, and services, has witnessed various technological advancements. These advancements have led to a growth in the number of molecular spectroscopy applications.
Multi-Channel Pipettor QC Trends 2014
HTStec

Multi-channel pipettors are essential tools in most life science laboratories today. Yet the impact of undertaking quality control (QC) measures on improving data quality, enhancing productivity/efficiency and reducing experimental failures has only relatively recently been recognized. Understanding how lab users approach the issue of pipettor QC is important as the industry struggles to adopt standards for automated pipetting.
Biomarkers Market 2013 - 2020
Allied Market Research

Disease diagnostic application remains the key area of application that is expected to reach 6.1 $billion in 2020. However, application of diagnostic biomarkers in forensics and molecular diagnostics is catching up quite significantly. Molecular diagnostics is expected to grow at a CAGR of 17.6% from 2013 to 2020.
DNA Sequencing
RI Technologies

This report presents an in depth analysis of DNA sequencing market. The study emphasizes on both, the methods and instruments/software of DNA sequencing in medical research, agriculture and animal husbandry and DNA testing and forensics application areas.
Blood - Components, Testing & Collection
RI Technologies

This market insight report gives an insight into global blood ? components, testing and collection market. The report also provides market analytics by Product Type.
Bionanotechnology
RI Technologies

This report on Bionanotechnology studies the impact of nanotechnology in various biotechnology applications. The study focuses on major applications including food, drug discovery and development, diagnostic tools and devices, and other (bionanosensors).
Multi-Mode Microplate Reader Trends 2013
HTStec

This market report summarizes the results of HTStec’s 4th industry-wide global web-based benchmarking survey on multi-mode microplate readers carried out in September 2013.
Scientific News
Monitoring Effectiveness Of Hay Fever Immunotherapy
A new test for measuring histamine release from certain white blood cells could help doctors monitor the effectiveness of immunotherapy for hay fever.
Developing a Noninvasive Test for Endometriosis
UCSF researchers identify patterns of genetic activity that could help in early detection of disorder.
Test Detects Early Brain Damage in Football Players
New Contrast-Enhanced MRI Developed by BGU Visualizes Brain Injury in the Blood-Brain Barrier Offering Significant Diagnostic Capabilities.
New Test Developed at Dana-Farber/Brigham and Women's Cancer Center
Rapid Heme Panel - A high-tech genetic test that speeds treatment decisions for blood cancer patients.
Urgent Need for Fast Dx to Help Tackle Antibiotic Resistance
£10 million Longitude Prize for an accurate, rapid, cost-effective and easy-to-use point-of-need diagnostic test for bacterial infections.
Test Developed To Rapidly Diagnose Bloodstream Infection
New technology can detect bacterial invaders with unprecedented speed and sensitivity.
Classification of Gene Mutations in Neuroblastoma
Penn Medicine and CHOP experts define riskier mutations in neuroblastoma, setting stage for clinical trial.
New Genetic Cause of Epilepsy Identified
San Diego girl improves after discovery of DNA mutation tied to potassium regulation.
Cancer Cell Fingerprints in the Blood May Speed up Childhood Cancer Diagnosis
Researchers found unique molecular fingerprints for 11 types of children’s tumours, to develop blood tests to diagnose these cancers.
Blood Test Developed to Diagnose Early Onset Alzheimer’s Disease
New blood-test could predict a person’s risk of developing AD much earlier than is currently possible.
Business News
Diagnostics Development Hub To Complement Biomed Research Launched
Hub will leverage strategic public-public and public-private partnerships to accelerate market readiness of locally developed diagnostic products.
Premaitha Health Wins Bionow Investment Deal of the Year Award
£7.2m reverse listing to AIM enabling commercialisation of ground-breaking test for Down’s syndrome.
Diagnostics Leader Delivers New Fertility Service For UK
Randox launches new fertility service.
USAID, Broad Institute and Illumina Form a Public-Private Partnership
Partnership aims to combat the Ebola epidemic in West Africa.
EKF Diagnostics Collaborates with Joslin Diabetes Center
Supporting the ongoing clinical and commercial development of early Diabetic Kidney Disease biomarkers.
Beckman Coulter Diagnostics and Seegene Supply Agreement
Supply agreement announced for multiplex reagents for VERIS molecular diagnostics system.
Enterome and Abbvie Enter Microbiome-Based Collaboration in Crohn’s Disease
Collaboration to generate novel diagnostic products to support personalized therapies for microbiome-related diseases.
Cepheid Awarded Funding To Develop Xpert Ebola
With Funding from the Paul G. Allen Family Foundation and the Bill & Melinda Gates Foundation, Cepheid expects to deliver prototype in as little as eight weeks.
Roche Receives FDA Clearance for Strep A Test
The cobas Strep A test is the first molecular point of care test to provide a result in 15 minutes for this common infection.
Humedics Closes 6.3 Million€ Financing Round
Cash inflow enables for commercialization of the LiMAx test.

Events
Event - Adaptive Designs: Concepts and
02 Dec 2014
Adaptive Designs: Concepts and ...
More information
Event - IVD Regulatory and Strategic F
02 Dec 2014
IVD Regulatory and Strategic F ...
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Event - Life Sciences Supply Chain Sum
03 Dec 2014
Life Sciences Supply Chain Sum ...
More information
Event - Asia Pacific Healthcare Policy
04 Dec 2014
Asia Pacific Healthcare Policy ...
More information

ePosters
"In-vitro studies on hydroxamic acid- CT DNA binding"
Research Scholar

In vitro studies of five the interaction between five different derivatives of hydroxamic acids, N-phenyl 2,4dichloro phenoxybutyro, N-m-tolyl 2,4 dichlorophenoxyglutero, N-m-tolyl-4-chlorophenoxyaceto, N-m-chloro-phenyl-tertiarybutylbenzo and N-p-tolyl-iso-valero hydroxamic acids and calf thymus DNA was investigated under simulated physiological condition.
Recent Technical Developments in the Standardized Separation and Measurement of Extracellular Vesicles
(1) Izon Science US Ltd, Christchurch, New Zealand (2) The University of Queensland, Brisbane, QLD, Australia

We present robust and practical solutions for the standardization of EV isolation and concentration measurement. EV concentration also needs to have a defined size range. With these solutions, significant improvement in the reproducibility and comparability of results between different researchers is possible.
High Titre BacMam viruses improve transduction efficiency of mammalian cells
Oxford Expression Technologies Ltd, Oxford Brookes University

We present a method for producing high titre BacMam virus vectors for the efficient transduction of mammalian cells.
Amino-Coated Metallofullerene Nanoparticles for Glioblastoma Mutiforme Tumor Detection
Department of Chemistry, Virginia Tech,Virginia Tech Carilion Research Institute

We report the preparation of a new functionalized trimetallic nitride endohedral metallofullerene, with a cage surface consisting of positively charged amino groups, which is expected to bind more efficiently to negatively charged cell phospholipid bi-layer cellular surfaces and will more readily undergo endocytosis. We now report that this Gd-nanoplatform when subsequently conjugated with an IL-13 peptide, (IL-13-Gd3N@C80(OH)x(NH2)y) exhibits enhanced targeting of U-251 GBM cell lines.
Performance of a hybrid gamma-optical camera for improved utility in diagnostic imaging
1Space Research Centre, University of Leicester, Leicester, LE1 7RH, UK. 2Clinical Imaging Group, Sandwell and West Birmingham Hospital NHS Trust, West Bromwich B71 4HJ, UK.
Performance of a hybrid gamma-optical camera for improved utility in diagnostic imaging
Next Generation Multivalent PRINT Nanoparticle Vaccine Targeting Pneumococcal Disease
Liquidia Technologies, PATH

A new generation PRINT nanoparticle Pneumococcal vaccine matrix has been designed to mimic size and structural aspects of bacterial pathogens to efficiently present and deliver polysaccharide and protein antigens to elicit robust immune responses.
Low-cost Electrochemical Microfluidic Immunoarrays for Cancer Diagnostics
Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, CT 06269

This poster describes the development and validation of a simple, low-cost, semi-automated microfluidic device for cancer biomarker protein detection to aid in cancer diagnosis and therapy monitoring.
Evidence for Integrating Point of Care Diagnostics as an Integral Part of Primary Healthcare in South African Rural Communities: A People-centred Health System-strengthening Approach
University of KwaZulu Natal, South Africa

Diagnostic systems designed in developed countries may not be immediately appropriate for use in the target developing countries. Therefore, a rigorous assessment for POC diagnostics outcomes of interest in the setting for which the test is designed should be carried out prior to adoption and scale up.

Correlation between plasma levels of lutein and oxidized low density lipoproteins: a short human intervention study
Università Politecnica delle Marche

The increase of plasma carotenoids, in particular lutein, after dietary treatment for two weeks is associated with a significant protective effect against lipid peroxidation of plasma lipoproteins.
DETERMINATION OF HOMOCYSTEINE THIOLACTONE IN URINE BY FIELD AMPLIFIED SAMPLE INJECTION AND SWEEPING MEKC METHOD WITH UV DETECTION
Department of Environmental Chemistry, Faculty of Chemistry, University of Lodz, 163 Pomorska Str., 90-236 Lodz, Poland

* The procedure does not overload the capillary and has positive effect on the increase in peak hight,
* The method allows about 70-fold increase in method sensitivity,
* The limits of detection and quantification are 0.1 nmol and 0.09 nmol of Hcy-thiolactone in 1 mL of urine, respectively,
* Presented assay can be used for the determination of Hcy-thiolactone in biological samples.
Application Notes
Sample preparation with the AC Extraction Plate: extraction of urinary THC metabolites for LC-MSMS quantification
Tecan Group Ltd.

In many countries, routine workplace drug testing involves screening for the free THC-COOH metabolite obtained by hydrolyzing THC-COOH glucuronide. Tecan’s AC Extraction Plate with TICE technology enables a straightforward workflow that is reproducible and cost efficient. Liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) provides an easy and cost-effective means for fast, sensitive and precise analysis of THC and its metabolites.
Automated sample preparation for the determination of testosterone in serum by LC-MSMS
Tecan Group Ltd.

For accurate, reproducible quantification of testosterone, a growing number of laboratories are shifting from immunoassay to liquid chromatography coupled with tandem mass spectrometry. This application note describes the preparation of serum samples for subsequent LC-MS analysis of testosterone, focusing on a streamlined workflow suitable for automation.
Validating the Expression Consistency of a Housekeeping Protein
Bio-Rad Laboratories

Housekeeping proteins (HKP) are typically used as loading controls because it is assumed that the HKP expression level remains consistent across samples. However, there is evidence that HKP expression levels change in many scenarios, including siRNA treatment, cell death, cell differentiation, etc.
A Method for Greater Reliability in Western Blot Loading Controls: Stain-Free Total Protein Quantitation
Bio-Rad Laboratories

Reliable assessment of changes in target protein levels by western blot requires measurement of both the target and loading control proteins in the linear dynamic range. Stain-free technology is a novel method introduced by Bio-Rad to visualize and quantify proteins in gels and blots.
General V3 Western Blotting Protocol
Bio-Rad Laboratories

Western blotting is a very useful and widely adopted lab technique, but the traditional procedure can be long and tedious. Researchers can assess only whether a blot image is captured at the end of the long procedure and the quality of western blot data is sometimes challenged due to poor loading controls.
Determining the Appropriate Sample Load When Using a Stain-Free V3 Western Workflow™
Bio-Rad Laboratories

Traditional western blot workflows require an appropriate sample load to detect both target proteins and loading control proteins. The discrepancy between these quantities often leads to oversaturated protein bands, forcing researchers to sometimes run two duplicate gels or titrate down the antibody concentration in order to get quantitative results.
Determining the Appropriate Film Exposure Time
Bio-Rad Laboratories

Film has a limited linear dynamic range for light detection and is often easily saturated by the chemiluminescent signals from the blot.
Determining the Appropriate Sample Load for Western Blots
Bio-Rad Laboratories

Reliable western blot data can be generated only when the proper sample amount of protein is used. Loading too much protein leads to signal saturation in western blots, yet too little produces weak signals.
Avoiding Housekeeping Protein Detection Saturation
Bio-Rad Laboratories

Reliable western blot data require detection of the target and loading control proteins in the linear dynamic range. Many published western blot images show saturated protein bands, indicating that they were not measured in the linear dynamic range. Quantitative analysis based on this type of data is not reliable.
Purification of Genomic DNA from Saliva Using Oragene® Discover Collection Kits and the Akonni TruTip® Extraction System on the Hamilton Microlab® STAR Liquid Handling Workstation
Hamilton

In the following studies, we have demonstrated the high precision of the automated TruTip extraction technology in processing genomic DNA from low-volume saliva samples and its advantage over competitors.
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