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Tuesday, January 27, 2015
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Featured Product - Unparalleled performance in clinical chemistry testingRandox
Unparalleled performance in clinical chemistry testing
Featured Product - AneuVysion Multicolor DNA Probe Kit Abbott Molecular Inc.
AneuVysion Multicolor DNA Probe Kit

Webcasts
Evidence Based Guidelines for the Pre-analytical Phase of RNA Testing in Blood SamplesEvidence Based Guidelines for the Pre-analytical Phase of RNA Testing in Blood Samples
Francesca Malentacchi, University of Florence, Speaking at Advances in qPCR and dPCR 2014
Next Generation DiagnosticsNext Generation Diagnostics
Birgit Sikkema-Raddatz, University Medical Center Groningen, speaking at NGS & Big Data 2014

Market Reports
Immunoassay Auto Trends 2014
HTStec

This report comprehensively documents current practices and preferences in immunoassays and to understand future user requirements, particularly with respect to immunoassay automation.
Epigenetic Modification Screening Trends 2014
HTStec

This market report summarizes the results of HTStec’s 3nd industry-wide global web-based benchmarking survey on epigenetic modification screening carried out in May 2014.
Chromatography Accessories and Consumables Market by Types, Technology & End-users - Trends & Global Forecasts to 2018
MarketsandMarkets

The chromatography accessories and consumables market demands significant investments in R&D in order to constantly come up with new and innovative products and technologies.
Molecular Spectroscopy Market by Technology & Application - Forecast to 2018
MarketsandMarkets

Over the years, the molecular spectroscopy market, comprising instruments, consumables, and services, has witnessed various technological advancements. These advancements have led to a growth in the number of molecular spectroscopy applications.
Multi-Channel Pipettor QC Trends 2014
HTStec

Multi-channel pipettors are essential tools in most life science laboratories today. Yet the impact of undertaking quality control (QC) measures on improving data quality, enhancing productivity/efficiency and reducing experimental failures has only relatively recently been recognized. Understanding how lab users approach the issue of pipettor QC is important as the industry struggles to adopt standards for automated pipetting.
Biomarkers Market 2013 - 2020
Allied Market Research

Disease diagnostic application remains the key area of application that is expected to reach 6.1 $billion in 2020. However, application of diagnostic biomarkers in forensics and molecular diagnostics is catching up quite significantly. Molecular diagnostics is expected to grow at a CAGR of 17.6% from 2013 to 2020.
DNA Sequencing
RI Technologies

This report presents an in depth analysis of DNA sequencing market. The study emphasizes on both, the methods and instruments/software of DNA sequencing in medical research, agriculture and animal husbandry and DNA testing and forensics application areas.
Blood - Components, Testing & Collection
RI Technologies

This market insight report gives an insight into global blood ? components, testing and collection market. The report also provides market analytics by Product Type.
Bionanotechnology
RI Technologies

This report on Bionanotechnology studies the impact of nanotechnology in various biotechnology applications. The study focuses on major applications including food, drug discovery and development, diagnostic tools and devices, and other (bionanosensors).
Multi-Mode Microplate Reader Trends 2013
HTStec

This market report summarizes the results of HTStec’s 4th industry-wide global web-based benchmarking survey on multi-mode microplate readers carried out in September 2013.
Scientific News
New Blood Test For Aggressive Bone Cancer
Researchers at the University of East Anglia are developing a simple blood test to diagnose bone cancer thanks to funding from the Big C.
Novel Approach to Visualize & Measure Protein Complexes in Tumors
Moffitt Cancer Center researchers have developed a PLA to analyze biological processes occurring within tumors.
Prognostic Test for E2F4 in Breast Cancer Developed
A gene signature in E2F4 has been identified which is predictive of estrogen receptor positive breast cancer.
Blood Test For Prostate Cancer
Vanderbilt team demonstrates that prostate cancer can accurately be detected by liquid biopsy.
Reducing Risk of Miscarriage in Prenatal Testing for Genetic Diseases
Early diagnosis and treatment are crucial to improving patient prognosis for 22q11 deletion syndrome and Wilson’s disease, two potentially life-threatening genetic conditions.
Predicting Sepsis
Altered white-blood-cell motion in burn patients may warn of infection.
Measuring Brain Volume can Help People with Multiple Sclerosis
icometrix has developed software for measuring the brain and brain lesion volume.
Metal Test Could Help Diagnose Breast Cancer Early
It may be possible to develop a simple blood test that, by detecting changes in the zinc in our bodies, could help to diagnose breast cancer early.
Gene Associated with an Aggressive Breast Cancer Identified
Over-expressed gene in triple negative breast cancer offers new diagnostics for risk assessment.
Raman Spectroscopy May Enable Non-Invasive Diagnosis of Bone Diseases
Detection of a genetic ‘brittle bone’ disease known as Osteogenesis Imperfecta (OI) is possible by simply scanning a patient’s limbs.
Business News
Featured Article - Wyss Institute Videos Now on LabTube
Wyss Institute Videos Now on LabTube
The Wyss Institute for Biologically Inspired Engineering has created a channel on Labtube.

Cypher Genomics And Sequenom Announce Development Agreement
Sequenom to apply Cypher's Mantis technology for advanced genome interpretation in NIPT.
DNAe Acquires nanoMR Inc.
Acquisition enables immediate presence in USA, a key market for bloodstream infection diagnosis and other applications.
Horizon Discovery Group plc Trading Update
Revenues expected to be ahead of consensus by approximately 7% driven by an increased global demand for expanded product, service and IP offering.
RealVNC Licenses Remote Access Technology to Beckman Coulter
Technology will be used as part of life sciences and diagnostics products.
Imperial Innovations Leads £18 Million Series B Funding Round in Veryan
Innovations will hold a 47.8% stake in the issued share capital of Veryan.
Randox Announce Plans for New Science Park
Plans include £161m investment and creation of 540 jobs.
ABL, University Hospitals Collaborate on NGS HIV Drug Resistance Assay
Advanced Biological Laboratories signs agreement with University Hospitals Case Medical Center to offer HIV drug resistance tests.
MDxHealth Licenses Epigenetic Technology to oncgnostics
Agreement will grant oncognostics a license for methylation specific PCR technology for diagnostic applications in cervical cancer.
£15m Initiative Puts Scotland at Forefront of Gene-Led Healthcare
Initiative sees the Universities of Edinburgh and Glasgow partner with Illumina.

Events
Diagnostics & Biomarkers - DB
27 Jan 2015
Diagnostics & Biomarkers - DB ...
More information
Sony DADC, SCIENION & Invetech
28 Jan 2015
Sony DADC, SCIENION & Invetech ...
More information
SLAS2015
07 Feb 2015
SLAS2015 ...
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Event - Medical Devices Summit
18 Feb 2015
Medical Devices Summit ...
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ePosters
Expression Profiling of Circulating Tumor Cells: a Prognostic and Predictive Biomarker in Cancer.
Bauer4.1TATAA Biocenter, Göteborg, Sweden (www.tataa.com); 2Inst. of Biotechnology, CAS, Czech Republic; 3AdnaGen GmbH, Ostpassage7, D-30853 Langenhagen, Germany (www.adnagen.com); 4Dep of Gynecoland

We show non-responders to treatment among breast cancer patients can be identified by expression profiling of circulating tumor cells
"In-vitro studies on hydroxamic acid- CT DNA binding"
Research Scholar

In vitro studies of five the interaction between five different derivatives of hydroxamic acids, N-phenyl 2,4dichloro phenoxybutyro, N-m-tolyl 2,4 dichlorophenoxyglutero, N-m-tolyl-4-chlorophenoxyaceto, N-m-chloro-phenyl-tertiarybutylbenzo and N-p-tolyl-iso-valero hydroxamic acids and calf thymus DNA was investigated under simulated physiological condition.
Recent Technical Developments in the Standardized Separation and Measurement of Extracellular Vesicles
(1) Izon Science US Ltd, Christchurch, New Zealand (2) The University of Queensland, Brisbane, QLD, Australia

We present robust and practical solutions for the standardization of EV isolation and concentration measurement. EV concentration also needs to have a defined size range. With these solutions, significant improvement in the reproducibility and comparability of results between different researchers is possible.
High Titre BacMam viruses improve transduction efficiency of mammalian cells
Oxford Expression Technologies Ltd, Oxford Brookes University

We present a method for producing high titre BacMam virus vectors for the efficient transduction of mammalian cells.
Amino-Coated Metallofullerene Nanoparticles for Glioblastoma Mutiforme Tumor Detection
Department of Chemistry, Virginia Tech,Virginia Tech Carilion Research Institute

We report the preparation of a new functionalized trimetallic nitride endohedral metallofullerene, with a cage surface consisting of positively charged amino groups, which is expected to bind more efficiently to negatively charged cell phospholipid bi-layer cellular surfaces and will more readily undergo endocytosis. We now report that this Gd-nanoplatform when subsequently conjugated with an IL-13 peptide, (IL-13-Gd3N@C80(OH)x(NH2)y) exhibits enhanced targeting of U-251 GBM cell lines.
Performance of a hybrid gamma-optical camera for improved utility in diagnostic imaging
1Space Research Centre, University of Leicester, Leicester, LE1 7RH, UK. 2Clinical Imaging Group, Sandwell and West Birmingham Hospital NHS Trust, West Bromwich B71 4HJ, UK.
Performance of a hybrid gamma-optical camera for improved utility in diagnostic imaging
Next Generation Multivalent PRINT Nanoparticle Vaccine Targeting Pneumococcal Disease
Liquidia Technologies, PATH

A new generation PRINT nanoparticle Pneumococcal vaccine matrix has been designed to mimic size and structural aspects of bacterial pathogens to efficiently present and deliver polysaccharide and protein antigens to elicit robust immune responses.
Low-cost Electrochemical Microfluidic Immunoarrays for Cancer Diagnostics
Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, CT 06269

This poster describes the development and validation of a simple, low-cost, semi-automated microfluidic device for cancer biomarker protein detection to aid in cancer diagnosis and therapy monitoring.
Evidence for Integrating Point of Care Diagnostics as an Integral Part of Primary Healthcare in South African Rural Communities: A People-centred Health System-strengthening Approach
University of KwaZulu Natal, South Africa

Diagnostic systems designed in developed countries may not be immediately appropriate for use in the target developing countries. Therefore, a rigorous assessment for POC diagnostics outcomes of interest in the setting for which the test is designed should be carried out prior to adoption and scale up.

Correlation between plasma levels of lutein and oxidized low density lipoproteins: a short human intervention study
Università Politecnica delle Marche

The increase of plasma carotenoids, in particular lutein, after dietary treatment for two weeks is associated with a significant protective effect against lipid peroxidation of plasma lipoproteins.
Application Notes
Sample preparation with the AC Extraction Plate: extraction of urinary THC metabolites for LC-MSMS quantification
Tecan Group Ltd.

In many countries, routine workplace drug testing involves screening for the free THC-COOH metabolite obtained by hydrolyzing THC-COOH glucuronide. Tecan’s AC Extraction Plate with TICE technology enables a straightforward workflow that is reproducible and cost efficient. Liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) provides an easy and cost-effective means for fast, sensitive and precise analysis of THC and its metabolites.
Automated sample preparation for the determination of testosterone in serum by LC-MSMS
Tecan Group Ltd.

For accurate, reproducible quantification of testosterone, a growing number of laboratories are shifting from immunoassay to liquid chromatography coupled with tandem mass spectrometry. This application note describes the preparation of serum samples for subsequent LC-MS analysis of testosterone, focusing on a streamlined workflow suitable for automation.
Validating the Expression Consistency of a Housekeeping Protein
Bio-Rad Laboratories

Housekeeping proteins (HKP) are typically used as loading controls because it is assumed that the HKP expression level remains consistent across samples. However, there is evidence that HKP expression levels change in many scenarios, including siRNA treatment, cell death, cell differentiation, etc.
A Method for Greater Reliability in Western Blot Loading Controls: Stain-Free Total Protein Quantitation
Bio-Rad Laboratories

Reliable assessment of changes in target protein levels by western blot requires measurement of both the target and loading control proteins in the linear dynamic range. Stain-free technology is a novel method introduced by Bio-Rad to visualize and quantify proteins in gels and blots.
General V3 Western Blotting Protocol
Bio-Rad Laboratories

Western blotting is a very useful and widely adopted lab technique, but the traditional procedure can be long and tedious. Researchers can assess only whether a blot image is captured at the end of the long procedure and the quality of western blot data is sometimes challenged due to poor loading controls.
Determining the Appropriate Sample Load When Using a Stain-Free V3 Western Workflow™
Bio-Rad Laboratories

Traditional western blot workflows require an appropriate sample load to detect both target proteins and loading control proteins. The discrepancy between these quantities often leads to oversaturated protein bands, forcing researchers to sometimes run two duplicate gels or titrate down the antibody concentration in order to get quantitative results.
Determining the Appropriate Film Exposure Time
Bio-Rad Laboratories

Film has a limited linear dynamic range for light detection and is often easily saturated by the chemiluminescent signals from the blot.
Determining the Appropriate Sample Load for Western Blots
Bio-Rad Laboratories

Reliable western blot data can be generated only when the proper sample amount of protein is used. Loading too much protein leads to signal saturation in western blots, yet too little produces weak signals.
Avoiding Housekeeping Protein Detection Saturation
Bio-Rad Laboratories

Reliable western blot data require detection of the target and loading control proteins in the linear dynamic range. Many published western blot images show saturated protein bands, indicating that they were not measured in the linear dynamic range. Quantitative analysis based on this type of data is not reliable.
Purification of Genomic DNA from Saliva Using Oragene® Discover Collection Kits and the Akonni TruTip® Extraction System on the Hamilton Microlab® STAR Liquid Handling Workstation
Hamilton

In the following studies, we have demonstrated the high precision of the automated TruTip extraction technology in processing genomic DNA from low-volume saliva samples and its advantage over competitors.
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