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Webcasts
Webcasts - Free up your time - Easy automation of your routine liquid handling tasksFree up your time - Easy automation of your routine liquid handling tasks
In this webinar we will discuss routine liquid handling tasks and illustrate how fast and effortless they can be transferred to our liquid handling workstation.
Webcasts - How to Optimize Sample Preparation Step Prior to ExtractionHow to Optimize Sample Preparation Step Prior to Extraction
Discover the benefits of bead-binding for sample preparation in this on demand webinar from Bertin Technologies.

Market Reports
Immunoassay Auto Trends 2014
HTStec

This report comprehensively documents current practices and preferences in immunoassays and to understand future user requirements, particularly with respect to immunoassay automation.
Epigenetic Modification Screening Trends 2014
HTStec

This market report summarizes the results of HTStec’s 3nd industry-wide global web-based benchmarking survey on epigenetic modification screening carried out in May 2014.
Multi-Channel Pipettor QC Trends 2014
HTStec

Multi-channel pipettors are essential tools in most life science laboratories today. Yet the impact of undertaking quality control (QC) measures on improving data quality, enhancing productivity/efficiency and reducing experimental failures has only relatively recently been recognized. Understanding how lab users approach the issue of pipettor QC is important as the industry struggles to adopt standards for automated pipetting.
Companion Diagnostics and Personalized Medicine
Select Biosciences Ltd

This is the latest and most up-to-date Market Report from Select Biosciences addressing the companion diagnostics (CDx) and personalized medicine marketplace. Personalized medicine is a broad field with several stakeholders all of which must be aligned in order to capture the immense potential value in targeting therapeutics to the correct patient population—the field of stratified medicine.
Molecular Diagnostics: Market Landscape
Datamonitor plc

This report analyzes the emerging sector of molecular diagnostics. It provides a clear classification, assessing the leading technologies and key tests that are positioned in this exciting area of diagnostics. The current MDx market size and leading players are analyzed, with a market forecast of the MDx segment as well as the total in vitro diagnostic market over 2010-16 provided.
Innovations in Combating Infectious Diseases: Opportunities in therapeutics and diagnostics through application of proteomics, genomics, nanotechnology, and novel sources of lead generation
Business Insights

This report makes a detailed and comprehensive analysis of the cutting edge of research aiming to reveal how bacteria, viruses, fungi, and prions infect and affect their hosts. It also assesses the new technologies and techniques that are being used to design and develop the anti-infective drugs and diagnostic methods of the 21st century.
The Future of Molecular Diagnostics: Innovative technologies driving market opportunities in personalized medicine
Business Insights

This report analyzes the current and potential world markets for molecular diagnostics, including advances in the field. This report generally forecasts future growth to 2015. The report breaks down market forecasts by type of test and by geography. It indicates which companies have key products in the market place. It also analyzes key drivers of this market.
Multiplexed Diagnostics 2010
Select Biosciences Ltd

The multiplexed diagnostics market has grown rapidly and generated sales of approximately $2.4 billon in 2009, but is now balanced on multiple tipping points.
Genomics, Proteomics and Metabolomics in Diagnostics: Market landscape, innovative technologies and future outlook
Business Insights

There has been a significant transition in the diagnostic techniques created with increasing technological innovations. In the future, the focus will be on genetic study and disease predisposition, which will test patients' probability of acquiring a disease or a disorder, enabling precautionary steps.
Scientific News
Over Two-Thirds of Cervical Cancer Deaths Prevented
Cervical screening prevents 70% of cervical cancer deaths and if all eligible women regularly attended screening this would rise to 83%.
Detecting Bacterial Infections in Newborns
Researchers tested an alternative way to diagnose bacterial infections in infants—by analyzing RNA biosignatures from a small blood sample.
Mechanisms of Parkinson’s Pathology
Defects that lead to cells’ failure to decommission faulty mitochondria cause nerve cells to die, triggering the symptoms of Parkinson’s disease.
Case for Liquid Biopsies Builds in Advanced Lung Cancer
Study addresses unmet need for better, non-invasive tests called out in recent "Moonshot" blue ribbon panel report
Genetic Misdiagnoses of Heart Condition
Analysis found several genetic variations previously linked with a heart condition were harmless, leading to condition misdiagnosis.
Opening Door to Oesophageal Cancer Targeted Treatments
Scientists have discovered that oesophageal cancer can be classified into three different subtypes.
Genetic Diversity of Enzymes Alters Metabolic Individuality
ToMMo scientists have shown that genetic polymorphisms, structural location of mutation and effect for phenotype correlate with each other.
IMM Uses Nanowizard® to Evaluate Cardiovascular Disease Risk
JPK Instruments reports on the use of their NanoWizard® AFM system at the Instituto de Medicina Molecular at the University of Lisbon.
$1M NIH Grant to Refine PCR Based Cancer Test
Researchers at Cornell University, Weill Cornell Medicine, the University of California, San Francisco, and the Infectious Diseases Institute in Kampala, Uganda, recieve a four-year, $1 million grant to hone technology for a quick, in-the-field diagnosis of Kaposi's sarcoma — a cancer frequently related to HIV infections.
Zika Reference Strain Sequenced
An international research team has sequenced a strain of Zika for use as a WHO reference strain.
Business News
Xcell Initiates New Collaborations with UCSF Researchers
Studies to assess the ability to predict prognosis and response to therapies by immunoprofiling of patients’ blood, cultured and conditioned with Xcell’s unique Avatar system.
UC Berkeley, Biohub $600M Partnership
UC Berkeley, UC San Francisco and Stanford University collaborate on research funded by a $600 million investment from Mark Zuckerberg and Priscilla Chan.
Rubicon Team Up with Curio Genomics
The partnership is set up to provide ultra-fast bioinformatics software designed for use with the new Rubicon ThruPLEX® Tag-seq kits.
SpeeDx Receives CE-IVD Mark for ResistancePlus™ MG
New molecular assay is only commercial test to detect both M. genitalium and antibiotic resistance for one of the world’s fastest spreading STD.
Next Phase Starts In the World's Largest Breath-Based Clinical Trial
Owlstone Medical commences the next phase of the world’s largest breath-based clinical trial for early cancer detection.
Guardant Health, IPS Genomix Collaborate
Collaboration to make its Guardant360 liquid biopsy test available to oncologists and their patients in the Middle East.
Roche Receives FDA Clearance for Zika Test
Roche has announced that the U.S. Food and Drug Administration (FDA) has issued an Emergency Use Authorization (EUA) for the LightMix® Zika rRT-PCR Test.
Dignity Health, CHI in Precision Medicine Partnership
Dignity Health and Catholic Health Initiatives team up to launch the largest community-based precision medicine program in the U.S.
10x Genomics, SCRUM Collaborate
Collaboration aims to bring the Chromium™ System and associated products to the rapidly expanding Japanese market.
Allergan to Acquire Vitae for $639M
Allergan are to acquire Vitae Pharmaceuticals, adding innovative development programs for dermatologic conditions.

Events
12th World Cancer Conference
26 Sep 2016
12th World Cancer Conference ...
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Unlocking the potential of syn
27 Sep 2016
Unlocking the potential of syn ...
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Medical Devices Sales & Market
29 Sep 2016
Medical Devices Sales & Market ...
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Event - Liquid Biopsies & Minimally-In
29 Sep 2016
Liquid Biopsies & Minimally-In ...
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ePosters
Blood Transcriptomic Diagnosis of Active TB with Five Genes
1Infection & Immunity, University College London, UK 2Department of Microbiology, University College London Hospitals NHS Trust, UK 3Blizard Institute, Queen Mary Univ

This study aimed to identify the minimal set of genes that can accurately diagnose active TB, both pulmonary and extrapulmonary, and evaluate their specificity.
Experimental design considerations for efficient and specific gene knockin using a CRISPR-Cas9 for HDR with synthetic crRNA and tracrRNA
Dharmacon, part of GE Healthcare

Precise genome engineering with CRISPR-Cas9 and single-stranded DNA oligo or double-stranded DNA plasmid donors via homology-directed repair (HDR).
Exosomes promote survival in squamous head and neck cancer cells after ionizing radiation
Helmholtz Zentrum München, Institute of Radiation Biology, Neuherberg, Germany / Department of Chemistry, Technical University of Munich, Munich, Germany

Exosomes are important intercellular communicators in the acute radiation stress-response. These nanometer-sized extracellular vesicles confer protective signals to neighboring cells and therefore promote the tumorigenic and radioresistant phenotype of head and neck cancer cells.
Development of a Homogenous RSV Neutralization Assay on the Mirrorball Fluorescence Cytometer: A Simple, Safe and Robust Approach for High-throughput Screening
TTP Labtech Ltd, Melbourn Science Park, Melbourn, Royston, Hertfordshire, SG86EE, UK.

Here we present the development and implementation of a simple RSV-neutralization assay on TTP Labtech’s mirrorball fluorescence cytometer.
Super-resolution single molecule localization microscopy of the exocytotic machinery underlying insulin secretion.
Heriot-Watt Univeristy

Single molecule imaging of the tSNARE proteins involved in insulin secretion.
Automated Sample Preparation of Whole Blood for Therapeutic Drug Monitoring and Diagnostics by LC-MS using a Commercial Autosampler
1 University of Applied Sciences and Arts Northwestern Switzerland FHNW, Institute for Chemistry and Bioanalytics , Gründenstrasse 40, 4132 Muttenz; 2 CTC Analytics AG; Industriestrasse 20, CH-4222 Zw

In this poster the parameters necessary to automatically prepare whole blood samples for online LC-MS applications in the field of diagnostics and TDM have been investigated. A strategy and the most important parameters are shown for the optimization of a PAL RTC autosampler
for the preparation of whole blood samples.
Deep Phenotyping - Harnessing Data Richness for Unsupervised High-Content Analysis
Institute of high performance Computing, Astar

Recognising the key challenges, we develop an end-to-end computational framework for HCA dubbed “Deep Phenotyping” that perform unsupervised analysis to leverage on the data richness for the discovery of unknown sub-phenotypes with minimal labeling cost.
Clinical Applications of “Liquid biopsy” in the Colorectal Cancer Treatmen
Saitama Medical Center, Jichi Medical University, Saitama. Japan

Liquid biopsy provides a circulating biomarker not only for treatment response but decision making of a sequential strategy.
Finite element modelling for the optimization of temperature control in Lab-on-a-Chip devices
(a) Thomas Johann Seebeck Department of Electronics, Tallinn University of Technology, Tallinn, Estonia; (b) SelfDiagnostics Deutschland GmbH, Leipzig, Germany

The presented finite element model aims to help in the development of Lab-on-a-Chip devices which require temperature control. The model simulates the thermal system in such devices to enable in silico validation of designs and geometry optimization, and aims to be a versatile tool supporting multiple temperature control methods.
Finite element modelling for the optimization of temperature control in Lab-on-a-Chip devices
(a) Thomas Johann Seebeck Department of Electronics, Tallinn University of Technology, Tallinn, Estonia; (b) SelfDiagnostics Deutschland GmbH, Leipzig, Germany

The presented finite element model aims to help in the development of Lab-on-a-Chip devices which require temperature control. The model simulates the thermal system in such devices to enable in silico validation of designs and geometry optimization, and aims to be a versatile tool supporting multiple temperature control methods.

Application Notes
Evaluation of the IntelliQube® for Gene Expression Analysis using a One-Step RT-PCR Workflow
Douglas Scientific

A recent study demonstrates the ability of the IntelliQube® and associated Array Tape®, to process RNA samples using a one-step RT-PCR workflow, opening the door to a variety of RNA screening applications including gene expression or viral detection and quantification.
Rapid Point of use DNAble® Assay for Salmonella enterica using the Douglas Scientific® AmpliFire®
Douglas Scientific

With greater portability than real-time PCR instrumentation, the AmpliFire produces rapid and accurate results in the field or in the lab without cumbersome equipment or reagents. In a recent study, the AmpliFire® accurately detected the presence of Salmonella enterica using both purified genomic DNA and a crude sample preparation method, making it a powerful tool for point of use applications.
Microbial Detection and Quantification Using the IntelliQube® from Douglas Scientific®
Douglas Scientific

Nucleic Acid Testing (NAT) is a powerful tool for the quantification of microorganisms and are used in many fields. In this study commercially available microbial NAT kits were successfully miniaturized from 20 µL to 1.6 µL reaction volumes using the IntelliQube. The IntelliQube delivers efficient and economical high throughput sample processing for microbial qPCR applications.
Evaluation of a New Accurate, Automated and Cost-effective Approach for the Analysis of Pharmacologically Important Copy Number Variation
Douglas Scientific

The IntelliQube® from Douglas Scientific® is designed to address the need for accurate and reliable results for studies such as CNV determination.
Sample preparation with the AC Extraction Plate: extraction of urinary THC metabolites for LC-MSMS quantification
Tecan Group Ltd.

In many countries, routine workplace drug testing involves screening for the free THC-COOH metabolite obtained by hydrolyzing THC-COOH glucuronide. Tecan’s AC Extraction Plate with TICE technology enables a straightforward workflow that is reproducible and cost efficient. Liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) provides an easy and cost-effective means for fast, sensitive and precise analysis of THC and its metabolites.
Automated sample preparation for the determination of testosterone in serum by LC-MSMS
Tecan Group Ltd.

For accurate, reproducible quantification of testosterone, a growing number of laboratories are shifting from immunoassay to liquid chromatography coupled with tandem mass spectrometry. This application note describes the preparation of serum samples for subsequent LC-MS analysis of testosterone, focusing on a streamlined workflow suitable for automation.
Validating the Expression Consistency of a Housekeeping Protein
Bio-Rad Laboratories

Housekeeping proteins (HKP) are typically used as loading controls because it is assumed that the HKP expression level remains consistent across samples. However, there is evidence that HKP expression levels change in many scenarios, including siRNA treatment, cell death, cell differentiation, etc.
A Method for Greater Reliability in Western Blot Loading Controls: Stain-Free Total Protein Quantitation
Bio-Rad Laboratories

Reliable assessment of changes in target protein levels by western blot requires measurement of both the target and loading control proteins in the linear dynamic range. Stain-free technology is a novel method introduced by Bio-Rad to visualize and quantify proteins in gels and blots.
General V3 Western Blotting Protocol
Bio-Rad Laboratories

Western blotting is a very useful and widely adopted lab technique, but the traditional procedure can be long and tedious. Researchers can assess only whether a blot image is captured at the end of the long procedure and the quality of western blot data is sometimes challenged due to poor loading controls.
Determining the Appropriate Sample Load When Using a Stain-Free V3 Western Workflow™
Bio-Rad Laboratories

Traditional western blot workflows require an appropriate sample load to detect both target proteins and loading control proteins. The discrepancy between these quantities often leads to oversaturated protein bands, forcing researchers to sometimes run two duplicate gels or titrate down the antibody concentration in order to get quantitative results.
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