Corporate Banner
Satellite Banner
Molecular & Clinical Diagnostics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Abbott Licenses Prostate Cancer Biomarkers

Published: Wednesday, April 18, 2012
Last Updated: Wednesday, April 18, 2012
Bookmark and Share
The exclusive license from Stanford University for several novel biomarkers could help develop a molecular diagnostic test that differentiates aggressive from nonaggressive prostate cancer.

Recent data point to certain genetic biomarkers that may identify which patients have fast-growing malignancies and should be treated aggressively versus those who can be directed to “active surveillance” or close monitoring. The National Comprehensive Cancer Network prostate cancer treatment guidelines were also recently updated to include recommendations for patients who fall into these categories.

"Developing a clinically validated prostate cancer prognostic assay with actionable data represents the 'holy grail' in improving disease management," said James Brooks, M.D., associate professor and acting chair, Department of Urology, Stanford University Medical Center. "It clearly would fulfill an unmet medical need to help men with prostate cancer know which treatment options will yield the best outcomes for their long-term survival and best quality of life. Certain men found to have slow-growing cancers could safely opt for no treatment and avoid life-altering side effects."

Prostate cancer, the second most common cancer in men, with an estimated U.S prevalence of 2.3 million, is usually diagnosed with a biopsy of prostate tissue. If cancer is found, the patient and physician must decide on treatment options, ranging from no treatment to aggressive management with radiation and chemotherapy or surgical removal of the prostate. Because prostate cancer treatments may have side effects like erectile dysfunction and urinary incontinence, treatment decisions may focus on balancing therapeutic goals with a patient’s age and other factors such as diet, exercise and lifestyle. In most cases, decisions rest on health-adjusted life expectancies.

In certain men, prostate tumors may grow so slowly that no treatment is required. However, there is no test or procedure available at this time that can optimally discriminate benign from aggressive disease. Fearing the worst outcomes, many men opt for aggressive treatment even though it might not be needed.

Abbott will develop a molecular assay based on its proprietary FISH (fluorescence in situ hybridization) technology to detect rearrangements of the ERG and ETV1 genes and measure loss of the PTEN gene. A study published in the British Journal of Cancer evaluated 308 men diagnosed with prostate cancer who were treated conservatively. Those who did not show ERG/ETV1 genetic aberrations with no PTEN gene loss had excellent prognosis, evidenced by an 85 percent survival rate after 11 years. Men who showed PTEN gene loss in the absence of the gene rearrangements had a poor survival rate of 13.7 percent. The study showed the promise of the new biomarkers to identify patients who would benefit most from intensive therapies.
Abbott’s FISH probes to detect the ERG/ETV1 gene and measure PTEN gene loss will be evaluated as part of scientific research starting some time later this year.

"This is a meaningful breakthrough for men who have to make the agonizing decision regarding treatments for prostate cancer," said Stafford O’Kelly, head of Abbott’s molecular diagnostics business. "Without knowing if the cancer is life threatening, men have no way to know if prostate surgery or chemotherapy is the right option. This newest advance in personalized medicine will provide individualized genetic evidence for informed clinical decision making in choosing the right approach to prostate cancer treatment."


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Abbott Completes Acquisition of Topera, Inc.
Company acquire all outstanding equity of Topera for $250 million upfront.
Tuesday, January 06, 2015
Abbott to Acquire Veropharm
The acquisition of the Russian pharmaceutical manufacturer is in keeping with the long term commitment to provide healthcare products to Russian patients.
Monday, June 23, 2014
Abbott Completes Separation of Research-Based Pharmaceuticals Business
Set to deliver industry-leading growth, expanding margins and strong cash flow.
Monday, January 07, 2013
Abbott Expands Agreement with GSK to Include Development of a Companion Diagnostic Test
Companion diagnostic tests identify specific DNA sequences for cancer immunotherapy antigen.
Tuesday, November 29, 2011
FDA Approves First Supplemental Test for Chagas Disease
The U.S. Food and Drug Administration have approved the first test for use as an additional, more specific test on human serum or plasma specimens found to be positive for antibodies to T. cruzi, which causes Chagas disease, a serious and potentially fatal parasitic infection.
Monday, November 21, 2011
Scientific News
Diagnostic Test Developed for Enterovirus D68
researchers at Washington University School of Medicine in St. Louis have developed a diagnostic test to quickly detect enterovirus D68 (EV-D68), a respiratory virus that caused unusually severe illness in children last year.
Tracking Breast Cancer Before it Grows
A team of scientists led by University of Saskatchewan researcher Saroj Kumar is using cutting-edge Canadian Light Source techniques to screen and treat breast cancer at its earliest changes.
The Light of Fireflies for Medical Diagnostics
EPFL scientists have exploited the light of fireflies in a new method that detects biological molecules without the need for complex devices and high costs.
Could a simple saliva test detect Alzheimer's?
Researchers have presented findings suggesting that a simple, non-invasive diagnostic for Alzheimer's could be within reach.
Cheap Diagnostics with a Portable "Paper Machine"
Scientists have developed a cheap, portable system for point of care diagnostics for a range of infectious diseases, genetic conditions and cancer.
New Variant of Streptococcal Bacteria
Scientists have discovered a new variant of streptococcal bacteria that has contributed to a rise in disease cases in the UK over the last 17 years.
New Insights into “Antenna” of Human Cells
Scientists from the University of Leeds have uncovered the most comprehensive list yet of genes implicated in a group of common inherited diseases.
Discordant NIPT Test Results May Reflect Presence of Maternal Cancer
Results published in Journal of the American Medical Association.
Sperm RNA Test May Improve Evaluation of Male Infertility
To help resolve uncertainty—and guide prospective parents to the right fertility treatments—scientists propose the use of a new kind of fertility test. It involves examining sperm RNA by means of next-generation sequencing.
Optical 'Dog's Nose' Developed to Detect Cancer, Other Diseases
Researchers are using optical spectroscopy to develop a quick, non-invasive “breath test” they believe will have the potential to screen for a variety of diseases, including diabetes, infections and cancers.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!