Corporate Banner
Satellite Banner
Molecular & Clinical Diagnostics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Study Validates Use of Vectra DA Test as an Objective Measure of RA Disease Activity

Published: Thursday, July 12, 2012
Last Updated: Wednesday, July 11, 2012
Bookmark and Share
Results published in Arthritis Care & Research support adoption of multi-biomarker blood test in combination with clinical assessment.

Crescendo Bioscience®, Inc. has announced the online publication of results validating the performance of Vectra™ DA to measure rheumatoid arthritis (RA) disease activity in Arthritis Care & Research, an official journal of the American College of Rheumatology (ACR).

Vectra DA is the only multi-biomarker blood test for RA disease activity that simultaneously integrates 12 key proteins consistently associated with RA disease activity into a single, objective and quantitative score to help physicians make more informed treatment decisions.

The study results demonstrate that Vectra DA has a statistically significant association with other validated clinical disease activity measures.

Moreover, changes in the Vectra DA algorithm score tracked over time significantly discriminated between clinical responders and non-responders to RA therapy such as TNF antagonists and methotrexate (MTX).

“Current RA treatment guidelines from the American College of Rheumatology recommend periodic quantitative disease assessment as an important component in any treatment plan for patients with RA,” said Jeffrey R. Curtis, MD, MS, MPH, lead author of the manuscript and director of the University of Alabama at Birmingham’s Arthritis Clinical Intervention Program.

Curtis continued, “This study shows that Vectra DA provides a valid and objective measure of disease activity. The results support the use of Vectra DA as a complement to existing clinical assessments to help clinicians assess disease activity over time and in response to RA treatments so as to impact care as well as potentially improve patient outcomes.”

Vectra DA was designed to be used in conjunction with existing clinical assessment measures, bringing the crucial understanding of individual disease biology into the mix of factors doctors traditionally consider before proposing or changing treatment plans.

The additional insight provided by Vectra DA has the potential to alert physicians to disease activity that is otherwise difficult to detect, given the limitations of clinical assessment methods developed over the last 30 years.

Study Results
The study found that Vectra DA’s multi-biomarker disease activity score had a statistically significant association (p<0.001) with DAS28-CRP, a composite algorithm score for the clinical assessment of RA disease activity that is commonly used in RA clinical trials.

The validity of the test was established in both seropositive patients (positive for either rheumatoid factor and/or anti-cyclic citrullinated peptide antibodies) and seronegative patients (negative for both).

Further, for patients initiating methotrexate or anti-TNF therapy, changes in the Vectra DA algorithm score were shown to be significantly associated with changes in clinically-assessed disease activity (p<0.001) and discriminated between clinical responders and non-responders to therapy. These findings confirm the validity of Vectra DA as an objective measure of RA disease activity to help inform patient management decisions.

“Based on the reported real-world experiences, and the study data reported to date, we believe Vectra DA represents a valuable new tool that has the potential to transform how rheumatologists manage RA patients,” said Oscar Segurado, MD, PhD, Chief Medical Officer at Crescendo Bioscience.

Segurado continued, “Importantly, it is the only quantitative metric available to these doctors that provides an objective value that can assess patients in different practice settings, or the same patients tracked over time, with an unprecedented level of precision and reproducibility. To date, Vectra DA has been ordered by over 400 US rheumatologists to inform the assessment of over 20,000 RA patients.”

Study Design
Serum samples from a total of 426 patients that were independent of prior research, both seropositive (230) and seronegative (196), were selected from three cohorts: the Index for Rheumatoid Arthritis Measurement [INFORM] (US), the Brigham and Women’s Hospital Rheumatoid Arthritis Sequential Study Registry [BRASS] (US), and the Leiden Early Arthritis Clinic cohort (Netherlands).

The study was designed to validate and evaluate the performance of Vectra DA compared to other clinical disease activity measures in both seropositive and seronegative patient groups.

The cross-sectional and longitudinal relationships between the Vectra DA score and clinical disease activity assessments were characterized separately in both seropositive and seronegative patient groups.

The changes associated with the Vectra DA algorithm score and clinical responses 6-12 weeks after initiation of anti-TNF or MTX treatment were evaluated in a separate cohort of 45 patients enrolled in BRASS.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Crescendo Bioscience® Secures $28 Million in Series D Financing
Vectra™ DA used in more than 30,000 patients in 2012 milestone.
Friday, January 04, 2013
Scientific News
Preparing for Potential Zika Outbreaks
Experts at the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) are developing tools to monitor the spread of the Zika virus and are conducting research to gather more solid data to better assess the risks associated with the infection.
What do Banana Peels and Human Skin Have in Common?
Human skin and banana peels have something in common: they produce the same enzyme when attacked. By studying fruit, researchers have come up with an accurate method for diagnosing the stages of this form of skin cancer.
Biomarker for Recurring HPV-Linked Oropharyngeal Cancers
A look-back analysis of HPV infection antibodies in patients treated for oropharyngeal (mouth and throat) cancers linked to HPV infection suggests at least one of the antibodies could be useful in identifying those at risk for a recurrence of the cancer, say scientists at the Johns Hopkins University.
Counting Cancer-busting Oxygen Molecules
Researchers from the Centre for Nanoscale BioPhotonics (CNBP), an Australian Research Centre of Excellence, have shown that nanoparticles used in combination with X-rays, are a viable method for killing cancer cells deep within the living body.
Genomic Signature Shared by Five Types of Cancer
National Institutes of Health researchers have identified a striking signature in tumor DNA that occurs in five different types of cancer.
Crowdfunding the Fight Against Cancer
From budding social causes to groundbreaking businesses to the next big band, crowdfunding has helped connect countless worthy projects with like-minded people willing to support their efforts, even in small ways. But could crowdfunding help fight cancer?
"Gene Fusion" Drives Childhood Brain Cancers
Study co-led by Penn scientists highlights potential targets for future cancer therapies.
Head Injury Patients Develop Brain Clumps Associated with Alzheimer’s Disease
Scientists have revealed that protein clumps associated with Alzheimer's disease are also found in the brains of people who have had a head injury.
New Way to Identify Brain Tumor Aggressiveness
Looking at a brain tumor’s epigenetic signature may help guide therapy.
OncoCyte, The Wistar Institute Enter Global Licensing Agreement
Exclusive rights to commercialize biomarker assay follows years of positive collaboration on lung cancer diagnostic test.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!