The first of these will be the applied markets division and will serve the diagnostics, testing and industrial markets, with current research unit president Frank Wicks to head up this group.
International region boss Eric Green will lead the new research markets business, which focuses on operations in the life science, academic, government and hospital sectors, while Giles Cottier will continue to lead the SAFC division, which is being renamed as the SAFC Commercial Markets division.
Other organisational changes will see Gerrit van den Dool become managing director for Europe instead of North America and Jason Apter taking charge of the Asia-Pacific region.
Further details of the change, which will help Sigma-Aldrich to better address the needs of its global customers and to drive sales growth, will be revealed in early 2013.
Last month, the company published its financial report for the third quarter of 2012, during which its reported revenues rose by two percent year over year to $639 million (400.9 million pounds).