Corporate Banner
Satellite Banner
Molecular & Clinical Diagnostics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

NIH-funded Study Finds More Precise Way to Estimate Kidney Function

Published: Thursday, April 04, 2013
Last Updated: Thursday, April 04, 2013
Bookmark and Share
New equation can be used for broader range of patients.

Measuring creatinine and cystatin C—two markers for chronic kidney disease (CKD)—more precisely estimates kidney function than either marker alone, according to a study funded by the National Institutes of Health. Results appear in the July 5 issue of the New England Journal of Medicine.

“Glomerular filtration rate, or GFR, estimates based on creatinine in the blood are routinely used to measure kidney function and diagnose chronic kidney disease. However, estimating GFR using creatinine alone is imprecise and may lead to over-diagnosis in some patients,” said Dr. Lesley Inker, a nephrologist at Tufts Medical Center in Boston and lead study author.

According to Dr. John Kusek, study co-author and senior scientific advisor, Division of Kidney, Urologic, and Hematologic Diseases at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of NIH, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) study illustrates the importance of research to more accurately estimate kidney function in order to improve the certainty of CKD diagnosis. “The findings in this most recent work represent an important step in that direction,” he said.

Creatinine is a waste product from protein in the diet and the normal breakdown of muscle tissue. Cystatin C is released by cells throughout the body. The kidneys remove both creatinine and cystatin from the blood. As kidney function worsens, the creatinine and cystatin levels in the blood increase.

“The new creatinine-cystatin equation is more accurate over a broader range of kidney function and body size, and less altered by other medical conditions,” said Inker. “Estimating kidney function based on creatinine and cystatin C could be used as a confirmatory test for chronic kidney disease in patients with an estimated GFR near 60—the usual threshold for diagnosing chronic kidney disease—although it will need to be standardized before the equation can be used widely.”

Testing kidney function is often part of routine medical care for adults, according to Inker. More than 80 percent of clinical laboratories currently estimate GFR from serum creatinine. Despite efforts to standardize serum creatinine measurement across all labs, GFR estimates remain relatively imprecise due to variation in creatinine levels that are not related to GFR, such as those affected by differences in muscle mass, malnutrition, and other chronic illnesses. This imprecision can potentially misclassify patients as having CKD when they may not, or conversely, miss the diagnosis in patients who do have CKD. Over-diagnosis can lead to unnecessary treatment such as medication and dietary changes.

The CKD-EPI study estimated kidney function based on creatinine alone and with cystatin C, developed in a diverse group of 5,352 people from 13 studies that measured kidney function.

The creatinine-cystatin C equation performed better than equations using only creatinine or cystatin C. In people whose estimated kidney function was between 45 and 74 based on creatinine, the combined equation improved classification for measured GFR below 60, correctly reclassifying 16.8 percent of those with estimated GFR of 45 to 59 to 60 or greater.

Based on projections from the National Health and Nutrition Examination Survey, using the creatinine-only equation, an estimated 23 million American adults may have CKD, and nearly 400,000 people in the United States and 2 million worldwide depend on dialysis to treat kidney failure.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

NIH Funds Zika Virus Study Involving U.S. Olympic Team
Researchers will monitor potential Zika virus exposure among a subset of athletes traveling to Brazil.
Wednesday, July 06, 2016
Implementation Science Approaches to Reduce Mother-to-Child HIV Transmission
The NIH study will investigate best practices to ease major disease burden in Sub-Saharan Africa.
Friday, July 01, 2016
Some Women With PCOS May Have Adrenal Disorder
Researchers at NIH have found that a subgroup of women with PCOS, a leading cause of infertility, may produce excess adrenal hormones.
Tuesday, June 28, 2016
NIH Sequences Genome of a Fungus
Researchers at the Institute have sequenced genome of human, mouse and rat Pneumocystis that cause life-threatening Pneumonia in immunosuppressed hosts.
Tuesday, April 12, 2016
Children With Cushing Syndrome May Have Higher Suicide Risk
Researchers at NIH have found that depression, anxiety and suicidal thoughts increase after treatment.
Wednesday, March 30, 2016
Couples’ Pre-Pregnancy Caffeine Consumption Linked to Miscarriage Risk
Researchers at NIH have found daily multivitamin before and after conception greatly reduces miscarriage risk.
Friday, March 25, 2016
Researchers Identify Molecule Needed for Sperm Activation
Researchers at NIH have discovered new options for male contraception as well as treatments for infertility resulting from problems with sperm mobility.
Friday, March 18, 2016
A Child’s First Eight Years Critical For Substance Abuse Prevention
Researchers at NIH have released summary of research on early childhood risk and protective factors.
Friday, March 11, 2016
Genomic Signature Shared by Five Types of Cancer
National Institutes of Health researchers have identified a striking signature in tumor DNA that occurs in five different types of cancer.
Monday, February 08, 2016
NIH Unveils FY2016–2020 Strategic Plan
Detailed plan sets course for advancing scientific discoveries and human health.
Thursday, December 17, 2015
$21M Invested in Research Hubs in Developing Countries
The National Institutes of Health and other U.S. and Canadian partners are investing $20.9 million dollars over five years to establish seven regional research and training centers in low- and middle-income countries (LMICs).
Friday, October 09, 2015
Scientists Create World’s Largest Catalog of Human Genomic Variation
An international team of scientists from the 1000 Genomes Project Consortium has created the world’s largest catalog of genomic differences among humans, providing researchers with powerful clues to help them establish why some people are susceptible to various diseases.
Thursday, October 01, 2015
NIH Framework Points The Way Forward For Developing The President’s Precision Medicine Initiative
The NIH Advisory Committee to the Director has presented to NIH Director Francis S. Collins, M.D., Ph.D., a detailed design framework for building a national research participant group, called a cohort, of 1 million or more Americans to expand our knowledge and practice of precision medicine.
Monday, September 21, 2015
Undiagnosed Diseases Network Launches Online Application Portal
UDN Gateway enables patients to apply to national network of clinical sites.
Thursday, September 17, 2015
Using Genetic Sequencing to Manage Cancer in Children
A team of scientists have investigated the feasibility of incorporating clinical sequencing information into the care of young cancer patients.
Tuesday, September 15, 2015
Scientific News
Liquid Biopsies: Miracle Diagnostic or Next New Fad?
Thanks to the development of highly specific gene-amplification and sequencing technologies liquid biopsies access more biomarkers relevant to more cancers than ever before.
Review of the Analysis of Haemoglobin A1c for Diabetes Diagnostics
This paper aims to clarify methods, units, quality requirements, reference and cutoff limits for hemoglobin A1c (HbA1c) and ratio of blood glucose/HbA1c on the basis of the results from Finnish quality control surveys by comparing them to the literature.
Colon Cancer Blocked in Mice
Case Western Reserve University Researchers block common type of colon cancer tumour in mice, laying groundwork for human clinical trial.
Drug - Gene 'One-Two' Punch Against Cancer
Researchers identify gene-drug combinations that, together, target and kill cancer cells while not targeting healthy cells.
Liquid Biopsies Treating Ovarian Cancer
Researchers have discovered a promising monitor and treat recurrence of ovarian cancer. Detecting cancer long before tumours reappear.
72% Rise in Metastatic Prostate Cancer
Over the 2003-2013 period metastatic cancer has increased by an average of 72%, this could be caused by lax screening, more aggressive disease or both.
Lab-Tested Diagnosis Needed When Treating Persistent Diarrhea
New PCR multiplex method makes lab testing more effective.
Biomarker for Multiple Sclerosis Detection Discovered
Winthrop-University Hospital researchers discover biomarker for multiple sclerosis detection.
Scientists Link Bipolar Disorder to Unexpected Brain Region
Researchers from The Scripps Research Institute have found that gene within the brain’s striatum could be linked to biopolar disorder.
Liquid Biopsies: DNA Size Matters
Study finds circulating tumour DNA can be distinguished from healthy DNA through fragment size identification.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!