Satellite Banner
Molecular & Clinical Diagnostics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New Imaging Technology Could Reveal Cellular Secrets

Published: Friday, April 26, 2013
Last Updated: Friday, April 26, 2013
Bookmark and Share
Researchers have married two biological imaging technologies, creating a new way to learn how good cells go bad.

"Let's say you have a large population of cells," said Corey Neu, an assistant professor in Purdue University's Weldon School of Biomedical Engineering. "Just one of them might metastasize or proliferate, forming a cancerous tumor. We need to understand what it is that gives rise to that one bad cell."

Such an advance makes it possible to simultaneously study the mechanical and biochemical behavior of cells, which could provide new insights into disease processes, said biomedical engineering postdoctoral fellow Charilaos "Harris" Mousoulis.

Being able to study a cell's internal workings in fine detail would likely yield insights into the physical and biochemical responses to its environment. The technology, which combines an atomic force microscope and nuclear magnetic resonance system, could help researchers study individual cancer cells, for example, to uncover mechanisms leading up to cancer metastasis for research and diagnostics.

The prototype's capabilities were demonstrated by taking nuclear magnetic resonance spectra of hydrogen atoms in water. Findings represent a proof of concept of the technology and are detailed in a research paper that appeared online April 11 in the journal Applied Physics Letters. The paper was co-authored by Mousoulis; research scientist Teimour Maleki; Babak Ziaie, a professor of electrical and computer engineering; and Neu.

"You could detect many different types of chemical elements, but in this case hydrogen is nice to detect because it's abundant," Neu said. "You could detect carbon, nitrogen and other elements to get more detailed information about specific biochemistry inside a cell."

An atomic force microscope (AFM) uses a tiny vibrating probe called a cantilever to yield information about materials and surfaces on the scale of nanometers, or billionths of a meter. Because the instrument enables scientists to "see" objects far smaller than possible using light microscopes, it could be ideal for studying molecules, cell membranes and other biological structures.

However, the AFM does not provide information about the biological and chemical properties of cells. So the researchers fabricated a metal microcoil on the AFM cantilever. An electrical current is passed though the coil, causing it to exchange electromagnetic radiation with protons in molecules within the cell and inducing another current in the coil, which is detected.

The Purdue researchers perform "mechanobiology" studies to learn how forces exerted on cells influence their behavior. In work focusing on osteoarthritis, their research includes the study of cartilage cells from the knee to learn how they interact with the complex matrix of structures and biochemistry between cells.

Future research might include studying cells in "microfluidic chambers" to test how they respond to specific drugs and environmental changes.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 4,000+ scientific posters on ePosters
  • More than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Electronic Sensor Tells Dead Bacteria From Live
The sensor, which measures 'osmoregulation', is a potential future tool for medicine and food safety.
Wednesday, June 15, 2016
A Future Tool for Medicine, Food Safety
A new type of electronic sensor that might be used to quickly detect and classify bacteria for medical diagnostics and food safety has passed a key hurdle by distinguishing between dead and living bacteria cells.
Wednesday, June 15, 2016
Zika Virus Structure Revealed
Team at Purdue becomes the first to determine the structure of the Zika virus, which reveals insights critical to the development of effective antiviral treatments and vaccines.
Monday, April 04, 2016
'Lipidomics' Could Bring Fast Cancer Diagnosis
Researchers have developed a new analytical tool for medical applications and biological research that might be used to diagnose cancer more rapidly than conventional methods.
Wednesday, February 24, 2016
Microsecond Raman Imaging Might Probe Cells, Organs for Disease
An advanced medical diagnostic tool for the early detection of cancer and other diseases.
Thursday, April 02, 2015
Keck Foundation to Fund Purdue Research into Spectroscopic Imaging
Ji-Xin Cheng leads a Purdue team awarded a $1 million W.M. Keck Foundation grant to develop a new type of imaging technology for cell and tissue analysis that could bring advanced medical diagnostics.
Tuesday, February 10, 2015
Cell-Detection System Promising for Medical Research, Diagnostics
Researchers are developing a system that uses tiny magnetic beads to quickly detect rare types of cancer cells circulating in a patient's blood.
Thursday, October 03, 2013
Purdue to Accelerate Drug Discovery, Development
Purdue Center for Drug Discovery adds to Purdue's strengths and the capacity to translate basic research into life-changing treatments.
Monday, September 16, 2013
Indiana Biosciences Research Institute Unveiled
Purdue University part of first industry-led collaborative life sciences research institute in the United States.
Monday, June 10, 2013
MolecularHUB Gives Scientific Information on Fast-moving Diseases
A scientific gateway website that will provide molecular and genetic information on infectious and emerging diseases has been released by Purdue University.
Thursday, October 25, 2012
Sensor Detects Glucose in Saliva and Tears for Diabetes Testing
Researchers have created a new type of biosensor that can detect minute concentrations of glucose in saliva, tears and urine and might be manufactured at low cost because it does not require many processing steps to produce.
Thursday, September 13, 2012
Scientific News
Accelerating the Detection of Foodborne Bacterial Outbreaks
The speed of diagnosis of foodborne bacterial outbreaks could be improved by a new technique developed by researchers at the Georgia Institute of Technology.
Cancer Gene Predicts Treatment Response in Leukaemia
Study indicates the patients suffering from a lethal for of acute myeloid leukemia may live longer when receiving milder chemotherapy drugs.
New Diagnostic Tool for Familial Mediterranean Fever
A new tool developed by researchers at VIB and Ghent University could improve the process of diagnosing Familial Mediterranean Fever.
'Lab on the Skin' for Sweat Analysis
Northwestern University researchers develop a low-cost wearable electronic device that collects and analyzes sweat for health monitoring.
Molecular Signature for Aggressive Brain Tumor Uncovered
Researchers have identified genetic mutations in a highly agressive brain cancer that distinguishes the agressive, from the benign forms of the cancer.
Malaria Parasite Evades Rapid Test Detection in Children
A study at the University of North Carolina found that gene deletion poses a threat to Malaria eradication efforts.
Novel Urine Test to Predict High-Risk Cervical Cancer
Preliminary studies affirm accuracy and potential cost savings to screen for virus-caused malignancy.
GFC Diagnostics Wins Longitude Prize Discovery Award
The global award was won for the development of a cheap, quick and simple MRSA Test.
Understanding Circulating Tumour Cells
Research team develops new tool to track traveling cancer cells in the bloodstream.
Blood Glucose Monitoring Device for Diabetes
Novel breathalyzer offers alternative to finger stick testing for people with type 1 and 2 diabetes.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
4,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!