Corporate Banner
Satellite Banner
Molecular & Clinical Diagnostics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Research Shows Promise of New Device to Detect Disease with Drop of Blood

Published: Wednesday, June 26, 2013
Last Updated: Wednesday, June 26, 2013
Bookmark and Share
An NJIT professor is overseeing the manufacture of a prototype lab-on-a-chip that would someday enable a physician to detect disease or virus from just one drop of liquid.

“Scalable nano-bioprobes with sub-cellular resolution for cell detection,” Biosensors and Bioelectronics, (Elsevier, Vol. 45), which will publish on July 15, 2013 but is available now online, describes how NJIT research professors Reginald Farrow and Alokik Kanwal, his former postdoctoral fellow, and their team have created a carbon nanotube-based device to noninvasively and quickly detect mobile single cells with the potential to maintain a high degree of spatial resolution.

“Using sensors, we created a device that will allow medical personnel to put a tiny drop of liquid on the active area of the device and measure the cells’ electrical properties,” said Farrow, the recipient of NJIT’s highest research honor, the NJIT Board of Overseers Excellence in Research Prize and Medal.  “Although we are not the only people by any means doing this kind of work, what we think is unique is how we measure the electrical properties or patterns of cells and how those properties differ between cell types.”

In the article, the NJIT researchers evaluated three different types of cells using three different electrical probes.  “It was an exploratory study and we don’t want to say that we have a signature,” Farrow added.  “What we do say here is that these cells differ based on electrical properties.  Establishing a signature, however, will take time, although we know that the distribution of electrical charges in a healthy cell changes markedly when it becomes sick.”

This research was originally funded by the military as a means to identify biological warfare agents.  However, Farrow believes that usage can go much further and potentially detect viruses, bacteria, even cancer.  The research may also someday even assess the health of good cells, such as brain neurons.  Since 2010, three U.S. patents, “Method of forming nanotube vertical field effect transistor,” #7,736,979 (2010); “Nanotube device and method of fabrication” #7,964,143 (2011); “Nanotube device and method of fabrication” #8,257,566 (2012) were awarded for this device.  In addition, more patents have been filed.

The device (shown in photo) utilizes standard complementary metal oxide semiconductor (CMOS) technologies for fabrication, allowing it to be easily scalable (down to a few nanometers).  Nanotubes are deposited using electrophoresis after fabrication in order to maintain CMOS compatibility.

The devices are spaced by six microns which is the same size or smaller than a single cell.  To demonstrate its capability to detect cells, the researchers performed impedance spectroscopy on mobile human embryonic kidney (HEK) cells, neurons from mice, and yeast cells.  Measurements were performed with and without cells and with and without nanotubes. Nanotubes were found to be crucial to successfully detect the presence of cells.

Carbon nanotubes are very strong, electrically conductive structures a single nanometer in diameter.  That’s one-billionth of a meter, or approximately ten hydrogen atoms in a row. Farrow’s breakthrough is a controlled method for firmly bonding one of these submicroscopic, crystalline electrical wires to a specific location on a substrate.  His method also introduces the option of simultaneously bonding an array of millions of nanotubes and efficiently manufacturing many devices at the same time.

Being able to position single carbon nanotubes that have specific properties opens the door to further significant advances.  Other possibilities include an artificial pancreas, three-dimensional electronic circuits and nanoscale fuel cells with unparalleled energy density.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More than 4,900+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
AACC 2016 Sees Clinical Chemistry Labs Drive Precision Medicine Offerings
Biomarker assays to enable precision medicine and risk assessment, mass spec-based tests designed for use in clinical labs large and small, and liquid biopsy technology captured the spotlight at the AACC annual meeting.
Diagnosing Bacterial Infections in Blood Samples
Researchers have diagnosed a bacterial infection from a blood sample in infants.
Neurodvelopmental Disorder Cause Linked to SON Gene
A genetic link has been discovered for a previously unxplained neurodevelopmental disorder.
World's Most In-Depth Study to Detect Alzheimer's Disease
A multisite team will see the most thorough and vigorous testing for Alzheimer's ever performed on volunteers.
Personalised Medicine: Dose by Design
Personalised medicine holds the promise of a new approach to healthcare, tailored exactly to our individual needs, as Congenica's Nick Lench discussed on a recent BBC Radio 4 programme.
Misdiagnosis in HCM Tests
Genetic tests for potentially fatal heart anomaly can misdiagnose condition in black Americans.
Computers Better Predict Lung Cancer Type, Severity
Study shows automating the analysis of cancer tissue samples increases the accuracy of tumor classification and patient prognoses.
Examining New Hypotheses for Undiagnosed Patients
UnDx Consortium gathers in San Diego to create new paths to identifying currently undiagnosed illnesses.
Automating Genetic Analysis
Researchers are looking to have computers help perform genetic analysis when scientists study a patient's genome to diagnose a disease.
Understanding Tumor Evolution
Study provides insight into tumor evolution; may point to improved diagnosis and treatment.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,900+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!