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VolitionRx Finds Simple Blood Test Detects 85% of Colorectal Cancers and Over 50% of Polyps

Published: Monday, December 02, 2013
Last Updated: Monday, December 02, 2013
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The new findings come from its ongoing prospective study with CHU Dinant Godinne | UCL Namur Hospital in Belgium.

VolitionRx Limited releases new data showing that when combining two of its proprietary NuQ® assays into one test, they can achieve  85% detection rates at  85% specificity for colorectal cancer. The data also shows that Volition’s two-assay test can detect more than 50% of precancerous polyps. 

Earlier this month, VolitionRx presented preliminary data from a 90 patient independent trial, later confirmed in a further 113 patients, at University Hospital Bonn in Germany. This data demonstrated 75% detection rates at 70% specificity when using a single NuQ assay. The Belgian team confirmed these results using the same single assay, but when combining it with another nucleosome biomarker they achieved even better results. They have now analysed 39 patients’ samples from the ongoing prospective trial which includes both healthy patients and patients with benign colon disorders. 

“This increased detection rate confirms our original hypothesis that combining nucleosomes increases the accuracy of the test,” comments Dr Jake Micallef, Chief Scientific Officer of VolitionRx.  “We hope to further increase the sensitivity and specificity by adding more biomarkers and developing a larger panel of nucleosome tests.”

Current diagnostic screening practices for colorectal cancer vary globally, from inviting at-risk groups to submit faecal occult blood tests to offering regular investigative colonoscopies. Unfortunately studies show compliance rates of between 30-60%  for faecal blood tests, likely due to the uncomfortable nature of the test.  Meanwhile, a US study found that less than 40%  of people who were offered a colonoscopy screening actually attended. 

Encouragingly, uptake of diagnostic blood tests is much higher, with one study showing annual prostate cancer screening compliance at higher than 80% . When VolitionRx’s NuQ blood test is made publically available, higher uptake could be very likely. Additionally, if the research team continue to identify at least 50% of polyps this could also have vast implications for diagnosing earlier-stage colorectal cancers.

Professor Hans Jørgen Nielsen, Professor of Surgical Oncology at Hvidovre Hospital in Denmark, recently expanded his prospective study evaluating VolitionRx’s NuQ panel as a colorectal cancer screening tool. He comments, “The 85% detection rate seen in this latest research is on par with rates achieved by faecal occult blood tests. If we could improve screening compliance by offering the public a simple, less intrusive test that is just as accurate, we could detect even more colorectal cancer cases in the earlier stages and survival rates could drastically improve.” 

This test has the potential to become a global first choice diagnostic tool, replacing faecal occult blood tests and preventing unnecessary colonoscopies around the world. The company hopes to apply for CE mark early next year and FDA approval roughly a year later.

Colorectal cancer is the third most prevalent cancer and fourth most common cause of cancer death worldwide.


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