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Clinical Applications of “Liquid biopsy” in the Colorectal Cancer Treatmen
Koichi Suzuki, Yuji Takayama, Kosuke Ichida, Taro Fukui, Nao Kakizawa, Fumiaki Watanabe, Fumi Hasegawa, Rina Kikugawa, Shingo Tsujinaka, Yasuyuki Miyakura, Toshiki Rikiyama

Liquid biopsy provides a circulating biomarker not only for treatment response but decision making of a sequential strategy.

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Finite element modelling for the optimization of temperature control in Lab-on-a-Chip devices
T. Pardy(a,b); T. Rang(a); I. Tulp(b)

The presented finite element model aims to help in the development of Lab-on-a-Chip devices which require temperature control. The model simulates the thermal system in such devices to enable in silico validation of designs and geometry optimization, and aims to be a versatile tool supporting multiple temperature control methods.

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Development of an Integrated Paper-based Molecular Diagnostic Platform
Manoharanehru Branavan, Wamadeva Balachandran

The poster describes a modular development of a paper-based molecular diagnostic device and the latest results obtained from a proof-of-concept device.

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Differences in the Neurophysiology of Infants with Down Syndrome May Predict Protective/Risk Markers for Subsequent Alzheimer’s Disease
Esha Massand1,2, Hana D’Souza1,2, George Ball1,2, Maria Eriksson1, Charlotte Dennison1, Joanna Ball1 & Annette Karmiloff-Smith1,2

Our work set out to understand early individual differences in memory abilities of infants with DS that may be predictive of subsequent cognitive phenotypes of AD.

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The Challenges of Genetic Testing in Patients Diagnosed with Breast Cancer; The Kent Oncology Centre Experience
Christos Mikropoulos1,2, Aaron Davies 1, Charlotte Abson1, Gill Sadler1, Gemma McCormick1, Questa Karlsson2, Julia Hall2

In this study we explore retrospective data to determine strategies for optimizing the genetic referral pathways for breast cancer.

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Translational Research of oral Neural Crest-Derived Stem Cells (oNCSCs) in Regenerative Dentistry
Grimm W.-D1,2,4, S. N. Alekseenko9, D. V. Bobryshev1, W. Duncan11, B. Giesenhagen3, E. Gubareva9, Sema S. Hakki6, O.V. Pershina7, I. Schau4, S. V. Sirak1, E.G. Skurikhin7, A. A. Sletov1, F. Witte10, G. Varga8, O. V. Vladimirova1, M.A. Vukovic2, D. Widera5

In this review poster, we summarize current knowledge on the oral neural crest-derived stem cell populations (oNCSCs) and discuss their potential in regenerative periodontology as a part of regenerative dentistry.

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Development of a nucleic acid-based amplification test as point-of-care rapid test detecting sexually-transmitted diseases for home-care
Vicky Tröger, Anja Scherber, Dirk Kuhlmeier, Indrek Tulp, Marko Lehes, Steffen Howitz, Toni Bohatzsch, Tamas Pardy

The main problem of early diagnosis of STI is the lack of suitable systems. Therefore a quick home test is needed. In this poster, a microfluidic cartridge combining an isothermal amplification with detection on a lateral flow strip is presented.

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A Microwave/Microfluidics Integrated Label-Free Detection and Content Sensing System for Point-of-Care Applications
Gurkan Yesiloz, Muhammed S. Boybay, Carolyn L. Ren

This poster presents a droplet-based microfluidic device integrated with a microwave wave sensor, which is also a heater, for simultaneous sensing and heating of individual nanoliter-sized droplets.

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LOHA Comprehensive Assay for Single Nucleotide Polymorphism, Copy Number Variants and Loss of Heterozygosity Using SureSelect Target Enrichment
Kyeong Soo Jeong, Arjun Vadapalli, Ashutosh Ashutosh, Paula Costa, Brian Peter, Stephanie Fulmer-Smentek, Magnus Isaksson, Jayati Ghosh, Douglas Roberts, Holly Hogrefe

Here we describe a comprehensive assay that enables researchers to identify SNP, INDEL, CNV, and LOH using SureSelect target enrichment. This design can be employed as a standalone entity or in concert with other bait designs for SNP and INDEL detection. We also describe methods for data analysis and visualization.

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Alterations in serum thrombotic biomarker in patients with acute myocardial infarction
Abdullah S. Alhomida

A combination of these biomarkers could serve as a useful biomarker tool to assess the prognosis of AMI. (This study was supported by National Plan for Science and Technology Program by King Saud University Project Number 08-BIO571-02).

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Scientific News
Releasing Cancer Cells for Better Analysis
A new device developed at the University of Michigan could provide a non-invasive way to monitor the progress of an advanced cancer treatment.
Releasing Cancer Cells for Better Analysis
A new device developed at the University of Michigan could provide a non-invasive way to monitor the progress of an advanced cancer treatment.
Magnetic Nanoparticles May Reveal Early Traces Of Cancer
Rice University students’ computer program aids MD Anderson diagnostic initiative .
New Blood Test for The Earlier Diagnosis of Breast Cancer Spread
Researchers at University of Westminster have confirmed that a new blood test can detect if breast cancer has spread to other parts of the body.
Genetic Approach May Lead to New Treatments for Digestive Diseases
Researchers at UMass Medical School have identified a new molecular pathway critical for maintaining the smooth muscle tone that allows the passage of materials through the digestive system.
Biomarkers for Profiling Prostate Cancer Patients
Exiqon A/S has announced the publication of validation of prognostic microRNA biomarkers for the aggressiveness of prostate cancer in independent cohorts.
World-First Blood Test For Parkinson's
La Trobe University researchers have developed a world-first diagnostic blood test which could change the lives of people with Parkinson's disease.
Parsortix Demonstrates Benefits Over Marker-Based Systems
Research published online in the International Journal of Cancer, shows the ParsortixTM System efficiently captures and harvests intact, viable circulating tumour cells (CTCs), including EpCAM-negative CTCs, to allow for broader downstream CTC analysis.
Hepatitis C Virus Testing Guidelines Miss Too Many Cases
Urban emergency departments a good place to enact universal screening for adults.
NIH Sequences Genome of a Fungus
Researchers at the Institute have sequenced genome of human, mouse and rat Pneumocystis that cause life-threatening Pneumonia in immunosuppressed hosts.
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