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SuNS microarray as novel biosensor for clinical diagnostics.
Pisanelli B., Dattilo D., Chetta M., Carducci F., De Ceglia G.

We here present an innovative microarray platform which aims to produce an higher standard of clinical microarray technology. The fabrication approach, involving a novel printing technology (Supramolecular Nano-Stamping) to reduce the production costs of the chips, together with a peculiar probe design, aiming to improve the assay sensitivity and workflow, intend to make the SuNS microarrays well poised to become an important element in the clinical diagnostics market.

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Bi-functional Magnetic Microcarriers for Point-of-Care Diagnostics
J.J. Palfreyman, D.M. Love, A.J. Philpott, K. Vyas, T. Mitrelias, C.H.W. Barnes

A novel type of microcarrier is presented, where a re-writable magnetic barcode is used to carry information. This technology has several advantages over the optical-based alternatives, whilst benefiting from the high-throughput of a microfluidic tool. Here, we present two different surface chemistries used to attach a probe and a control strand of DNA to an individual microcarrier. This is demonstrated with red and green fluorophores, clearly seen on either side.

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Chemically Modified Primers for Improved Multiplex PCR
Elena Hidalgo Ashrafi, Tony Le, Alexandre Lebedev, Richard Hogrefe, Victor Timoshchuk, Sabrina Shore, Inna Koukhareva and Natasha Paul

Multiplex PCR is an advantageous technique used in PCR applications to amplify multiple targets in a single reaction. As useful as it is, this technique presents a new set of challenges that further complicates PCR setup. For example, reactions are more prone to off-target amplifications such as mis-priming and primer dimer due to the increased number of primer pairs.

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Proteomic non-small cell lung carcinoma biomarker screening in bronchoalveolar lavage fluid
Tonio Oumeraci 1, Bernd Schmidt 3, Thomas Wolf 1,4, Marc Zapatka 4, Andreas Pich 2, Benedikt Brors 4, Roland Eils 4,5, Brigitte Schlegelberger 1, Nils von Neuhoff 1

Using a standardized method to acquire MALDI-TOF proteome profile spectra of bronchoalveolar lavage fluid (BALF), we have shown the upregulation of histatin 3 and calgranulin C in a small pilot cohort of NSCLC patients. This pilot study serves to demonstrate that it is feasible to screen a larger NSCLC patient cohort for BALF proteome level biomarkers in a clinical setting.

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Chemically Modified Primers for Improved Multiplexed PCR
Elena Hidalgo Ashrafi, Tony Le, Alexandre Lebedev, Richard Hogrefe, Victor Timoshchuk, Sabrina Shore, Inna Koukhareva and Natasha Paul

Multiplex PCR is an advantageous technique used in PCR applications to amplify multiple targets in a single reaction. As useful as it is, this technique presents a new set of challenges that further complicates PCR setup. For example, reactions are more prone to off-target amplifications such as mis-priming and primer dimer due to the increased number of primer pairs. Furthermore, preferential amplification of certain targets leads to an unequal distribution of amplicon products, making quantifi

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Hot Start dNTPs - A Novel Tool for Controlled Nucleotide Incorporation in PCR
Tony Le, Elena Hidalgo Ashrafi, Sabrina Shore, Victor Timoshchuk, Natasha Paul, Richard Hogrefe, Inna Koukhareva, Alexandre Lebedev

PCR is a widely used scientific tool employed by a variety of applications. Various Hot Start technologies have already been developed using modified PCR components to increase specificity of a reaction. Recently developed CleanAmpTM dNTPs are modified nucleoside triphosphates with a thermolabile 3’-tetrahydrofuranyl protecting group that is released at higher temperatures. These modified dNTPs prevent low temperature primer extension, which can often be a significant problem in PCR. At higher t

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Evaluation of microfluidic digital PCR for the detection of cancer biomarkers
Rebecca Sanders, Claire Bushell, Carole Foy, Daniel J. Scott

dPCR is achieved by sample partitioning prior to PCR amplification such that each reaction chamber contains one copy or less of target DNA. This dilution becomes the limiting factor and an accurate target molecule count is achievable. This study evaluates dPCR’s quantitative capabilities and investigates parameters influencing copy number quantification, using the Fluidigm Biomark instrument. Biomark technology combines dPCR theory with a microfluidics platform.

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Software for Genomic/Epigenomic Research
A.S.Tanas, V.V.Shkarupo, E.B.Kuznetsova, D.V.Zaletayev, V.V. Strelnikov

We present two computer programs: 1) AIMS in silico - a suggestion tool for Amplification of Intermethylated Sites experimental design and results analysis; and 2) PeakPick – a tool to view & analyse capillary electrophoregrams Our computer software is intended to standardize AIMS applications and to turn it into one of the principal approaches towards cancer methylomes studies as well as towards diagnostics in oncology, including early screening.

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HIV POC testing by ssDNA coupled with NALF
Natasha Gous, Lesley E. Scott, Alexio Capovilla, Natela Rekhviasvili, Wendy Stevens

A isothermal amplification termed Reverse Transcription Loop Dependant Amplification (RT-LDA) was developed with an affordable nucleic acid lateral flow detection (NALF) system, as one component of a potential POC HIV-1 RNA assay for subtypeC. RT-LDA makes use of a primer design that efficiently converts viral RNA into ssDNA amplicons, in 1 hour at 53ºC. Due to the single stranded nature of the product, the amplicon could be detected using NALF.

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Scientific News
Alzheimer's Disease Linked To Heart's Effect On The Brain
Theory suggests that Alzheimer’s Disease has its origin in the heart and vascular system.
On Time, On Target
A novel tool could help personalize cancer treatments.
Single-Cell, 42-plexed Protein Analysis Achieved with a New Microchip Technology
A novel microdevice capable of detecting 42 unique immune effector proteins has been developed.
Ground-Breaking Lung Cancer Breath Test In Clinical Trial
University of Leicester and Leicester’s Hospitals to evaluate revolutionary device which detects lung cancer in early stages.
Saliva Test to Diagnose Autism
A spit test may one day be able to diagnose autism according to researchers at Clarkson University and the State University of New York at Plattsburgh.
Paper Test for Ebola
Prototype is designed to detect diseases and deliver real-time epidemiological data.
New €25 Blood Test A Breakthrough In The Diagnosis Of Bowel Cancer
New blood test will spot bowel cancer at earliest stage, removing the need for ‘unpleasant’ faecal screens.
New Biomarkers To Spot Pancreatic Cancer Early
A combination of two biomarkers can identify pre-clinical pancreatic cancer.
NIH Launches Tool to Advance Down Syndrome Research
Web portal will help approved professionals to plan clinical studies.
New Blood Test For Aggressive Bone Cancer
Researchers at the University of East Anglia are developing a simple blood test to diagnose bone cancer thanks to funding from the Big C.
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