Corporate Banner
Satellite Banner
Technology Networks Header
Friday, November 28, 2014
Technology Networks
 
Register | Sign in
Home Page > Videos > Results From Serum-Tumorautoantibody Profiling of Breast, Colon, Lung and Prostate Cancers Using a 16k Protein Array for Improving Minimal Invasive Diagnostics
  Videos

Return

Results From Serum-Tumorautoantibody Profiling of Breast, Colon, Lung and Prostate Cancers Using a 16k Protein Array for Improving Minimal Invasive Diagnostics
Austrian Institute of Technology GmbH

Andreas Weinhäusel, Senior Scientist, Austrian Institute of Technology GmbH

Abstract
In Europe there were an estimated 3.2 million new cases of cancer in 2008. The most commonly reported cases in Europe were colorectal cancers ( 13.6%), breast cancer (13.1%), lung cancer (12.2%) and prostate cancer (11.9%). These 4 big cancer entities make up more than 50% of all cancers. It is well accepted that early detection of cancer does improve patient survival, thus there is a pressing need to improve early cancer detection.  This can be best fulfilled by an easy and simple test suitable for minimal invasive testing. Tumour-associated antigens (TAA) can be detected prior to clinical diagnosis and thus would be ideal biomarkers for early detection of cancer using only a few microliters of a patient's serum.We have developed an 16k protein-microarray using the UNIPEX human cDNA expression library. During methods optimization we studies the influence of different serum and plasma sampling procedures and finally came up with an optimized protocol using purified IgG from samples for TAA profiling. This protocol enabled definition of TAA classifier panels with very promising classification success of patients versus controls for the big 4 cancer entities. Currently we set up targeted microarrays for validation of our screening results. In addition in silico design of antigenic peptides from sero-reactive clone-sequences has also been conducted and preliminary data enabled an improved classification compared to corresponding proteins. Thus multiplexed protein and peptide based serum-analyses could further improve cancer diagnostics

Request more information
Company product page



For access to this article, enter your email address to instantly recieve a Password Reset link.

Please enter your email address below:

Existing users please Sign In here. Don't have an account? Register Here for free access.

Don't have an account? | Register Here

Scientific News
Monitoring Effectiveness Of Hay Fever Immunotherapy
A new test for measuring histamine release from certain white blood cells could help doctors monitor the effectiveness of immunotherapy for hay fever.
Developing a Noninvasive Test for Endometriosis
UCSF researchers identify patterns of genetic activity that could help in early detection of disorder.
Test Detects Early Brain Damage in Football Players
New Contrast-Enhanced MRI Developed by BGU Visualizes Brain Injury in the Blood-Brain Barrier Offering Significant Diagnostic Capabilities.
New Test Developed at Dana-Farber/Brigham and Women's Cancer Center
Rapid Heme Panel - A high-tech genetic test that speeds treatment decisions for blood cancer patients.
Urgent Need for Fast Dx to Help Tackle Antibiotic Resistance
£10 million Longitude Prize for an accurate, rapid, cost-effective and easy-to-use point-of-need diagnostic test for bacterial infections.
Test Developed To Rapidly Diagnose Bloodstream Infection
New technology can detect bacterial invaders with unprecedented speed and sensitivity.
Classification of Gene Mutations in Neuroblastoma
Penn Medicine and CHOP experts define riskier mutations in neuroblastoma, setting stage for clinical trial.
New Genetic Cause of Epilepsy Identified
San Diego girl improves after discovery of DNA mutation tied to potassium regulation.
Cancer Cell Fingerprints in the Blood May Speed up Childhood Cancer Diagnosis
Researchers found unique molecular fingerprints for 11 types of children’s tumours, to develop blood tests to diagnose these cancers.
Blood Test Developed to Diagnose Early Onset Alzheimer’s Disease
New blood-test could predict a person’s risk of developing AD much earlier than is currently possible.
Scroll Up
Scroll Down
Skyscraper Banner
SELECTBIO Market Reports
Follow TechNetcom1 on Twitter
Technology Networks Ltd. on LinkedIn
Go to LabTube.tv