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Fast HPLC Separation of 19 Targeted Phthalates in Drinking Water

Published: Wednesday, June 12, 2013
Last Updated: Wednesday, June 12, 2013
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Determination of phthalates by UHPLC with UV detection in less than 25 minutes.

Thermo Fisher Scientific has developed an efficient high-performance liquid chromatography (HPLC) method using ultraviolet detection for the simultaneous determination in drinking water of all 19 phthalate compounds listed in key environmental regulatory documents.

Application Note 1045: Determination of Phthalates in Drinking Water by UHPLC with UV Detection demonstrates that the phthalates listed in European Union Directive 2005/84/EC, U.S. Environmental Protection Agency Methods 606 and 8061A, the Chinese HJ/T 72-2001, and the Standardization Administration of China GB/T 20388-2006 and GB/T 21911-2008 are well separated on a reversed-phase HPLC column in less than 25 minutes.

Phthalates are a class of chemical compounds widely used as plasticizers for polyvinyl chloride resins, adhesives, and cellulose film coating.

Phthalates are potentially hazardous to human health-especially to children’s health-due to their classification as endocrine disruptors.

This has resulted in regulations regarding the types and levels of phthalates allowable in plastic toys, water containers, textiles, and foods.


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