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Trace Analysis of Isothiazolinones in Water Samples by Large-Volume Direct Injection Liquid Chromatography Tandem Mass Spectrometry


Isothiazolinones are used as preservatives, biocides and desinfectants in variety of industrial and domestic applications. The purpose of this study was to develop and optimize an LC–MS/MS method that would enable the determination without any derivatization or preconcentration step of isothiazolinones used in membrane technology for water purification and in household products, at levels relevant for the water cycle.

Date Posted: 07/12/2010

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