Waters Introduces the SYNAPT G2-Si to its Mass Spectrometer Product Line

Waters Corporation has unveiled the new Waters® SYNAPT® G2-Si Mass Spectrometer at the 61st conference of the American Society of Mass Spectrometry (ASMS).

The company is also previewing its UNIFI® CCS Research Edition and the new TransOmics Version 2.0 informatics products for the new SYNAPT G2-Si mass spectrometer and demonstrating their benefits for a variety of small molecule applications and cutting-edge Omics-focused research.

The SYNAPT G2-Si System integrates a third dimension of resolution and separation power into a new suite of untargeted and targeted LC/MS/MS workflows.

This powerful new tool gives researchers a means with which to gain a deeper understanding of molecular biology and disease mechanisms, to develop the next generation of healthcare treatments or chemical materials, or to screen food products or environmental samples for contaminants.

The SYNAPT G2-Si mass spectrometer now combines the unique power of Travelling Wave (T-Wave) Ion Mobility Separations with new data acquisition and informatics technologies, and collision cross section (CCS) measurements to bring to the toughest analytical applications, unparalleled information and confidence at a level not possible by mass and chromatographic separation alone.

The SYNAPT G2-Si mass spectrometer is the first MS system to elevate CCS alongside retention time and mass to charge ratio (m/z) as a robust, reliable identification parameter in library-based screening.

“CCS measurements have the potential to transform the way people screen for known compounds, because unlike parameters like retention time, CCS values are unaffected by different matrices and chromatographic methods, and give you a much higher level of confidence that you found what you’re looking for,” said Dr. Severine Goscinny, Belgium Scientific Institute for Public Health, Brussels, Belgium.

Dr. Goscinny continued, “The SYNAPT G2-Si system exemplifies Waters continuing commitment to innovation in mass spectrometry and collaborating with researchers on their journey of exploration.”

The collision cross section of a molecule is an important distinguishing feature that is directly related to its chemical structure and three-dimensional conformation in the gas-phase.

Like molecular mass, this additional orthogonal property of a molecule (through the use of high-efficiency T-wave ion mobility technology) gives scientists increased coverage and clarity for profiling mixtures or gaining additional measurements with which they can investigate chemical structures or better confirm a molecule’s identity.

Integrating separation by CCS into targeted and untargeted experiments through new high-definition data-directed-analysis (HD-DDA) and high definition multiple reaction monitoring (HD-MRM) modes brings compelling benefits to the most challenging qualitative and quantitative applications.

• Maximized time-of-flight (Tof) duty cycle and effective sensitivity - of up to 10x in MS/MS mode - for targeted discovery and quantitation
• Improved LC/MS/MS efficiency with a 40% improvement in the numbers of proteins identified from an E. coli sample and the identification of more than 2,000 proteins from a HeLa sample
• Routine ultra-sensitive MS/MS assays with the benefit of high resolution and accurate mass for targeted quantification experiments
• Physical separation of interferences away from the molecule or transition of interest on the basis of their collision cross section for improved selectivity when working with very complex matrices.
• A new and faster 2.5KHz solid state laser combined with new software for improved spatial resolution (down to 15µm) for cleaner mass spectral data and greater image throughput when performing experiments with MALDI imaging and T-wave ion mobility

As evidence of the successful use of T-Wave ion mobility mass spectrometry for the research laboratory, the International Journal of Ion Mobility Spectrometry in February of this year published an exclusive, two-volume special edition series on T-Wave ion mobility featuring 13 scientific articles by some of the world’s top scientists.

As the newest member of the SYNAPT family of mass spectrometers, the SYNAPT G2-Si system can separate individual isomers, conformers, and isobaric compounds; help determine sites of biotransformation; study structure at physiological concentrations; comprehensively profile complex mixtures and minimize false positives and negatives in screening experiments.

For more information: www.waters.com/synaptg2si.

Waters Enhances its Omics Research Platform Solution with TransOmics 2.0 Informatics

At ASMS Waters is previewing an enhanced range of Omics Research Platform Solutions, powered by TransOmics™ 2.0 Informatics.

The new TransOmics 2.0 informatics packages for proteomics and metabolomics/lipidomics, created exclusively for Waters by its strategic business partner Nonlinear Dynamics (Newcastle upon Tyne, UK), are based on extended versions of the Nonlinear Dynamics Progenesis™ LC-MS and CoMet products.

The TransOmics 2.0 informatics packages are specifically designed to process and visualize SYNAPT High Definition Mass Spectrometry (HDMS) Omics data, denominated with Collision Cross Section (CCS), from the new Waters SYNAPT G2-Si HDMS mass spectrometer.

Proteomics, metabolomics and lipidomics researchers routinely acquire large, content-rich, data sets that need to be efficiently reduced and intuitively visualized to facilitate the extraction of biologically significant results.

TransOmics 2.0 has been developed specifically to address these issues and reveal the potential of CCS denominated Omics data.

University of Washington Researcher, Matthew F. Bush, to Receive ASMS Research Award Sponsored by Waters Corporation

On Tuesday, June 11, Dr. Matthew Bush of the University of Washington will receive the 2013 ASMS Research Award sponsored by Waters Corporation in recognition of his research on intact protein complexes using mass spectrometry.

The award, which comes with a cash prize of $35,000, is being awarded to Dr. Bush for his laboratory’s research into developing and applying fast and sensitive mass spectrometry techniques for characterizing biological assemblies. This is the 27th year of award sponsorship by Waters Corporation.