Corporate Banner
Satellite Banner
Food & Beverage Analysis
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Chemist to Study ‘Orally Effective Therapy’ to Fight Obesity

Published: Thursday, August 15, 2013
Last Updated: Thursday, August 15, 2013
Bookmark and Share
A chemist has received a federal grant to study the oral administration of PYY3-36, a peptide that inhibits food intake by naturally switching off one's appetite.

The project is said to have major implications for people struggling with obesity and associated diseases, such as cardiovascular disease and diabetes.

Robert Doyle, associate professor of chemistry, has been awarded $221,000 by the National Institute of Diabetes and Digestive and Kidney Diseases at the National Institutes of Health. His project will last for two years, with the option of a third, and will involve Christian L. Roth, a pediatric endocrinologist at Seattle Children’s Hospital.

The award comes on the heels of a landmark decision by the American Medical Association to categorize obesity as a disease requiring a “range of interventions,” including weight-loss counseling, medication and surgery.

“Obesity is one of today’s leading health challenges—not only in North America and Europe, but also in Asia and Australia,” says Doyle, whose expertise spans chemistry and biology. “The prevalence of obesity among children and adolescents is of particular concern, despite public health education and initiatives.”

At the heart of Doyle's project is PYY3-36, a gut hormone that presumably supports the long-term benefits of bariatric surgery—currently, the only effective long-term exogenous treatment for obesity.
Doyle plans to utilize vitamin B12, which supports functioning of the brain and nervous system, to help protect and carry PYY3-36 through the gastrointestinal tract.

“We will trick the digestive system into carrying our peptide [PYY3-36], along with the B12,” says Doyle, who also holds faculty appointments in biology and biochemistry. “PYY3-36 will then send messages between the intestine and the brain, as well as in the brain, itself, telling you when you’re full. That’s why it’s called the ‘satiety peptide.’”

Since pharmacotherapy is merely an adjunct treatment for obesity management, the race is on to develop novel anti-obesity drugs that are safe and effective.

Doyle believes that orally effective therapy—particularly involving PYY3-36’s appetite-suppressing properties—may be the way forward.

“Ultimately, we want to develop an oral formulation that takes advantage of our bodies’ own appetite-control elements,” he says. “But first, we need to study its effects.”

Doyle, who earned a Ph.D. from Trinity College in Dublin, joined SU’s faculty in 2005. Since then, he has produced award-winning research that may lead to new treatments and diagnostic tools for diabetes and cancer. Much of his work, such as the utilization of B12 to orally deliver proteins, draws on chemical or systems biology research.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,400+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Apricot Kernels Pose Risk of Cyanide Poisoning
Eating more than three small raw apricot kernels, or less than half of one large kernel, in a serving can exceed safe levels. Toddlers consuming even one small apricot kernel risk being over the safe level.
Soy Shows Promise as Natural Anti-Microbial Agent
Researchers from University of Guelph show that soy isoflavones and peptides could be used to reduce microbial contamination of food.
First DNA Vaccine in the EU Recommended for Use in Salmon
Clynav to protect Atlantic salmon from serious infectious disease.
Grant to Fund Million Peaks Project
The European Research Council (ERC) has awarded a prestigious Advanced Grant to Prof. Peter Schoenmakers, Prof. Albert Polman and Prof. Huib Bakker, all three of whom work at the University of Amsterdam (UvA).
Finding Inorganic Arsenic in Foodstuffs
A new European standard method to determine the content of inorganic arsenic in foodstuffs has been developed at the National Food Institute, Technical University of Denmark.
Effective Identification of Low-Gliadin Wheat Lines
Researchers have demonstrated the use of NIRS to identify low-gliadin wheat lines.
Virus Causing Tilapia Die-Offs Identified
Discovery of the virus causing Tilapia die-offs in Israel and Ecuador points the way to protecting a fish that feeds multitudes.
Interactive Maps Reveal Global Obesity
World’s obese population hits 640 million, according to largest ever study.
Eating Green Could be in Your Genes
Genetic variation uncovered that has evolved in populations that have historically favored vegetarian diets, such as in India, Africa and parts of East Asia.
Detecting Bacterial Growth in Packaged Food
New technique enables fast, accurate and noninvasive measurement of bacteria levels.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,400+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!