Corporate Banner
Satellite Banner
Food & Beverage Analysis
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Oxygen Starvation Regulates Fat Cells in Obesity

Published: Monday, September 30, 2013
Last Updated: Monday, September 30, 2013
Bookmark and Share
Studies of the effects of oxygen deprivation in the body fat of obese animals have revealed links with the regulation of fat cell generation.

Researchers at Kanazawa University have identified the role of the protein TIS7 in processes that regulate adipogenesis, whereby non-specialised cells become adipose or fat cells. They add, “TIS7 could be a target for the discovery and development of a drug useful for the treatment and therapy of obesity or a variety of obesity-related metabolic diseases including type-2 diabetes and atherosclerosis.”

Adipose tissue is essential for whole body homeostasis, storing excess energy and potentially a number of other physiological processes. Deregulation of these functions is found in obesity, prompting further study of the mechanisms behind white adipose tissue development.

Adipose tissue is poorly oxygenated in obese humans and animals. Poor oxygenation or ‘hypoxia’ has been linked to a number of diseases including heart and lung disorders, anemia, and circulation problems. There have also been reports indicating that the protein TIS7 is expressed in tissues following injuries, such as ischemia, stroke or muscle trauma. Yukio Yoneda and colleagues at the University of Kanazawa monitored TIS7 expression in vitro and found that it was drastically increased by hypoxic stress.

The researchers then compared mice fed different diets and found significant up-regulation of TIS7 in the white adipose tissue of mice fed a high fat diet. Following further studies of various aspects of adipogenesis and the role of hypoxia and TIS7, the researchers conclude, “It thus appears that TIS7 is a novel pivotal transcriptional regulator of hypoxia-induced repression of adipogenesis.” They add that further studies are needed to understand the exact mechanism underlying the up-regulation of TIS7 under hypoxia in cells prior to adipogenesis.

Publication and Affiliation

Yukari Nakamura 1, Eiichi Hinoi 1, Takashi Iezaki, Saya Takada, Syota Hashizume, Yoshifumi Takahata, Emiko Tsuruta, Satoshi Takahashi, Yukio Yoneda *

Repression of adipogenesis through promotion of Wnt/β-catenin signaling by TIS7 up-regulated in adipocytes under hypoxia. Biochimica et Biophysica Acta 1832 (2013) 1117–1128

1. Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School,Kanazawa, Ishikawa 920-1192, Japan

*corresponding author, e-mail address: yyoneda@p.kanazawa-u.ac.jp

1 These authors equally contributed to this work.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Chemical Used to Replace BPA is Potentially Toxic
This study is the first to examine the effects of BPA and BPS on brain cells and genes that control the growth and function of organs involved in reproduction.
Toxic Pollutants Found in Fish Across the World's Oceans
Scripps researchers' analysis shows highly variable pollutant concentrations in fish meat.
Weight-loss Supplements Containing Raspberry Ketone May Be Harmful
New study by the researchers suggests that raspberry ketone may have several adverse effects.
Quantifying C. botulinum Spores
A study from the Institute of Food Research has provided new evidence on the background levels of spores of Clostridium botulinum in raw food ingredients that is helping the food industry deliver safe chilled foods more sustainably.
Single Molecule Detection of Contaminants, Explosives or Diseases
A technique that combines the ultrasensitivity of surface-enhanced Raman scattering (SERS) with a slippery surface invented by Penn State researchers will make it feasible to detect single molecules of a number of chemical and biological species from gaseous, liquid or solid samples.
Should I Throw Away Food Once a Fly Has Landed on it?
Flies can be a substantial annoyance and may also be a potential health risk.
New Year, Old Beer
A bottle of Alexander Keith’s beer has been keeping Dal Engineering prof Andrew MacIntosh busy at work this week.
Sensor Detects Toxins Leaching from Plastic
Engineers from Massey University have developed a highly sensitive device able to detect synthetic compounds that leach from plastic food packaging into the contained food or beverage.
New BPA Detection Tests
Scientists from the JRC developed fit-for-purpose analytical methods for the determination of bisphenol A and 12 similar substances (analogues) in food matrices to support possible future monitoring studies.
The MaxSignal Colistin ELISA Test Kit from Bioo Scientific
Kit can help prevent the antibiotic apocalypse by keeping last resort drugs out of the food supply.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!