Corporate Banner
Satellite Banner
Food & Beverage Analysis
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

LC-MS/MS-Based Multibiomarker Approaches for the Assessment of Human Exposure to Mycotoxins

Published: Wednesday, November 13, 2013
Last Updated: Wednesday, November 13, 2013
Bookmark and Share
To overcome the disadvantages of indirect methods, biomarker approaches were developed as a biomonitoring tool for some major mycotoxins.

Abstract
Mycotoxins are toxic fungal secondary metabolites that frequently contaminate food and feed worldwide, and hence represent a major hazard for food and feed safety. To estimate human exposure arising from contaminated food, so-called biomarker approaches have been developed as a complementary biomonitoring tool besides traditional food analysis. The first methods based on radioimmunoassays and enzyme-linked immunosorbent assays as well as on liquid chromatography were developed in the late 1980s and early 1990s for the carcinogenic aflatoxins and in the last two decades further tailor-made methods for some major mycotoxins have been published. Since 2010, there has been a clear trend towards the development and application of multianalyte methods based on liquid chromatography-electrospray ionization tandem mass spectrometry for assessment of mycotoxin exposure made possible by the increased sensitivity and selectivity of modern mass spectrometry instrumentation and sophisticated sample cleanup approaches. With use of these advanced methods, traces of mycotoxins and relevant breakdown and conjugation products can be quantified simultaneously in human urine as so-called biomarkers and can be used to precisely describe the real exposure, toxicokinetics, and bioavailability of the toxins present. In this article, a short overview and comparison of published multibiomarker methods focusing on the determination of mycotoxins and relevant excretion products in human urine is presented. Special attention is paid to the main challenges when analyzing these toxic food contaminants in urine, i.e., very low analyte concentrations, appropriate sample preparation, matrix effects, and a lack of authentic, NMR-confirmed calibrants and reference materials. Finally, the progress in human exposure assessment studies facilitated by these analytical methods is described and an outlook on probable developments and possibilities is presented.

The article is published online in the journal Analytical and Bioanalytical Chemistry and is free to access. 


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Acetaldehyde and Formaldehyde Content in Foods
Korean researchers have determined the content of the toxic and carcinogenic aldehydes, acetaldehyde and formaldehyde, in a variety of food groups.
Monday, November 09, 2015
Comparison of Caffeinated and Decaffeinated Coffee - Implications for Alzheimer's Disease
Researchers from the National University of Singapore successfully demonstrated the viability of GC-TOF-MS as an analytical platform for metabolomics analysis of coffee samples.
Monday, September 08, 2014
Immunochromatographic Assay for Rapid Salmonella Detection
The test strip described in the study would be beneficial for poultry farms and other veterinary production for the monitoring of S. Typhimurium and/or S. Enteritidis contamination.
Tuesday, August 12, 2014
Application of MALDI-TOF MS for the Identification of Food Borne Bacteria
MALDI-TOF MS is a promising platform for quick, flexible, and reliable identification of food microbial isolates.
Tuesday, April 29, 2014
Monitoring and Risk Assessment of Pesticide Residues in Commercially Dried Vegetables
The study aimed to analyze the presence of 253 pesticides commonly used on dried vegetables and to check their compliance with existing regulations.
Tuesday, March 11, 2014
Determination of Cyanogenic Compounds in Edible Plants by Ion Chromatography
Ion chromatography following acid hydrolysis was employed to prevent thiocyanate interference of the colorimetric methods.
Tuesday, December 10, 2013
Predictors of Obesity: The "Power" of the Omics
Diet and nutrient biomarkers should provide objective measures of dietary intake and nutritional status, as well as an integrated measure of intake, absorption and metabolism.
Friday, October 25, 2013
Optical Biosensors for Food Quality and Safety Assurance
With high specificity, convenience and quick response there is growing interest in biosensors for food safety testing.
Monday, October 07, 2013
Pesticide Residue Screening Using a Novel Artificial Neural Network Combined with a Bioelectric Cellular Biosensor
Researchers have developed and trained a customized feed forward artificial neural network for the classification of the pesticide groups, pyrethroids, carbamates, and organophosphates.
Friday, September 20, 2013
Effect of Trans Fatty Acid Intake on LC-MS and NMR Plasma Profiles
In this study, NMR and LC-MS untargeted metabolomics has been used as an approach to explore the impact of trans fatty acid intake on plasma metabolites.
Tuesday, August 13, 2013
Low Density Solvent-Based Dispersive Liquid-Liquid Microextraction for the Determination of Synthetic Antioxidants in Beverages by HPLC
In this study, researchers propose a method that could be used for monitoring as well as controlling the synthetic antioxidants in aqueous food samples.
Wednesday, July 31, 2013
What's New in the Diagnosis and Management of Food Allergy in Children?
With the increasing worldwide prevalence of food allergy comes a renewed impetus for improving diagnosis and management.
Monday, June 24, 2013
Genetically Modified Crops and Food Security
Although GM crops are not a panacea for the problems of hunger and malnutrition, evidence suggests that GM crops can be an important component in a broader food security strategy.
Monday, June 24, 2013
A Simple HPLC Method for Determining the Purine Content of Beer and Beer-Like Alcoholic Beverages
In this article researchers from Teikyo University report an improved method for determining small amounts of purines in alcoholic beverages.
Wednesday, May 29, 2013
Use of FT-IR Spectra and PCA to the Bulk Characterization of Cell Wall Residues of Fruits and Vegetables Along a Fraction Process
The study has demonstrated that discrimination between the cell wall residues of fruits and vegetables is possible with the use of FT-IR spectra analysed using the PCA method.
Thursday, May 16, 2013
Scientific News
Detecting Pesticides, Nerve Gas With an Electronic Nose
Detecting pesticides and nerve gas in very low concentrations? An international team of researchers led by Ivo Stassen and Rob Ameloot from KU Leuven have made it possible.
Massive Helium Discovery a "Game Changer" for Medical Industry
A new development is gas exploration has yielded the discovery of a huge helium gas field, which could help relieve the dwindling supply.
A “Micro Winery” That Makes Wine Continuously
An American professor, working in collaboration with EPFL, is developing a miniature device for producing wine non-stop and testing different fermentation processes.
Supplement May Switch off Cravings for High-Calorie Foods
Researchers have found that inulin-propionate ester supplement curbs cravings for junk food.
Link Between Canned Food, BPA Exposure Revealed
New Stanford research resolves the debate on the link between canned food and exposure to the hormone-disrupting chemical known as Bisphenol A, or BPA.
Peanut Allergy Prevention Strategy is Nutritionally Safe
Early-life peanut consumption does not affect duration of breastfeeding or children’s growth and nutrition.
ASMS 2016: Targeting Mass Spectrometry Tools for the Masses
The expanding application range of MS in life sciences, food, energy, and health sciences research was highlighted at this year's ASMS meeting in San Antonio, Texas.
A Future Tool for Medicine, Food Safety
A new type of electronic sensor that might be used to quickly detect and classify bacteria for medical diagnostics and food safety has passed a key hurdle by distinguishing between dead and living bacteria cells.
Local Microbes Can Predict Wine’s Chemical Profile
Regionally distinctive groups of bacteria and fungi, associated with local climate and environmental conditions, may leave a very specific “fingerprint” on a wine’s chemical composition, report University of California, Davis, researchers who collaborated on a new study with two Napa Valley wineries.
What Makes a Good Scientist?
It’s the journey, not just the destination that counts as a scientist when conducting research.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!