Corporate Banner
Satellite Banner
Food & Beverage Analysis
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Curie-Cancer and Meiogenix Sign Two Partnership Agreements

Published: Tuesday, November 19, 2013
Last Updated: Tuesday, November 19, 2013
Bookmark and Share
Curie-Cancer and Meiogenix will develop the SpiX technology in yeast and in mice to unlock unexplored genetic diversity.

Curie-Cancer announces two three-year partnership agreements with Meiogenix. Meiogenix develops SpiX technology under license from Institut Curie and Institut National de la Recherche Agronomique (INRA).

This technology will be deployed in yeast and mice to exploit the unexplored natural biodiversity of organisms.

The process of homologous recombination enables the exchange of nucleotide sequences between two similar or identical DNA strands. It occurs naturally in every cell. In somatic cells, it is mostly involved in the repair of genotoxic lesions, while in germline cells, it is involved in the exchange of genetic material between the parental chromosomes, with the outcome that the traits of a descendant are a ‘mixture’ of traits from its parents. 

Meiotic recombination occurs at numerous places along the chromosome, generating the genetic diversity transmitted by the gametes, but not everywhere and not at the same rate. Some chromosomal regions frequently recombine, but others are ‘cold’, resulting in the fact that they remain in parental configuration in the vast majority of gametes for many generations.

Alain Nicolas, CNRS Research Director at Institut Curie and his team developed this technology to target and enhance meiotic recombination in cold regions. The technology is based on Spo11, an evolutionary conserved endonuclease that naturally catalyzes the formation of meiotic double-strand breaks. SpiX(R) technology is based on the use of Spo11. It modulates the process of homologous recombination in the genome by increasing its frequency in cold regions. By stimulating the process in ‘regions of rare exchange’, SpiX can unlock unexplored genetic diversity.

"Our goals are twofold. Firstly, to investigate the possibilities offered by SpiX in an animal model, in this case mice. A validation in mice could lead to other possible applications in close species such as rats, which are  widely used animal models for studying many diseases such as cancer for example,” said Alain Nicolas “The other objective is to investigate a second generation of the technology and new techniques to control meiotic recombination in yeast, an organism in which we have extensively validated the technology.”

“As an SME, it is not always easy to access academic expertise,” said Giacomo Bastianelli, CEO of Meiogenix. “However, in Curie-Cancer we have found a partner who understands our need to develop the technology and to create industrial value from day one. We anticipate that the results of all our on-going research programs will be of enormous interest in major industrial fields, ranging from agrobiotech, biofuels, industrial yeasts, or animal breeding.”

“These agreements may ultimately help with the treatment of cancer, but they are also touching on other subject areas such as agriculture. This is why we are delighted to be able to contribute to the development of a French SME like Meiogenix,” said Damien Salauze, director of Curie-Cancer. “This partnership embodies the principles of the Institut Carnot label which we were awarded by the French government in 2011 in recognition of our drive to provide genuine solutions for industry and ultimately for patients.”

New perspectives in plants and agronomy
The original focus in the development of the technology was to treat cancer. However, Meiogenix also identified major applications for plants or for  yeast which have been widely used in food production processes for bread, cheese, wine and beer. SpiX technology can be used to target meiotic recombination in specific cold regions of genomes by fusing Spo11 to highly specific binding domains (ZFNs, TALENs). This can help breeders to unlock the genetic diversity that is hard to obtain with current techniques or that will require long breeding cycles.

The current research programs at Meiogenix aim to demonstrate that SpiX is able to increase the frequency of meiotic recombination in cold regions of plant genomes (rice, corn, wheat, etc), resulting in new commercial varieties of plants with interesting traits (resistance to dryness for example). This may have  the potential to meet the food needs of the growing worldwide population.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Decrease in Foodborne Outbreaks in Denmark
Almost every other registered salmonella infection in Denmark in 2014 was brought back by Danes travelling overseas.
How Safe Is Your Ground Beef?
If you don’t know how the ground beef you eat was raised, you may be putting yourself at higher risk of illness from dangerous bacteria. You okay with that?
Sweeteners Detected in Human Breast Milk
New data show that multiple types of NNS can be passed to nursing infants.
Food Science Team Finds Key to Tasty, Salt-Reduced Bread
Three food science researchers at the University of Alberta have discovered how to reduce salt in bread by half without compromising its taste or texture.
Yorkshire Scientists Could Hold Key to Preventing Future Horsemeat Scandals
Incidents like the horse meat scandal, which caused extensive damage to the UK’s farming and retail industry, could be consigned to the past thanks to revolutionary technology developed in the UK.
Detecting Hidden Ingredients
Researchers from China have used mass spectrometry to reveal the use of undeclared substances in dietary supplements.
Study Questions Presence in Blood of Heart-Healthy Molecules from Fish Oil Supplements
A new study from the Perelman School of Medicine at the University of Pennsylvania questions the relevance of fish oil-derived SPMs and their purported anti-inflammatory effects in humans.
How To Keep Your Rice Arsenic-Free
Researchers at Queen’s University Belfast have made a breakthrough in discovering how to lower worrying levels of arsenic in rice that is eaten all over the world.
Pesticide Found in 70 Percent of Massachusetts’ Honey Samples
New Harvard University study says that the pesticide commonly found in honey samples is implicated in Colony Collapse Disorder.
Printed "Smart Cap" Detects Spoiled Food
It might not be long before consumers can just hit “print” to create an electronic circuit or wireless sensor in the comfort of their homes.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!