Corporate Banner
Satellite Banner
Food & Beverage Analysis
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Ingested Nanoparticles May Damage Liver

Published: Tuesday, August 12, 2014
Last Updated: Tuesday, August 12, 2014
Bookmark and Share
Although nanoparticles in food, sunscreen and other everyday products have many benefits, researchers from Cornell are finding that at certain doses, the particles might cause human organ damage.

A recently published study in Lab on a Chip by the Royal Society of Chemistry and led by senior research associate Mandy Esch shows that nanoparticles injure liver cells when they are in microfluidic devices designed to mimic organs of the human body. The injury was worse when tested in two-organ systems, as opposed to single organs – potentially raising concerns for humans and animals. The study was highlighted in Chemistry World.

Esch works in the lab of Michael Shuler, the Samuel B. Eckert Professor of Chemical Engineering. She participated in a widely read 2012 study about toxicity of nanoparticles in chickens.

“We are looking at the effects of what are considered to be harmless nanoparticles in humans,” Esch said. “These particles are not necessarily lethal, but … are there other consequences? We’re looking at the non-lethal consequences.”

She used 50-nanometer carboxylated polystyrene nanoparticles, found in some animal food sources and considered model inert particles. Shuler’s lab specializes in “body-on-a-chip” microfluidics, which are engineered chips with carved compartments that contain cell cultures to represent the chemistry of individual organs.

In Esch’s experiment, she made a human intestinal compartment, a liver compartment and a compartment to represent surrounding tissues in the body. She then observed the effects of fluorescently labeled nanoparticles as they traveled through the system.

Esch found that both single nanoparticles as well as small clusters crossed the gastrointestinal barrier and reached liver cells, and the liver cells released an enzyme called aspartate transaminase, known to be released during cell death or damage.

It’s unclear exactly what damage is occurring or why, but the results indicate that the nanoparticles must be undergoing changes as they cross the gastrointestinal barrier, and that these alterations may change their toxic potential, Esch said. Long-term consequences for organs in proximity could be a concern, she said.

“The motivation behind this study was twofold: one, to show that multi-organ, in vitro systems give us more information when testing for the interaction of a substance with the human body, and two … to look at nanoparticles because they have a huge potential for medicine, yet adverse effects have not been studied in detail yet,” Esch said.

The paper, “Body-on-a-Chip Simulation With Gastrointestinal Tract and Liver Tissues Suggests That Ingested Nanoparticles Have the Potential to Cause Liver Injury,” is co-authored by Shuler; former postdoctoral associate Gretchen Mahler, now an assistant professor at SUNY Binghamton; and Tracy Stokol, associate professor in the College of Veterinary Medicine.

The research was supported by the Army Corps of Engineers, the National Science Foundation and the National Institutes of Health. Microfabrication was performed at the NSF-supported Cornell NanoScale Science and Technology Facility.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

On Planes, Savory Tomato Becomes Favored Flavor
Study shows the effect that airplane noise has on passengers' taste preferences.
Friday, May 15, 2015
On the Environmental Trail of Food Pathogens
Learning where Listeria dwells can aid the search for other food pathogens.
Tuesday, December 23, 2014
Foodborne Pathogen Detection Speeds Up Dramatically
Next-generation sequencing techniques allow rapidly identification of strains of salmonella, quickening responses to potential outbreaks.
Monday, July 21, 2014
Dairy Farmers Should Alternate Pesticides to Kill Flies
Flies spread disease and a host of pathogens that cost farms hundreds of millions of dollars in annual losses.
Thursday, June 26, 2014
New York Secures $3.4M to Bolster Food Research
Funds will go toward the $13M needed to modernize the Fruit and Vegetable Processing Pilot Plant, Phase I of the proposed $47M Agricultural Science Research Laboratory project.
Thursday, June 26, 2014
Cornell University at Forefront of Dairy Safety Outreach
Cornell’s Food Science Dairy Extension Program faculty and professionals are helping New York cheesemakers and dairy producers provide safe, high-quality products for consumers.
Friday, June 13, 2014
Paving the Way for Better Dietary Zinc Test
Cornell research unveils a new method to test for zinc deficiency, a vital measurement that has posed problems for doctors and scientists.
Friday, April 11, 2014
Senator to Tout Cornell Food Safety, Dairy Expertise to Feds
Cornell University is positioned to be a national center of excellence in dairy and food safety.
Monday, September 09, 2013
New Method Makes Puffed Rice Pop with More Nutrients
Puffed rice just got more snap, crackle and pop, thanks to a new method for making puffed rice that retains nutrients and allows producers to fortify cereals with vitamins and protein.
Wednesday, March 20, 2013
Green Food Labels Make Nutrition-Poor Food Seem Healthy
Consumers to perceive a candy bar as more healthful when it has a green calorie label compared to a red one.
Tuesday, March 12, 2013
Changes in Epigenome Control Tomato Ripening
Everyone loves a juicy, perfectly ripened tomato, and scientists have long sought ways to control the ripening process to improve fruit quality and prevent spoilage.
Wednesday, January 30, 2013
Grant Will Help Reduce Incidence of Johne's Disease in Dairy Cows
Dangerous bacterium in milk could also be linked to Crohn’s disease in humans.
Tuesday, January 08, 2013
Tracing Foodborne Pathogens on the Farm
Remote sensing, microbiology used to trace foodborne pathogens.
Thursday, December 06, 2012
Federal Grants will Fund Study of Food System, Environment
Cornell University grant will help tackle some of the biggest questions in affecting agriculture.
Thursday, November 01, 2012
Branding Sells Healthy Cafeterias Foods
A new study finds that children will choose healthier cafeteria foods if they are branded with stickers of popular culture figures.
Thursday, August 23, 2012
Scientific News
Decrease in Foodborne Outbreaks in Denmark
Almost every other registered salmonella infection in Denmark in 2014 was brought back by Danes travelling overseas.
How Safe Is Your Ground Beef?
If you don’t know how the ground beef you eat was raised, you may be putting yourself at higher risk of illness from dangerous bacteria. You okay with that?
Sweeteners Detected in Human Breast Milk
New data show that multiple types of NNS can be passed to nursing infants.
Food Science Team Finds Key to Tasty, Salt-Reduced Bread
Three food science researchers at the University of Alberta have discovered how to reduce salt in bread by half without compromising its taste or texture.
Yorkshire Scientists Could Hold Key to Preventing Future Horsemeat Scandals
Incidents like the horse meat scandal, which caused extensive damage to the UK’s farming and retail industry, could be consigned to the past thanks to revolutionary technology developed in the UK.
Detecting Hidden Ingredients
Researchers from China have used mass spectrometry to reveal the use of undeclared substances in dietary supplements.
Study Questions Presence in Blood of Heart-Healthy Molecules from Fish Oil Supplements
A new study from the Perelman School of Medicine at the University of Pennsylvania questions the relevance of fish oil-derived SPMs and their purported anti-inflammatory effects in humans.
How To Keep Your Rice Arsenic-Free
Researchers at Queen’s University Belfast have made a breakthrough in discovering how to lower worrying levels of arsenic in rice that is eaten all over the world.
Pesticide Found in 70 Percent of Massachusetts’ Honey Samples
New Harvard University study says that the pesticide commonly found in honey samples is implicated in Colony Collapse Disorder.
Printed "Smart Cap" Detects Spoiled Food
It might not be long before consumers can just hit “print” to create an electronic circuit or wireless sensor in the comfort of their homes.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!