A Reduced Workflow Solution for the Analysis of Gamma-Hydroxybutyrate (GHB) in Human Hair Samples Via an Automated Bead Mill as a Precursor to GCxGC-TOFMS and GC-HRT
Gamma-hydroxybutyrate (GHB) is an endogenous compound and is also a drug commonly used by bodybuilders, observed in the club scene, and used in drug-facilitated sexual assaults. GHB has been shown to have an elimination rate of 18 mg/L/h, so it is typically cleared from the blood within approximately 6 hours and from the urine within 12 hours after it is taken orally. Hair samples have proven valuable in detecting exposure to drugs of abuse over extended time periods.
Some of the analytical challenges associated with hair analysis include:
• Complexity of the Hair Matrix
• Chemical Diversity of Compounds in Hair
• Coelution of Analytes (e.g., Urea and GHB)
• Concentration Range of Sample Constituents
• Inappropriate Sample Preparation Methods
• Unsuitable Analysis Protocol
Some of the analytical challenges associated with hair analysis include:
• Complexity of the Hair Matrix
• Chemical Diversity of Compounds in Hair
• Coelution of Analytes (e.g., Urea and GHB)
• Concentration Range of Sample Constituents
• Inappropriate Sample Preparation Methods
• Unsuitable Analysis Protocol
