Thursday, May 17, 2012
Technology Networks
Technology Networks
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 | Chemical Restriction Length Polymorphism (CLFP) for Detection and Characterization of Bacterial Pathogens Byron Brehm-Stecher, Iowa State University, speaking at Advances in Biosensors and Biotedection 2011. |
 | Non-Coding RNAs and Genomic Imprinting: Insights From the Gnas Cluster Professor Jo Peters, University of Oxford, speaking at Epigenetics 2011. |
Next Generation Sequencing (NGS) Market
MarketsandMarkets
by technology (pyrosequencing & others), competitors (Illumina, 454 Roche, Life Science Technologies), applications & tools - global trends & forecasts (2011 – 2016)
Life Science and Chemical Instrumentation Market (2011 - 2016)
MarketsandMarkets
Spectroscopy, Chromatography, DNA Sequencer & Amplifier, Lab Automation, Array, Flow Cytometer, Electrophoresis, Immuno Assay & Others
Personalized Medicine Market - Advances in Human Genomics and Proteomics to Challenge Traditional Therapeutics
GBI Research
The report provides key data, information and analysis of the major trends and issues in Personalized Medicine Market. The report provides a comprehensive insight into the role of Human Genomics and Proteomics to challenge traditional therapeutics.
Personalized Medicine for Cancer
GlobalData
The report is an essential source of information on the Personalized Medicine for Cancer . The report also provides insights on the companion diagnostics and marketed personalized drugs for cancer.
Biomarkers Market (Discovery Technologies, Applications & Indications) – Global Trends, Opportunities & Forecasts (2011 – 2020)
MarketsandMarkets
This Biomarkers Market research report categorizes on the basis of discovery technologies and application market across major indications; forecasting revenues and analyzing trends.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2012
Select Biosciences Ltd
In this report, we focus upon the biology of CTCs and CSCs as well as explore the inter-relationship between these cell types based upon molecular events. Also presented are research trends which are for the isolation and study of CTCs, a potentially important tool for cancer diagnostics with special relevance to cancer metastatic mechanisms.
Circulating Tumor Cells (CTCs) Market Trends 2011
Select Biosciences Ltd
This is the latest and most up-to-date Market Report from Select Biosciences addressing the circulating tumor cells (CTCs) space. In this report, we focus upon the emerging marketplace for the isolation and study of CTCs, a potentially important tool for cancer diagnostics with special relevance to cancer metastasis and mechanisms thereof.
Next-Gen Sequencing Trends 2011
HTStec
This market report summarizes the results of HTStec’s 2nd industry-wide global web-based benchmarking survey on next-generation sequencing (NGS) carried out in March 2011.
Small-Scale Benchtop Automation Trends 2011
HTStec
This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on small-scale benchtop automation carried out in June 2011.
Single Cell Omics 2011
Select Biosciences Ltd
The single cell Omics revolution is the potential transformation of cellular heterogeneity from a source of noise to a source of new, as yet hidden discoveries.
MarketsandMarkets
by technology (pyrosequencing & others), competitors (Illumina, 454 Roche, Life Science Technologies), applications & tools - global trends & forecasts (2011 – 2016)
Life Science and Chemical Instrumentation Market (2011 - 2016)
MarketsandMarkets
Spectroscopy, Chromatography, DNA Sequencer & Amplifier, Lab Automation, Array, Flow Cytometer, Electrophoresis, Immuno Assay & Others
Personalized Medicine Market - Advances in Human Genomics and Proteomics to Challenge Traditional Therapeutics
GBI Research
The report provides key data, information and analysis of the major trends and issues in Personalized Medicine Market. The report provides a comprehensive insight into the role of Human Genomics and Proteomics to challenge traditional therapeutics.
Personalized Medicine for Cancer
GlobalData
The report is an essential source of information on the Personalized Medicine for Cancer . The report also provides insights on the companion diagnostics and marketed personalized drugs for cancer.
Biomarkers Market (Discovery Technologies, Applications & Indications) – Global Trends, Opportunities & Forecasts (2011 – 2020)
MarketsandMarkets
This Biomarkers Market research report categorizes on the basis of discovery technologies and application market across major indications; forecasting revenues and analyzing trends.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2012
Select Biosciences Ltd
In this report, we focus upon the biology of CTCs and CSCs as well as explore the inter-relationship between these cell types based upon molecular events. Also presented are research trends which are for the isolation and study of CTCs, a potentially important tool for cancer diagnostics with special relevance to cancer metastatic mechanisms.
Circulating Tumor Cells (CTCs) Market Trends 2011
Select Biosciences Ltd
This is the latest and most up-to-date Market Report from Select Biosciences addressing the circulating tumor cells (CTCs) space. In this report, we focus upon the emerging marketplace for the isolation and study of CTCs, a potentially important tool for cancer diagnostics with special relevance to cancer metastasis and mechanisms thereof.
Next-Gen Sequencing Trends 2011
HTStec
This market report summarizes the results of HTStec’s 2nd industry-wide global web-based benchmarking survey on next-generation sequencing (NGS) carried out in March 2011.
Small-Scale Benchtop Automation Trends 2011
HTStec
This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on small-scale benchtop automation carried out in June 2011.
Single Cell Omics 2011
Select Biosciences Ltd
The single cell Omics revolution is the potential transformation of cellular heterogeneity from a source of noise to a source of new, as yet hidden discoveries.
Finnish Researchers Discover Genes Inhibiting the Spread of Prostate Cancer
Researchers utilize the cell spot micro array technology to study the impacts of all genes in an entire genome in a single experiment.
Stabilizing Fanconi Anemia with Antioxidants
Fanconi anemia (FA) is a rare genetic disorder which affects one person in 350,000.
Scientists Make Groundbreaking Discovery Of Mutation Causing Genetic Disorder In Humans
Scientists at A*STAR's Institute of Medical Biology (IMB), in collaboration with doctors and scientists in Jordan, Turkey, Switzerland and USA, have identified the genetic cause of a birth defect known as Hamamy syndrome.
Genetic Predictor of Breast Cancer Response to Chemotherapy
Gene expression 'signatures' to measure the susceptibility of tumor cells to chemotherapy.
Nature Highlights Advancements in Biocatalysis
Highlights potential impact on the production of biofuels, renewable chemicals, and pharmaceuticals.
New Muscular Dystrophy Treatment Approach Developed Using Human Stem Cells
New process makes the production of human muscle cells from stem cells efficient and effective.
Revolutionary New Cancer Targeting Technology Described in Nature Medicine
Immunocore scientists manage to overcome cancer problem by boosting the ability of cancer-specific TCRs.
New Biomarkers Could Offer Vital Clues for Cancer Research
European funding for cancer research has led to some interesting results in recent years, says Carl-Johan Ivarsson, CEO at Qlucore.
Idera Pharmaceuticals Announces Top-line Results from Phase 2 Clinical Trial
IMO-2055 to be used in treatment of patients with advanced head and neck cancer.
National Data Center for Cancer Genome Research
In the wake of personalized medicine, scientists at the University of California, Santa Cruz, make progress in the management and analysis of large data sets.
Researchers utilize the cell spot micro array technology to study the impacts of all genes in an entire genome in a single experiment.
Stabilizing Fanconi Anemia with Antioxidants
Fanconi anemia (FA) is a rare genetic disorder which affects one person in 350,000.
Scientists Make Groundbreaking Discovery Of Mutation Causing Genetic Disorder In Humans
Scientists at A*STAR's Institute of Medical Biology (IMB), in collaboration with doctors and scientists in Jordan, Turkey, Switzerland and USA, have identified the genetic cause of a birth defect known as Hamamy syndrome.
Genetic Predictor of Breast Cancer Response to Chemotherapy
Gene expression 'signatures' to measure the susceptibility of tumor cells to chemotherapy.
Nature Highlights Advancements in Biocatalysis
Highlights potential impact on the production of biofuels, renewable chemicals, and pharmaceuticals.
New Muscular Dystrophy Treatment Approach Developed Using Human Stem Cells
New process makes the production of human muscle cells from stem cells efficient and effective.
Revolutionary New Cancer Targeting Technology Described in Nature Medicine
Immunocore scientists manage to overcome cancer problem by boosting the ability of cancer-specific TCRs.
New Biomarkers Could Offer Vital Clues for Cancer Research
European funding for cancer research has led to some interesting results in recent years, says Carl-Johan Ivarsson, CEO at Qlucore.
Idera Pharmaceuticals Announces Top-line Results from Phase 2 Clinical Trial
IMO-2055 to be used in treatment of patients with advanced head and neck cancer.
National Data Center for Cancer Genome Research
In the wake of personalized medicine, scientists at the University of California, Santa Cruz, make progress in the management and analysis of large data sets.
Plexpress Announces Collaboration with Admescope
CRO to offer TRAC gene expression analysis for pre-clinical ADME-Tox studies.
European Life Science Awards Nominees Announced
The awards ceremony celebrates the very best of the industry’s achievements and precedes the Second European Lab Automation (ELA) conference and exhibition taking place from 30th- 31st May at the Congress Centre Hamburg.
Agilent Technologies Reports Second-Quarter 2012 Results
Third-quarter fiscal year 2012 revenue guidance of $1.77 billion - $1.79 billion and non-GAAP earnings guidance of $0.82 - $0.84 per share.
Antisense Pharma Internationalizes Management Board
Dr. Philippe Calais appointed Chief Executive Officer.
DNASTAR Awarded Antibody Engineering SBIR Grant
NIH awarded grant to build antibody engineering software.
Fluidigm Reports Financial Results for First Quarter 2012
Q1 total revenue up 26% compared to Q1 2011.
Agios Strengthens Team with Key Appointments and Promotion
The appointments include Robert J. DeVita, Ph.D., to the role of vice president of chemistry and Marion Dorsch, Ph.D., to the role of vice president of biology.
Roche 454 Life Sciences and SoftGenetics Sign Co-Promotion Agreement
Agreement designed to provide users next-gen sequencing software tools.
Beckman Coulter, Inc. Obtains CLIA Certificate, Licensure for Clinical Sequencing
Certification paves the way for genetic testing of patient samples by Beckman Coulter Genomics.
Plexpress and SBW Partner to Offer TRAC Gene Expression Analysis
CRO adds TRAC to service portfolio for pre-clinical ADME-Tox studies.
CRO to offer TRAC gene expression analysis for pre-clinical ADME-Tox studies.
European Life Science Awards Nominees Announced
The awards ceremony celebrates the very best of the industry’s achievements and precedes the Second European Lab Automation (ELA) conference and exhibition taking place from 30th- 31st May at the Congress Centre Hamburg.
Agilent Technologies Reports Second-Quarter 2012 Results
Third-quarter fiscal year 2012 revenue guidance of $1.77 billion - $1.79 billion and non-GAAP earnings guidance of $0.82 - $0.84 per share.
Antisense Pharma Internationalizes Management Board
Dr. Philippe Calais appointed Chief Executive Officer.
DNASTAR Awarded Antibody Engineering SBIR Grant
NIH awarded grant to build antibody engineering software.
Fluidigm Reports Financial Results for First Quarter 2012
Q1 total revenue up 26% compared to Q1 2011.
Agios Strengthens Team with Key Appointments and Promotion
The appointments include Robert J. DeVita, Ph.D., to the role of vice president of chemistry and Marion Dorsch, Ph.D., to the role of vice president of biology.
Roche 454 Life Sciences and SoftGenetics Sign Co-Promotion Agreement
Agreement designed to provide users next-gen sequencing software tools.
Beckman Coulter, Inc. Obtains CLIA Certificate, Licensure for Clinical Sequencing
Certification paves the way for genetic testing of patient samples by Beckman Coulter Genomics.
Plexpress and SBW Partner to Offer TRAC Gene Expression Analysis
CRO adds TRAC to service portfolio for pre-clinical ADME-Tox studies.
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Volume-Related Inhibitors Standardization for Reverse Transcription Quantitative Polymerase Chain Reaction Experiments
IRBA
This poster addresses the reliability of qPCR data and its dependence on technical variations. The proposal is that constant volume of RNA extract in order to improve reliability.
Defining off-target cleavage in a pair of Zinc Finger Nucleases
University of Utah
This study looks at off-target cleavage of Zinc Finger Nucleases (ZNFs) in Drosophila in an attempt to analyze potential cleavage spots, with a view to designing more efficient ZFNs.
Gene Expression Profiling: qPCR Toolkit for Quality Control
TATAA Biocenter
TATAA Biocenter explain how they developedand optimized high-throughput gene expression qPCR with ValidPrime quality control, compensating for inter-run variations.
Cytotoxicity Screen of Mangiferin and its Major Metabolite Norathyriol in Human Tumor Cell Lines
DKFZ
Many natural products are available worldwide as potential chemoprotective agents against commonly occurring cancers, for example Mangiferin which has low bioavailability and is thought to be mainly available in the colon.
Polarized Cell Expansion and Heterochronic Shift in Angiosperm Spermatogenesis
UEB
This study evaluates genetic factors and common pathways in polarized cell-tip expansion.
Identification and Characterisation of Disease Resistance Pathway Genes in Jute (Corchorus spp.)
Plant Molecular Biology Laboratory, University of Dhaka, Bangladesh
Study aims include identification and characterisation of all NBS containing genes in jute using degenerate primers designed from the conserved NBS domain, by using two species of jute; susceptible and wild type resistant varieties.
Effect of Liquid Handling Quality Control on Biological Assay Performance
Biomanufacturing Training and Education Center
High quality assays are required in order to take forward potential drugs, post screening. Therefore the liquid handling must be accurate and precise, as demonstrated in this experiment.
Why Is My Assay Failing? An Approach to Assay Equipment Optimization
Artel
Assays can produce unexpected or failing results for a multitude of reasons. Variability may be introduced at any point within the assay process.
An Automated, Cell-based Platform for the Rapid Detection of Novel Androgen Receptor Modulators
BioTek Instruments
The Androgen Receptor (AR) is a member of the family of nuclear receptors responsive to steroid hormones. This poster aims to devise, validate and perform a preliminary automated HTS screening campaign to identify novel modulators of AR activity.
Automated Solutions for Cellular Screening and Characterization of Therapeutic Antibodies for Antibody-Dependent Cellular Cytotoxicity Utility
BioTek Instruments
Since the end of the 1990’s, the pharmaceutical industry has seen an increased interest in biologics, especially in the therapeutic areas of oncology and inflammation. Here we present the automation of two assays for the characterization and selection of potent antibody drug candidates. Both assays rely on HTRF® detection. The first assay quantifies the binding affinity of antibodies to their target antigen, on live cells.
IRBA
This poster addresses the reliability of qPCR data and its dependence on technical variations. The proposal is that constant volume of RNA extract in order to improve reliability.
Defining off-target cleavage in a pair of Zinc Finger Nucleases
University of Utah
This study looks at off-target cleavage of Zinc Finger Nucleases (ZNFs) in Drosophila in an attempt to analyze potential cleavage spots, with a view to designing more efficient ZFNs.
Gene Expression Profiling: qPCR Toolkit for Quality Control
TATAA Biocenter
TATAA Biocenter explain how they developedand optimized high-throughput gene expression qPCR with ValidPrime quality control, compensating for inter-run variations.
Cytotoxicity Screen of Mangiferin and its Major Metabolite Norathyriol in Human Tumor Cell Lines
DKFZ
Many natural products are available worldwide as potential chemoprotective agents against commonly occurring cancers, for example Mangiferin which has low bioavailability and is thought to be mainly available in the colon.
Polarized Cell Expansion and Heterochronic Shift in Angiosperm Spermatogenesis
UEB
This study evaluates genetic factors and common pathways in polarized cell-tip expansion.
Identification and Characterisation of Disease Resistance Pathway Genes in Jute (Corchorus spp.)
Plant Molecular Biology Laboratory, University of Dhaka, Bangladesh
Study aims include identification and characterisation of all NBS containing genes in jute using degenerate primers designed from the conserved NBS domain, by using two species of jute; susceptible and wild type resistant varieties.
Effect of Liquid Handling Quality Control on Biological Assay Performance
Biomanufacturing Training and Education Center
High quality assays are required in order to take forward potential drugs, post screening. Therefore the liquid handling must be accurate and precise, as demonstrated in this experiment.
Why Is My Assay Failing? An Approach to Assay Equipment Optimization
Artel
Assays can produce unexpected or failing results for a multitude of reasons. Variability may be introduced at any point within the assay process.
An Automated, Cell-based Platform for the Rapid Detection of Novel Androgen Receptor Modulators
BioTek Instruments
The Androgen Receptor (AR) is a member of the family of nuclear receptors responsive to steroid hormones. This poster aims to devise, validate and perform a preliminary automated HTS screening campaign to identify novel modulators of AR activity.
Automated Solutions for Cellular Screening and Characterization of Therapeutic Antibodies for Antibody-Dependent Cellular Cytotoxicity Utility
BioTek Instruments
Since the end of the 1990’s, the pharmaceutical industry has seen an increased interest in biologics, especially in the therapeutic areas of oncology and inflammation. Here we present the automation of two assays for the characterization and selection of potent antibody drug candidates. Both assays rely on HTRF® detection. The first assay quantifies the binding affinity of antibodies to their target antigen, on live cells.
Automation of a Generic Fluorescent Methyltransferase Activity Assay
BioTek Instruments
The primary function of this application note is to demonstrate automated methods for a HTS-ready universal methyltransferase activity assay.
Performance Qualification of an Automated Plate Washer Using the Artel MVS®
Artel
The purpose of this application note is to demonstrate the ability of the MVS® Multichannel Verification System to test the performance of an automated plate washer. The previously written application notes, Using the MVS to Measure Residual Volumes Remaining in a Plate After Sample Aspiration: General Approach1 will be cited within as these unique applications relate to this discussion involving tests for (1) bulk dispense precision and accuracy and (2) volume evacuation efficiency.
Using the MVS to Measure Residual Volumes Remaining in a Plate After Sample Aspiration: General Approach
Artel
The purpose of this application note is to demonstrate an alternative use for the Artel MVS® Multichannel Verification System. As opposed to measuring the accuracy and precision for a volume transfer of sample into a microtiter plate, the MVS is instead used to measure resididual liquid after sample is aspirated out of each well.
Artel MVS as a Tool For Measuring Liquid Mixing Efficacy in Microplates
Artel
This application note describes how the ARTEL MVS® Multichannel Verification System can be used as a tool for measuring the efficacy of liquid mixing protocols.
Evaluation of Forward and Reverse Mode Liquid Handling Techniques Using the ARTEL MVS®
Artel
This study illustrates the use of the Artel MVS® Multichannel Verification System to rapidly evaluate the accuracy and precision of dispensed volumes from the Caliper RapidPlate liquid handler.
Dual-Glo Luciferase Reporter-Gene Assay on the SpectraMax M5, LMax II384 and Analyst GT Microplate Readers
Molecular Devices
Reporter-gene assays are used to study eukaryotic gene expression. Dual genetic reporters are commonly used in transient transfections of cultured cells to minimize experimental variability. Recently, Promega introduced a Dual-Glo Lucoferase assay system which replaced the outdated ‘flash’ assays used previously. Ensuring both genetic reporters have different substrate requirements enables them to be detected using a single reaction mixture.
Sequence-Specific DNA Assay
Molecular Devices
The Threshold® system from Molecular Devices, together with the Immuno Ligand Assay (ILA) kit can be used to measure specific DNA sequences. Biotinylated or fluorescienated oligonucleotide probes, specific to the target sequence, anneal to the digested target DNA creating a probe-target hybrid which can then be detected and quantified against a standard curve, with pleasing results.
Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers
Molecular Devices
The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.
Overcoming the Challenge of Reliable Multi-way Fluidic Connections
Dolomite
If you are struggling to create fast and reliable microfluidic connections, Multiflux™ may be the solution you are looking for.
DNA Measurements in Low Volume Samples, Microplates and Cuvettes on the SPECTROstar Nano
BMG LabTech
This application note details how the SPECTROstar Nano absorbance reader measures nucleotides such as DNA in microplates, cuvettes and low volume samples with the BMG LABTECH’s LVis Plate.
BioTek Instruments
The primary function of this application note is to demonstrate automated methods for a HTS-ready universal methyltransferase activity assay.
Performance Qualification of an Automated Plate Washer Using the Artel MVS®
Artel
The purpose of this application note is to demonstrate the ability of the MVS® Multichannel Verification System to test the performance of an automated plate washer. The previously written application notes, Using the MVS to Measure Residual Volumes Remaining in a Plate After Sample Aspiration: General Approach1 will be cited within as these unique applications relate to this discussion involving tests for (1) bulk dispense precision and accuracy and (2) volume evacuation efficiency.
Using the MVS to Measure Residual Volumes Remaining in a Plate After Sample Aspiration: General Approach
Artel
The purpose of this application note is to demonstrate an alternative use for the Artel MVS® Multichannel Verification System. As opposed to measuring the accuracy and precision for a volume transfer of sample into a microtiter plate, the MVS is instead used to measure resididual liquid after sample is aspirated out of each well.
Artel MVS as a Tool For Measuring Liquid Mixing Efficacy in Microplates
Artel
This application note describes how the ARTEL MVS® Multichannel Verification System can be used as a tool for measuring the efficacy of liquid mixing protocols.
Evaluation of Forward and Reverse Mode Liquid Handling Techniques Using the ARTEL MVS®
Artel
This study illustrates the use of the Artel MVS® Multichannel Verification System to rapidly evaluate the accuracy and precision of dispensed volumes from the Caliper RapidPlate liquid handler.
Dual-Glo Luciferase Reporter-Gene Assay on the SpectraMax M5, LMax II384 and Analyst GT Microplate Readers
Molecular Devices
Reporter-gene assays are used to study eukaryotic gene expression. Dual genetic reporters are commonly used in transient transfections of cultured cells to minimize experimental variability. Recently, Promega introduced a Dual-Glo Lucoferase assay system which replaced the outdated ‘flash’ assays used previously. Ensuring both genetic reporters have different substrate requirements enables them to be detected using a single reaction mixture.
Sequence-Specific DNA Assay
Molecular Devices
The Threshold® system from Molecular Devices, together with the Immuno Ligand Assay (ILA) kit can be used to measure specific DNA sequences. Biotinylated or fluorescienated oligonucleotide probes, specific to the target sequence, anneal to the digested target DNA creating a probe-target hybrid which can then be detected and quantified against a standard curve, with pleasing results.
Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers
Molecular Devices
The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.
Overcoming the Challenge of Reliable Multi-way Fluidic Connections
Dolomite
If you are struggling to create fast and reliable microfluidic connections, Multiflux™ may be the solution you are looking for.
DNA Measurements in Low Volume Samples, Microplates and Cuvettes on the SPECTROstar Nano
BMG LabTech
This application note details how the SPECTROstar Nano absorbance reader measures nucleotides such as DNA in microplates, cuvettes and low volume samples with the BMG LABTECH’s LVis Plate.
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