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Wednesday, January 28, 2015
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Webcasts
No image is availableNovel Technologies for Studying Functional Genomics at the Level of Single Cells
David Galbraith, University of Arizona, speaking at Advances in Plant Genomics 2014
Webcasts - Applying the Reference Genome to Cotton ImprovementApplying the Reference Genome to Cotton Improvement
Andrew Paterson, University of Georgia, speaking at Advances in Plant Genomics 2014

Market Reports
Analytical Instrument Market in the US 2014-2018
Infinity Research

TechNavio's report focuses on the US and has been prepared based on an in-depth market analysis with inputs from industry experts.
Epigenetic Modification Screening Trends 2014
HTStec

This market report summarizes the results of HTStec’s 3nd industry-wide global web-based benchmarking survey on epigenetic modification screening carried out in May 2014.
Multi-Channel Pipettor QC Trends 2014
HTStec

Multi-channel pipettors are essential tools in most life science laboratories today. Yet the impact of undertaking quality control (QC) measures on improving data quality, enhancing productivity/efficiency and reducing experimental failures has only relatively recently been recognized. Understanding how lab users approach the issue of pipettor QC is important as the industry struggles to adopt standards for automated pipetting.
Stem Cell Research
Stem Cell Research

This report on Stem Cell Research gives a market insight into the ever progressing and debatable market of Stem Cell Research segmented by type, technology and therapeutic area.
Security Technologies in Biotechnology
RI Technologies

The report serves as a guide to security technology industry for biotechnology applications, covering more than 350 companies that are engaged in security technology/products and services.
DNA Sequencing
RI Technologies

This report presents an in depth analysis of DNA sequencing market. The study emphasizes on both, the methods and instruments/software of DNA sequencing in medical research, agriculture and animal husbandry and DNA testing and forensics application areas.
Multi-Mode Microplate Reader Trends 2013
HTStec

This market report summarizes the results of HTStec’s 4th industry-wide global web-based benchmarking survey on multi-mode microplate readers carried out in September 2013.
Bioinformatics
RI Technologies

This report gives a market insight into products and services used in the bioinformatics industry. The market is analyzed by product and applications; Database, Software and Hardware form the product categories, finding applications in Genomics, Proteomics, Metabolomics, and other (Drug Discovery, Cheminformatics, and Pharmacogenomics).
Biomarkers
RI Technologies

This report on focuses on the different types of biomarkers and their impact on various disease areas. The study also provides global market analysis for biomarkers by disease area and by prominent biomarker identification technologies.
Big Data Market in India 2013
Netscribes

The report highlights the current as well as the future big data market scenario in India. The report furnishes explicit details on the crucial aspects of the overall market to provide a holistic view, with the aide of crisp and insightful representation of market data.
Scientific News
Gene Changes That Affect Brain Size Identified
The identity of eight common mutations may one day reveal more about Alzheimer’s, autism and other neurological disorders.
Major Study Links Gene to Drug Resistance in Testicular Cancer
Researchers used a genetic technique called whole-exome sequencing to examine tumour samples.
New 'Systems Genetics' Study Identifies Possible Target For Epilepsy Treatment
A single gene that coordinates a network of about 400 genes involved in epilepsy could be a target for new treatments, according to research.
First Major Analysis Of Human Protein Atlas Published
A research article published in Science presents the first major analysis based on the Human Protein Atlas, including a detailed picture of the proteins that are linked to cancer, the number of proteins present in the bloodstream, and the targets for all approved drugs on the market.
New Blood Test For Aggressive Bone Cancer
Researchers at the University of East Anglia are developing a simple blood test to diagnose bone cancer thanks to funding from the Big C.
NIH Researchers Tackle Thorny Side of Gene Therapy
Pre-clinical studies in mice reveal ways to reduce cancer risk with modified treatment.
Tumor Suppressor Protein Plays Key Role In Maintaining Immune Balance
St. Jude Children’s Research Hospital scientists show that the PTEN tumor suppressor protein is essential for proper regulatory T cell function; discovery offers new focus for improving treatment of autoimmune diseases.
A Combination Of Genes Results In Malaria Drug Resistance
The largest genome-wide study of the malaria parasite finds that the drug resistance occurs because of a key mutation happening on top of 'background' mutations which make the parasite more likely to develop drug resistance later.
Insights Into A Rare Genetic Disease
Study shows mutation in NGLY1 gene is linked to a genetic disorder with severe consequences.
Hidden Cell Types Revealed
New statistical method for RNA-seq analysis identifies, corrects for hidden structure between cells.
Business News
Featured Article
Wyss Institute Videos Now on LabTube
The Wyss Institute for Biologically Inspired Engineering has created a channel on Labtube.

Aprea Granted European Orphan Drug Designation for APR-246 in Ovarian Cancer
Company is currently conducting a Phase Ib/II trial of APR-246.
Cypher Genomics And Sequenom Announce Development Agreement
Sequenom to apply Cypher's Mantis technology for advanced genome interpretation in NIPT.
RainDance Technologies Appoints Scott Bortner Vice President of Intellectual Property
Pioneer in droplet-based genetic analysis IP committed to expanding its foundational patent portfolio to advance novel liquid biopsy applications.
New Oncology and University Hospital Oslo Announce Genomic Profiling Collaboration
Collaboration to identify alterations in cancer-related tumour genes.
Trovagene, Genomac Expand Colorectal Cancer Collaboration
Prospective clinical studies to evaluate Trovagene's Precision Cancer Monitoring platform to determine the emergence of resistance mutations using circulating tumor DNA.
Abcam Acquires Firefly BioWorks
Acquisition will expand Abcam’s capabilities in multiplex analysis.
Awards for Bio-Rad's Protein Expression Products and Genomic Workflow Solutions
BioInformatics LLC has recognized Bio-Rad with two prestigious Life Science Industry Awards for “Best Protein Expression & Analysis Products” and “Best Workflow Solutions — Genomics.”
Horizon Discovery Group plc Trading Update
Revenues expected to be ahead of consensus by approximately 7% driven by an increased global demand for expanded product, service and IP offering.
Prof. Dr. Helga Rübsamen-Schaeff and Joerg von Petrikowsky Join 4SC AG
Prof. Dr. Rübsamen-Schaeff and Mr. von Petrikowsky will replace the Supervisory Board members Dr. Thomas Werner and Klaus Kühn.

Events
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28 Jan 2015
Sony DADC, SCIENION & Invetech ...
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07 Feb 2015
SLAS2015 ...
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22 Feb 2015
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08 Mar 2015
Pittcon 2015 ...
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ePosters
Automated detection and control of controlled substances
Scitegrity Limited

Scitegrity, in conjunction with the Pistoia Alliance and a number of pharmaceutical companies, have developed Controlled Substances Squared to scan large chemical libraries (millions of compounds) and determine whether a compound is considered as controlled in a selected country.
Population characterization of Brazilian isolates of Ceratocystis spp. using microsatellites
1Faculdade de ciências agronômicas, UNESP Botucatu, SP. Brazil   2Forestry and Agricultural Biotechnology Institute (FABI), Private Bag X20, University of Pretoria, Pretoria, 0028, South Africa

The genus Ceratocystis includes several species of economically important plant pathogens and has a global distribution. In Brazil, species in the genus cause disease and death of hosts such as cacao, eucalypts and mango. This study aimed to characterize the population structure and diversity of isolates of Ceratocystis fimbriata sensu lato collected from diseased Eucalyptus species and to compare these to isolates from cacao, mango, teak, fig, rubber and atemoya.
Identifying marker-trait associations for Fiber Components in Sugarcane with Simple Sequence Repeat Markers
1 Institute of Biosciences, Department of Genetics , University of São Paulo state “Júlio de Mesquita Filho”, Brazil; 2 CTC- Center of Sugarcane Technology, Brazil; 3 Texas A&M Agrilife Research,

Identifying marker-trait associations for Fiber Components in Sugarcane with Simple Sequence Repeat Markers.

TFAP2B is Associated with WNT/ß-catenin Pathway in Luminal Breast Cancer
1. Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Germany 2. Department of Clinical Chemistry, University Medical Center Hamburg-Eppendorf, Germany 3. Department of Clinica

Here we aimed to investigate which molecular mechanisms are associated with TFAP2B expression in luminal breast cancer.
Transcription Factors to Classify Tumor Types and Subtypes
1. Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Germany 2. Department of Clinical Chemistry, University Medical Center Hamburg-Eppendorf, Germany 3. Department of Clinica

Here we introduce the use of the unsupervised approach to identify transcription factors (TFs) that are specific for different tumor types.
Expression Profiling of Circulating Tumor Cells: a Prognostic and Predictive Biomarker in Cancer.
Bauer4.1TATAA Biocenter, Göteborg, Sweden (www.tataa.com); 2Inst. of Biotechnology, CAS, Czech Republic; 3AdnaGen GmbH, Ostpassage7, D-30853 Langenhagen, Germany (www.adnagen.com); 4Dep of Gynecoland

We show non-responders to treatment among breast cancer patients can be identified by expression profiling of circulating tumor cells
LC-MS/MS METHOD FOR THE QUANTIFICATION OF PITOFENONE IN HUMAN PLASMA
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS University, Mysore – 570 015, Karnataka, India

We developed LCMS/MS bioanalytical method for quantitative estimation of Pitofenone HCl in plasma is simple, sensitive, accurate, precise, and selective. Percentage recovery shows that the method is free from interference of matrix. The analytical method presented here has proved to be useful for investigation of the characteristics of Pitofenone in human plasma in pharmacokinetic and pharmacogenetic studies.
Experimental Evolution in Diatoms - Thermal longterm acclimation in two model diatom species
1 University of East Anglia, School of Environmental Science, Norwich, UK 2Institute of Evolutionary Biology, University of Edinburgh, Kings Building, Ashworth Laboratories, West

Experimental Evolution in two model Diatoms
Antioxidant and Free Radicals Scavenging Activity of Biomolecules: Hydroxamic Acids
School of Study in Chemistry, Pt. Ravishankar Shukla University, Raipur-492010, Chhattisgarh, India

In the present poster attention is focused towards the investigation of antioxidant and free radicals scavenging activity of N-aryl substituted hydroxamic acids by DPPH method which is based on the reduction of alcoholic DPPH solutions in presence of a hydrogen donating antioxidant, hydroxamic acids.
"In-vitro studies on hydroxamic acid- CT DNA binding"
Research Scholar

In vitro studies of five the interaction between five different derivatives of hydroxamic acids, N-phenyl 2,4dichloro phenoxybutyro, N-m-tolyl 2,4 dichlorophenoxyglutero, N-m-tolyl-4-chlorophenoxyaceto, N-m-chloro-phenyl-tertiarybutylbenzo and N-p-tolyl-iso-valero hydroxamic acids and calf thymus DNA was investigated under simulated physiological condition.
Application Notes
Approaching Single-Cell Sequencing by Understanding NGS Library Complexity and Bias
Swift Biosciences Inc

This application note describes the sequence coverage performance andp reservation of molecular complexity of next generation sequencing (NGS) libraries generated from human and microbial genomic DNA using the Accel-NGS™ 2S DNA Library Kit for whole-genome sequencing (WGS) on the Illumina® platform.
Automated Illumina TruSeq® Nano DNA Sample Preparation
Tecan Group Ltd.

The TruSeq Nano DNA Sample Preparation Kit enables efficient investigation of samples where the amount of DNA available is limited. This low-input method generates excellent quality data from as little at 100 ng of DNA, allowing the study of samples with restricted DNA availability, for example from tumors, and helping to preserve precious sample material for use in future studies.
Double stranded DNA quantitation using Promega QuantiFluor® Dyes
Tecan Group Ltd.

Achieving selective and sensitive quantitation of double stranded DNA (dsDNA) using spectrophotometric methods can be problematic. Recognizing these difficulties, researchers have incorporated fluorescence-based quantitation techniques in their workflows to obtain the required sensitivity and target selectivity.
Simple sample preparation for the determination of vitamin D in serum by LC-MSMS
Tecan Group Ltd.

A growing number of laboratories have moved from the use of immunoassay methods to liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) for the determination of vitamin D. The advantage of the latter method is unparalleled specificity combined with high sensitivity, offering the potential for the determination of multiple analytes, such as 25OH-vitamin D3 and 25OH-vitamin D2.
Automated Sample Preparation of 25-OH-Vitamin D3/D2 from Serum with the AC Extraction Plate and the Tecan Freedom EVO® for the quantification by LC-MS/MS
Tecan Group Ltd.

There is an increasing demand for the determination of Vitamin D status which is based on the quantification of the two metabolites 25-OH-Vitamin D3/D2. Numerous laboratories have moved from the use of immunoassay methods to liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) because of its specificity combined with high sensitivity. Moreover LC-MS/MS offers the potential for multianalyte determination which is required for Vitamin D status determination.
Automated sample preparation for the determination of testosterone in serum by LC-MSMS
Tecan Group Ltd.

For accurate, reproducible quantification of testosterone, a growing number of laboratories are shifting from immunoassay to liquid chromatography coupled with tandem mass spectrometry. This application note describes the preparation of serum samples for subsequent LC-MS analysis of testosterone, focusing on a streamlined workflow suitable for automation.
3D Cell Culture: mimicking real tissue
Tecan Group Ltd.

Technological advances in the last couple of years have enabled 3D scaffolds to be engineered that offer a real proxy for the in vivo environment which can be easily and routinely used in a cell culture laboratory. Alvetex Scaffold enables cells to develop natural, in vivo-like intercellular interactions, providing an ideal environment for real three-dimensional growth and nutrient exchange that is comparable to intra-capillary exchange in living tissues.
Colony Picking - fully automated screening of fungi
Tecan Group Ltd.

Manual screening processes are very costly and time consuming. This ambitious project for high throughput screening (HTS) of cellulase-producing fungal strains demonstrates the high capacity and unique features of the Freedom EVO colony picking workstation. The picking of fungi is more complex than for typical bacterial colonies, and requires advanced selection criteria to be combined with complex pipetting and a tip movement that mimics the manual picking process.
Automating ELISAs on Tecan’s Freedom EVO® using Optimiser™ technology from Siloam Biosciences
Tecan Group Ltd.

One of the challenges in life sciences research today is to discover methods for running key assays more quickly, more reliably and using lower volumes of reagents and sample, but still with improved sensitivity. One area where this particularly holds true is for traditional enzyme-linked immunosorbent assays (ELISAs), whose application provides a useful measurement of antigens, including cytokines and a host of other biomarkers.
Molecular indexing for improved RNA-Seq analysis
Bioo Scientific

Most modern methods for nucleic acid analysis require the use of enzyme processing, such as DNA polymerase reactions, in the sample preparation or measurement steps. Although necessary, these enzymatic steps introduce errors in the form of incorrect sequence and misrepresented copy number. NEXTflex™ qRNA-Seq™ Kit from Bioo Scientific adds no additional steps to the work flow, costs no more than a conventional library preparation kit and increases the precision of downstream analysis.
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