Genomic Sequencing in Clinical Trials
In this article, researchers from Northwestern University Feinberg review the current and future directions of clinical research with respect to genomic sequencing.

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Foundation Medicine and Dana-Farber Cancer Institute Identify Novel Genomic Alterations in Lung and Colorectal Cancer
Findings highlight clinical application of next-generation sequencing to suggest targeted therapeutic options for patients.

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Transformational Fruit Fly Genome Catalog Completed
Scientists now have a reference manual that should speed gene discoveries in everything from pest control to personalized medicine.

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Animal Cell Therapies Announces Cell Inventory Value at $6 Million
The evaluation demonstrates the importance of this first step in the company's mission to improve and extend the lives of dogs through innovative stem cell products and services.

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Diffusion Pharmaceuticals Begins Clinical Trial for Treatment of Primary Brain Cancer
Company announced clinical trial testing of its lead drug candidate trans sodium crocetinate (TSC) as a first-line treatment for newly diagnosed primary brain cancer, also known as glioblastoma or GBM.

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Drug Halts Organ Damage in Inflammatory Genetic Disorder
NIH study shows benefits of long-term Kineret therapy in people with NOMID.

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Syndax Pharmaceuticals Announces Entinostat Enhanced Activity of Cancer Immunotherapies
Data highlights novel immunomodulatory effects of entinostat in renal and prostate cancer models.

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Hunting Could Hurt Genetic Diversity of Sandhill Cranes, UW Research Suggests
Research uses DNA fingerprinting to assess the genetic makeup of cranes.

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Results From Phase I Clinical Trials Demonstrate Positive Safety Data of AVI BioPharma's RNA-Based Therapeutics
AVI BioPharma, Inc. have announced positive safety results from all six dose cohorts in the single ascending dose studies of AVI-6002 and AVI-6003, AVI's lead drug candidates being evaluated for the treatment of Ebola virus and Marburg virus, respectively.

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Compugen Cancer Target Results Demonstrate Significant Potential for Cancer Immunotherapy
Findings support CGEN-15001T's potential as a powerful drug target for cancer immunotherapy.

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OGT Signs Licensing Deal for Colorectal Cancer Biomarkers
OGT has entered into an exclusive licensing agreement with Inven2.

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Expression Analysis Announces RNA-SEQ Grant Program
EA teams with Golden Helix and Illumina to offer three fully-funded grants for RNA-Seq studies.

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Debiopharm and Curis Announce Initiation of Phase Ib Expansion Study of Debio 0932
Company expects to initiate a combination Phase I/II study in NSCLC patients in the second quarter of 2012.

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PRECOS to Unveil New Service Portfolio at Cancer Targets & Therapeutics and AACR 2012
2012 conference examines new and emerging targets and therapeutics in the area of cancer research.

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PRECOS Appoints Dr Martin Page as Scientific Consultant
Appointment reinforces the ambition of PRECOS to contribute to the growing cancer therapy market.

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New England Biolabs Introduces NEBNext® Oligo Modules
Modules enable the construction of singleplex or multiplex high yield libraries for DNA, ChIP-Seq or mRNA sequencing on Illumina® instruments. NEBNext Oligo Modules contain a novel adaptor that ligates efficiently to end-repaired, dA-tailed DNA.

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Dolomite and GigaGen Collaborate to Develop Novel Droplet Merging Technology
Development of a novel Droplet Merger Chip for massively parallel single cell genetic analysis.

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American Clinical Laboratory Association Welcomes Pathway Genomics as New Member
ACLA was created in 1971 and is committed to promoting public awareness about the value of laboratory services in preventing illness, diagnosing disease, and monitoring medical treatment.

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Moffitt, Sanford-Burnham and Florida Hospital Create Personalized Medicine Partnership
The partnership will conduct collaborative research to accelerate discovery and to develop new treatments in the areas of cancer and metabolic diseases.

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BD Diagnostics Expands Portfolio with Automated Instrumentation Technologies
Company announced the expansion of its microbiology portfolio to include new automated instrumentation technologies that will enable the Company to offer innovative total lab automation solutions to hospitals and laboratories worldwide.

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An Automated, Cell-based Platform for the Rapid Detection of Novel Androgen Receptor Modulators
BioTek Instruments

The Androgen Receptor (AR) is a member of the family of nuclear receptors responsive to steroid hormones. This poster aims to devise, validate and perform a preliminary automated HTS screening campaign to identify novel modulators of AR activity.

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Automated Solutions for Cellular Screening and Characterization of Therapeutic Antibodies for Antibody-Dependent Cellular Cytotoxicity Utility
BioTek Instruments

Since the end of the 1990’s, the pharmaceutical industry has seen an increased interest in biologics, especially in the therapeutic areas of oncology and inflammation. Here we present the automation of two assays for the characterization and selection of potent antibody drug candidates. Both assays rely on HTRF® detection. The first assay quantifies the binding affinity of antibodies to their target antigen, on live cells.

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Automation of a Generic Fluorescence Methyltransferase Activity Assay
BioTek Instruments

Epigenetic processes are attracting considerable attention in drug discovery as their fundamental roles in controlling normal cell development and contributions to disease states become more clearly defined. This work combines a fluorescence-based assay with liquid handling and dispensing instrumentation and a multi-mode reader which can be used to monitor the biological activity of the histone methyltransferase (HMT) G9a, a model system.

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Automation of a Novel Cell-Based ELISA for Cell Signaling Pathway Analysis
BioTek Instruments

Monitoring and quantifying cell signaling pathways is critical for understanding the behavior of cell processes and many disease states. Monitoring and quantifying cell signaling pathways is critical for understanding the behavior of cell processes and many disease states.

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Efficacy of Using a Combination Microplate Washer for Vacuum-Based DNA Sequencing Reaction Cleanup
BioTek Instruments

The ability to determine the specific pattern of base pairs in DNA molecules is an indispensable part of contemporary molecular biology. This poster demonstrates how the vacuum filtration module available on the BioTek 405 Touch effectively cleans contaminating artifacts from DNA sequencing reactions, which wil contribute to the genomic workflow typical of many molecular biology laboratories and core facilities.

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Improving Cell-Mediated Cytotoxicity Assessment through the Use of an Automated Luminescent ADCC Assay
BioTek Instruments

Assays that can assess the ability of a biosimilar to act in a manner similar to the original biologic have seen increased interest. This poster describes the use of a non-radioactive luminescent chemistry to simplify the assay process and provide improved data quality.

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Expression of Pluripotency-determining Factors in in vitro Fertilized Buffalo Embryos and Embryonic Stem Cells
Animal Biotechnology Centre, NDRI

The POU octamer-binding domain transcription factor Oct-4, Stage-specific embryonic antigens (SSEAs), and Tumor rejection antigens (TRAs), are developmentally regulated during early embryogenesis.

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In Silico Identification of Conserved Domains from EST Database in Safflower
Directorate of Oilseeds Researh, Hyderabad

Identified conserved domains or gene families from the ESTs could be utilised for the identification of gene-targeted markers and for development of functional markers to accelerate marker assisted backcross breeding in safflower.

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UBS109, a novel curcumin analogue, promotes apoptosis in Head and Neck cancer cells through activating death receptor signaling pathway
Emory Chemical Biology Discovery Center

UBS109, a new curcumin analogue, exhibited a potent anticancer activity, inhibiting colony formation and cancer cell growth in vitro, and tumor growth in a xenograft animal model in vivo. 2. UBS109 rapidly blocks the NF-?B signaling pathway through the

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Visualizing the Dynamic Epigenome
1 Junior Professorship for Computational EvoDevo, Department for Computer Science, University of Leipzig, Germany; 2 Interdisciplinary Center for Bioinformatics, University of Leipzig, Germany

A method is presented to visualize genome-wide information from epigenetic data. It is capable to integrate additional information. Applied to mouse data consisting of H3K4, H3K27, and H3K9 trimethylation for 3 different celltypes, the dynamic behavior and interplay was investigated.

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Performance Qualification of an Automated Plate Washer Using the Artel MVS®
Artel

The purpose of this application note is to demonstrate the ability of the MVS® Multichannel Verification System to test the performance of an automated plate washer. The previously written application notes, Using the MVS to Measure Residual Volumes Remaining in a Plate After Sample Aspiration: General Approach1 will be cited within as these unique applications relate to this discussion involving tests for (1) bulk dispense precision and accuracy and (2) volume evacuation efficiency.

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Using the MVS to Measure Residual Volumes Remaining in a Plate After Sample Aspiration: General Approach
Artel

The purpose of this application note is to demonstrate an alternative use for the Artel MVS® Multichannel Verification System. As opposed to measuring the accuracy and precision for a volume transfer of sample into a microtiter plate, the MVS is instead used to measure resididual liquid after sample is aspirated out of each well.

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Artel MVS as a Tool For Measuring Liquid Mixing Efficacy in Microplates
Artel

This application note describes how the ARTEL MVS® Multichannel Verification System can be used as a tool for measuring the efficacy of liquid mixing protocols.

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Evaluation of Forward and Reverse Mode Liquid Handling Techniques Using the ARTEL MVS®
Artel

This study illustrates the use of the Artel MVS® Multichannel Verification System to rapidly evaluate the accuracy and precision of dispensed volumes from the Caliper RapidPlate liquid handler.

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Dual-Glo Luciferase Reporter-Gene Assay on the SpectraMax M5, LMax II384 and Analyst GT Microplate Readers
Molecular Devices

Reporter-gene assays are used to study eukaryotic gene expression. Dual genetic reporters are commonly used in transient transfections of cultured cells to minimize experimental variability. Recently, Promega introduced a Dual-Glo Lucoferase assay system which replaced the outdated ‘flash’ assays used previously. Ensuring both genetic reporters have different substrate requirements enables them to be detected using a single reaction mixture.

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Sequence-Specific DNA Assay
Molecular Devices

The Threshold® system from Molecular Devices, together with the Immuno Ligand Assay (ILA) kit can be used to measure specific DNA sequences. Biotinylated or fluorescienated oligonucleotide probes, specific to the target sequence, anneal to the digested target DNA creating a probe-target hybrid which can then be detected and quantified against a standard curve, with pleasing results.

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Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers
Molecular Devices

The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.

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Overcoming the Challenge of Reliable Multi-way Fluidic Connections
Dolomite

If you are struggling to create fast and reliable microfluidic connections, Multiflux™ may be the solution you are looking for.

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DNA Measurements in Low Volume Samples, Microplates and Cuvettes on the SPECTROstar Nano
BMG LabTech

This application note details how the SPECTROstar Nano absorbance reader measures nucleotides such as DNA in microplates, cuvettes and low volume samples with the BMG LABTECH’s LVis Plate.

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Application of the Amplifluor® SNPs Genotyping System using a FLUOstar OPTIMA Microplate Reader
BMG Labtech

The detection of SNPs (single nucleotide polymorphisms) is an important tool for researchers in order to find mutations in DNA sequences. In this application note we describe a homogeneous fluorescence assay based on PCR. The Amplifluor® SNPs HT Genotyping System from Millipore was used to screen a number of samples with the help of the FLUOstar OPTIMA multidetection microplate reader from BMG LABTECH.

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