Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Castor Bean Genome Published by Research Team Including Scientists from the Venter Institute

Published: Wednesday, August 25, 2010
Last Updated: Wednesday, August 25, 2010
Bookmark and Share
A research team published the sequence and analysis of the castor bean genome in Nature Biotechnology.

A research team co-led by scientists from the J. Craig Venter Institute (JCVI) and the Institute for Genome Sciences (IGS), University of Maryland School of Medicine, published the sequence and analysis of the castor bean (Ricinus communis) genome in Nature Biotechnology.

Agnes P. Chan, Ph.D., JCVI, and Jonathan Crabtree, Ph.D., IGS were co-lead authors on the paper describing the 4.5X coverage of this important oilseed crop. The availability of the castor bean genome also has important biodefense implications since the plant produces the powerful toxin, ricin.

The castor bean, a tropical perennial shrub found in Africa and other tropical and subtropical regions in the world, is a member of the Euphorbiaceae family. There are approximately 6,300 species in this family that includes the cassava, rubber tree, ornamental poinsettias and jatropha. While the castor bean genome is the first to be sequenced and published from this family, the jatropha genome has been sequenced by JCVI and the company Synthetic Genomics Inc. Jatropha is also an oilseed crop.

The sequencing of the castor bean genome to 4.5 X coverage was conducted at JCVI. The results of this work show that the genome is 350 Mb and has an estimated 31,237 genes. Because of the potential use of castor bean as a biofuel and its production of the potent toxin ricin, the team focused efforts on genes related to oil and ricin production. They analyzed important metabolic pathways and regulatory genes involved in the production and storage of oils in the castor bean. The analyses could be important for comparative studies with other oilseed crops, and could also allow for genetic engineering of castor bean to produce oil without ricin.

Identifying and understanding the ricin-producing gene family in castor bean will be important in preventing and dealing with potential bioterrorism events. Genomics enables enhanced diagnostic and forensic methods for the detection of ricin and precise identification of strains and geographical origins.

The team discovered that the ricin gene family was larger than previously thought, and they revealed approximately 28 genes in the ricin producing family. As a next step, the group suggest further comparative genomic studies with the close relative cassava, a major crop in the developing world, to further elucidate their disease resistance aspects.

Dr. Chan stated, "The availability of the castor bean genome will encourage more research into the positive aspects of this oilseed crop as a potential biofuel. Further study will also elucidate many aspects about ricin and enable researchers to potentially eliminate the bioterrorism threat of this natural toxin."


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

JCVI Awarded 5 Year, Approximately $25 Million NIH Grant to Establish GCID
Center will utilize next generation genomic sequencing and analysis technologies to better understand infectious disease pathogens, and create resource for the research community.
Saturday, June 07, 2014
137 Marine Microbial Genomes from Cultured Samples are Sequenced
Research gives clearer picture of inhabitants living in ocean surface and gleans insights into how they adapt and survive.
Thursday, November 18, 2010
Venter Institute Scientists Sequence 178 Microbial Reference Genomes Associated with the Human Body
Consortium members of the NIH's Human Microbiome project finds greater microbial diversity in human microbiome than previously known.
Friday, May 28, 2010
JCVI Researchers Clone and Engineer Bacterial Genomes in Yeast and Transplant Genomes Back into Bacterial Cells
New methods allow for engineering of bacterial chromosomes and the creation of modified bacterial species; should also play key role in boot up of synthetic cell.
Friday, August 21, 2009
J. Craig Venter Institute Researchers Publish Significant Advance in Genome Assembly Technology
Researchers publish paper describing a significant advance in genome assembly in which the team can now assemble the whole bacterial genome in one step.
Monday, December 08, 2008
First Individual Diploid Human Genome Published by Researchers at J. Craig Venter Institute
Sequence reveals that human to human variation is substantially greater than earlier estimates.
Thursday, September 06, 2007
JCVI Scientists Publish First Bacterial Genome Transplantation Changing One Species to Another
Research is important step in further advancing field of synthetic genomics
Thursday, June 28, 2007
J. Craig Venter Institute Announces Management Team and Organizational Structure
The Institute will no longer be organized under the two research divisions TIGR and TCAG, but will now encompass an administrative team and several research groups.
Friday, April 13, 2007
CEO of a Newly Expanded J. Craig Venter Institute to Speak at SEQNSYNTECH
Craig Venter became president and CEO of a newly expanded J. Craig Venter Institute after it absorbed the Institute for Genomic Research and the J. Craig Venter Science Foundation.
Monday, October 16, 2006
Scientific News
Poor Survival Rates in Leukemia Linked to Persistent Genetic Mutations
For patients with an often-deadly form of leukemia, new research suggests that lingering cancer-related mutations – detected after initial treatment with chemotherapy – are associated with an increased risk of relapse and poor survival.
Searching Big Data Faster
Theoretical analysis could expand applications of accelerated searching in biology, other fields.
Growing Hepatitis C in the Lab
Recent discovery allows study of naturally occurring forms of hepatitis C virus (HCV) in the lab.
Inciting an Immune Attack on Cancer Cells
A new minimally invasive vaccine that combines cancer cells and immune-enhancing factors could be used clinically to launch a destructive attack on tumors.
Reprogramming Cancer Cells
Researchers on Mayo Clinic’s Florida campus have discovered a way to potentially reprogram cancer cells back to normalcy.
Genetic Overlapping in Multiple Autoimmune Diseases May Suggest Common Therapies
CHOP genomics expert leads analysis of genetic architecture, with eye on repurposing existing drugs.
Surprising Mechanism Behind Antibiotic-Resistant Bacteria Uncovered
Now, scientists at TSRI have discovered that the important human pathogen Staphylococcus aureus, develops resistance to this drug by “switching on” a previously uncharacterized set of genes.
How DNA ‘Proofreader’ Proteins Pick and Edit Their Reading Material
Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have discovered how two important proofreader proteins know where to look for errors during DNA replication and how they work together to signal the body’s repair mechanism.
Fat in the Family?
Study could lead to therapeutics that boost metabolism.
Tissue Bank Pays Dividends for Brain Cancer Research
Checking what’s in the bank – the Brisbane Breast Bank, that is – has paid dividends for UQ cancer researchers.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!