Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Sigma® Life Science Enters Genetically Modified Cell Market

Published: Monday, September 06, 2010
Last Updated: Monday, September 06, 2010
Bookmark and Share
Sigma Life Science launches range of engineered cell lines exploiting CompoZr® zinc finger nuclease technology.

Sigma Life Science, the innovative biological products and research services business of Sigma-Aldrich® Corporation announced the global release of a pioneering range of engineered mammalian cell lines. This new product range combines Sigma’s proprietary CompoZr zinc finger nuclease (ZFN) technology with the Company’s extensive experience in gene silencing, to offer innovative tools for drug discovery, compound screening and fundamental research applications.

This new range of products includes immortalized cell lines for a broad spectrum of applications, each precisely engineered to help scientists answer specific biological questions. By exploiting the revolutionary genomic editing capabilities of ZFNs, Sigma’s scientists can manufacture stable cell lines with precise, well characterized genetic manipulations.

“CompoZr ZFN technology is a significant breakthrough for cell-based research. It enables scientists to generate precisely controlled additions, deletions and modifications to the genome of a living cell,” said Dr. Supriya Shivakumar, Global Commercial Marketing Manager for Functional Genomics at Sigma Life Science. “Leveraging this innovative and powerful technology to develop ready-to-use, validated cell lines is part of Sigma’s ongoing commitment to furthering our understanding of biology.”

The program will use ZFNs to incorporate and develop cell lines with a variety of cellular markers expected to aid in compound screening studies and biochemical pathway analysis, as well as specific isogenic lines designed to advance colorectal and breast cancer research.

In addition, Sigma offers a custom cell line engineering service, creating bespoke cell lines to perfectly match a researcher’s application. “At Sigma Life Science, we have both the advanced technologies and manufacturing expertise to produce high quality, reliable tools for life science research. By offering complete modified cell lines alongside our portfolio of advanced bioediting technologies, we can provide a complete range of solutions to help accelerate our customers’ research,” Dr. Shivakumar added.

Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,200+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Sigma Life Science Collaborates with Cofactor Genomics to Develop Publically Available Rat Genome Database
Sigma Life Science announces that its SAGE Labs initiative has partnered with Cofactor Genomics in an effort to sequence genomes for six of the most widely used strains of rat. Cofactor Genomics plans to generate and analyze sequence data using next generation sequencing systems, while SAGE Labs plans to provide the samples and to host a new, free public database at in late 2011.
Thursday, February 03, 2011
Sigma® Life Science Awarded Silver in Top Ten Innovations 2010
Company’s CompoZr® cell lines ranked second as The Scientist magazine unveils this year’s best life science innovations.
Monday, December 06, 2010
Sigma® Life Science and Switchgear Genomics to Co-Develop Simplified Novel MicroRNA Target Validation System
SwitchGear Genomics and Sigma’s lentiviral technology combined to simplify miRNA target validation, enabling researchers to investigate gene regulation.
Tuesday, August 10, 2010
Sigma-Proligo Expands into Genopole® d'Evry Biopark
Sigma-Proligo provides researchers with high-quality oligonucleotides due to a high throughput synthesis platform.
Friday, October 20, 2006
Sigma-Aldrich Announces Service Provider for WGA Technology
Sigma announces MOgene as its first service provider of the GenomePlex® Whole Genome Amplification technology.
Wednesday, May 31, 2006
Sigma-Aldrich Sponsors Full-Text Article on High Content Viral Library Screens
The authors reported the creation of a lentiviral shRNA library to knock down genes for genome-wide screening.
Thursday, April 27, 2006
Sigma-Aldrich Expands Position in Whole Genome Amplification
Sigma-Aldrich enters licensing agreement to offer GenomePlex® Whole Genome Amplification kits to service providers.
Monday, February 20, 2006
Sigma-Aldrich Names Jai Nagarkatti as Chief Executive Officer
The appointment will be effective on January 1, 2006.
Wednesday, November 09, 2005
Sigma Granted Patent for REDTaq™ DNA Polymerase Product Line
REDTaq™ products are a blend of various DNA polymerases combined with an inert red dye that allows quick visual confirmation of enzyme addition and reaction homogeneity.
Friday, September 16, 2005
Sigma-Aldrich Launches Online STAIN EXPERT™ Application
A Flash Platform is designed to guide customers through a wide range of staining procedures while reducing the complexity of multi-step processes.
Thursday, September 08, 2005
Scientific News
Integrated Omics Analysis
Studying multi-omics promises to give a more holistic picture of the organism and its place in its ecosystem, however despite the complexities involved those within the field are optimistic.
Unravelling the Role of Key Genes and DNA Methylation in Blood Cell Malignancies
Researchers from the University of Nebraska Medical Center have demonstrated the role of Dnmt3a in safeguarding normal haematopoiesis.
Zika Virus Infection Alters Human and Viral RNA
Researchers have discovered that Zika infections results in human and viral genetic modification.
Agilent Presents Early Career Professor Award to Dr. Roeland Verhaak
JAX professor recognized for the development and implementation of workflows for the analysis of big-data from transcriptomics to next generation sequencing approaches.
Ovarian Cancer Insight
Study showed tumours release cytokines to attract macrophages, which secrete growth factors that in turn promote tumour growth.
Bacterial Genes Boost Current in Human Cells
Borrowing and tweaking bacterial genes to enhance electrical activity might treat heart, nervous system injury.
Less Frequent Cervical Cancer Screening
HPV-vaccinated women may only need one screening every 5 to 10 years with screening starting later in life.
Questioning the Safety of Selenium to Combat Cancer
Research indicates the need for change in practice as selenium supplements cannot be recommended for preventing colorectal cancer.
Supercomputers Could Improve Cancer Diagnostics
Researchers push the boundaries of cancer research through high-performance computing to map the human immunone.
Transgenomic, Precipio Diagnostics Merger
Merger will creates a robust diagnostic platform focused on improving accuracy of cancer diagnoses.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,200+ scientific videos