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Sigma® Life Science Awarded Silver in Top Ten Innovations 2010

Published: Monday, December 06, 2010
Last Updated: Monday, December 06, 2010
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Company’s CompoZr® cell lines ranked second as The Scientist magazine unveils this year’s best life science innovations.

Sigma Life Science, the biological products and research services business of Sigma-Aldrich® Corporation has announced that its genetically modified reporter cell lines – based on the CompoZr zinc finger nuclease (ZFN) technology – has taken the silver medal position in The Scientist magazine’s Top Ten Innovations for 2010.

This latest award continues Sigma Life Science’s track record of success in the magazine’s prestigious life science innovation competition, following third place in 2008’s inaugural awards for the CompoZr custom zinc finger nuclease service, and fifth place for SAGE™ Labs’ SAGEspeed™ rat model creation process in 2009.

This latest success recognizes the power of Sigma Life Science’s CompoZr ZFN technology for genetic manipulation, and underscores the potential of Sigma’s newly launched portfolio of genetically modified mammalian cell lines for furthering fundamental understanding of cell biology and accelerating cell-based research. The proprietary ZFN technology allows precise insertion, substitution or deletion of genes of interest.

Dave Smoller, president of Sigma Life Science, commented: “The power of ZFN technology is rapidly being recognized as the new benchmark for genetic manipulation, and Sigma Life Science is dedicated to pushing the limits of this technology while ensuring scientists have access to the research tools they need. Our ongoing success in The Scientist’s Top Ten Innovations competition demonstrates our commitment to use the CompoZr platform to deliver innovative products that will help to drive scientific discovery.”

This potent technology has been harnessed to create an exciting new range of genetically modified reporter cell lines, as well as specific isogenic lines initially designed to advance colorectal and breast cancer research. The first CompoZr cellular reporter cell lines were launched in November 2010, and have been optimized for live cell imaging applications.

Incorporating fluorescent tags at endogenous loci of the genes of interest, these new offerings avoid the additional stresses and potential toxicity issues associated with protein overexpression in live cells, as well as eliminating the need for tedious staining procedures.


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